{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:22:01Z","timestamp":1793910121427,"version":"4.8.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100602"],"award-info":[{"award-number":["82100602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.molmet.2024.101882","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T08:52:20Z","timestamp":1705827140000},"page":"101882","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Hepatic regulator of G protein signaling 14 ameliorates NAFLD through activating cAMP-AMPK signaling by targeting Gi\u03b11\/3"],"prefix":"10.1016","volume":"80","author":[{"given":"Junyong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunduan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangdong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.molmet.2024.101882_bib1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jhep.2017.09.003","article-title":"Genetics and epigenetics of NAFLD and NASH: clinical impact","volume":"68","author":"Eslam","year":"2018","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.molmet.2024.101882_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"7681","key":"10.1016\/j.molmet.2024.101882_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/d41586-017-06926-1","article-title":"Drug development: sprint finish","volume":"551","author":"Drew","year":"2017","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.molmet.2024.101882_bib4","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1001\/jama.2020.2298","article-title":"Nonalcoholic steatohepatitis: a review","volume":"323","author":"Sheka","year":"2020","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.molmet.2024.101882_bib5","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/hep.26698","article-title":"Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice","volume":"59","author":"Yang","year":"2014","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.molmet.2024.101882_bib6","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.molmet.2024.101882_bib7","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1002\/hep.31852","article-title":"Therapeutic potential of G protein-coupled receptors against nonalcoholic steatohepatitis","volume":"74","author":"Sun","year":"2021","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.molmet.2024.101882_bib8","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.cell.2022.02.011","article-title":"Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling","volume":"185","author":"Anton","year":"2022","journal-title":"Cell"},{"issue":"1\u20132","key":"10.1016\/j.molmet.2024.101882_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cell.2017.11.033","article-title":"Pharmacogenomics of GPCR drug targets","volume":"172","author":"Hauser","year":"2018","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.molmet.2024.101882_bib10","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrd.2018.135","article-title":"Targeting G protein-coupled receptor signalling by blocking G proteins","volume":"17","author":"Campbell","year":"2018","journal-title":"Nat Rev Drug Discov"},{"issue":"3","key":"10.1016\/j.molmet.2024.101882_bib11","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cellsig.2009.10.005","article-title":"RGS14 is a multifunctional scaffold that integrates G protein and Ras\/Raf MAPkinase signalling pathways","volume":"22","author":"Shu","year":"2010","journal-title":"Cell Signal"},{"issue":"5177","key":"10.1016\/j.molmet.2024.101882_bib12","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1126\/science.8073283","article-title":"Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis","volume":"265","author":"Coleman","year":"1994","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.molmet.2024.101882_bib13","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/CIRCRESAHA.110.231423","article-title":"Regulators of G-protein signaling in the heart and their potential as therapeutic targets","volume":"109","author":"Zhang","year":"2011","journal-title":"Circ Res"},{"issue":"7","key":"10.1016\/j.molmet.2024.101882_bib14","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.tcb.2005.05.001","article-title":"GDIs: central regulatory molecules in Rho GTPase activation","volume":"15","author":"DerMardirossian","year":"2005","journal-title":"Trends Cell Biol"},{"issue":"11","key":"10.1016\/j.molmet.2024.101882_bib15","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.tips.2011.07.005","article-title":"RGS14 at the interface of hippocampal signaling and synaptic plasticity","volume":"32","author":"Vellano","year":"2011","journal-title":"Trends Pharmacol Sci"},{"issue":"2","key":"10.1016\/j.molmet.2024.101882_bib16","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/hep.32133","article-title":"Regulator of G-protein signaling 14 protects the liver from ischemia-reperfusion injury by suppressing TGF-\u03b2-activated kinase 1 activation","volume":"75","author":"Zhang","year":"2022","journal-title":"Hepatology"},{"issue":"624","key":"10.1016\/j.molmet.2024.101882_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abg8117","article-title":"Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis","volume":"13","author":"Zhang","year":"2021","journal-title":"Sci Transl Med"},{"issue":"5","key":"10.1016\/j.molmet.2024.101882_bib18","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1002\/hep.32045","article-title":"Fatty acid synthase-suppressor screening identifies sorting Nexin 8 as a therapeutic target for NAFLD","volume":"74","author":"Hu","year":"2021","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.molmet.2024.101882_bib19","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41419-022-04562-w","article-title":"Combining adoptive NK cell infusion with a dopamine-releasing peptide reduces senescent cells in aged mice","volume":"13","author":"Bai","year":"2022","journal-title":"Cell Death Dis"},{"issue":"4","key":"10.1016\/j.molmet.2024.101882_bib20","doi-asserted-by":"crossref","first-page":"G462","DOI":"10.1152\/ajpgi.00358.2018","article-title":"Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals","volume":"316","author":"Suppli","year":"2019","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"7","key":"10.1016\/j.molmet.2024.101882_bib21","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.molmet.2024.101882_bib22","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1074\/jbc.M408163200","article-title":"RGS14 is a centrosomal and nuclear cytoplasmic shuttling protein that traffics to promyelocytic leukemia nuclear bodies following heat shock","volume":"280","author":"Cho","year":"2005","journal-title":"J\u00a0Biol Chem"},{"issue":"14","key":"10.1016\/j.molmet.2024.101882_bib23","doi-asserted-by":"crossref","first-page":"9037","DOI":"10.1074\/jbc.M114.634329","article-title":"Integration of G protein \u03b1 (G\u03b1) signaling by the regulator of G protein signaling 14 (RGS14)","volume":"290","author":"Brown","year":"2015","journal-title":"J\u00a0Biol Chem"},{"issue":"44","key":"10.1016\/j.molmet.2024.101882_bib24","doi-asserted-by":"crossref","first-page":"38659","DOI":"10.1074\/jbc.M111.274928","article-title":"G\u00a0protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14\u00b7G\u03b1i1 complex in live cells","volume":"286","author":"Vellano","year":"2011","journal-title":"J\u00a0Biol Chem"},{"issue":"14","key":"10.1016\/j.molmet.2024.101882_bib25","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1111\/jcmm.17414","article-title":"Puerarin attenuates diabetic kidney injury through interaction with Guanidine nucleotide-binding protein Gi subunit alpha-1 (Gnai1) subunit","volume":"26","author":"Zhu","year":"2022","journal-title":"J\u00a0Cell Mol Med"},{"issue":"54","key":"10.1016\/j.molmet.2024.101882_bib26","doi-asserted-by":"crossref","first-page":"30213","DOI":"10.18632\/oncotarget.25727","article-title":"G\u03b1(i3) signaling is associated with sexual dimorphic expression of the clock-controlled output gene Dbp in murine liver","volume":"9","author":"Singh","year":"2018","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.molmet.2024.101882_bib27","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1165\/rcmb.2021-0526OC","article-title":"Rhinovirus C15 attenuates relaxation and cAMP production in human airways and smooth muscle","volume":"69","author":"Gebski","year":"2023","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"10.1016\/j.molmet.2024.101882_bib28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12964-022-00852-0","article-title":"Receptor activity-modifying protein 1 regulates mouse skin fibroblast proliferation via the G\u03b1i3-PKA-CREB-YAP axis","volume":"20","author":"Yin","year":"2022","journal-title":"Cell Commun Signal"},{"issue":"2","key":"10.1016\/j.molmet.2024.101882_bib29","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/hep.32708","article-title":"Hepatocyte leukotriene B4 receptor 1 promotes NAFLD development in obesity","volume":"78","author":"Liu","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.molmet.2024.101882_bib30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/164_2015_32","article-title":"Role of the cAMP pathway in glucose and lipid metabolism","volume":"233","author":"Ravnskjaer","year":"2016","journal-title":"Handb Exp Pharmacol"},{"issue":"10","key":"10.1016\/j.molmet.2024.101882_bib31","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1038\/leu.2014.112","article-title":"PKA\/AMPK signaling in relation to adiponectin's antiproliferative effect on multiple myeloma cells","volume":"28","author":"Medina","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.molmet.2024.101882_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104657","article-title":"Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in\u00a0vitro and in\u00a0vivo","volume":"153","author":"Liang","year":"2020","journal-title":"Pharmacol Res"},{"issue":"5","key":"10.1016\/j.molmet.2024.101882_bib33","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.cmet.2020.04.011","article-title":"Low-dose Sorafenib acts as a mitochondrial uncoupler and ameliorates nonalcoholic steatohepatitis","volume":"31","author":"Jian","year":"2020","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.molmet.2024.101882_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/nu12020329","article-title":"Sesamol alleviates obesity-related hepatic steatosis via activating hepatic PKA pathway","volume":"12","author":"Xu","year":"2020","journal-title":"Nutrients"},{"issue":"10290","key":"10.1016\/j.molmet.2024.101882_bib35","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.molmet.2024.101882_bib36","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"issue":"1\u20132","key":"10.1016\/j.molmet.2024.101882_bib37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cell.2017.11.033","article-title":"Pharmacogenomics of GPCR drug targets","volume":"172","author":"Hauser","year":"2018","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.molmet.2024.101882_bib38","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/hep.31242","article-title":"Hepatic regulator of G protein signaling 5 ameliorates nonalcoholic fatty liver disease by suppressing transforming growth factor beta-activated kinase 1-c-Jun-N-terminal kinase\/p38 signaling","volume":"73","author":"Wang","year":"2021","journal-title":"Hepatology"},{"issue":"13","key":"10.1016\/j.molmet.2024.101882_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136823","article-title":"RGS14 regulation of post-synaptic signaling and spine plasticity in brain","volume":"22","author":"Harbin","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.molmet.2024.101882_bib40","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41575-018-0009-6","article-title":"Triggering and resolution of inflammation in NASH","volume":"15","author":"Schuster","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"8","key":"10.1016\/j.molmet.2024.101882_bib41","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.metabol.2016.02.014","article-title":"Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease","volume":"65","author":"Mota","year":"2016","journal-title":"Metabolism"},{"issue":"5","key":"10.1016\/j.molmet.2024.101882_bib42","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.cellsig.2009.01.015","article-title":"Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis","volume":"21","author":"Omar","year":"2009","journal-title":"Cell Signal"},{"issue":"2","key":"10.1016\/j.molmet.2024.101882_bib43","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.cmet.2018.01.004","article-title":"Kynurenic acid and Gpr35 regulate adipose tissue energy homeostasis and inflammation","volume":"27","author":"Agudelo","year":"2018","journal-title":"Cell Metab"},{"issue":"3","key":"10.1016\/j.molmet.2024.101882_bib44","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cellsig.2009.10.005","article-title":"RGS14 is a multifunctional scaffold that integrates G protein and Ras\/Raf MAPkinase signalling pathways","volume":"22","author":"Shu","year":"2010","journal-title":"Cell Signal"},{"issue":"4","key":"10.1016\/j.molmet.2024.101882_bib45","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/hep.30364","article-title":"Cannabinoid-1 receptor antagonism improves glycemic control and increases energy expenditure through Sirtuin-1\/mechanistic target of Rapamycin complex 2 and 5'Adenosine monophosphate-activated protein kinase signaling","volume":"69","author":"Liu","year":"2019","journal-title":"Hepatology"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824000139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824000139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T02:08:54Z","timestamp":1718935734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877824000139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":45,"alternative-id":["S2212877824000139"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2024.101882","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic regulator of G protein signaling 14 ameliorates NAFLD through activating cAMP-AMPK signaling by targeting Gi\u03b11\/3","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2024.101882","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"101882"}}