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foam cell formation in hyperlipidemic mice","volume":"29","author":"Manning-Tobin","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.molmet.2023.101730_bib89","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.jhep.2021.12.012","article-title":"Macrophage scavenger receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease","volume":"76","author":"Govaere","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.molmet.2023.101730_bib90","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ijbiomac.2022.06.111","article-title":"Comparative study of the immunomodulatory effects of different fucoidans from Saccharina japonica mediated by scavenger receptors on RAW 264.7 macrophages","volume":"215","author":"Cui","year":"2022","journal-title":"Int J Biol 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and efficacy of topical cytosolic phospholipase A2 inhibitor, AVX001, in patients with mild to moderate plaque psoriasis","volume":"31","author":"Omland","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.molmet.2023.101730_bib100","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.048884","article-title":"Synergic effect of atorvastatin and ambrisentan on sinusoidal and hemodynamic alterations in a rat model of NASH","volume":"14","author":"Bravo","year":"2021","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.molmet.2023.101730_bib101","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/s41565-021-01030-y","article-title":"Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles","volume":"17","author":"Hatit","year":"2022","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.molmet.2023.101730_bib102","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.addr.2020.06.026","article-title":"Lipid 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metabolism by improving mitochondrial redox balance","volume":"222","author":"Wu","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.molmet.2023.101730_bib114","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1021\/acs.biochem.9b00857","article-title":"J. 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