{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:32:06Z","timestamp":1793140326098,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK054254"],"award-info":[{"award-number":["R01-DK054254"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G071922N"],"award-info":[{"award-number":["G071922N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1243121 N"],"award-info":[{"award-number":["1243121 N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009451","name":"Osteopathic Heritage Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009451","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DK128289"],"award-info":[{"award-number":["R01-DK128289"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DK124126"],"award-info":[{"award-number":["R01-DK124126"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.molmet.2024.102010","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T06:01:56Z","timestamp":1724047316000},"page":"102010","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation"],"prefix":"10.1016","volume":"88","author":[{"given":"Harrison T.","family":"Muturi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda E.","family":"Ghadieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Asalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumona G.","family":"Lester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Getachew D.","family":"Belew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sobia","family":"Zaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raziyeh","family":"Abdolahipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek P.","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes O.","family":"Portuphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah L.","family":"Stankus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghd Abu","family":"Helal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefaan","family":"Verhulst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Zarrinpar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo A.","family":"van Grunsven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Schwabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Terry D.","family":"Hinds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivarajan","family":"Kumarasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6209-8902","authenticated-orcid":false,"given":"Sonia M.","family":"Najjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.molmet.2024.102010_bib1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jhep.2018.10.033","article-title":"Non-alcoholic fatty liver disease - a global public health perspective","volume":"70","author":"Younossi","year":"2019","journal-title":"J Hepatol"},{"issue":"3","key":"10.1016\/j.molmet.2024.102010_bib2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41591-023-02242-6","article-title":"Challenges and opportunities in NASH drug development","volume":"29","author":"Harrison","year":"2023","journal-title":"Nat Med"},{"issue":"716","key":"10.1016\/j.molmet.2024.102010_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adi0759","article-title":"Found in translation-Fibrosis in metabolic dysfunction-associated steatohepatitis (MASH)","volume":"15","author":"Wang","year":"2023","journal-title":"Sci Transl Med"},{"issue":"5","key":"10.1016\/j.molmet.2024.102010_bib4","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1002\/hep.31599","article-title":"NAFLD: reporting histologic findings in clinical practice","volume":"73","author":"Brunt","year":"2021","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.molmet.2024.102010_bib5","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.molmet.2024.102010_bib6","doi-asserted-by":"crossref","first-page":"G713","DOI":"10.1152\/ajpgi.00251.2017","article-title":"Hepatic stellate cells retain retinoid-laden lipid droplets after cellular transdifferentiation into activated myofibroblasts","volume":"315","author":"Jophlin","year":"2018","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"10.1016\/j.molmet.2024.102010_bib7","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1053\/gast.2003.50015","article-title":"Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells","volume":"124","author":"Hellemans","year":"2003","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.molmet.2024.102010_bib8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/2045-3701-2-34","article-title":"GW501516-activated PPARbeta\/delta promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation","volume":"2","author":"Kostadinova","year":"2012","journal-title":"Cell Biosci"},{"issue":"12","key":"10.1016\/j.molmet.2024.102010_bib9","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1128\/MCB.01742-08","article-title":"All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor beta\/delta and retinoic acid receptor","volume":"29","author":"Berry","year":"2009","journal-title":"Mol Cell Biol"},{"issue":"9","key":"10.1016\/j.molmet.2024.102010_bib10","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1073\/pnas.94.9.4312","article-title":"Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta","volume":"94","author":"Forman","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.molmet.2024.102010_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4093\/dmj.2023.0240","article-title":"Hepatic fibrosis and cancer: the silent threats of metabolic syndrome","volume":"48","author":"Friedman","year":"2024","journal-title":"Diabetes Metab J"},{"issue":"9","key":"10.1016\/j.molmet.2024.102010_bib12","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.2337\/db08-0379","article-title":"Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism","volume":"57","author":"DeAngelis","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2024.102010_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.metabol.2019.01.008","article-title":"Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis","volume":"93","author":"Ghadieh","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.molmet.2024.102010_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154801","article-title":"Regulation of hepatic fibrosis by carcinoembryonic antigen-related cell adhesion molecule 1","volume":"121","author":"Helal","year":"2021","journal-title":"Metabolism"},{"issue":"7","key":"10.1016\/j.molmet.2024.102010_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/eci.14177","article-title":"Loss of CEACAM1 in hepatocytes causes hepatic fibrosis","volume":"54","author":"Zaidi","year":"2024","journal-title":"Eur J Clin Invest"},{"issue":"1","key":"10.1016\/j.molmet.2024.102010_bib16","first-page":"35","article-title":"Exenatide induces carcinoembryonic antigen-related cell adhesion molecule 1 expression to prevent hepatic steatosis. Hepatol","volume":"2","author":"Ghadieh","year":"2018","journal-title":"Commun Now"},{"key":"10.1016\/j.molmet.2024.102010_bib17","doi-asserted-by":"crossref","first-page":"155562","DOI":"10.1016\/j.metabol.2023.155562","article-title":"Loss of CEACAM1 in endothelial cells causes hepatic fibrosis","volume":"144","author":"Muturi","year":"2023","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.molmet.2024.102010_bib18","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00418-016-1505-9","article-title":"The role of CEA-related cell adhesion molecule-1 (CEACAM1) in vascular homeostasis","volume":"146","author":"Rueckschloss","year":"2016","journal-title":"Histochem Cell Biol"},{"issue":"29","key":"10.1016\/j.molmet.2024.102010_bib19","doi-asserted-by":"crossref","first-page":"26729","DOI":"10.18632\/oncotarget.4925","article-title":"Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells","volume":"6","author":"El Taghdouini","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.molmet.2024.102010_bib20","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.molmet.2024.102010_bib21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13069-015-0031-z","article-title":"In\u00a0vitro reversion of activated primary human hepatic stellate cells","volume":"8","author":"El Taghdouini","year":"2015","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"2","key":"10.1016\/j.molmet.2024.102010_bib22","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nprot.2015.017","article-title":"High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers","volume":"10","author":"Mederacke","year":"2015","journal-title":"Nat Protoc"},{"issue":"2","key":"10.1016\/j.molmet.2024.102010_bib23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/hep.20538","article-title":"Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis","volume":"41","author":"Schiffer","year":"2005","journal-title":"Hepatology"},{"issue":"50","key":"10.1016\/j.molmet.2024.102010_bib24","doi-asserted-by":"crossref","first-page":"42911","DOI":"10.1074\/jbc.M111.311662","article-title":"Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma (PPARgamma)","volume":"286","author":"Hinds","year":"2011","journal-title":"J\u00a0Biol Chem"},{"issue":"15","key":"10.1016\/j.molmet.2024.102010_bib25","doi-asserted-by":"crossref","first-page":"8121","DOI":"10.1074\/jbc.M116.714014","article-title":"PPARalpha (peroxisome proliferator-activated receptor alpha) activation reduces hepatic CEACAM1 protein expression to regulate fatty acid oxidation during fasting-refeeding transition","volume":"291","author":"Ramakrishnan","year":"2016","journal-title":"J\u00a0Biol Chem"},{"issue":"7","key":"10.1016\/j.molmet.2024.102010_bib26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.molmet.2024.102010_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034945","article-title":"Replacement of retinyl esters by polyunsaturated triacylglycerol species in lipid droplets of hepatic stellate cells during activation","volume":"7","author":"Testerink","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.molmet.2024.102010_bib28","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s13105-011-0101-7","article-title":"Vitamin A and lipid metabolism: relationship between hepatic stellate cells (HSCs) and adipocytes","volume":"67","author":"Sauvant","year":"2011","journal-title":"J\u00a0Physiol Biochem"},{"issue":"30","key":"10.1016\/j.molmet.2024.102010_bib29","doi-asserted-by":"crossref","first-page":"12436","DOI":"10.1074\/jbc.M117.778472","article-title":"Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation","volume":"292","author":"Tuohetahuntila","year":"2017","journal-title":"J\u00a0Biol Chem"},{"issue":"2","key":"10.1016\/j.molmet.2024.102010_bib30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbalip.2014.12.003","article-title":"Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells","volume":"1851","author":"Tuohetahuntila","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"10.1016\/j.molmet.2024.102010_bib31","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/cr.2009.73","article-title":"Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells","volume":"19","author":"Wobser","year":"2009","journal-title":"Cell Res"},{"issue":"2","key":"10.1016\/j.molmet.2024.102010_bib32","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1074\/jbc.M108415200","article-title":"Shc and CEACAM1 interact to regulate the mitogenic action of insulin","volume":"277","author":"Poy","year":"2002","journal-title":"J\u00a0Biol Chem"},{"issue":"7","key":"10.1016\/j.molmet.2024.102010_bib33","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1172\/JCI200421786","article-title":"CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation","volume":"114","author":"Abou-Rjaily","year":"2004","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.molmet.2024.102010_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109090","article-title":"Role of epidermal growth factor receptor in liver injury and lipid metabolism: emerging new roles for an old receptor","volume":"324","author":"Bhushan","year":"2020","journal-title":"Chem Biol Interact"},{"issue":"6","key":"10.1016\/j.molmet.2024.102010_bib35","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1074\/jbc.M410078200","article-title":"Adipogenic transcriptional regulation of hepatic stellate cells","volume":"280","author":"She","year":"2005","journal-title":"J\u00a0Biol Chem"},{"issue":"9","key":"10.1016\/j.molmet.2024.102010_bib36","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.metabol.2015.05.002","article-title":"Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: impact on non-alcoholic fatty liver disease","volume":"64","author":"Ganji","year":"2015","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.molmet.2024.102010_bib37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.intimp.2014.07.006","article-title":"Niacin attenuates the production of pro-inflammatory cytokines in LPS-induced mouse alveolar macrophages by HCA2 dependent mechanisms","volume":"23","author":"Zhou","year":"2014","journal-title":"Int Immunopharm"},{"issue":"42","key":"10.1016\/j.molmet.2024.102010_bib38","doi-asserted-by":"crossref","first-page":"16975","DOI":"10.1073\/pnas.1315862110","article-title":"STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor","volume":"110","author":"Wang","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"49","key":"10.1016\/j.molmet.2024.102010_bib39","doi-asserted-by":"crossref","first-page":"31092","DOI":"10.1074\/jbc.272.49.31092","article-title":"Transcriptional regulation of the human monocyte chemoattractant protein-1 gene. Cooperation of two NF-kappaB sites and NF-kappaB\/Rel subunit specificity","volume":"272","author":"Ueda","year":"1997","journal-title":"J\u00a0Biol Chem"},{"issue":"49","key":"10.1016\/j.molmet.2024.102010_bib40","doi-asserted-by":"crossref","first-page":"34342","DOI":"10.1074\/jbc.M109.042671","article-title":"CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization","volume":"284","author":"Roca","year":"2009","journal-title":"J\u00a0Biol Chem"},{"issue":"6","key":"10.1016\/j.molmet.2024.102010_bib41","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.molmet.2024.102010_bib42","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.3389\/fimmu.2019.03087","article-title":"miR-221-3p drives the shift of M2-macrophages to a pro-inflammatory function by suppressing JAK3\/STAT3 activation","volume":"10","author":"Quero","year":"2019","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.molmet.2024.102010_bib43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1242\/dmm.012062","article-title":"Diverse functions of matrix metalloproteinases during fibrosis","volume":"7","author":"Giannandrea","year":"2014","journal-title":"Dis. Model Mech."},{"issue":"6","key":"10.1016\/j.molmet.2024.102010_bib44","doi-asserted-by":"crossref","first-page":"C1200","DOI":"10.1152\/ajpcell.00062.2020","article-title":"New aspects of hepatic endothelial cells in physiology and nonalcoholic fatty liver disease","volume":"318","author":"Sun","year":"2020","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"10.1016\/j.molmet.2024.102010_bib45","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cmet.2005.06.001","article-title":"Insulin acutely decreases hepatic fatty acid synthase activity","volume":"2","author":"Najjar","year":"2005","journal-title":"Cell Metabol"},{"issue":"1","key":"10.1016\/j.molmet.2024.102010_bib46","article-title":"FASN inhibition targets multiple drivers of NASH by reducing steatosis, inflammation and fibrosis in preclinical models","volume":"12","author":"O'Farrell","year":"2022","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.molmet.2024.102010_bib47","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1172\/JCI57728","article-title":"Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype","volume":"121","author":"Li","year":"2011","journal-title":"J\u00a0Clin Invest"},{"issue":"8","key":"10.1016\/j.molmet.2024.102010_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084335","article-title":"Aortic fibrosis in insulin-sensitive mice with endothelial cell-specific deletion of Ceacam1 gene","volume":"23","author":"Abu Helal","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.molmet.2024.102010_bib49","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41419-024-06437-8","article-title":"Activated hepatic stellate cell-derived Bmp-1 induces liver fibrosis via mediating hepatocyte epithelial-mesenchymal transition","volume":"15","author":"Wan","year":"2024","journal-title":"Cell Death Dis"},{"issue":"4","key":"10.1016\/j.molmet.2024.102010_bib50","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/hep.26898","article-title":"Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma","volume":"59","author":"Fuchs","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.molmet.2024.102010_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114386","article-title":"Hyperphosphorylation of EGFR\/ERK signaling facilitates long-term arsenite-induced hepatocytes epithelial-mesenchymal transition and liver fibrosis in sprague-dawley rats","volume":"249","author":"Wang","year":"2023","journal-title":"Ecotoxicol Environ Saf"},{"issue":"11","key":"10.1016\/j.molmet.2024.102010_bib52","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1111\/liv.15404","article-title":"Management of NAFLD in primary care settings","volume":"42","author":"Wong","year":"2022","journal-title":"Liver Int"},{"issue":"10","key":"10.1016\/j.molmet.2024.102010_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103110","article-title":"CEACAM1 in liver injury, metabolic and immune regulation","volume":"19","author":"Horst","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.molmet.2024.102010_bib54","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.2337\/db23-0171","article-title":"IL-6 trans-signaling is increased in diabetes, impacted by glucolipotoxicity, and associated with liver stiffness and fibrosis in fatty liver disease","volume":"72","author":"Gunes","year":"2023","journal-title":"Diabetes"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824001418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824001418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T09:19:33Z","timestamp":1726391973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877824001418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":54,"alternative-id":["S2212877824001418"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2024.102010","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2024.102010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102010"}}