{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:57:26Z","timestamp":1793908646815,"version":"4.8.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008644","name":"Japan Diabetes Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008644","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.molmet.2024.101934","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T08:45:40Z","timestamp":1712652340000},"page":"101934","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Hepatic ketone body regulation of renal gluconeogenesis"],"prefix":"10.1016","volume":"84","author":[{"given":"Ryo","family":"Hatano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Hirahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Shimano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Miki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2024.101934_bib1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3389\/fendo.2018.00802","article-title":"Unraveling the regulation of hepatic gluconeogenesis","volume":"9","author":"Zhang","year":"2019","journal-title":"Front Endocrinol"},{"issue":"8","key":"10.1016\/j.molmet.2024.101934_bib2","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/ndt\/gfaa302","article-title":"Renal gluconeogenesis: an underestimated role of the kidney in systemic glucose metabolism","volume":"37","author":"Legouis","year":"2022","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"10.1016\/j.molmet.2024.101934_bib3","doi-asserted-by":"crossref","first-page":"382","DOI":"10.2337\/diacare.24.2.382","article-title":"Renal gluconeogenesis: its importance in human glucose homeostasis","volume":"24","author":"Gerich","year":"2001","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.molmet.2024.101934_bib4","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2337\/diabetes.48.2.292","article-title":"Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting","volume":"48","author":"Ekberg","year":"1999","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.molmet.2024.101934_bib5","doi-asserted-by":"crossref","first-page":"E419","DOI":"10.1152\/ajpendo.00032.2001","article-title":"Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis","volume":"282","author":"Meyer","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.molmet.2024.101934_bib6","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.2337\/diabetes.52.6.1386","article-title":"Renal compensation for impaired hepatic glucose release during hypoglycemia in type 2 diabetes: further evidence for hepatorenal reciprocity","volume":"52","author":"Woerle","year":"2003","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.molmet.2024.101934_bib7","first-page":"298","article-title":"Hepatorenal glucose reciprocity in physiologic and pathologic conditions","volume":"15","author":"Gerich","year":"2002","journal-title":"Diabetes Nutr Metab"},{"issue":"11","key":"10.1016\/j.molmet.2024.101934_bib8","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.2337\/db10-1032","article-title":"Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy","volume":"59","author":"Rizza","year":"2010","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.molmet.2024.101934_bib9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1097-2765(05)00015-8","article-title":"Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction","volume":"6","author":"Michael","year":"2000","journal-title":"Mol Cell"},{"issue":"4","key":"10.1016\/j.molmet.2024.101934_bib10","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1172\/JCI115997","article-title":"Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study","volume":"90","author":"Magnusson","year":"1992","journal-title":"J\u00a0Clin Invest"},{"issue":"1","key":"10.1016\/j.molmet.2024.101934_bib11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1053\/meta.2001.19422","article-title":"Quantitative contributions of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitus","volume":"50","author":"Wajngot","year":"2001","journal-title":"Metabolism"},{"issue":"10","key":"10.1016\/j.molmet.2024.101934_bib12","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.2337\/diabetes.52.10.2475","article-title":"Measurement of fractional whole-body gluconeogenesis in humans from blood samples using 2H nuclear magnetic resonance spectroscopy","volume":"52","author":"Kunert","year":"2003","journal-title":"Diabetes"},{"issue":"29","key":"10.1016\/j.molmet.2024.101934_bib13","doi-asserted-by":"crossref","first-page":"12121","DOI":"10.1073\/pnas.0812547106","article-title":"Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes","volume":"106","author":"Samuel","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.molmet.2024.101934_bib14","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1172\/JCI2415","article-title":"Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus","volume":"102","author":"Meyer","year":"1998","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.molmet.2024.101934_bib15","doi-asserted-by":"crossref","first-page":"E1049","DOI":"10.1152\/ajpendo.00041.2004","article-title":"Abnormal renal, hepatic, and muscle glucose metabolism following glucose ingestion in type 2 diabetes","volume":"287","author":"Meyer","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.molmet.2024.101934_bib16","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.2337\/db16-1602","article-title":"Dual regulation of gluconeogenesis by insulin and glucose in the proximal tubules of the kidney","volume":"66","author":"Sasaki","year":"2017","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.molmet.2024.101934_bib17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.kint.2019.08.021","article-title":"Insulin promotes sodium transport but suppresses gluconeogenesis via distinct cellular pathways in human and rat renal proximal tubules","volume":"97","author":"Nakamura","year":"2020","journal-title":"Kidney Int"},{"issue":"120","key":"10.1016\/j.molmet.2024.101934_bib18","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1038\/ki.2010.509","article-title":"Glucose handling by the kidney","author":"Mather","year":"2011","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.molmet.2024.101934_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/srep17565","article-title":"Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L\/+) mice fed high-fat-diet","volume":"5","author":"Lee","year":"2015","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.molmet.2024.101934_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/ki.2012.308","article-title":"Ezrin, a membrane cytoskeletal cross-linker, is essential for the regulation of phosphate and calcium homeostasis","volume":"83","author":"Hatano","year":"2013","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.molmet.2024.101934_bib21","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1038\/s41598-018-22846-0","article-title":"Loss of ezrin expression reduced the susceptibility to the glomerular injury in mice","volume":"8","author":"Hatano","year":"2018","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.molmet.2024.101934_bib22","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1248\/bpb.b17-00992","article-title":"Investigation of metabolomic changes in sunitinib-resistant human renal carcinoma 786-O cells by capillary electrophoresis-time of flight mass spectrometry","volume":"41","author":"Hatakeyama","year":"2018","journal-title":"Biol Pharm Bull"},{"issue":"13","key":"10.1016\/j.molmet.2024.101934_bib23","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.1073\/pnas.96.13.7473","article-title":"A\u00a0critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPAR\u03b1-null mouse as a model of fatty acid oxidation disorders","volume":"96","author":"Leone","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.molmet.2024.101934_bib24","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.cmet.2020.03.017","article-title":"Pimozide alleviates hyperglycemia in diet-induced obesity by inhibiting skeletal muscle ketone oxidation","volume":"31","author":"Al Batran","year":"2020","journal-title":"Cell Metabol"},{"issue":"7","key":"10.1016\/j.molmet.2024.101934_bib25","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.bbamcr.2017.05.003","article-title":"Withaferin A, a natural compound with anti-tumor activity, is a potent inhibitor of transcription factor C\/EBP\u03b2","volume":"1864","author":"Falkenberg","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"11","key":"10.1016\/j.molmet.2024.101934_bib26","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.3390\/antiox9111107","article-title":"Tackling chronic inflammation with withanolide phytochemicals-A withaferin a perspective","volume":"9","author":"Logie","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.molmet.2024.101934_bib27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-nutr-071816-064916","article-title":"\u03b2-Hydroxybutyrate: a signaling metabolite","volume":"37","author":"Newman","year":"2017","journal-title":"Annu Rev Nutr"},{"issue":"6116","key":"10.1016\/j.molmet.2024.101934_bib28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1126\/science.1227166","article-title":"Suppression of oxidative stress by \u03b2-hydroxybutyrate, an endogenous histone deacetylase inhibitor","volume":"339","author":"Shimazu","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.molmet.2024.101934_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101578","article-title":"Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight loss, glycemic normalization and induces adaptations of ketogenic pathways in liver and kidney","volume":"65","author":"Nasser","year":"2022","journal-title":"Mol Metabol"},{"issue":"2","key":"10.1016\/j.molmet.2024.101934_bib30","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.molcel.2016.03.036","article-title":"Metabolic regulation of gene expression by histone lysine \u03b2-hydroxybutyrylation","volume":"62","author":"Xie","year":"2016","journal-title":"Mol Cell"},{"issue":"5 Pt 2","key":"10.1016\/j.molmet.2024.101934_bib31","first-page":"F762","article-title":"Transport of beta-hydroxybutyrate and acetoacetate along rat nephrons: a micropuncture study","volume":"262","author":"Ferrier","year":"1992","journal-title":"Am J Physiol"},{"issue":"1","key":"10.1016\/j.molmet.2024.101934_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41556-019-0440-0","article-title":"Ketogenesis-generated \u03b2-hydroxybutyrate is an epigenetic regulator of CD8+ T-cell memory development","volume":"22","author":"Zhang","year":"2020","journal-title":"Nat Cell Biol"},{"issue":"1","key":"10.1016\/j.molmet.2024.101934_bib33","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1074\/jbc.M007576200","article-title":"Mice with a deletion in the gene for CCAAT\/enhancer-binding protein beta have an attenuated response to cAMP and impaired carbohydrate metabolism","volume":"276","author":"Croniger","year":"2001","journal-title":"J\u00a0Biol Chem"},{"issue":"48","key":"10.1016\/j.molmet.2024.101934_bib34","doi-asserted-by":"crossref","first-page":"31629","DOI":"10.1074\/jbc.273.48.31629","article-title":"C\/EBP and the control of phosphoenolpyruvate carboxykinase gene transcription in the liver","volume":"273","author":"Croniger","year":"1998","journal-title":"J\u00a0Biol Chem"},{"issue":"4","key":"10.1016\/j.molmet.2024.101934_bib35","doi-asserted-by":"crossref","first-page":"F649","DOI":"10.1152\/ajprenal.2001.281.4.F649","article-title":"C\/EBPbeta contributes to cAMP-activated transcription of phosphoenolpyruvate carboxykinase in LLC-PK1-F+ cells","volume":"281","author":"Liu","year":"2001","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.molmet.2024.101934_bib36","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0140-6736(87)90484-3","article-title":"Diagnosis of type 1a and type 1c glycogen storage diseases in adults","volume":"329","author":"Burchell","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.molmet.2024.101934_bib37","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3389\/fped.2020.00591","article-title":"Kidney and metabolic phenotypes in glycogen storage disease type-I patients","volume":"8","author":"Aoun","year":"2020","journal-title":"Front Pediatr"},{"issue":"6","key":"10.1016\/j.molmet.2024.101934_bib38","doi-asserted-by":"crossref","first-page":"F532","DOI":"10.1152\/ajprenal.00038.2023","article-title":"PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells","volume":"324","author":"Verissimo","year":"2023","journal-title":"Am J Physiol Ren Physiol"},{"issue":"4","key":"10.1016\/j.molmet.2024.101934_bib39","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/ki.2014.102","article-title":"Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy","volume":"86","author":"Clar","year":"2014","journal-title":"Kidney Int"},{"issue":"24","key":"10.1016\/j.molmet.2024.101934_bib40","doi-asserted-by":"crossref","first-page":"473","DOI":"10.21037\/atm.2018.10.57","article-title":"Fatty acid oxidation disorders","volume":"6","author":"Merritt","year":"2018","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.molmet.2024.101934_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmg.2020.104086","article-title":"Expanding phenotypic and mutational spectra of mitochondrial HMG-CoA synthase deficiency","volume":"63","author":"Rojnueangnit","year":"2020","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.molmet.2024.101934_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.601594","article-title":"A\u00a0Low-Carbohydrate diet improves glucose metabolism in lean insulinopenic Akita mice along with sodium-glucose cotransporter 2 inhibitor","volume":"11","author":"Fujita","year":"2020","journal-title":"Front Endocrinol"},{"issue":"1","key":"10.1016\/j.molmet.2024.101934_bib43","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41387-020-00142-z","article-title":"Effect of the ketogenic diet on glycemic control, insulin resistance, and lipid metabolism in patients with T2DM: a systematic review and meta-analysis","volume":"10","author":"Yuan","year":"2020","journal-title":"Nutr Diabetes"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824000656?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824000656?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T14:09:10Z","timestamp":1727186950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877824000656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":43,"alternative-id":["S2212877824000656"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2024.101934","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic ketone body regulation of renal gluconeogenesis","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2024.101934","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"101934"}}