{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T19:15:11Z","timestamp":1768590911268,"version":"3.49.0"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.molmet.2024.101898","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T12:13:22Z","timestamp":1707826402000},"page":"101898","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Letter-to-the-editor on \u201cA low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice\u201d"],"prefix":"10.1016","volume":"81","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2041-8987","authenticated-orcid":false,"given":"Bo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2024.101898_bib1","doi-asserted-by":"crossref","first-page":"101675","DOI":"10.1016\/j.molmet.2023.101675","article-title":"A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice","volume":"69","author":"Long","year":"2023","journal-title":"Mol Metabol"},{"key":"10.1016\/j.molmet.2024.101898_bib2","article-title":"Importance of temperature on immuno-metabolic regulation and cancer progression","author":"Wang","year":"2022","journal-title":"FEBS J"},{"key":"10.1016\/j.molmet.2024.101898_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205726","article-title":"Uncoupling protein-1 deficiency promotes brown adipose tissue inflammation and ER stress","volume":"13","author":"Bond","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.molmet.2024.101898_bib4","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s12967-019-2104-z","article-title":"The management of very low-calorie ketogenic diet in obesity outpatient clinic: a practical guide","volume":"17","author":"Muscogiuri","year":"2019","journal-title":"J Transl Med"},{"key":"10.1016\/j.molmet.2024.101898_bib5","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s40618-019-01061-2","article-title":"Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology (SIE)","volume":"42","author":"Caprio","year":"2019","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.molmet.2024.101898_bib6","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jacl.2019.08.003","volume":"13","author":"Kirkpatrick","year":"2019","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.molmet.2024.101898_bib7","doi-asserted-by":"crossref","first-page":"730","DOI":"10.14218\/JCTH.2021.00494","article-title":"Current evidence concerning effects of ketogenic diet and intermittent fasting in patients with nonalcoholic fatty liver","volume":"10","author":"Sripongpun","year":"2022","journal-title":"J\u00a0Clin Transl Hepatol"},{"key":"10.1016\/j.molmet.2024.101898_bib8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.nutres.2018.11.007","article-title":"Weight loss, improved physical performance, cognitive function, eating behavior, and metabolic profile in a 12-week ketogenic diet in obese adults","volume":"62","author":"Mohorko","year":"2019","journal-title":"Nutr Res"},{"key":"10.1016\/j.molmet.2024.101898_bib9","doi-asserted-by":"crossref","first-page":"702802","DOI":"10.3389\/fnut.2021.702802","article-title":"Ketogenic diets and chronic disease: weighing the benefits against the risks","volume":"8","author":"Crosby","year":"2021","journal-title":"Front Nutr"},{"key":"10.1016\/j.molmet.2024.101898_bib10","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.cmet.2018.01.005","article-title":"An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans","volume":"27","author":"Mardinoglu","year":"2018","journal-title":"Cell Metabol"},{"key":"10.1016\/j.molmet.2024.101898_bib11","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000515381","article-title":"European guidelines for obesity management in adults with a very low-calorie ketogenic diet: a systematic review and meta-analysis","volume":"14","author":"Muscogiuri","year":"2021","journal-title":"Obes Facts"},{"key":"10.1016\/j.molmet.2024.101898_bib12","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1017\/S0007114513000548","article-title":"Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials","volume":"110","author":"Bueno","year":"2013","journal-title":"Br J Nutr"},{"key":"10.1016\/j.molmet.2024.101898_bib13","article-title":"Weight, insulin resistance, blood lipids, and diet quality changes associated with ketogenic and ultra low-fat dietary patterns: a secondary analysis of the DIETFITS randomized clinical trial","volume":"10","author":"Aronica","year":"2023","journal-title":"Front Nutr"},{"key":"10.1016\/j.molmet.2024.101898_bib14","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1113\/JP283552","article-title":"The ketogenic diet prevents steatosis and insulin resistance by reducing lipogenesis, diacylglycerol accumulation and protein kinase C activity in male rat liver","volume":"600","author":"Jani","year":"2022","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.molmet.2024.101898_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3698","article-title":"Very low-calorie ketogenic diet: a valuable and fashionable nutritional therapy. When could it become dangerous?","author":"Gorini","year":"2023","journal-title":"Diabetes Metab Res Rev"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824000292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824000292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:35:14Z","timestamp":1761957314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877824000292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":15,"alternative-id":["S2212877824000292"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2024.101898","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Letter-to-the-editor on \u201cA low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice\u201d","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2024.101898","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2024.101897","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2023.101675","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"101898"}}