{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:04:59Z","timestamp":1790010299840,"version":"4.0.1"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR061052"],"award-info":[{"award-number":["AR061052"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE023105"],"award-info":[{"award-number":["DE023105"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["RA210159"],"award-info":[{"award-number":["RA210159"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG048388"],"award-info":[{"award-number":["AG048388"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.molmet.2022.101630","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T13:59:38Z","timestamp":1667570378000},"page":"101630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Rb1 negatively regulates bone formation and remodeling through inhibiting transcriptional regulation of YAP in Glut1 and OPG expression and glucose metabolism in male mice"],"prefix":"10.1016","volume":"66","author":[{"given":"Yang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-6901","authenticated-orcid":false,"given":"Shuying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2022.101630_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-07316-5","article-title":"Glucose metabolism induced by Bmp signaling is essential for murine skeletal development","volume":"9","author":"Lee","year":"2018","journal-title":"Nature Communications"},{"issue":"8","key":"10.1016\/j.molmet.2022.101630_bib2","doi-asserted-by":"crossref","first-page":"11058","DOI":"10.1096\/fj.202000771R","article-title":"Both aerobic glycolysis and mitochondrial respiration are required for osteoclast differentiation","volume":"34","author":"Li","year":"2020","journal-title":"FASEB Journal"},{"key":"10.1016\/j.molmet.2022.101630_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102373","article-title":"IFT20 governs mesenchymal stem cell fate through positively regulating TGF-\u03b2-Smad2\/3-Glut1 signaling mediated glucose metabolism","volume":"54","author":"Li","year":"2022","journal-title":"Redox Biology"},{"issue":"5","key":"10.1016\/j.molmet.2022.101630_bib4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11914-015-0286-8","article-title":"Diabetes and its effect on bone and fracture healing","volume":"13","author":"Jiao","year":"2015","journal-title":"Current Osteoporosis Reports"},{"issue":"8","key":"10.1016\/j.molmet.2022.101630_bib5","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4239\/wjd.v10.i8.421","article-title":"Bone health in diabetes and prediabetes","volume":"10","author":"Costantini","year":"2019","journal-title":"World Journal of Diabetes"},{"key":"10.1016\/j.molmet.2022.101630_bib6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bone.2017.08.008","article-title":"Glucose metabolism in bone","volume":"115","author":"Karner","year":"2018","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.molmet.2022.101630_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1210\/er.2017-00064","article-title":"Energy metabolism of the osteoblast: implications for osteoporosis","volume":"38","author":"Lee","year":"2017","journal-title":"Endocrine Reviews"},{"issue":"7","key":"10.1016\/j.molmet.2022.101630_bib8","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1172\/JCI92233","article-title":"Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism","volume":"127","author":"Matsumoto","year":"2017","journal-title":"Journal of Clinical Investigation"},{"issue":"3","key":"10.1016\/j.molmet.2022.101630_bib9","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1172\/JCI97794","article-title":"Vhl deletion in osteoblasts boosts cellular glycolysis and improves global glucose metabolism","volume":"128","author":"Dirckx","year":"2018","journal-title":"Journal of Clinical Investigation"},{"issue":"7","key":"10.1016\/j.molmet.2022.101630_bib10","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.cell.2015.05.029","article-title":"Glucose uptake and Runx2 synergize to orchestrate osteoblast differentiation and bone formation","volume":"161","author":"Wei","year":"2015","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.molmet.2022.101630_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-021-00254-5","article-title":"TAZ is required for chondrogenesis and skeletal development","volume":"7","author":"Li","year":"2021","journal-title":"Cell Discovery"},{"issue":"3","key":"10.1016\/j.molmet.2022.101630_bib12","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/jcb.240560303","article-title":"Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy","volume":"56","author":"Bruder","year":"1994","journal-title":"Journal of Cellular Biochemistry"},{"issue":"4","key":"10.1016\/j.molmet.2022.101630_bib13","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/stmcls\/sxac011","article-title":"Erk5 in bone marrow mesenchymal stem cells regulates bone homeostasis by preventing osteogenesis in adulthood","volume":"40","author":"Horie","year":"2022","journal-title":"Stem Cells"},{"issue":"1069","key":"10.1016\/j.molmet.2022.101630_bib14","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/postgradmedj-2013-132387","article-title":"Mesenchymal stem cells: mechanisms and role in bone regeneration","volume":"90","author":"Qin","year":"2014","journal-title":"Postgraduate Medical Journal"},{"issue":"12","key":"10.1016\/j.molmet.2022.101630_bib15","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1172\/JCI96221","article-title":"Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation","volume":"128","author":"Lee","year":"2018","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.molmet.2022.101630_bib16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/B978-0-12-380916-2.00005-X","article-title":"RB1, development, and cancer","volume":"94","author":"Chinnam","year":"2011","journal-title":"Current Topics in Developmental Biology"},{"issue":"7310","key":"10.1016\/j.molmet.2022.101630_bib17","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/nature09264","article-title":"Rb regulates fate choice and lineage commitment in\u00a0vivo","volume":"466","author":"Calo","year":"2010","journal-title":"Nature"},{"issue":"47","key":"10.1016\/j.molmet.2022.101630_bib18","doi-asserted-by":"crossref","first-page":"18402","DOI":"10.1073\/pnas.0805925105","article-title":"Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-\/- mice","volume":"105","author":"Gutierrez","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"10.1016\/j.molmet.2022.101630_bib19","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ceb.2013.07.012","article-title":"The multiple connections between pRB and cell metabolism","volume":"25","author":"Nicolay","year":"2013","journal-title":"Current Opinion in Cell Biology"},{"key":"10.1016\/j.molmet.2022.101630_bib20","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.2019.33.1_supplement.652.4","article-title":"Loss of the retinoblastoma protein modulates glucose metabolism in lung cancer","volume":"33","author":"Clem","year":"2019","journal-title":"FASEB Journal"},{"issue":"1","key":"10.1016\/j.molmet.2022.101630_bib21","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1038\/s41467-020-18020-8","article-title":"GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer","volume":"11","author":"Wu","year":"2020","journal-title":"Nature Communications"},{"issue":"2","key":"10.1016\/j.molmet.2022.101630_bib22","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1002\/mco2.131","article-title":"Deletion of Trp53 and Rb1 in Ctsk-expressing cells drives osteosarcoma progression by activating glucose metabolism and YAP signaling","volume":"3","author":"Li","year":"2022","journal-title":"MedComm"},{"issue":"8","key":"10.1016\/j.molmet.2022.101630_bib23","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.3390\/cells11081361","article-title":"Verteporfin inhibits the progression of spontaneous osteosarcoma caused by Trp53 and Rb1 deficiency in ctsk-expressing cells via impeding hippo pathway","volume":"11","author":"Li","year":"2022","journal-title":"Cells"},{"issue":"22","key":"10.1016\/j.molmet.2022.101630_bib24","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100294","article-title":"Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth","volume":"37","author":"Cox","year":"2018","journal-title":"EMBO J"},{"key":"10.1016\/j.molmet.2022.101630_bib25","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.biopha.2017.08.091","article-title":"YAP1-TEAD1-Glut1 axis dictates the oncogenic phenotypes of breast cancer cells by modulating glycolysis","volume":"95","author":"Lin","year":"2017","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"10.1016\/j.molmet.2022.101630_bib26","doi-asserted-by":"crossref","DOI":"10.1172\/JCI150595","article-title":"YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload","volume":"132","author":"Kashihara","year":"2022","journal-title":"Journal of Clinical Investigation"},{"issue":"1","key":"10.1016\/j.molmet.2022.101630_bib27","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41467-019-14146-6","article-title":"Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk","volume":"11","author":"Wang","year":"2020","journal-title":"Nature Communications"},{"issue":"10","key":"10.1016\/j.molmet.2022.101630_bib28","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1002\/jbmr.477","article-title":"Conditional deletion of Bmpr1a in differentiated osteoclasts increases osteoblastic bone formation, increasing volume of remodeling bone in mice","volume":"26","author":"Okamoto","year":"2011","journal-title":"Journal of Bone and Mineral Research"},{"issue":"14","key":"10.1016\/j.molmet.2022.101630_bib29","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1038\/s41388-020-01599-z","article-title":"RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling","volume":"40","author":"Li","year":"2021","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.molmet.2022.101630_bib30","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41420-022-01105-2","article-title":"Trp53 controls chondrogenesis and endochondral ossification by negative regulation of TAZ activity and stability via beta-TrCP-mediated ubiquitination","volume":"8","author":"Li","year":"2022","journal-title":"Cell Death Discovery"},{"issue":"6","key":"10.1016\/j.molmet.2022.101630_bib31","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41419-022-04916-4","article-title":"Mice with Trp53 and Rb1 deficiency in chondrocytes spontaneously develop chondrosarcoma via overactivation of YAP signaling","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death and Disease"},{"issue":"6","key":"10.1016\/j.molmet.2022.101630_bib32","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/febs.14026","article-title":"Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism","volume":"284","author":"Li","year":"2017","journal-title":"FEBS Journal"},{"key":"10.1016\/j.molmet.2022.101630_bib33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejmech.2016.07.013","article-title":"Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors","volume":"123","author":"Li","year":"2016","journal-title":"European Journal of Medicinal Chemistry"},{"key":"10.1016\/j.molmet.2022.101630_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11024","article-title":"Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation","volume":"7","author":"Yuan","year":"2016","journal-title":"Nature Communications"},{"issue":"10","key":"10.1016\/j.molmet.2022.101630_bib35","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm.2448","article-title":"Matrix-embedded cells control osteoclast formation","volume":"17","author":"Xiong","year":"2011","journal-title":"Nature Medicine"},{"issue":"19","key":"10.1016\/j.molmet.2022.101630_bib36","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1242\/dev.125.19.3831","article-title":"Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs","volume":"125","author":"ten Berge","year":"1998","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.molmet.2022.101630_bib37","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/s41598-018-37139-9","article-title":"Tsc1 ablation in Prx1 and Osterix lineages causes renal cystogenesis in mouse","volume":"9","author":"Wu","year":"2019","journal-title":"Science Reports"},{"issue":"8","key":"10.1016\/j.molmet.2022.101630_bib38","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.celrep.2016.10.069","article-title":"SHP1 regulates bone mass by directing mesenchymal stem cell differentiation","volume":"17","author":"Jiang","year":"2016","journal-title":"Cell Reports"},{"issue":"38","key":"10.1016\/j.molmet.2022.101630_bib39","doi-asserted-by":"crossref","first-page":"32995","DOI":"10.1074\/jbc.M111.244236","article-title":"Osteoblast-specific transcription factor osterix (osx) is an upstream regulator of Satb2 during bone formation","volume":"286","author":"Tang","year":"2011","journal-title":"Journal of Biological Chemistry"},{"issue":"5","key":"10.1016\/j.molmet.2022.101630_bib40","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/jcb.24439","article-title":"Genetic and molecular control of osterix in skeletal formation","volume":"114","author":"Sinha","year":"2013","journal-title":"Journal of Cellular Biochemistry"},{"issue":"2","key":"10.1016\/j.molmet.2022.101630_bib41","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00223-014-9945-5","article-title":"Osterix-cre transgene causes craniofacial bone development defect","volume":"96","author":"Wang","year":"2015","journal-title":"Calcified Tissue International"},{"issue":"1","key":"10.1016\/j.molmet.2022.101630_bib42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13018-019-1084-2","article-title":"High-fat and high-glucose microenvironment decreases Runx2 and TAZ expression and inhibits bone regeneration in the mouse","volume":"14","author":"Wu","year":"2019","journal-title":"Journal of Orthopaedic Surgery and Research"},{"issue":"5","key":"10.1016\/j.molmet.2022.101630_bib43","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1096\/fj.201700872R","article-title":"Skeletal cell YAP and TAZ combinatorially promote bone development","volume":"32","author":"Kegelman","year":"2018","journal-title":"FASEB Journal"},{"key":"10.1016\/j.molmet.2022.101630_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-018-0018-7","article-title":"YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating beta-catenin signaling","volume":"6","author":"Pan","year":"2018","journal-title":"Bone Research"},{"key":"10.1016\/j.molmet.2022.101630_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.00047","article-title":"Destroy to rebuild: the connection between bone tissue remodeling and matrix metalloproteinases","volume":"11","author":"Hardy","year":"2020","journal-title":"Frontiers in Physiology"},{"issue":"2","key":"10.1016\/j.molmet.2022.101630_bib46","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1530\/JME-15-0067","article-title":"Bone remodeling in the context of cellular and systemic regulation: the role of osteocytes and the nervous system","volume":"55","author":"Niedzwiedzki","year":"2015","journal-title":"Journal of Molecular Endocrinology"},{"key":"10.1016\/j.molmet.2022.101630_bib47","article-title":"SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts","volume":"8","author":"Xu","year":"2017","journal-title":"Nature Communications"},{"issue":"1","key":"10.1016\/j.molmet.2022.101630_bib48","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41413-022-00190-4","article-title":"Mechanical regulation of bone remodeling","volume":"10","author":"Wang","year":"2022","journal-title":"Bone Research"},{"issue":"3","key":"10.1016\/j.molmet.2022.101630_bib49","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4103\/2230-8210.83401","article-title":"Role of RANKL-RANK\/osteoprotegerin molecular complex in bone remodeling and its immunopathologic implications","volume":"15","author":"Kohli","year":"2011","journal-title":"Indian Journal of Endocrinology and Metabolism"},{"issue":"Suppl 1","key":"10.1016\/j.molmet.2022.101630_bib50","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/ar2165","article-title":"Biology of RANK, RANKL, and osteoprotegerin","volume":"9","author":"Boyce","year":"2007","journal-title":"Arthritis Research & Therapy"},{"issue":"2","key":"10.1016\/j.molmet.2022.101630_bib51","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","article-title":"Functions of RANKL\/RANK\/OPG in bone modeling and remodeling","volume":"473","author":"Boyce","year":"2008","journal-title":"Archives of Biochemistry and Biophysics"},{"issue":"1","key":"10.1016\/j.molmet.2022.101630_bib52","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13046-018-1001-2","article-title":"RANKL\/RANK\/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives","volume":"38","author":"Infante","year":"2019","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"issue":"1","key":"10.1016\/j.molmet.2022.101630_bib53","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41418-020-0590-4","article-title":"Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin","volume":"28","author":"Velletri","year":"2021","journal-title":"Cell Death and Differentiation"},{"issue":"2","key":"10.1016\/j.molmet.2022.101630_bib54","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1172\/JCI70050","article-title":"Bone marrow mesenchymal stem cells and TGF-beta signaling in bone remodeling","volume":"124","author":"Crane","year":"2014","journal-title":"Journal of Clinical Investigation"},{"issue":"13","key":"10.1016\/j.molmet.2022.101630_bib55","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1101\/gad.282145.116","article-title":"RB1: a prototype tumor suppressor and an enigma","volume":"30","author":"Dyson","year":"2016","journal-title":"Genes & Development"},{"issue":"12","key":"10.1016\/j.molmet.2022.101630_bib56","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1101\/gad.1656808","article-title":"Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease","volume":"22","author":"Walkley","year":"2008","journal-title":"Genes & Development"},{"issue":"33","key":"10.1016\/j.molmet.2022.101630_bib57","doi-asserted-by":"crossref","first-page":"11851","DOI":"10.1073\/pnas.0805462105","article-title":"Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage","volume":"105","author":"Berman","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"9","key":"10.1016\/j.molmet.2022.101630_bib58","first-page":"2377","article-title":"Dysregulation of glucose metabolism by oncogenes and tumor suppressors in cancer cells","volume":"19","author":"Marbaniang","year":"2018","journal-title":"Asian Pacific Journal of Cancer Prevention (APJCP)"},{"key":"10.1016\/j.molmet.2022.101630_bib59","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2013.85","article-title":"Cancer cell metabolism: implications for therapeutic targets","volume":"45","author":"Jang","year":"2013","journal-title":"Experimental and Molecular Medicine"},{"issue":"10","key":"10.1016\/j.molmet.2022.101630_bib60","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1042\/BCJ20190888","article-title":"Glut1 expression is increased by p53 reduction to switch metabolism to glycolysis during osteoblast differentiation","volume":"477","author":"Ohnishi","year":"2020","journal-title":"Biochemical Journal"},{"issue":"5","key":"10.1016\/j.molmet.2022.101630_bib61","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1172\/JCI124590","article-title":"Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation","volume":"129","author":"Han","year":"2019","journal-title":"Journal of Clinical Investigation"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877822001995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877822001995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:32:30Z","timestamp":1761957150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877822001995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":61,"alternative-id":["S2212877822001995"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2022.101630","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rb1 negatively regulates bone formation and remodeling through inhibiting transcriptional regulation of YAP in Glut1 and OPG expression and glucose metabolism in male mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2022.101630","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"101630"}}