{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:09:46Z","timestamp":1792008586938,"version":"4.4.0"},"reference-count":164,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK47348"],"award-info":[{"award-number":["R01DK47348"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2R01DK092587"],"award-info":[{"award-number":["2R01DK092587"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AT011683"],"award-info":[{"award-number":["1R01AT011683"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.molmet.2023.101817","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T20:33:34Z","timestamp":1696624414000},"page":"101817","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Sensory spinal interoceptive pathways and energy balance regulation"],"prefix":"10.1016","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1152-4884","authenticated-orcid":false,"given":"Heike","family":"M\u00fcnzberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Rudolf","family":"Berthoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried L.","family":"Neuhuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2023.101817_bib1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/obr.12551","article-title":"Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation","volume":"18","author":"Bray","year":"2017","journal-title":"Obes Rev"},{"key":"10.1016\/j.molmet.2023.101817_bib2","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.cell.2021.02.012","article-title":"Metabolic consequences of obesity and type 2 diabetes: balancing genes and environment for personalized care","volume":"184","author":"Pillon","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2023.101817_bib3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/obr.12625","article-title":"On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations","volume":"19","author":"Qasim","year":"2018","journal-title":"Obes Rev"},{"issue":"Suppl 2","key":"10.1016\/j.molmet.2023.101817_bib4","article-title":"Physiology of weight regain: lessons from the classic Minnesota Starvation Experiment on human body composition regulation","volume":"22","author":"Dulloo","year":"2021","journal-title":"Obes Rev"},{"key":"10.1016\/j.molmet.2023.101817_bib5","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1007\/s11695-020-05160-5","article-title":"Weight regain and insufficient weight loss after bariatric surgery: definitions, prevalence, mechanisms, predictors, prevention and management strategies, and knowledge gaps-a scoping review","volume":"31","author":"El Ansari","year":"2021","journal-title":"Obes Surg"},{"key":"10.1016\/j.molmet.2023.101817_bib6","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.eprac.2021.11.082","article-title":"Is obesity or adiposity-based chronic disease curable: the set point theory, the environment, and second-generation medications","volume":"28","author":"Garvey","year":"2022","journal-title":"Endocr Pract"},{"key":"10.1016\/j.molmet.2023.101817_bib7","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.3945\/ajcn.2008.26333","article-title":"Modeling weight-loss maintenance to help prevent body weight regain","volume":"88","author":"Hall","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.molmet.2023.101817_bib8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/oby.20967","article-title":"NIH working group report: innovative research to improve maintenance of weight loss","volume":"23","author":"MacLean","year":"2015","journal-title":"Obesity"},{"issue":"Suppl 1","key":"10.1016\/j.molmet.2023.101817_bib9","first-page":"S25","article-title":"Physiology of energy intake in the weight-reduced state","volume":"29","author":"Berthoud","year":"2021","journal-title":"Obesity"},{"key":"10.1016\/j.molmet.2023.101817_bib10","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0149-7634(02)00014-3","article-title":"Multiple neural systems controlling food intake and body weight","volume":"26","author":"Berthoud","year":"2002","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.molmet.2023.101817_bib11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1210\/er.2017-00111","article-title":"Obesity pathogenesis: an endocrine society scientific statement","volume":"38","author":"Schwartz","year":"2017","journal-title":"Endocr Rev"},{"key":"10.1016\/j.molmet.2023.101817_bib12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3181\/00379727-77-18766","article-title":"Localization of a \"feeding center\" in the hypothalamus of the rat","volume":"77","author":"Anand","year":"1951","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.molmet.2023.101817_bib13","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1126\/science.135.3501.375","article-title":"Hypothalamic control of feeding and self-stimulation","volume":"135","author":"Hoebel","year":"1962","journal-title":"Science"},{"key":"10.1016\/j.molmet.2023.101817_bib14","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-physiol-021115-104948","article-title":"Three pillars for the neural control of appetite","volume":"79","author":"Sternson","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1566-0702(00)00215-0","article-title":"Functional and chemical anatomy of the afferent vagal system","volume":"85","author":"Berthoud","year":"2000","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.molmet.2023.101817_bib16","doi-asserted-by":"crossref","first-page":"G718","DOI":"10.1152\/ajpgi.00293.2020","article-title":"Neural control of gut homeostasis","volume":"319","author":"Abdullah","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib17","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143768","article-title":"The gut, its microbiome, and the brain: connections and communications","volume":"131","author":"Gershon","year":"2021","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.molmet.2023.101817_bib18","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1053\/j.gastro.2019.04.034","article-title":"Extrinsic primary afferent neurons link visceral pain to colon motility through a spinal reflex in mice","volume":"157","author":"Smith-Edwards","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmet.2023.101817_bib19","series-title":"The integrative action of the autonomic nerveous system","author":"Jaenig","year":"2022"},{"key":"10.1016\/j.molmet.2023.101817_bib20","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0006-8993(78)90292-5","article-title":"Visceral afferent projections to the dorsal column nuclei","volume":"150","author":"Rigamonti","year":"1978","journal-title":"Brain Res"},{"key":"10.1016\/j.molmet.2023.101817_bib21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13064-018-0117-6","article-title":"Sympathetic tales: subdivisons of the autonomic nervous system and the impact of developmental studies","volume":"13","author":"Ernsberger","year":"2018","journal-title":"Neural Dev"},{"key":"10.1016\/j.molmet.2023.101817_bib22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0165-1838(97)00133-1","article-title":"Integrative properties of the major pelvic ganglion in the rat","volume":"69","author":"Felix","year":"1998","journal-title":"J\u00a0Auton Nerv Syst"},{"key":"10.1016\/j.molmet.2023.101817_bib23","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0306-4522(94)00595-V","article-title":"Visualization and immunohistochemical characterization of sympathetic and parasympathetic neurons in the male rat major pelvic ganglion","volume":"66","author":"Keast","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.molmet.2023.101817_bib24","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41586-021-04359-5","article-title":"Sensory representation and detection mechanisms of gut osmolality change","volume":"602","author":"Ichiki","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2023.101817_bib25","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/328632a0","article-title":"Induction of c-fos-like protein in spinal cord neurons following sensory stimulation","volume":"328","author":"Hunt","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2023.101817_bib26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0165-0173(89)90009-X","article-title":"False-positive artifacts of tracer strategies distort autonomic connectivity maps","volume":"14","author":"Fox","year":"1989","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.molmet.2023.101817_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0165-0270(80)90054-0","article-title":"Uptake sites of horseradish peroxidase after injection into peritoneal structures: defining some pitfalls","volume":"2","author":"Yu","year":"1980","journal-title":"J\u00a0Neurosci Methods"},{"key":"10.1016\/j.molmet.2023.101817_bib28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF00177756","article-title":"Substance P and calcitonin gene-related peptide: immunohistochemical localisation and microvascular effects in rabbit skeletal muscle","volume":"336","author":"Ohlen","year":"1987","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"10.1016\/j.molmet.2023.101817_bib29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/cne.21736","article-title":"Distribution and neurochemical identification of pancreatic afferents in the mouse","volume":"509","author":"Fasanella","year":"2008","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0165-5728(99)00014-4","article-title":"Requirement of peptidergic sensory innervation for disease activity in murine models of immune hepatitis and protection by beta-adrenergic stimulation","volume":"96","author":"Tiegs","year":"1999","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.molmet.2023.101817_bib31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF01187853","article-title":"Neuropeptides in interscapular and perirenal brown adipose tissue in the rat: a plurality of innervation","volume":"17","author":"Norman","year":"1988","journal-title":"J\u00a0Neurocytol"},{"key":"10.1016\/j.molmet.2023.101817_bib32","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/s41593-018-0141-1","article-title":"Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types","volume":"21","author":"Haring","year":"2018","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.molmet.2023.101817_bib33","doi-asserted-by":"crossref","DOI":"10.1177\/1744806917693003","article-title":"Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn","volume":"13","author":"Todd","year":"2017","journal-title":"Mol Pain"},{"key":"10.1016\/j.molmet.2023.101817_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuron.2020.10.003","article-title":"A\u00a0functional topographic map for spinal sensorimotor reflexes","volume":"109","author":"Gatto","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.molmet.2023.101817_bib35","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1097\/j.pain.0000000000002194","article-title":"Spinoparabrachial projection neurons form distinct classes in the mouse dorsal horn","volume":"162","author":"Browne","year":"2021","journal-title":"Pain"},{"key":"10.1016\/j.molmet.2023.101817_bib36","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.neuron.2017.01.008","article-title":"A\u00a0brainstem-spinal cord inhibitory circuit for mechanical pain modulation by GABA and enkephalins","volume":"93","author":"Francois","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.molmet.2023.101817_bib37","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1172\/JCI81156","article-title":"Identifying local and descending inputs for primary sensory neurons","volume":"125","author":"Zhang","year":"2015","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.molmet.2023.101817_bib38","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/cne.903320305","article-title":"Quantitative analysis of central terminal projections of visceral and somatic unmyelinated (C) primary afferent fibers in the Guinea pig","volume":"332","author":"Sugiura","year":"1993","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib39","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1113\/jphysiol.1981.sp013801","article-title":"Spinal cord collaterals from axons of type II slowly adapting units in the cat","volume":"316","author":"Brown","year":"1981","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib40","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/BF00315762","article-title":"The central projections of visceral primary afferent neurons of the inferior mesenteric plexus and hypogastric nerve and the location of the related sensory and preganglionic sympathetic cell bodies in the rat","volume":"164","author":"Neuhuber","year":"1982","journal-title":"Anat Embryol"},{"key":"10.1016\/j.molmet.2023.101817_bib41","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1113\/jphysiol.1983.sp014611","article-title":"Somatic and visceral inputs to the thoracic spinal cord of the cat: effects of noxious stimulation of the biliary system","volume":"337","author":"Cervero","year":"1983","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib42","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1113\/jphysiol.1968.sp008666","article-title":"Cord cells responding to fine myelinated afferents from viscera, muscle and skin","volume":"199","author":"Pomeranz","year":"1968","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib43","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0006-8993(83)90986-1","article-title":"Supraspinal connections of neurones in the thoracic spinal cord of the cat: ascending projections and effects of descending impulses","volume":"275","author":"Cervero","year":"1983","journal-title":"Brain Res"},{"key":"10.1016\/j.molmet.2023.101817_bib44","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1113\/jphysiol.1987.sp016620","article-title":"Somatic and visceral inputs to the thoracic spinal cord of the cat: marginal zone (lamina I) of the dorsal horn","volume":"388","author":"Cervero","year":"1987","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib45","doi-asserted-by":"crossref","first-page":"G285","DOI":"10.1152\/ajpgi.00013.2019","article-title":"Colonic afferent input and dorsal horn neuron activation differs between the thoracolumbar and lumbosacral spinal cord","volume":"317","author":"Harrington","year":"2019","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib46","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0306-4522(89)90195-4","article-title":"Termination patterns of identified group II and III afferent fibres from deep tissues in the spinal cord of the cat","volume":"28","author":"Hoheisel","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/j.molmet.2023.101817_bib47","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/cne.10619","article-title":"Central projection of unmyelinated (C) primary afferent fibers from gastrocnemius muscle in the Guinea pig","volume":"461","author":"Ling","year":"2003","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib48","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/0306-4522(88)90117-0","article-title":"Spinal and supraspinal terminations of primary afferent fibers from the gastrocnemius-soleus muscle in the cat","volume":"26","author":"Mense","year":"1988","journal-title":"Neuroscience"},{"key":"10.1016\/j.molmet.2023.101817_bib49","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/cne.902800206","article-title":"Central distribution of cervical primary afferents in the rat, with emphasis on proprioceptive projections to vestibular, perihypoglossal, and upper thoracic spinal nuclei","volume":"280","author":"Neuhuber","year":"1989","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib50","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fnint.2018.00057","article-title":"Sugar metabolism regulates flavor preferences and portal glucose sensing","volume":"12","author":"Zhang","year":"2018","journal-title":"Front Integr Neurosci"},{"key":"10.1016\/j.molmet.2023.101817_bib51","series-title":"The rat nervous system","first-page":"67","article-title":"Ascending and descending pathways in the spinal cord","author":"Tracey","year":"1995"},{"key":"10.1016\/j.molmet.2023.101817_bib52","series-title":"The human nervous system","first-page":"233","article-title":"Spinal cord: connections","author":"Sengul","year":"2012"},{"key":"10.1016\/j.molmet.2023.101817_bib53","doi-asserted-by":"crossref","first-page":"R886","DOI":"10.1152\/ajpregu.00060.2014","article-title":"Short and long sympathetic-sensory feedback loops in white fat","volume":"306","author":"Ryu","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib54","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.molmet.2016.06.013","article-title":"Lipolysis sensation by white fat afferent nerves triggers brown fat thermogenesis","volume":"5","author":"Garretson","year":"2016","journal-title":"Mol Metabol"},{"key":"10.1016\/j.molmet.2023.101817_bib55","doi-asserted-by":"crossref","first-page":"R132","DOI":"10.1152\/ajpregu.00344.2016","article-title":"Separate and shared sympathetic outflow to white and brown fat coordinately regulates thermoregulation and beige adipocyte recruitment","volume":"312","author":"Nguyen","year":"2017","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib56","series-title":"Cerebellar prediction and feeding behaviour","author":"Iosif","year":"2022"},{"key":"10.1016\/j.molmet.2023.101817_bib57","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41586-021-04143-5","article-title":"Reverse-translational identification of a cerebellar satiation network","volume":"600","author":"Low","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2023.101817_bib58","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1113\/jphysiol.1969.sp008806","article-title":"The projection of splanchnic afferents on the cerebellum of the cat","volume":"202","author":"Newman","year":"1969","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib59","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0165-1838(83)90032-2","article-title":"Splanchnic afferent input to the lateral reticular nucleus of the cat","volume":"8","author":"Perrin","year":"1983","journal-title":"J\u00a0Auton Nerv Syst"},{"key":"10.1016\/j.molmet.2023.101817_bib60","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41586-020-2860-1","article-title":"Parallel ascending spinal pathways for affective touch and pain","volume":"587","author":"Choi","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2023.101817_bib61","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.yfrne.2014.04.001","article-title":"Neural innervation of white adipose tissue and the control of lipolysis","volume":"35","author":"Bartness","year":"2014","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.molmet.2023.101817_bib62","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/nyas.14119","article-title":"Sympathetic innervation of the interscapular brown adipose tissue in mouse","volume":"1454","author":"Francois","year":"2019","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.molmet.2023.101817_bib63","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/cne.25031","article-title":"Sympathetic innervation of inguinal white adipose tissue in the mouse","volume":"529","author":"Huesing","year":"2021","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib64","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1002\/cne.25281","article-title":"Organization of sympathetic innervation of interscapular brown adipose tissue in the mouse","volume":"530","author":"Huesing","year":"2022","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib65","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2535\/ofaj1936.72.2-3_119","article-title":"Descending projections from the paraventricular hypothalamic nucleus to the spinal cord: anterograde tracing study in the rat","volume":"72","author":"Zheng","year":"1995","journal-title":"Okajimas Folia Anat Jpn"},{"key":"10.1016\/j.molmet.2023.101817_bib66","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/cne.1137","article-title":"Neuropeptide expression in rat paraventricular hypothalamic neurons that project to the spinal cord","volume":"433","author":"Hallbeck","year":"2001","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib67","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/cne.902050306","article-title":"Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat","volume":"205","author":"Sawchenko","year":"1982","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib68","doi-asserted-by":"crossref","first-page":"15306","DOI":"10.1523\/JNEUROSCI.0226-14.2014","article-title":"Control of food intake and energy expenditure by Nos1 neurons of the paraventricular hypothalamus","volume":"34","author":"Sutton","year":"2014","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.molmet.2023.101817_bib69","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1523\/JNEUROSCI.19-08-03171.1999","article-title":"Hypothalamic hypocretin (orexin): robust innervation of the spinal cord","volume":"19","author":"van den Pol","year":"1999","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.molmet.2023.101817_bib70","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/(SICI)1096-9861(19970623)383:1<94::AID-CNE8>3.0.CO;2-G","article-title":"Organization of the descending projections from the parabrachial nucleus to the trigeminal sensory nuclear complex and spinal dorsal horn in the rat","volume":"383","author":"Yoshida","year":"1997","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib71","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0306-4522(93)90338-G","article-title":"Rectospinal neurons: cell bodies, pathways, immunocytochemistry and ultrastructure","volume":"56","author":"Neuhuber","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.molmet.2023.101817_bib72","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0306-4522(83)90002-7","article-title":"The origins, pathways and terminations of neurons with VIP-like immunoreactivity in the Guinea-pig small intestine","volume":"8","author":"Costa","year":"1983","journal-title":"Neuroscience"},{"key":"10.1016\/j.molmet.2023.101817_bib73","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0165-1838(00)00159-4","article-title":"Identification of intestinofugal neurons projecting to the coeliac and superior mesenteric ganglia in the rat","volume":"83","author":"Furness","year":"2000","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.molmet.2023.101817_bib74","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0165-1838(95)00053-1","article-title":"Chemical coding of neurons that project from different regions of intestine to the coeliac ganglion of the Guinea pig","volume":"56","author":"Mann","year":"1995","journal-title":"J\u00a0Auton Nerv Syst"},{"key":"10.1016\/j.molmet.2023.101817_bib75","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1016\/j.cell.2022.05.007","article-title":"An inter-organ neural circuit for appetite suppression","volume":"185","author":"Zhang","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2023.101817_bib76","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pneurobio.2003.12.004","article-title":"Intrinsic primary afferent neurons and nerve circuits within the intestine","volume":"72","author":"Furness","year":"2004","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.molmet.2023.101817_bib77","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1126\/science.abd6176","article-title":"Microbiota-modulated CART(+) enteric neurons autonomously regulate blood glucose","volume":"370","author":"Muller","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.molmet.2023.101817_bib78","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cell.2017.05.034","article-title":"Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways","volume":"170","author":"Bellono","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2023.101817_bib79","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/s42003-022-03876-x","article-title":"Disengaging spinal afferent nerve communication with the brain in live mice","volume":"5","author":"Kyloh","year":"2022","journal-title":"Commun Biol"},{"key":"10.1016\/j.molmet.2023.101817_bib80","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0163-1047(86)80004-8","article-title":"The splanchnic nerve and food intake regulation","volume":"45","author":"Deutsch","year":"1986","journal-title":"Behav Neural Biol"},{"key":"10.1016\/j.molmet.2023.101817_bib81","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.cmet.2020.12.018","article-title":"Hypothalamic detection of macronutrients via multiple gut-brain pathways","volume":"33","author":"Goldstein","year":"2021","journal-title":"Cell Metabol"},{"key":"10.1016\/j.molmet.2023.101817_bib82","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0031-9384(02)00968-X","article-title":"Selective effects of vagal deafferentation and celiac-superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients","volume":"78","author":"Sclafani","year":"2003","journal-title":"Physiol Behav"},{"key":"10.1016\/j.molmet.2023.101817_bib83","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1172\/JCI20449","article-title":"Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control","volume":"113","author":"Karai","year":"2004","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.molmet.2023.101817_bib84","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.bbamcr.2016.05.007","article-title":"Activation of endogenous TRPV1 fails to induce overstimulation-based cytotoxicity in breast and prostate cancer cells but not in pain-sensing neurons","volume":"1863","author":"Pecze","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.molmet.2023.101817_bib85","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/0024-3205(94)00636-9","article-title":"Comparison of [3H]resiniferatoxin binding by the vanilloid (capsaicin) receptor in dorsal root ganglia, spinal cord, dorsal vagal complex, sciatic and vagal nerve and urinary bladder of the rat","volume":"55","author":"Acs","year":"1994","journal-title":"Life Sci"},{"key":"10.1016\/j.molmet.2023.101817_bib86","doi-asserted-by":"crossref","first-page":"E96","DOI":"10.1152\/ajpendo.00415.2006","article-title":"Hypoglycemic detection at the portal vein is mediated by capsaicin-sensitive primary sensory neurons","volume":"293","author":"Fujita","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.molmet.2023.101817_bib87","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cmet.2021.12.020","article-title":"A\u00a0distinct hypothalamus-to-beta cell circuit modulates insulin secretion","volume":"34","author":"Papazoglou","year":"2022","journal-title":"Cell Metabol"},{"key":"10.1016\/j.molmet.2023.101817_bib88","doi-asserted-by":"crossref","first-page":"R1028","DOI":"10.1152\/ajpregu.00648.2004","article-title":"Sensory or sympathetic white adipose tissue denervation differentially affects depot growth and cellularity","volume":"288","author":"Shi","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib89","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74964","article-title":"Enteroendocrine cell types that drive food reward and aversion","volume":"11","author":"Bai","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.molmet.2023.101817_bib90","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.cell.2019.10.031","article-title":"Genetic identification of vagal sensory neurons that control feeding","volume":"179","author":"Bai","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2023.101817_bib91","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.celrep.2019.04.096","article-title":"An atlas of vagal sensory neurons and their molecular specialization","volume":"27","author":"Kupari","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.molmet.2023.101817_bib92","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/s41586-022-05266-z","article-title":"Gut-brain circuits for fat preference","volume":"610","author":"Li","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2023.101817_bib93","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41586-020-2199-7","article-title":"The gut-brain axis mediates sugar preference","volume":"580","author":"Tan","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2023.101817_bib94","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1136\/gutjnl-2017-315631","article-title":"Single-cell RNAseq reveals seven classes of colonic sensory neuron","volume":"68","author":"Hockley","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.molmet.2023.101817_bib95","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41586-019-1900-1","article-title":"The emergence of transcriptional identity in somatosensory neurons","volume":"577","author":"Sharma","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2023.101817_bib96","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.3881","article-title":"Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing","volume":"18","author":"Usoskin","year":"2015","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.molmet.2023.101817_bib97","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1016\/j.cell.2023.07.007","article-title":"DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon","volume":"186","author":"Wolfson","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2023.101817_bib98","doi-asserted-by":"crossref","first-page":"G342","DOI":"10.1152\/ajpgi.00095.2017","article-title":"Validation and characterization of a novel method for selective vagal deafferentation of the gut","volume":"313","author":"Diepenbroek","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib99","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.cmet.2021.05.002","article-title":"Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism","volume":"33","author":"Borgmann","year":"2021","journal-title":"Cell Metabol"},{"key":"10.1016\/j.molmet.2023.101817_bib100","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1523\/JNEUROSCI.4671-10.2011","article-title":"Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis","volume":"31","author":"Garami","year":"2011","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.molmet.2023.101817_bib101","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1210\/en.2010-0284","article-title":"Mice lacking the neuropeptide alpha-calcitonin gene-related peptide are protected against diet-induced obesity","volume":"151","author":"Walker","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.molmet.2023.101817_bib102","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.cell.2017.01.025","article-title":"Gut-brain cross-talk in metabolic control","volume":"168","author":"Clemmensen","year":"2017","journal-title":"Cell"},{"issue":"Suppl 2","key":"10.1016\/j.molmet.2023.101817_bib103","doi-asserted-by":"crossref","first-page":"ii5","DOI":"10.1136\/gut.2003.033415","article-title":"What activates visceral afferents?","volume":"53","author":"Grundy","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.molmet.2023.101817_bib104","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.autneu.2006.01.009","article-title":"Signalling the state of the digestive tract","volume":"125","author":"Grundy","year":"2006","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.molmet.2023.101817_bib105","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S1566-0702(01)00311-3","article-title":"Effects of vagal and splanchnic section on food intake, weight, serum leptin and hypothalamic neuropeptide Y in rat","volume":"92","author":"Furness","year":"2001","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.molmet.2023.101817_bib106","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0031-9384(96)80018-7","article-title":"Abdominal vagotomy does not block carbohydrate-conditioned flavor preferences in rats","volume":"60","author":"Sclafani","year":"1996","journal-title":"Physiol Behav"},{"key":"10.1016\/j.molmet.2023.101817_bib107","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0419-20.2021","article-title":"The medullary targets of neurally conveyed sensory information from the rat hepatic portal and superior mesenteric veins","volume":"8","author":"Garcia-Luna","year":"2021","journal-title":"eNeuro"},{"key":"10.1016\/j.molmet.2023.101817_bib108","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/hep.1840060423","article-title":"Calcitonin gene-related peptide in the hepatic and splanchnic vascular systems of the rat","volume":"6","author":"Sasaki","year":"1986","journal-title":"Hepatology"},{"key":"10.1016\/j.molmet.2023.101817_bib109","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/BF00185458","article-title":"An anterograde tracing study of the vagal innervation of rat liver, portal vein and biliary system","volume":"186","author":"Berthoud","year":"1992","journal-title":"Anat Embryol"},{"key":"10.1016\/j.molmet.2023.101817_bib110","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1126\/science.1163971","article-title":"Regulation of pancreatic beta cell mass by neuronal signals from the liver","volume":"322","author":"Imai","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.molmet.2023.101817_bib111","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0165-1838(93)90046-W","article-title":"Characterization of vagal innervation to the rat celiac, suprarenal and mesenteric ganglia","volume":"42","author":"Berthoud","year":"1993","journal-title":"J\u00a0Auton Nerv Syst"},{"key":"10.1016\/j.molmet.2023.101817_bib112","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00441-007-0413-7","article-title":"Vagal innervation of intestines: afferent pathways mapped with new en bloc horseradish peroxidase adaptation","volume":"329","author":"Wang","year":"2007","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.molmet.2023.101817_bib113","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.663022","article-title":"Optical imaging of pancreatic innervation","volume":"12","author":"Makhmutova","year":"2021","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.molmet.2023.101817_bib114","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0165-1838(89)90015-5","article-title":"Vagal afferent fibers almost exclusively innervate islets in the rat pancreas as demonstrated by anterograde tracing","volume":"29","author":"Neuhuber","year":"1989","journal-title":"J\u00a0Auton Nerv Syst"},{"key":"10.1016\/j.molmet.2023.101817_bib115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00007890-200101150-00002","article-title":"Reinnervation of syngeneic pancreatico-duodenal grafts in rats","volume":"71","author":"Korsgren","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.molmet.2023.101817_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101260","article-title":"Deconstructing the origins of sexual dimorphism in sensory modulation of pancreatic beta cells","volume":"53","author":"McEwan","year":"2021","journal-title":"Mol Metabol"},{"key":"10.1016\/j.molmet.2023.101817_bib117","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1523\/JNEUROSCI.07-09-02674.1987","article-title":"Dual intrinsic and extrinsic origins of CGRP- and NPY-immunoreactive nerves of rat gut and pancreas","volume":"7","author":"Su","year":"1987","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.molmet.2023.101817_bib118","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.molmet.2018.10.002","article-title":"TRPV1 neurons regulate beta-cell function in a sex-dependent manner","volume":"18","author":"Bou Karam","year":"2018","journal-title":"Mol Metabol"},{"key":"10.1016\/j.molmet.2023.101817_bib119","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1053\/j.gastro.2020.10.034","article-title":"Pancreatic beta-cells communicate with vagal sensory neurons","volume":"160","author":"Makhmutova","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmet.2023.101817_bib120","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nrn2555","article-title":"How do you feel--now? The anterior insula and human awareness","volume":"10","author":"Craig","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.molmet.2023.101817_bib121","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00429-010-0248-y","article-title":"The sentient self","volume":"214","author":"Craig","year":"2010","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.molmet.2023.101817_bib122","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.cell.2006.10.038","article-title":"TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes","volume":"127","author":"Razavi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2023.101817_bib123","doi-asserted-by":"crossref","first-page":"G938","DOI":"10.1152\/ajpgi.00105.2002","article-title":"Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats","volume":"283","author":"Nathan","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib124","doi-asserted-by":"crossref","first-page":"R1243","DOI":"10.1152\/ajpregu.00679.2005","article-title":"White adipose tissue lacks significant vagal innervation and immunohistochemical evidence of parasympathetic innervation","volume":"291","author":"Giordano","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib125","doi-asserted-by":"crossref","first-page":"R514","DOI":"10.1152\/ajpregu.00036.2005","article-title":"White adipose tissue sensory nerve denervation mimics lipectomy-induced compensatory increases in adiposity","volume":"289","author":"Shi","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib126","doi-asserted-by":"crossref","first-page":"R324","DOI":"10.1152\/ajpregu.00456.2015","article-title":"Bidirectional crosstalk between the sensory and sympathetic motor systems innervating brown and white adipose tissue in male Siberian hamsters","volume":"312","author":"Ryu","year":"2017","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib127","doi-asserted-by":"crossref","first-page":"R501","DOI":"10.1152\/ajpregu.90786.2008","article-title":"Anterograde transneuronal viral tract tracing reveals central sensory circuits from white adipose tissue","volume":"296","author":"Song","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.molmet.2023.101817_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2020.112846","article-title":"The drive to eat in homo sapiens: energy expenditure drives energy intake","volume":"219","author":"Blundell","year":"2020","journal-title":"Physiol Behav"},{"key":"10.1016\/j.molmet.2023.101817_bib129","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/ajcn\/4.2.169","article-title":"Relation between caloric intake, body weight, and physical work: studies in an industrial male population in West Bengal","volume":"4","author":"Mayer","year":"1956","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.molmet.2023.101817_bib130","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/17446651.2019.1618185","article-title":"The influence of skeletal muscle on appetite regulation","volume":"14","author":"Grannell","year":"2019","journal-title":"Expet Rev Endocrinol Metabol"},{"key":"10.1016\/j.molmet.2023.101817_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111947","article-title":"GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia","volume":"42","author":"Kim-Muller","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.molmet.2023.101817_bib132","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.celrep.2016.04.057","article-title":"Impaired mitochondrial fat oxidation induces FGF21 in muscle","volume":"15","author":"Vandanmagsar","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.molmet.2023.101817_bib133","doi-asserted-by":"crossref","DOI":"10.3390\/nu12061899","article-title":"The role of exercise in the interplay between myokines, hepatokines, osteokines, adipokines, and modulation of inflammation for energy substrate redistribution and fat mass loss: a review","volume":"12","author":"Gonzalez-Gil","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.molmet.2023.101817_bib134","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2302\/kjm.48.22","article-title":"A\u00a0new concept of skin-associated lymphoid tissue (SALT): UVB light impaired cutaneous immunity reveals a prominent role for cutaneous nerves","volume":"48","author":"Streilein","year":"1999","journal-title":"Keio J Med"},{"key":"10.1016\/j.molmet.2023.101817_bib135","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1523\/JNEUROSCI.6433-10.2011","article-title":"Preoptic-raphe connections for thermoregulatory vasomotor control","volume":"31","author":"Tanaka","year":"2011","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.molmet.2023.101817_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101161","article-title":"Sensory neurons expressing calcitonin gene-related peptide alpha regulate adaptive thermogenesis and diet-induced obesity","volume":"45","author":"Makwana","year":"2021","journal-title":"Mol Metabol"},{"key":"10.1016\/j.molmet.2023.101817_bib137","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuron.2013.01.030","article-title":"Peptidergic CGRPalpha primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold","volume":"78","author":"McCoy","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.molmet.2023.101817_bib138","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s12276-021-00677-w","article-title":"Role of the gut-brain axis in energy and glucose metabolism","volume":"54","author":"Wachsmuth","year":"2022","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.molmet.2023.101817_bib139","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF00317648","article-title":"Spinal ganglion cells innervating the stomach of the rat as demonstrated by somatopetal transport of horseradish peroxidase (HRP)","volume":"155","author":"Neuhuber","year":"1979","journal-title":"Anat Embryol"},{"key":"10.1016\/j.molmet.2023.101817_bib140","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.1365-2982.2003.00456.x","article-title":"Characterization of the primary spinal afferent innervation of the mouse colon using retrograde labelling","volume":"16","author":"Robinson","year":"2004","journal-title":"Neuro Gastroenterol Motil"},{"key":"10.1016\/j.molmet.2023.101817_bib141","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.neuroscience.2008.06.071","article-title":"Distinct chemical classes of medium-sized transient receptor potential channel vanilloid 1-immunoreactive dorsal root ganglion neurons innervate the adult mouse jejunum and colon","volume":"156","author":"Tan","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.molmet.2023.101817_bib142","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0165-1838(83)90108-X","article-title":"The afferent and preganglionic parasympathetic innervation of the rat liver, demonstrated by the retrograde transport of horseradish peroxidase","volume":"8","author":"Magni","year":"1983","journal-title":"J\u00a0Auton Nerv Syst"},{"key":"10.1016\/j.molmet.2023.101817_bib143","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/0016-5085(84)90088-X","article-title":"Sensory substance P innervation of the stomach and pancreas. Demonstration of capsaicin-sensitive sensory neurons in the rat by combined immunohistochemistry and retrograde tracing","volume":"87","author":"Sharkey","year":"1984","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmet.2023.101817_bib144","doi-asserted-by":"crossref","first-page":"E1338","DOI":"10.1152\/ajpendo.00021.2013","article-title":"Leptin-sensitive sensory nerves innervate white fat","volume":"304","author":"Murphy","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.molmet.2023.101817_bib145","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1097\/j.pain.0000000000002511","article-title":"Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain","volume":"163","author":"Wang","year":"2022","journal-title":"Pain"},{"key":"10.1016\/j.molmet.2023.101817_bib146","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1523\/JNEUROSCI.5329-03.2004","article-title":"Anterograde transneuronal viral tracing of central viscerosensory pathways in rats","volume":"24","author":"Rinaman","year":"2004","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.molmet.2023.101817_bib147","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/cne.902300108","article-title":"Distribution of somatic and visceral primary afferent fibres within the thoracic spinal cord of the cat","volume":"230","author":"Cervero","year":"1984","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib148","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/cne.902280309","article-title":"Somatic and visceral primary afferents in the lower thoracic dorsal root ganglia of the cat","volume":"228","author":"Cervero","year":"1984","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib149","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF00318344","article-title":"The central projections of primary afferent neurons of greater splanchnic and intercostal nerves in the rat. A horseradish peroxidase study","volume":"174","author":"Neuhuber","year":"1986","journal-title":"Anat Embryol"},{"key":"10.1016\/j.molmet.2023.101817_bib150","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/cne.902380204","article-title":"The afferent and sympathetic components of the lumbar spinal outflow to the colon and pelvic organs in the cat. III. The colonic nerves, incorporating an analysis of all components of the lumbar prevertebral outflow","volume":"238","author":"Baron","year":"1985","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib151","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/cne.902430104","article-title":"The spinal distribution of sympathetic preganglionic and visceral primary afferent neurons that send axons into the hypogastric nerves of the cat","volume":"243","author":"Morgan","year":"1986","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib152","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/cne.902010308","article-title":"The distribution of visceral primary afferents from the pelvic nerve to Lissauer's tract and the spinal gray matter and its relationship to the sacral parasympathetic nucleus","volume":"201","author":"Morgan","year":"1981","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib153","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF00321134","article-title":"The distribution of anterogradely labeled I--IV primary afferents in histochemically defined compartments of the rat's sternomastoid muscle","volume":"177","author":"Zenker","year":"1988","journal-title":"Anat Embryol"},{"key":"10.1016\/j.molmet.2023.101817_bib154","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/cne.903470203","article-title":"Morphological relationships of choleragenoid horseradish peroxidase-labeled spinal primary afferents with myenteric ganglia and mucosal associated lymphoid tissue in the cat esophagogastric junction","volume":"347","author":"Clerc","year":"1994","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib155","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0306-4522(97)00058-4","article-title":"Ultrastructural relationships of spinal primary afferent fibres with neuronal and non-neuronal cells in the myenteric plexus of the cat oesophago-gastric junction","volume":"80","author":"Mazzia","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.molmet.2023.101817_bib156","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1002\/cne.24006","article-title":"Different types of spinal afferent nerve endings in stomach and esophagus identified by anterograde tracing from dorsal root ganglia","volume":"524","author":"Spencer","year":"2016","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib157","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/nmo.12266","article-title":"A\u00a0novel anterograde neuronal tracing technique to selectively label spinal afferent nerve endings that encode noxious and innocuous stimuli in visceral organs","volume":"26","author":"Kyloh","year":"2014","journal-title":"Neuro Gastroenterol Motil"},{"key":"10.1016\/j.molmet.2023.101817_bib158","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1002\/cne.24854","article-title":"Identification of spinal afferent nerve endings in the colonic mucosa and submucosa that communicate directly with the spinal cord: the gut-brain axis","volume":"528","author":"Spencer","year":"2020","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.molmet.2023.101817_bib159","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00441-020-03192-y","article-title":"Sensory nerve endings arising from single spinal afferent neurons that innervate both circular muscle and myenteric ganglia in mouse colon: colon-brain axis","volume":"381","author":"Spencer","year":"2020","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.molmet.2023.101817_bib160","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/01.mpa.0000240600.72946.23","article-title":"Intrapancreatic axonal hyperbranching of dorsal root ganglia neurons in chronic pancreatitis model rats and its relation to pancreatic pain","volume":"33","author":"Takamido","year":"2006","journal-title":"Pancreas"},{"key":"10.1016\/j.molmet.2023.101817_bib161","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047849","article-title":"Gastric electrical stimulation decreases gastric distension-induced central nociception response through direct action on primary afferents","volume":"7","author":"Ouelaa","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.molmet.2023.101817_bib162","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0306-4522(01)00548-6","article-title":"The expression of Fos-labeled spinal neurons in response to colorectal distension is enhanced after chronic spinal cord transection in the rat","volume":"110","author":"Landrum","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.molmet.2023.101817_bib163","article-title":"Involvement of Brn3a-positive spinal dorsal horn neurons in the transmission of visceral pain in inflammatory bowel disease model mice","volume":"3","author":"Nishida","year":"2022","journal-title":"Front Pain Res (Lausanne)"},{"key":"10.1016\/j.molmet.2023.101817_bib164","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/cne.901860203","article-title":"Spinal termination of functionally identified primary afferent neurons with slowly conducting myelinated fibers","volume":"186","author":"Light","year":"1979","journal-title":"J Comp Neurol"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877823001515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877823001515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:23:09Z","timestamp":1778851389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877823001515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":164,"alternative-id":["S2212877823001515"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2023.101817","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sensory spinal interoceptive pathways and energy balance regulation","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2023.101817","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"101817"}}