{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:47:46Z","timestamp":1793238466862,"version":"4.5.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HD102726-01"],"award-info":[{"award-number":["R01HD102726-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["5 P30DK048520-27"],"award-info":[{"award-number":["5 P30DK048520-27"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K01DK112967-05"],"award-info":[{"award-number":["K01DK112967-05"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P20 GM103418"],"award-info":[{"award-number":["P20 GM103418"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P20 GM144269"],"award-info":[{"award-number":["P20 GM144269"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1S10OD028598-01"],"award-info":[{"award-number":["1S10OD028598-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01BX002567-01"],"award-info":[{"award-number":["1I01BX002567-01"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.molmet.2024.101908","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T11:53:26Z","timestamp":1709294006000},"page":"101908","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["VCD-induced menopause mouse model reveals reprogramming of hepatic metabolism"],"prefix":"10.1016","volume":"82","author":[{"given":"Roshan","family":"Kumari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Ponte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edziu","family":"Franczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Prom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura F.","family":"O'Neil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela E.","family":"Sardiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Lutkewitte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lane K.","family":"Christenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartik","family":"Shankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Matthew","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Thyfault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.molmet.2024.101908_bib1","first-page":"23","article-title":"The demographic changes of menopausal and geripausal women in Korea","volume":"22","author":"Kim","year":"2015","journal-title":"J\u00a0Bone Metab"},{"issue":"1","key":"10.1016\/j.molmet.2024.101908_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/nu12010202","article-title":"Menopause-associated lipid metabolic disorders and foods beneficial for postmenopausal women","volume":"12","author":"Ko","year":"2020","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.molmet.2024.101908_bib3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1210\/er.2009-0006","article-title":"Ovarian aging: mechanisms and clinical consequences","volume":"30","author":"Broekmans","year":"2009","journal-title":"Endocr Rev"},{"issue":"2","key":"10.1016\/j.molmet.2024.101908_bib4","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1590\/2359-3997000000253","article-title":"Prevalence of metabolic syndrome in pre- and postmenopausal women","volume":"61","author":"Marchi","year":"2017","journal-title":"Arch Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.molmet.2024.101908_bib5","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1097\/gme.0b013e3181cec85d","article-title":"Obesity and reproductive hormone levels in the transition to menopause","volume":"17","author":"Freeman","year":"2010","journal-title":"Menopause"},{"issue":"2","key":"10.1016\/j.molmet.2024.101908_bib6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0095-4543(03)00012-5","article-title":"The menopause and obesity","volume":"30","author":"Lovejoy","year":"2003","journal-title":"Prim Care Clin Off Pract"},{"issue":"4","key":"10.1016\/j.molmet.2024.101908_bib7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1152\/physiol.00057.2014","article-title":"The VCD mouse model of menopause and perimenopause for the study of sex differences in cardiovascular disease and the metabolic syndrome","volume":"31","author":"Brooks","year":"2016","journal-title":"Physiology"},{"issue":"1","key":"10.1016\/j.molmet.2024.101908_bib8","first-page":"59","article-title":"Metabolic disorders in menopause","volume":"14","author":"Stachowiak","year":"2015","journal-title":"Prz Menopauzalny"},{"issue":"10","key":"10.1016\/j.molmet.2024.101908_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12100954","article-title":"Metabolic disorders in menopause","volume":"12","author":"Jeong","year":"2022","journal-title":"Metabolites"},{"issue":"1","key":"10.1016\/j.molmet.2024.101908_bib10","first-page":"87","article-title":"Relationship between obesity and obesity-related morbidities weakens with aging","volume":"69","author":"Canning","year":"2013","journal-title":"J\u00a0Gerontol: Series A"},{"issue":"1","key":"10.1016\/j.molmet.2024.101908_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s40618-021-01616-2","article-title":"Aging and changes in adiposity indices: the impact of menopause","volume":"45","author":"Farahmand","year":"2022","journal-title":"J\u00a0Endocrinol Invest"},{"issue":"1","key":"10.1016\/j.molmet.2024.101908_bib12","first-page":"9","article-title":"Non alcoholic fatty liver disease and metabolic syndrome","volume":"13","author":"Paschos","year":"2009","journal-title":"Hippokratia"},{"issue":"3","key":"10.1016\/j.molmet.2024.101908_bib13","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ogc.2019.04.008","article-title":"Menopause: hormones, lifestyle, and optimizing aging","volume":"46","author":"Minkin","year":"2019","journal-title":"Obstet Gynecol Clin N Am"},{"key":"10.1016\/j.molmet.2024.101908_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2168381","article-title":"Prevalence of metabolic syndrome and nonalcoholic fatty liver disease among premenopausal and postmenopausal women in Ho municipality: a cross-sectional study","volume":"2020","author":"Setroame","year":"2020","journal-title":"BioMed Res Int"},{"issue":"4","key":"10.1016\/j.molmet.2024.101908_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19042096","article-title":"Prevalence and risk factors of metabolic-associated fatty liver disease among 73,566 individuals in Beijing, China","volume":"19","author":"Yuan","year":"2022","journal-title":"Int J Environ Res Publ Health"},{"issue":"6","key":"10.1016\/j.molmet.2024.101908_bib16","doi-asserted-by":"crossref","first-page":"E1020","DOI":"10.1152\/ajpendo.00013.2021","article-title":"Estradiol treatment or modest exercise improves hepatic health and mitochondrial outcomes in female mice following ovariectomy","volume":"320","author":"Fuller","year":"2021","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.molmet.2024.101908_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molmet.2018.05.008","article-title":"Sex differences in lipid and lipoprotein metabolism","volume":"15","author":"Palmisano","year":"2018","journal-title":"Mol Metabol"},{"issue":"5","key":"10.1016\/j.molmet.2024.101908_bib18","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jhep.2009.11.030","article-title":"Mitochondrial dysfunction precedes insulin resistance\u00a0and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model","volume":"52","author":"Rector","year":"2010","journal-title":"J\u00a0Hepatol"},{"issue":"6","key":"10.1016\/j.molmet.2024.101908_bib19","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.cmet.2011.11.004","article-title":"Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease","volume":"14","author":"Sunny","year":"2011","journal-title":"Cell Metabol"},{"issue":"13","key":"10.1016\/j.molmet.2024.101908_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23137280","article-title":"Mitochondrial dysfunction plays central role in nonalcoholic fatty liver disease","volume":"23","author":"Ramanathan","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.molmet.2024.101908_bib21","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1194\/jlr.M023382","article-title":"Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver","volume":"53","author":"Satapati","year":"2012","journal-title":"J\u00a0Lipid Res"},{"issue":"5","key":"10.1016\/j.molmet.2024.101908_bib22","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.cmet.2015.04.004","article-title":"Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis","volume":"21","author":"Koliaki","year":"2015","journal-title":"Cell Metabol"},{"issue":"4","key":"10.1016\/j.molmet.2024.101908_bib23","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1172\/JCI86695","article-title":"Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver","volume":"126","author":"Satapati","year":"2016","journal-title":"J\u00a0Clin Invest"},{"issue":"10","key":"10.1016\/j.molmet.2024.101908_bib24","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa134","article-title":"NAFLD and NASH in postmenopausal women: implications for diagnosis and treatment","volume":"161","author":"DiStefano","year":"2020","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.molmet.2024.101908_bib25","doi-asserted-by":"crossref","first-page":"546","DOI":"10.2174\/1570161116666180711121949","article-title":"Menopause and non-alcoholic fatty liver disease: a review focusing on therapeutic perspectives","volume":"17","author":"Venetsanaki","year":"2019","journal-title":"Curr Vasc Pharmacol"},{"issue":"2","key":"10.1016\/j.molmet.2024.101908_bib26","first-page":"69","article-title":"The 2020\u00a0menopausal hormone therapy guidelines","volume":"26","author":"Lee","year":"2020","journal-title":"J\u00a0Menopausal Med"},{"issue":"24","key":"10.1016\/j.molmet.2024.101908_bib27","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.1113\/JP276539","article-title":"Hepatic mitochondrial adaptations to physical activity: impact of sexual dimorphism, PGC1\u03b1 and BNIP3-mediated mitophagy","volume":"596","author":"Von Schulze","year":"2018","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.molmet.2024.101908_bib28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.maturitas.2016.01.015","article-title":"Modeling menopause: the utility of rodents in translational behavioral endocrinology research","volume":"87","author":"Koebele","year":"2016","journal-title":"Maturitas"},{"issue":"2","key":"10.1016\/j.molmet.2024.101908_bib29","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1194\/jlr.M028969","article-title":"Differential effects of estrogen\/androgen on the prevention of nonalcoholic fatty liver disease in the male rat","volume":"54","author":"Zhang","year":"2013","journal-title":"J\u00a0Lipid Res"},{"issue":"1","key":"10.1016\/j.molmet.2024.101908_bib30","first-page":"46","article-title":"Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes","volume":"59","author":"Muhammad","year":"2009","journal-title":"Comp Med"},{"issue":"3","key":"10.1016\/j.molmet.2024.101908_bib31","doi-asserted-by":"crossref","first-page":"R587","DOI":"10.1152\/ajpregu.90762.2008","article-title":"Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome","volume":"297","author":"Romero-Aleshire","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.molmet.2024.101908_bib32","first-page":"e4389","article-title":"Performing vaginal lavage, crystal violet staining, and vaginal cytological evaluation for mouse estrous cycle staging identification","volume":"67","author":"McLean","year":"2012","journal-title":"J\u00a0Vis Exp"},{"issue":"10","key":"10.1016\/j.molmet.2024.101908_bib33","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1002\/oby.22925","article-title":"Difference in housing temperature-induced energy expenditure elicits sex-specific diet-induced metabolic adaptations in mice","volume":"28","author":"Morris","year":"2020","journal-title":"Obesity"},{"issue":"6","key":"10.1016\/j.molmet.2024.101908_bib34","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.molmet.2015.03.001","article-title":"Integration of body temperature into the analysis of energy expenditure in the mouse","volume":"4","author":"Abreu-Vieira","year":"2015","journal-title":"Mol Metabol"},{"issue":"8","key":"10.1016\/j.molmet.2024.101908_bib35","doi-asserted-by":"crossref","first-page":"G979","DOI":"10.1152\/ajpgi.00169.2012","article-title":"PGC-1\u03b1 overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion","volume":"303","author":"Morris","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"10.1016\/j.molmet.2024.101908_bib36","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jhep.2022.04.010","article-title":"Lack of VMP1 impairs hepatic lipoprotein secretion and promotes non-alcoholic steatohepatitis","volume":"77","author":"Jiang","year":"2022","journal-title":"J\u00a0Hepatol"},{"issue":"2","key":"10.1016\/j.molmet.2024.101908_bib37","doi-asserted-by":"crossref","first-page":"E298","DOI":"10.1152\/ajpendo.00098.2019","article-title":"Sex modulates hepatic mitochondrial adaptations to high-fat diet and physical activity","volume":"317","author":"McCoin","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.molmet.2024.101908_bib38","first-page":"F1000Res","article-title":"RNA-seq analysis is easy as 1-2-3 with limma","volume":"5","author":"Law","year":"2016","journal-title":"Glimma and edgeR"},{"issue":"W1","key":"10.1016\/j.molmet.2024.101908_bib39","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"10.1016\/j.molmet.2024.101908_bib40","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/nn.4353","article-title":"Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder","volume":"19","author":"Krishnan","year":"2016","journal-title":"Nat Neurosci"},{"issue":"1","key":"10.1016\/j.molmet.2024.101908_bib41","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41596-018-0082-x","article-title":"Single-pot, solid-phase-enhanced sample preparation for proteomics experiments","volume":"14","author":"Hughes","year":"2019","journal-title":"Nat Protoc"},{"issue":"1","key":"10.1016\/j.molmet.2024.101908_bib42","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1038\/s41467-018-07454-w","article-title":"Chromatogram libraries improve peptide detection and quantification by data independent acquisition mass spectrometry","volume":"9","author":"Searle","year":"2018","journal-title":"Nat Commun"},{"issue":"40","key":"10.1016\/j.molmet.2024.101908_bib43","doi-asserted-by":"crossref","first-page":"25625","DOI":"10.1021\/acsomega.0c02564","article-title":"proteiNorm - a user-friendly tool for normalization and analysis of tmt and label-free protein quantification","volume":"5","author":"Graw","year":"2020","journal-title":"ACS Omega"},{"issue":"7","key":"10.1016\/j.molmet.2024.101908_bib44","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.molmet.2024.101908_bib45","doi-asserted-by":"crossref","first-page":"5184","DOI":"10.21105\/joss.05184","article-title":"proteoDA: a package for quantitative proteomics","volume":"8","author":"Thurman","year":"2023","journal-title":"J\u00a0Open Source Softw"},{"issue":"D1","key":"10.1016\/j.molmet.2024.101908_bib46","doi-asserted-by":"crossref","first-page":"D1541","DOI":"10.1093\/nar\/gkaa1011","article-title":"MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations","volume":"49","author":"Rath","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"13","key":"10.1016\/j.molmet.2024.101908_bib47","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1016\/j.celrep.2018.08.091","article-title":"Mitochondrial diagnostics: a multiplexed assay platform for comprehensive assessment of mitochondrial energy fluxes","volume":"24","author":"Fisher-Wellman","year":"2018","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.molmet.2024.101908_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-74718-1","article-title":"Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs","volume":"10","author":"McLaughlin","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.molmet.2024.101908_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.828522","article-title":"Sex and species differences in the development of diet-induced obesity and metabolic disturbances in rodents","volume":"9","author":"Maric","year":"2022","journal-title":"Front Nutr"},{"issue":"6","key":"10.1016\/j.molmet.2024.101908_bib50","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/ijo.2008.25","article-title":"Increased visceral fat and decreased energy expenditure during the menopausal transition","volume":"32","author":"Lovejoy","year":"2008","journal-title":"Int J Obes"},{"issue":"6","key":"10.1016\/j.molmet.2024.101908_bib51","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1210\/jc.2003-030242","article-title":"The emergence of the metabolic syndrome with menopause","volume":"88","author":"Carr","year":"2003","journal-title":"J\u00a0Clin Endocrinol Metabol"},{"issue":"5","key":"10.1016\/j.molmet.2024.101908_bib52","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1210\/en.2016-1677","article-title":"Sex hormones and cardiometabolic health: role of estrogen and estrogen receptors","volume":"158","author":"Clegg","year":"2017","journal-title":"Endocrinology"},{"issue":"Pt 3","key":"10.1016\/j.molmet.2024.101908_bib53","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.mce.2015.05.020","article-title":"Impaired estrogen receptor action in the pathogenesis of the metabolic syndrome","volume":"418","author":"Hevener","year":"2015","journal-title":"Mol Cell Endocrinol"},{"issue":"1\u20132","key":"10.1016\/j.molmet.2024.101908_bib54","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.mce.2014.02.002","article-title":"Estrogen biology: new insights into GPER function and clinical opportunities","volume":"389","author":"Prossnitz","year":"2014","journal-title":"Mol Cell Endocrinol"},{"issue":"8","key":"10.1016\/j.molmet.2024.101908_bib55","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1055\/s-0042-110320","article-title":"Metabolism regulation by estrogens and their receptors in the central nervous system before and after menopause","volume":"48","author":"Coyoy","year":"2016","journal-title":"Horm Metab Res"},{"issue":"6","key":"10.1016\/j.molmet.2024.101908_bib56","doi-asserted-by":"crossref","first-page":"bvad053","DOI":"10.1210\/jendso\/bvad053","article-title":"Pre- and post-sexual maturity liver-specific ER\u03b1 knockout does not impact hepatic mitochondrial function","volume":"7","author":"Fuller","year":"2023","journal-title":"J\u00a0Endocr Soc"},{"issue":"4","key":"10.1016\/j.molmet.2024.101908_bib57","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1249\/JES.0000000000000160","article-title":"Modulation of energy expenditure by estrogens and exercise in women","volume":"46","author":"Gavin","year":"2018","journal-title":"Exerc Sport Sci Rev"},{"issue":"7","key":"10.1016\/j.molmet.2024.101908_bib58","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/hep4.1363","article-title":"Selective liver estrogen receptor \u03b1 modulation prevents steatosis, diabetes, and obesity through the anorectic growth differentiation factor 15 hepatokine in mice","volume":"3","author":"Guillaume","year":"2019","journal-title":"Hepatol Commun"},{"issue":"5","key":"10.1016\/j.molmet.2024.101908_bib59","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1210\/en.2008-0971","article-title":"Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice","volume":"150","author":"Riant","year":"2009","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.molmet.2024.101908_bib60","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jsbmb.2008.03.026","article-title":"Human models of aromatase deficiency","volume":"109","author":"Zirilli","year":"2008","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"issue":"3","key":"10.1016\/j.molmet.2024.101908_bib61","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3181\/00379727-180-42204","article-title":"Effects of estrogen on food intake, body weight, and temperature\u00a0of male and female obese mice","volume":"180","author":"Dubuc","year":"1985","journal-title":"Proc Soc Exp Biol Med"},{"issue":"1\u20133","key":"10.1016\/j.molmet.2024.101908_bib62","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jsbmb.2010.06.012","article-title":"Metabolic impact of estrogen signalling through ERalpha and ERbeta","volume":"122","author":"Foryst-Ludwig","year":"2010","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"issue":"1","key":"10.1016\/j.molmet.2024.101908_bib63","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1530\/JOE-11-0044","article-title":"The diversity of sex steroid action: regulation of metabolism by estrogen signaling","volume":"212","author":"Faulds","year":"2012","journal-title":"J\u00a0Endocrinol"},{"issue":"9","key":"10.1016\/j.molmet.2024.101908_bib64","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1210\/en.2011-2006","article-title":"Adipose tissue inflammation and reduced insulin sensitivity in ovariectomized mice occurs in the absence of increased adiposity","volume":"153","author":"Vieira Potter","year":"2012","journal-title":"Endocrinology"},{"issue":"7656","key":"10.1016\/j.molmet.2024.101908_bib65","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature22342","article-title":"Blocking FSH induces thermogenic adipose tissue and reduces body fat","volume":"546","author":"Liu","year":"2017","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.molmet.2024.101908_bib66","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJMcibr1704542","article-title":"Preventing fat gain by blocking follicle-stimulating hormone","volume":"377","author":"Kohrt","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"46","key":"10.1016\/j.molmet.2024.101908_bib67","doi-asserted-by":"crossref","first-page":"28971","DOI":"10.1073\/pnas.2014588117","article-title":"First-in-class humanized FSH blocking antibody targets bone and fat","volume":"117","author":"Gera","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.molmet.2024.101908_bib68","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/gme.0b013e318185e249","article-title":"Relative androgen excess during the menopausal transition predicts incident metabolic syndrome in midlife women: study of Women's Health across the Nation","volume":"16","author":"Torr\u00e9ns","year":"2009","journal-title":"Menopause"},{"issue":"4","key":"10.1016\/j.molmet.2024.101908_bib69","first-page":"151","article-title":"Changes of androgens levels in menopausal women","volume":"19","author":"Brzozowska","year":"2020","journal-title":"Prz Menopauzalny"},{"issue":"2","key":"10.1016\/j.molmet.2024.101908_bib70","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2337\/db19-0719","article-title":"Impaired metabolic flexibility to high-fat overfeeding predicts future weight gain in healthy adults","volume":"69","author":"Begaye","year":"2020","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.molmet.2024.101908_bib71","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1152\/japplphysiol.00035.2020","article-title":"Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice","volume":"128","author":"Fuller","year":"2020","journal-title":"J\u00a0Appl Physiol"},{"issue":"3","key":"10.1016\/j.molmet.2024.101908_bib72","doi-asserted-by":"crossref","first-page":"R353","DOI":"10.1152\/ajpregu.00216.2022","article-title":"High-fat\/high-sucrose diet worsens metabolic outcomes and widespread hypersensitivity following early-life stress exposure in female mice","volume":"324","author":"Frick","year":"2023","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"9","key":"10.1016\/j.molmet.2024.101908_bib73","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1093\/ajcn\/34.9.1816","article-title":"Energy expenditure and fat-free mass in men and women","volume":"34","author":"Webb","year":"1981","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1016\/j.molmet.2024.101908_bib74","doi-asserted-by":"crossref","first-page":"E132","DOI":"10.1152\/ajpendo.2002.282.1.E132","article-title":"Body-size dependence of resting energy expenditure can be attributed to nonenergetic homogeneity of fat-free mass","volume":"282","author":"Heymsfield","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.molmet.2024.101908_bib75","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fphys.2013.00047","article-title":"Issues in characterizing resting energy expenditure in obesity and after weight loss","volume":"4","author":"Bosy-Westphal","year":"2013","journal-title":"Front Physiol"},{"issue":"3","key":"10.1016\/j.molmet.2024.101908_bib76","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/ajhb.21137","article-title":"Evaluation of specific metabolic rates of major organs and tissues: comparison between men and women","volume":"23","author":"Wang","year":"2011","journal-title":"Am J Hum Biol"},{"key":"10.1016\/j.molmet.2024.101908_bib77","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev-nutr-071715-050656","article-title":"Alterations of mitochondrial function and insulin sensitivity in human obesity and diabetes mellitus","volume":"36","author":"Koliaki","year":"2016","journal-title":"Annu Rev Nutr"},{"issue":"5","key":"10.1016\/j.molmet.2024.101908_bib78","first-page":"739","article-title":"Hepatic energy metabolism in human diabetes mellitus, obesity and non-alcoholic fatty liver disease","volume":"21","author":"Koliaki","year":"2013","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"10.1016\/j.molmet.2024.101908_bib79","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/hep.32324","article-title":"Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD","volume":"76","author":"Moore","year":"2022","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.molmet.2024.101908_bib80","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1210\/me.2007-0121","article-title":"Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver","volume":"22","author":"Gao","year":"2008","journal-title":"Mol Endocrinol"},{"issue":"334","key":"10.1016\/j.molmet.2024.101908_bib81","doi-asserted-by":"crossref","first-page":"334ra354","DOI":"10.1126\/scitranslmed.aad3815","article-title":"Skeletal muscle action of estrogen receptor \u03b1 is critical for the maintenance of mitochondrial function and metabolic homeostasis in females","volume":"8","author":"Ribas","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.molmet.2024.101908_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101566","article-title":"The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR","volume":"64","author":"Steffen","year":"2022","journal-title":"Mol Metabol"},{"key":"10.1016\/j.molmet.2024.101908_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101802","article-title":"Partial\u00a0skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in\u00a0diet-induced obese mice, but not in lean mice","volume":"77","author":"Kugler","year":"2023","journal-title":"Mol Metabol"},{"issue":"1","key":"10.1016\/j.molmet.2024.101908_bib84","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/hep.32604","article-title":"Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation","volume":"77","author":"Ma","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.molmet.2024.101908_bib85","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.541040","article-title":"The functional impact of mitochondrial structure across subcellular scales","volume":"11","author":"Glancy","year":"2020","journal-title":"Front Physiol"},{"issue":"10","key":"10.1016\/j.molmet.2024.101908_bib86","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1016\/j.celrep.2018.02.041","article-title":"Estrogen deficiency promotes hepatic steatosis via a glucocorticoid receptor-dependent mechanism in mice","volume":"22","author":"Quinn","year":"2018","journal-title":"Cell Rep"},{"issue":"3","key":"10.1016\/j.molmet.2024.101908_bib87","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4103\/ijem.IJEM_585_17","article-title":"Nonalcoholic fatty liver disease and type 2 diabetes mellitus","volume":"22","author":"Dharmalingam","year":"2018","journal-title":"Indian J Endocrinol Metab"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824000395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824000395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:35:52Z","timestamp":1761957352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877824000395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":87,"alternative-id":["S2212877824000395"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2024.101908","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.12.14.571644","asserted-by":"object"}]},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"VCD-induced menopause mouse model reveals reprogramming of hepatic metabolism","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2024.101908","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"101908"}}