{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:12:08Z","timestamp":1789164728228,"version":"build-2803163510"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006390","name":"University of Lausanne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006390","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["CRSK-3_220825"],"award-info":[{"award-number":["CRSK-3_220825"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011594","name":"Penn State College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.molmet.2024.101987","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T22:26:26Z","timestamp":1720304786000},"page":"101987","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["A review on cell-free RNA profiling: Insights into metabolic diseases and predictive value for bariatric surgery outcomes"],"prefix":"10.1016","volume":"87","author":[{"given":"Manvita","family":"Mareboina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Mouratidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson S.","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Pitteloud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Georgakopoulos-Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-6067","authenticated-orcid":false,"given":"Dionysios V.","family":"Chartoumpekis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.molmet.2024.101987_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13112652","article-title":"Urine as a source of liquid biopsy for cancer","volume":"13","author":"Oshi","year":"2021","journal-title":"Cancers"},{"issue":"10","key":"10.1016\/j.molmet.2024.101987_bib2","article-title":"Extrinsic and intrinsic preanalytical variables affecting liquid biopsy in cancer","volume":"4","author":"Batool","year":"2023","journal-title":"Cell Rep Med"},{"issue":"1","key":"10.1016\/j.molmet.2024.101987_bib3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12967-023-03960-8","article-title":"Liquid biopsies: the future of cancer early detection","volume":"21","author":"Connal","year":"2023","journal-title":"J\u00a0Transl Med"},{"issue":"10","key":"10.1016\/j.molmet.2024.101987_bib4","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.jtho.2021.06.017","article-title":"Liquid biopsy for advanced NSCLC: a consensus statement from the International Association for the Study of Lung Cancer","volume":"16","author":"Rolfo","year":"2021","journal-title":"J\u00a0Thorac Oncol"},{"issue":"1","key":"10.1016\/j.molmet.2024.101987_bib5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40364-022-00409-w","article-title":"Current challenges and best practices for cell-free long RNA biomarker discovery","volume":"10","author":"Cab\u00fas","year":"2022","journal-title":"Biomark Res"},{"issue":"10","key":"10.1016\/j.molmet.2024.101987_bib6","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1111\/jcmm.12625","article-title":"The circulating transcriptome as a source of non-invasive cancer biomarkers: concepts and controversies of non-coding and coding RNA in body fluids","volume":"19","author":"Fernandez-Mercado","year":"2015","journal-title":"J\u00a0Cell Mol Med"},{"issue":"1","key":"10.1016\/j.molmet.2024.101987_bib7","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1038\/s41467-021-22444-1","article-title":"A\u00a0comprehensive characterization of the cell-free transcriptome reveals tissue- and subtype-specific biomarkers for cancer detection","volume":"12","author":"Larson","year":"2021","journal-title":"Nat Commun"},{"issue":"7893","key":"10.1016\/j.molmet.2024.101987_bib8","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41586-021-04249-w","article-title":"RNA profiles reveal signatures of future health and disease in pregnancy","volume":"601","author":"Rasmussen","year":"2022","journal-title":"Nature"},{"issue":"50","key":"10.1016\/j.molmet.2024.101987_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb1654","article-title":"Noninvasive characterization of Alzheimer's disease by circulating, cell-free messenger RNA next-generation sequencing","volume":"6","author":"Toden","year":"2020","journal-title":"Sci Adv"},{"issue":"8","key":"10.1016\/j.molmet.2024.101987_bib10","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s43587-021-00088-6","article-title":"RNA sequencing of whole blood reveals early alterations in immune cells and gene expression in Parkinson's disease","volume":"1","author":"Craig","year":"2021","journal-title":"Nat Aging"},{"issue":"4","key":"10.1016\/j.molmet.2024.101987_bib11","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1159\/000443088","article-title":"Circulating LncRNAs as novel, non-invasive biomarkers for prenatal detection of fetal congenital heart defects","volume":"38","author":"Gu","year":"2016","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"10.1016\/j.molmet.2024.101987_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1152\/physiolgenomics.00086.2020","article-title":"Cell-free DNA and RNA-measurement and applications in clinical diagnostics with focus on metabolic disorders","volume":"53","author":"Drag","year":"2021","journal-title":"Physiol Genomics"},{"issue":"8","key":"10.1016\/j.molmet.2024.101987_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10082047","article-title":"Diagnostic and therapeutic potential of circulating-free DNA and cell-free RNA in cancer management","volume":"10","author":"Hassan","year":"2022","journal-title":"Biomedicines"},{"issue":"7","key":"10.1016\/j.molmet.2024.101987_bib14","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/s41431-018-0132-4","article-title":"Circulating cell-free nucleic acids: characteristics and applications","volume":"26","author":"P\u00f6s","year":"2018","journal-title":"Eur J Hum Genet"},{"issue":"2","key":"10.1016\/j.molmet.2024.101987_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1515\/bmc-2017-0002","article-title":"Circulating cell-free microRNAs as clinical cancer biomarkers","volume":"8","author":"Armand-Labit","year":"2017","journal-title":"Biomol Concepts"},{"issue":"1","key":"10.1016\/j.molmet.2024.101987_bib16","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res"},{"issue":"3","key":"10.1016\/j.molmet.2024.101987_bib17","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1089\/bio.2022.0004","article-title":"Evaluating the effects of storage conditions on multiple cell-free RNAs in plasma by high-throughput sequencing","volume":"21","author":"Sun","year":"2023","journal-title":"Biopreserv Biobanking"},{"issue":"3","key":"10.1016\/j.molmet.2024.101987_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030704","article-title":"Evaluation of storage tubes for combined analysis of circulating nucleic acids in liquid biopsies","volume":"20","author":"Ward Gahlawat","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.molmet.2024.101987_bib19","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/s41587-021-01188-9","article-title":"Cell types of origin of the cell-free transcriptome","volume":"40","author":"Vorperian","year":"2022","journal-title":"Nat Biotechnol"},{"issue":"8","key":"10.1016\/j.molmet.2024.101987_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160577","article-title":"Diurnal variations of human circulating cell-free micro-RNA","volume":"11","author":"Heegaard","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.molmet.2024.101987_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-73350-3","article-title":"Diurnal stability of cell-free DNA and cell-free RNA in human plasma samples","volume":"10","author":"Wagner","year":"2020","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.molmet.2024.101987_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140488","article-title":"MiRNA analysis by quantitative PCR in preterm human breast milk reveals daily fluctuations of hsa-miR-16-5p","volume":"10","author":"Floris","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.molmet.2024.101987_bib23","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1080\/15592294.2020.1816774","article-title":"Cell-free DNA methylation and transcriptomic signature prediction of pregnancies with adverse outcomes","volume":"16","author":"Del Vecchio","year":"2021","journal-title":"Epigenetics"},{"issue":"6","key":"10.1016\/j.molmet.2024.101987_bib24","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1097\/HEP.0000000000000520","article-title":"A\u00a0multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"78","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.molmet.2024.101987_bib25","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1053\/j.gastro.2012.04.001","article-title":"The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology","volume":"142","author":"Chalasani","year":"2012","journal-title":"Gastroenterology"},{"issue":"Suppl","key":"10.1016\/j.molmet.2024.101987_bib26","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.3350\/cmh.2022.0365","article-title":"Global incidence and prevalence of nonalcoholic fatty liver disease","volume":"29","author":"Teng","year":"2023","journal-title":"Clin Mol Hepatol"},{"issue":"2","key":"10.1016\/j.molmet.2024.101987_bib27","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/hep.32285","article-title":"Hepatic fibrosis 2022: unmet needs and a blueprint for the future","volume":"75","author":"Friedman","year":"2022","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.molmet.2024.101987_bib28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1373\/clinchem.2009.133355","article-title":"Aberrant concentrations of liver-derived plasma albumin mRNA in liver pathologies","volume":"56","author":"Chan","year":"2010","journal-title":"Clin Chem"},{"issue":"7","key":"10.1016\/j.molmet.2024.101987_bib29","doi-asserted-by":"crossref","first-page":"e302","DOI":"10.1111\/liv.12429","article-title":"Significance of serum and hepatic microRNA-122 levels in patients with non-alcoholic fatty liver disease","volume":"34","author":"Miyaaki","year":"2014","journal-title":"Liver Int"},{"issue":"5","key":"10.1016\/j.molmet.2024.101987_bib30","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1136\/gutjnl-2014-306996","article-title":"Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis","volume":"64","author":"Pirola","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.molmet.2024.101987_bib31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cca.2013.05.021","article-title":"Associations between circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver","volume":"424","author":"Yamada","year":"2013","journal-title":"Clin Chim Acta"},{"issue":"8","key":"10.1016\/j.molmet.2024.101987_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105192","article-title":"A\u00a0pilot study of serum microRNAs panel as potential biomarkers for diagnosis of nonalcoholic fatty liver disease","volume":"9","author":"Tan","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.molmet.2024.101987_bib33","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/hep4.1501","article-title":"Differential associations of circulating microRNAs with pathogenic factors in NAFLD","volume":"4","author":"Ezaz","year":"2020","journal-title":"Hepatol Commun"},{"issue":"4","key":"10.1016\/j.molmet.2024.101987_bib34","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/cob.12192","article-title":"Elevation of circulating microRNA levels in obese children compared to healthy controls","volume":"7","author":"Thompson","year":"2017","journal-title":"Clin Obes"},{"key":"10.1016\/j.molmet.2024.101987_bib35","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.3389\/fphys.2018.01256","article-title":"Cell-free circulating nucleic acids as early biomarkers for NAFLD and NAFLD-associated disorders","volume":"9","author":"Turchinovich","year":"2018","journal-title":"Front Physiol"},{"issue":"2","key":"10.1016\/j.molmet.2024.101987_bib36","doi-asserted-by":"crossref","first-page":"142","DOI":"10.2174\/1566523214666141224095610","article-title":"miR-122 is a unique molecule with great potential in diagnosis, prognosis of liver disease, and therapy both as miRNA mimic and antimir","volume":"15","author":"Thakral","year":"2015","journal-title":"Curr Gene Ther"},{"issue":"8","key":"10.1016\/j.molmet.2024.101987_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023937","article-title":"Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease","volume":"6","author":"Cermelli","year":"2011","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.molmet.2024.101987_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142661","article-title":"Performance of serum microRNAs -122, -192 and -21 as biomarkers in patients with non-alcoholic steatohepatitis","volume":"10","author":"Becker","year":"2015","journal-title":"PLoS One"},{"issue":"44","key":"10.1016\/j.molmet.2024.101987_bib39","doi-asserted-by":"crossref","first-page":"9844","DOI":"10.3748\/wjg.v22.i44.9844","article-title":"Disease-specific miR-34a as diagnostic marker of non-alcoholic steatohepatitis in a Chinese population","volume":"22","author":"Liu","year":"2016","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.molmet.2024.101987_bib40","doi-asserted-by":"crossref","DOI":"10.1186\/s12876-016-0557-6","article-title":"Analysis of association between circulating miR-122 and histopathological features of nonalcoholic fatty liver disease in patients free of hepatocellular carcinoma","volume":"16","author":"Akuta","year":"2016","journal-title":"BMC Gastroenterol"},{"issue":"4","key":"10.1016\/j.molmet.2024.101987_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153497","article-title":"Association of circulating serum miR-34a and miR-122 with dyslipidemia among patients with non-alcoholic fatty liver disease","volume":"11","author":"Salvoza","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.molmet.2024.101987_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/srep38262","article-title":"Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism-the Young Finns Study","volume":"6","author":"Raitoharju","year":"2016","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.molmet.2024.101987_bib43","doi-asserted-by":"crossref","first-page":"G439","DOI":"10.1152\/ajpgi.00397.2020","article-title":"Noninvasive stratification of nonalcoholic fatty liver disease by whole transcriptome cell-free mRNA characterization","volume":"320","author":"Chalasani","year":"2021","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"11","key":"10.1016\/j.molmet.2024.101987_bib44","doi-asserted-by":"crossref","first-page":"8270","DOI":"10.1002\/jcp.29483","article-title":"Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p","volume":"235","author":"Chen","year":"2020","journal-title":"J\u00a0Cell Physiol"},{"issue":"21","key":"10.1016\/j.molmet.2024.101987_bib45","doi-asserted-by":"crossref","first-page":"9569","DOI":"10.18632\/aging.102405","article-title":"TGF-\u03b2- and lipopolysaccharide-induced upregulation of circular RNA PWWP2A promotes hepatic fibrosis via sponging miR-203 and miR-223","volume":"11","author":"Liu","year":"2019","journal-title":"Aging"},{"issue":"11","key":"10.1016\/j.molmet.2024.101987_bib46","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.7150\/thno.42423","article-title":"Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p\/FBXW7 axis","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.molmet.2024.101987_bib47","article-title":"Circular RNA CREBBP suppresses hepatic fibrosis via targeting the hsa-miR-1291\/LEFTY2 Axis","volume":"12","author":"Yang","year":"2021","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.molmet.2024.101987_bib48","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11010-021-04269-0","article-title":"Acetylation of H3K27 activated lncRNA NEAT1 and promoted hepatic lipid accumulation in non-alcoholic fatty liver disease via regulating miR-212-5p\/GRIA3","volume":"477","author":"Hu","year":"2022","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"10.1016\/j.molmet.2024.101987_bib49","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbrc.2018.03.127","article-title":"Long noncoding RNA lncARSR promotes hepatic lipogenesis via Akt\/SREBP-1c pathway and contributes to the pathogenesis of nonalcoholic steatohepatitis","volume":"499","author":"Zhang","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.molmet.2024.101987_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/biom13030560","article-title":"LncRNA and circRNA in patients with non-alcoholic fatty liver disease: a systematic review","volume":"13","author":"Zeng","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.molmet.2024.101987_bib51","article-title":"Atherosclerosis","author":"Pahwa","year":"2023"},{"issue":"10372","key":"10.1016\/j.molmet.2024.101987_bib52","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0140-6736(22)02079-7","article-title":"Machine learning-based marker for coronary artery disease: derivation and validation in two longitudinal cohorts","volume":"401","author":"Forrest","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.molmet.2024.101987_bib53","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1194\/jlr.E800008-JLR200","article-title":"PCSK9 function and physiology","author":"Peterson","year":"2008","journal-title":"J\u00a0Lipid Res"},{"issue":"6","key":"10.1016\/j.molmet.2024.101987_bib54","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/eurheartj\/ehv637","article-title":"Prognostic value of PCSK9 levels in patients with acute coronary syndromes","volume":"37","author":"Gencer","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.molmet.2024.101987_bib55","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.atherosclerosis.2016.03.010","article-title":"PCSK9 in relation to coronary plaque inflammation: results of the ATHEROREMO-IVUS study","volume":"248","author":"Cheng","year":"2016","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.molmet.2024.101987_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/genes14030632","article-title":"Interplay between microRNAs, serum proprotein convertase subtilisin\/kexin type 9 (PCSK9), and lipid parameters in patients with very high lipoprotein(a) treated with PCSK9 inhibitors","volume":"14","author":"Levstek","year":"2023","journal-title":"Genes"},{"issue":"11","key":"10.1016\/j.molmet.2024.101987_bib57","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1042\/CS20150235","article-title":"Circulating miR-33a and miR-33b are up-regulated in familial hypercholesterolaemia in paediatric age","volume":"129","author":"Martino","year":"2015","journal-title":"Clin Sci"},{"issue":"5","key":"10.1016\/j.molmet.2024.101987_bib58","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1161\/CIRCRESAHA.116.309528","article-title":"MicroRNA-33 controls adaptive fibrotic response in the remodeling heart by preserving lipid raft cholesterol","volume":"120","author":"Nishiga","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.molmet.2024.101987_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154768","article-title":"MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice","volume":"119","author":"Xu","year":"2021","journal-title":"Metabolism"},{"issue":"11","key":"10.1016\/j.molmet.2024.101987_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080345","article-title":"Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina","volume":"8","author":"D'Alessandra","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.molmet.2024.101987_bib61","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s11033-018-4186-8","article-title":"Inhibition of miR-486 and miR-92a decreases liver and plasma cholesterol levels by modulating lipid-related genes in hyperlipidemic hamsters","volume":"45","author":"Niculescu","year":"2018","journal-title":"Mol Biol Rep"},{"issue":"4","key":"10.1016\/j.molmet.2024.101987_bib62","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00059-022-05121-x","article-title":"Correlation between decreased plasma miR-29a and vascular endothelial injury induced by hyperlipidemia","volume":"48","author":"An","year":"2023","journal-title":"Herz"},{"issue":"9","key":"10.1016\/j.molmet.2024.101987_bib63","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1139\/cjpp-2020-0539","article-title":"MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating \u03b2-catenin signaling in hyperlipidemia","volume":"99","author":"Chen","year":"2021","journal-title":"Can J Physiol Pharmacol"},{"issue":"5","key":"10.1016\/j.molmet.2024.101987_bib64","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/CIRCRESAHA.109.215566","article-title":"Circulating microRNAs in patients with coronary artery disease","volume":"107","author":"Fichtlscherer","year":"2010","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.molmet.2024.101987_bib65","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11892-022-01453-4","article-title":"Recent developments in biomarkers for diagnosis and screening of type 2 diabetes mellitus","volume":"22","author":"Ortiz-Mart\u00ednez","year":"2022","journal-title":"Curr Diabetes Rep"},{"issue":"5","key":"10.1016\/j.molmet.2024.101987_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17050665","article-title":"Characterization of micro-RNA changes during the progression of type 2 diabetes in Zucker diabetic fatty rats","volume":"17","author":"Delic","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.molmet.2024.101987_bib67","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1210\/en.2012-1744","article-title":"Circulating miR-375 as a biomarker of \u03b2-cell death and diabetes in mice","volume":"154","author":"Erener","year":"2013","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/j.molmet.2024.101987_bib68","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00109-015-1296-9","article-title":"miR-375 gene dosage in pancreatic \u03b2-cells: implications for regulation of \u03b2-cell mass and biomarker development","volume":"93","author":"Latreille","year":"2015","journal-title":"J\u00a0Mol Med"},{"issue":"1","key":"10.1016\/j.molmet.2024.101987_bib69","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00592-010-0226-0","article-title":"Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study","volume":"48","author":"Kong","year":"2011","journal-title":"Acta Diabetol"},{"issue":"4","key":"10.1016\/j.molmet.2024.101987_bib70","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.metabol.2014.12.003","article-title":"Identification of circulating miR-101, miR-375 and miR-802 as biomarkers for type 2 diabetes","volume":"64","author":"Higuchi","year":"2015","journal-title":"Metabolism"},{"issue":"5","key":"10.1016\/j.molmet.2024.101987_bib71","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.2337\/dc13-1847","article-title":"Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization","volume":"37","author":"Ortega","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.molmet.2024.101987_bib72","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.biopha.2018.06.104","article-title":"LncRNA-NR_033515 promotes proliferation, fibrogenesis and epithelial-to-mesenchymal transition by targeting miR-743b-5p in diabetic nephropathy","volume":"106","author":"Gao","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.molmet.2024.101987_bib73","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbacli.2015.09.001","article-title":"Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus","volume":"4","author":"Carter","year":"2015","journal-title":"BBA Clin"},{"issue":"6","key":"10.1016\/j.molmet.2024.101987_bib74","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1016\/j.gendis.2022.05.022","article-title":"Clinical relevance of circulating non-coding RNAs in metabolic diseases: emphasis on obesity, diabetes, cardiovascular diseases and metabolic syndrome","volume":"10","author":"Dandare","year":"2023","journal-title":"Genes Dis"},{"issue":"4","key":"10.1016\/j.molmet.2024.101987_bib75","first-page":"1865","article-title":"Screening of circular RNAs and validation of circANKRD36 associated with inflammation in patients with type 2 diabetes mellitus","volume":"42","author":"Fang","year":"2018","journal-title":"Int J Mol Med"},{"issue":"2","key":"10.1016\/j.molmet.2024.101987_bib76","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2337\/db16-0731","article-title":"Circulating microRNA-122 is associated with the risk of new-onset metabolic syndrome and type 2 diabetes","volume":"66","author":"Willeit","year":"2017","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.molmet.2024.101987_bib77","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/qjmed\/hcx152","article-title":"Complications of obesity","volume":"111","author":"Kinlen","year":"2018","journal-title":"QJM"},{"key":"10.1016\/j.molmet.2024.101987_bib78","series-title":"National Health and Nutrition Examination Survey 2017 - March 2020 Prepandemic Data Files: Development of Files and Prevalence Estimates for Selected Health Outcomes","author":"Steirman","year":"2021"},{"key":"10.1016\/j.molmet.2024.101987_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121850","article-title":"Polycationic PAMAM ameliorates obesity-associated chronic inflammation and focal adiposity","volume":"293","author":"Huang","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.molmet.2024.101987_bib80","first-page":"86","article-title":"Generation 3 PAMAM dendrimer TAMRA conjugates containing precise dye\/dendrimer ratios","volume":"4","author":"Manono","year":"2015","journal-title":"Mater Today"},{"issue":"7642","key":"10.1016\/j.molmet.2024.101987_bib81","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature21365","article-title":"Adipose-derived circulating miRNAs regulate gene expression in other tissues","volume":"542","author":"Thomou","year":"2017","journal-title":"Nature"},{"issue":"48","key":"10.1016\/j.molmet.2024.101987_bib82","doi-asserted-by":"crossref","first-page":"12158","DOI":"10.1073\/pnas.1808855115","article-title":"Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice","volume":"115","author":"Casta\u00f1o","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.molmet.2024.101987_bib83","article-title":"Differentially expressed circulating LncRNAs and mRNA identified by microarray analysis in obese patients","volume":"6","author":"Sun","year":"2016","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.molmet.2024.101987_bib84","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s10038-020-0753-7","article-title":"Identifying potential functional lncRNAs in metabolic syndrome by constructing a lncRNA-miRNA-mRNA network","volume":"65","author":"Yao","year":"2020","journal-title":"J\u00a0Hum Genet"},{"issue":"4","key":"10.1016\/j.molmet.2024.101987_bib85","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00125-020-05090-y","article-title":"Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation","volume":"63","author":"Zhang","year":"2020","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.molmet.2024.101987_bib86","doi-asserted-by":"crossref","first-page":"E846","DOI":"10.1210\/jc.2010-2701","article-title":"Differential miRNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers","volume":"96","author":"Heneghan","year":"2011","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.molmet.2024.101987_bib87","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41574-019-0260-0","article-title":"The clinical potential of circulating microRNAs in obesity","volume":"15","author":"Ji","year":"2019","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"10.1016\/j.molmet.2024.101987_bib88","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1373\/clinchem.2012.195776","article-title":"Targeting the circulating microRNA signature of obesity","volume":"59","author":"Ortega","year":"2013","journal-title":"Clin Chem"},{"issue":"5","key":"10.1016\/j.molmet.2024.101987_bib89","doi-asserted-by":"crossref","first-page":"e1899","DOI":"10.1210\/clinem\/dgac023","article-title":"Circulating levels of microRNA-122 and hepatic fat change in response to weight-loss interventions: CENTRAL trial","volume":"107","author":"Wang","year":"2022","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.molmet.2024.101987_bib90","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ajcnut.2022.10.001","article-title":"Circulating thrifty microRNA is related to insulin sensitivity, adiposity, and energy metabolism in adults with overweight and obesity: the POUNDS Lost trial","volume":"117","author":"Heianza","year":"2023","journal-title":"Am J Clin Nutr"},{"issue":"10","key":"10.1016\/j.molmet.2024.101987_bib91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077251","article-title":"Serum circulating microRNA profiling for identification of potential type 2 diabetes and obesity biomarkers","volume":"8","author":"Pescador","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.molmet.2024.101987_bib92","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088661","article-title":"Maternal obesity affects fetal neurodevelopmental and metabolic gene expression: a pilot study","volume":"9","author":"Edlow","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.molmet.2024.101987_bib93","doi-asserted-by":"crossref","first-page":"E1655","DOI":"10.1210\/jc.2013-1496","article-title":"Changes in circulating microRNAs are associated with childhood obesity","volume":"98","author":"Prats-Puig","year":"2013","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.molmet.2024.101987_bib94","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s12072-016-9729-2","article-title":"Impact of circulating miR-122 for histological features and hepatocellular carcinoma of nonalcoholic fatty liver disease in Japan","volume":"10","author":"Akuta","year":"2016","journal-title":"Hepatol Int"},{"key":"10.1016\/j.molmet.2024.101987_bib95","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12263-016-0525-3","article-title":"Circulating microRNAs are deregulated in overweight\/obese children: preliminary results of the I.Family study","volume":"11","author":"Iacomino","year":"2016","journal-title":"Genes Nutr"},{"issue":"5","key":"10.1016\/j.molmet.2024.101987_bib96","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.clnu.2018.09.024","article-title":"Circulating microRNAs and adipokines as markers of metabolic syndrome in adolescents with obesity","volume":"38","author":"Al-Rawaf","year":"2019","journal-title":"Clin Nutr"},{"issue":"11","key":"10.1016\/j.molmet.2024.101987_bib97","doi-asserted-by":"crossref","DOI":"10.3390\/genes14112070","article-title":"The regulatory role of microRNAs in obesity and obesity-derived ailments","volume":"14","author":"Benavides-Aguilar","year":"2023","journal-title":"Genes"},{"issue":"8","key":"10.1016\/j.molmet.2024.101987_bib98","article-title":"Meta-analysis of differential miRNA expression after bariatric surgery","volume":"8","author":"Langi","year":"2019","journal-title":"J\u00a0Clin Med Res"},{"key":"10.1016\/j.molmet.2024.101987_bib99","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40608-018-0199-z","article-title":"Improved physiology and metabolic flux after Roux-en-Y gastric bypass is associated with temporal changes in the circulating microRNAome: a longitudinal study in humans","volume":"5","author":"Alkandari","year":"2018","journal-title":"BMC Obes"},{"key":"10.1016\/j.molmet.2024.101987_bib100","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3389\/fendo.2018.00773","article-title":"Changes in blood microRNA expression and early metabolic responsiveness 21 days following bariatric surgery","volume":"9","author":"Atkin","year":"2018","journal-title":"Front Endocrinol"},{"issue":"10","key":"10.1016\/j.molmet.2024.101987_bib101","first-page":"620","article-title":"Elevated levels of miR-122 in serum may contribute to improved endothelial function and lower oncologic risk following bariatric surgery","volume":"19","author":"Blum","year":"2017","journal-title":"Isr Med Assoc J"},{"issue":"9","key":"10.1016\/j.molmet.2024.101987_bib102","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1007\/s11695-018-3247-3","article-title":"Reduction of premature aging markers after gastric bypass surgery in morbidly obese patients","volume":"28","author":"Hohensinner","year":"2018","journal-title":"Obes Surg"},{"issue":"12","key":"10.1016\/j.molmet.2024.101987_bib103","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1007\/s11695-015-1711-x","article-title":"A\u00a0pilot study: the effect of Roux-en-Y gastric bypass on the serum microRNAs of the type 2 diabetes patient","volume":"25","author":"Lirun","year":"2015","journal-title":"Obes Surg"},{"issue":"7","key":"10.1016\/j.molmet.2024.101987_bib104","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/ijo.2015.33","article-title":"Metabolic phenotype-microRNA data fusion analysis of the systemic consequences of Roux-en-Y gastric bypass surgery","volume":"39","author":"Wu","year":"2015","journal-title":"Int J Obes"},{"issue":"2","key":"10.1016\/j.molmet.2024.101987_bib105","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/oby.22379","article-title":"Bariatric surgery alters microRNA content of circulating exosomes in patients with obesity","volume":"27","author":"Bae","year":"2019","journal-title":"Obesity"},{"issue":"5","key":"10.1016\/j.molmet.2024.101987_bib106","doi-asserted-by":"crossref","DOI":"10.3390\/life12050633","article-title":"Relationship between the levels of lncRNA H19 in plasma and different adipose tissue depots with patients' response to bariatric surgery","volume":"12","author":"Artemyeva","year":"2022","journal-title":"Life"},{"issue":"1","key":"10.1016\/j.molmet.2024.101987_bib107","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/oby.21709","article-title":"Circulating adipocyte-derived exosomal microRNAs associated with decreased insulin resistance after gastric bypass","volume":"25","author":"Hubal","year":"2017","journal-title":"Obesity"},{"issue":"11","key":"10.1016\/j.molmet.2024.101987_bib108","doi-asserted-by":"crossref","first-page":"E1467","DOI":"10.1210\/jc.2015-2357","article-title":"Surgery-induced weight loss is associated with the downregulation of genes targeted by microRNAs in adipose tissue","volume":"100","author":"Ortega","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.molmet.2024.101987_bib109","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1159\/000487287","article-title":"Expression of MicroRNA-448 and SIRT1 and prognosis of obese type 2 diabetic mellitus patients after laparoscopic bariatric surgery","volume":"45","author":"Wang","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"4","key":"10.1016\/j.molmet.2024.101987_bib110","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1053\/j.gastro.2012.07.114","article-title":"Effects of bariatric surgery on glucose homeostasis and type 2 diabetes","volume":"143","author":"Bradley","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmet.2024.101987_bib111","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.742496","article-title":"Non-invasive characterization of the pancreas during bariatric surgery circulating pancreatic specific cell-free messenger RNA","volume":"12","author":"Kiat Whye","year":"2021","journal-title":"Front Genet"},{"issue":"20","key":"10.1016\/j.molmet.2024.101987_bib112","doi-asserted-by":"crossref","first-page":"7361","DOI":"10.1073\/pnas.1405528111","article-title":"Noninvasive in\u00a0vivo monitoring of tissue-specific global gene expression in humans","volume":"111","author":"Koh","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.molmet.2024.101987_bib113","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jss.2015.05.055","article-title":"Roux-en-Y gastric bypass stimulates hypothalamic miR-122 and inhibits cardiac and hepatic miR-122 expressions","volume":"199","author":"Kwon","year":"2015","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.molmet.2024.101987_bib114","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3389\/fendo.2019.00232","article-title":"Obesity-related epigenetic changes after bariatric surgery","volume":"10","author":"Izquierdo","year":"2019","journal-title":"Front Endocrinol"},{"issue":"2","key":"10.1016\/j.molmet.2024.101987_bib115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167969","article-title":"Stability of circulating blood-based microRNAs - pre-analytic methodological considerations","volume":"12","author":"Glinge","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.molmet.2024.101987_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104645","article-title":"A\u00a0comprehensive evaluation of full-spectrum cell-free RNAs highlights cell-free RNA fragments for early-stage hepatocellular carcinoma detection","volume":"93","author":"Ning","year":"2023","journal-title":"EBioMedicine"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824001182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824001182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T15:36:31Z","timestamp":1732376191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877824001182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":116,"alternative-id":["S2212877824001182"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2024.101987","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A review on cell-free RNA profiling: Insights into metabolic diseases and predictive value for bariatric surgery outcomes","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2024.101987","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"101987"}}