{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:52:37Z","timestamp":1789005157739,"version":"build-2803163510"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005402","name":"Dasman Diabetes Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.molmet.2024.102063","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T13:40:57Z","timestamp":1731505257000},"page":"102063","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Essential role of germ cell glycerol-3-phosphate phosphatase for sperm health, oxidative stress control and male fertility in mice"],"prefix":"10.1016","volume":"90","author":[{"given":"Abel","family":"Oppong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yat Hei","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anindya","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Line","family":"Peyot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maril\u00e8ne","family":"Paquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh J.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahd","family":"Al-Mulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R. Murthy","family":"Madiraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Boerboom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"O'Flaherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Prentki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.molmet.2024.102063_bib1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/humrep\/dey020","article-title":"'Man Up': the importance and strategy for placing male reproductive health centre stage in the political and research agenda","volume":"33","author":"Barratt","year":"2018","journal-title":"Hum Reprod"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1152\/physrev.00017.2015","article-title":"Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility","volume":"96","author":"Skakkebaek","year":"2016","journal-title":"Physiol Rev"},{"issue":"7","key":"10.1016\/j.molmet.2024.102063_bib3","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2174\/1381612822666151209151550","article-title":"Male fertility and obesity: are ghrelin, leptin and glucagon-like peptide-1 pharmacologically relevant?","volume":"22","author":"Alves","year":"2016","journal-title":"Curr Pharmaceut Des"},{"issue":"8","key":"10.1016\/j.molmet.2024.102063_bib4","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41585-024-00866-y","article-title":"Signatures of metabolic diseases on spermatogenesis and testicular metabolism","volume":"21","author":"Carrageta","year":"2024","journal-title":"Nat Rev Urol"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib5","doi-asserted-by":"crossref","DOI":"10.1530\/REP-23-0067","article-title":"The concentration of glucose in the media influences the susceptibility of stallion spermatozoa to ferroptosis","volume":"167","author":"Martin-Cano","year":"2024","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.molmet.2024.102063_bib6","first-page":"519","article-title":"Low glucose and high pyruvate reduce the production of 2-oxoaldehydes, improving mitochondrial efficiency, redox regulation, and stallion sperm functiondagger","volume":"105","author":"Ortiz-Rodriguez","year":"2021","journal-title":"Biol Reprod"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10010098","article-title":"Mitochondrial functionality in male fertility: from spermatogenesis to fertilization","volume":"10","author":"Park","year":"2021","journal-title":"Antioxidants"},{"issue":"11","key":"10.1016\/j.molmet.2024.102063_bib8","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/molehr\/gax049","article-title":"Glycerol and testicular activity: the good, the bad and the ugly","volume":"23","author":"Crisostomo","year":"2017","journal-title":"Mol Hum Reprod"},{"issue":"5","key":"10.1016\/j.molmet.2024.102063_bib9","first-page":"625","article-title":"Glycerol disrupts tight junction-associated actin microfilaments, occludin, and microtubules in Sertoli cells","volume":"21","author":"Wiebe","year":"2000","journal-title":"J\u00a0Androl"},{"issue":"8","key":"10.1016\/j.molmet.2024.102063_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/and.14119","article-title":"Attenuation of aquaporin-3 may be contributing to low sperm motility and is associated with activated caspase-3 in asthenozoospermic individuals","volume":"53","author":"Mohammadi","year":"2021","journal-title":"Andrologia"},{"issue":"4","key":"10.1016\/j.molmet.2024.102063_bib11","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/aja.2010.40","article-title":"Aquaporins in spermatozoa and testicular germ cells: identification and potential role","volume":"12","author":"Yeung","year":"2010","journal-title":"Asian J Androl"},{"issue":"6","key":"10.1016\/j.molmet.2024.102063_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/and.13588","article-title":"Aquaporin3 expression and the potential role of aquaporins in motility and mitochondrial membrane potential in human spermatozoa","volume":"52","author":"Alyasin","year":"2020","journal-title":"Andrologia"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3390\/ijms18010066","article-title":"Aquaporin-mediated water and hydrogen peroxide transport is involved in normal human spermatozoa functioning","volume":"18","author":"Laforenza","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.molmet.2024.102063_bib14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3109\/19396368.2011.644385","article-title":"Immunolocalization of aquaporin 7 in human sperm and its relationship with semen parameters","volume":"58","author":"Moretti","year":"2012","journal-title":"Syst Biol Reprod Med"},{"issue":"6","key":"10.1016\/j.molmet.2024.102063_bib15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1210\/er.2008-0007","article-title":"Glycerolipid metabolism and signaling in health and disease","volume":"29","author":"Prentki","year":"2008","journal-title":"Endocr Rev"},{"issue":"3","key":"10.1016\/j.molmet.2024.102063_bib16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0026-0495(96)90291-7","article-title":"Effect of endurance training on glycerol kinetics during strenuous exercise in humans","volume":"45","author":"Klein","year":"1996","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.molmet.2024.102063_bib17","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.cmet.2014.04.003","article-title":"alpha\/beta-Hydrolase domain-6-accessible monoacylglycerol controls glucose-stimulated insulin secretion","volume":"19","author":"Zhao","year":"2014","journal-title":"Cell Metabol"},{"issue":"4","key":"10.1016\/j.molmet.2024.102063_bib18","doi-asserted-by":"crossref","first-page":"E430","DOI":"10.1073\/pnas.1514375113","article-title":"Identification of a mammalian glycerol-3-phosphate phosphatase: role in metabolism and signaling in pancreatic beta-cells and hepatocytes","volume":"113","author":"Mugabo","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.molmet.2024.102063_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101471","article-title":"Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic \u03b2-cells that controls insulin secretion and metabolic stress","volume":"60","author":"Al-Mass","year":"2022","journal-title":"Mol Metabol"},{"key":"10.1016\/j.molmet.2024.102063_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101609","article-title":"Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia","volume":"66","author":"Al-Mass","year":"2022","journal-title":"Mol Metabol"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib21","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1038\/s41467-023-40857-y","article-title":"Glycerol 3-phosphate phosphatase\/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans","volume":"14","author":"Possik","year":"2023","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41467-021-27803-6","article-title":"Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans","volume":"13","author":"Possik","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.molmet.2024.102063_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.706607","article-title":"New mammalian glycerol-3-phosphate phosphatase: role in beta-cell, liver and adipocyte metabolism","volume":"12","author":"Possik","year":"2021","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.molmet.2024.102063_bib24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.biochi.2017.08.001","article-title":"Glycerol-3-phosphate phosphatase\/PGP: role in intermediary metabolism and target for cardiometabolic diseases","volume":"143","author":"Possik","year":"2017","journal-title":"Biochimie"},{"issue":"7","key":"10.1016\/j.molmet.2024.102063_bib25","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/hmg\/ddm012","article-title":"Success and failure in human spermatogenesis as revealed by teratozoospermic RNAs (Supplementary material on GeoProfiles)","volume":"16","author":"Platts","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.molmet.2024.102063_bib26","article-title":"Altered gene expression in the testis of infertile patients with nonobstructive azoospermia","volume":"2021","author":"Wang","year":"2021","journal-title":"Comput Math Methods Med"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib27","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/aja.aja_17_19","article-title":"Reduced semen quality in patients with testicular cancer seminoma is associated with alterations in the expression of sperm proteins","volume":"22","author":"Dias","year":"2020","journal-title":"Asian J Androl"},{"issue":"7","key":"10.1016\/j.molmet.2024.102063_bib28","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/molehr\/gax031","article-title":"Long-chain fatty acid triglyceride (TG) metabolism disorder impairs male fertility: a study using adipose triglyceride lipase deficient mice","volume":"23","author":"Masaki","year":"2017","journal-title":"Mol Hum Reprod"},{"issue":"2","key":"10.1016\/j.molmet.2024.102063_bib29","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1073\/pnas.97.2.787","article-title":"Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity","volume":"97","author":"Osuga","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"20","key":"10.1016\/j.molmet.2024.102063_bib30","doi-asserted-by":"crossref","first-page":"17467","DOI":"10.1074\/jbc.M110.215434","article-title":"Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance","volume":"286","author":"Taschler","year":"2011","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1530\/jrf.0.0940129","article-title":"Metabolism of glycerol by mature boar spermatozoa","volume":"94","author":"Jones","year":"1992","journal-title":"J\u00a0Reprod Fertil"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1530\/reprod\/119.1.129","article-title":"Substrates for endogenous metabolism by mature boar spermatozoa","volume":"119","author":"Jones","year":"2000","journal-title":"J\u00a0Reprod Fertil"},{"issue":"2","key":"10.1016\/j.molmet.2024.102063_bib33","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1530\/jrf.0.1060321","article-title":"Metabolism of glycerol 3-phosphate by mature boar spermatozoa","volume":"106","author":"Jones","year":"1996","journal-title":"J\u00a0Reprod Fertil"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/rmb2.12353","article-title":"Oxidative stress and male infertility","volume":"20","author":"Takeshima","year":"2021","journal-title":"Reprod Med Biol"},{"issue":"6","key":"10.1016\/j.molmet.2024.102063_bib35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/dvg.20310","article-title":"Generation of a germ cell-specific mouse transgenic Cre line, Vasa-Cre","volume":"45","author":"Gallardo","year":"2007","journal-title":"Genesis"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ydbio.2008.06.017","article-title":"Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth","volume":"321","author":"John","year":"2008","journal-title":"Dev Biol"},{"issue":"5","key":"10.1016\/j.molmet.2024.102063_bib37","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1530\/rep.1.00333","article-title":"Impaired fertility in T-stock female mice after superovulation","volume":"128","author":"Zudova","year":"2004","journal-title":"Reproduction"},{"issue":"3","key":"10.1016\/j.molmet.2024.102063_bib38","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1095\/biolreprod.110.088542","article-title":"Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility","volume":"85","author":"Bedard","year":"2011","journal-title":"Biol Reprod"},{"key":"10.1016\/j.molmet.2024.102063_bib39","article-title":"Epididymal sperm count","volume":"16","author":"Wang","year":"2003","journal-title":"Curr Protoc Toxicol Chapter"},{"key":"10.1016\/j.molmet.2024.102063_bib40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.redox.2015.02.004","article-title":"Advancing age increases sperm chromatin damage and impairs fertility in peroxiredoxin 6 null mice","volume":"5","author":"Ozkosem","year":"2015","journal-title":"Redox Biol"},{"issue":"3","key":"10.1016\/j.molmet.2024.102063_bib41","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1095\/biolreprod.115.137646","article-title":"Absence of peroxiredoxin 6 amplifies the effect of oxidant stress on mobility and SCSA\/CMA3 defined chromatin quality and impairs fertilizing ability of mouse spermatozoa","volume":"94","author":"Ozkosem","year":"2016","journal-title":"Biol Reprod"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13411-2","article-title":"Deficiency of peroxiredoxin 6 or inhibition of its phospholipase A(2) activity impair the in\u00a0vitro sperm fertilizing competence in mice","volume":"7","author":"Moawad","year":"2017","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.molmet.2024.102063_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11020226","article-title":"Peroxiredoxin 6 peroxidase and Ca(2+)-independent phospholipase A(2) activities are essential to support male-mouse fertility","volume":"11","author":"Bumanlag","year":"2022","journal-title":"Antioxidants"},{"issue":"7","key":"10.1016\/j.molmet.2024.102063_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9070613","article-title":"A\u00a0novel combination of gamma-tocopherol-rich mixture of tocopherols and ascorbic acid restores fertility in cases of tyrosine nitration-associated male infertility in mice","volume":"9","author":"Scarlata","year":"2020","journal-title":"Antioxidants"},{"issue":"12","key":"10.1016\/j.molmet.2024.102063_bib45","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41422-018-0099-2","article-title":"The adult human testis transcriptional cell atlas","volume":"28","author":"Guo","year":"2018","journal-title":"Cell Res"},{"issue":"2","key":"10.1016\/j.molmet.2024.102063_bib46","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.stem.2019.12.005","article-title":"The dynamic transcriptional cell atlas of testis development during human puberty","volume":"26","author":"Guo","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.molmet.2024.102063_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/srep35160","article-title":"An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation","volume":"6","author":"Segerer","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib48","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0014-5793(97)01159-9","article-title":"High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria","volume":"416","author":"Korshunov","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.molmet.2024.102063_bib49","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/978-1-4939-7831-1_22","article-title":"Relation between mitochondrial membrane potential and ROS formation","volume":"1782","author":"Suski","year":"2018","journal-title":"Methods Mol Biol"},{"issue":"2","key":"10.1016\/j.molmet.2024.102063_bib50","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1046\/j.1432-1327.1999.00522.x","article-title":"Effect of glucose and deoxyglucose on the redistribution of calcium in ehrlich ascites tumour and Zajdela hepatoma cells and its consequences for mitochondrial energetics. Further arguments for the role of Ca(2+) in the mechanism of the crabtree effect","volume":"263","author":"Wojtczak","year":"1999","journal-title":"Eur J Biochem"},{"issue":"3","key":"10.1016\/j.molmet.2024.102063_bib51","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1677\/jme.1.01666","article-title":"Disruption of the murine PIASx gene results in reduced testis weight","volume":"34","author":"Santti","year":"2005","journal-title":"J\u00a0Mol Endocrinol"},{"issue":"47","key":"10.1016\/j.molmet.2024.102063_bib52","doi-asserted-by":"crossref","first-page":"17718","DOI":"10.1073\/pnas.0608556103","article-title":"Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells","volume":"103","author":"Zhang","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"10.1016\/j.molmet.2024.102063_bib53","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/mrd.21218","article-title":"Role of glycerol-3-phosphate dehydrogenase 2 in mouse sperm capacitation","volume":"77","author":"Kota","year":"2010","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.molmet.2024.102063_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/celldisc.2017.30","article-title":"Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility","volume":"3","author":"Chen","year":"2017","journal-title":"Cell Discov"},{"issue":"2","key":"10.1016\/j.molmet.2024.102063_bib55","first-page":"155","article-title":"Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis","volume":"65","author":"Shimada","year":"2019","journal-title":"J\u00a0Reprod Dev"},{"issue":"18","key":"10.1016\/j.molmet.2024.102063_bib56","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1042\/BCJ20161018","article-title":"Glycerol-3-phosphate acyltransferase 2 is essential for normal spermatogenesis","volume":"474","author":"Garcia-Fabiani","year":"2017","journal-title":"Biochem J"},{"issue":"15","key":"10.1016\/j.molmet.2024.102063_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/cells12152003","article-title":"Aquaporin-7-Mediated glycerol permeability is linked to human sperm motility in asthenozoospermia and during sperm capacitation","volume":"12","author":"Ribeiro","year":"2023","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.molmet.2024.102063_bib58","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/cr.2010.169","article-title":"Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration","volume":"21","author":"Chen","year":"2011","journal-title":"Cell Res"},{"issue":"5","key":"10.1016\/j.molmet.2024.102063_bib59","article-title":"Energy metabolism in mammalian sperm motility","volume":"14","author":"Amaral","year":"2022","journal-title":"WIREs Mech Dis"},{"issue":"6","key":"10.1016\/j.molmet.2024.102063_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13061273","article-title":"Elevated expression of glycerol-3-phosphate phosphatase as a biomarker of poor prognosis and aggressive prostate cancer","volume":"13","author":"Lounis","year":"2021","journal-title":"Cancers"},{"issue":"2","key":"10.1016\/j.molmet.2024.102063_bib61","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1095\/biolreprod31.2.221","article-title":"Suppression of spermatogenesis by testosterone in adult male rats: effect on fertility, pregnancy outcome and progeny","volume":"31","author":"Robaire","year":"1984","journal-title":"Biol Reprod"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib62","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/aja.2008.50","article-title":"The usefulness and significance of assessing rapidly progressive spermatozoa","volume":"12","author":"Bjorndahl","year":"2010","journal-title":"Asian J Androl"},{"issue":"6","key":"10.1016\/j.molmet.2024.102063_bib63","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrurol.2012.77","article-title":"Metabolic regulation is important for spermatogenesis","volume":"9","author":"Rato","year":"2012","journal-title":"Nat Rev Urol"},{"issue":"2","key":"10.1016\/j.molmet.2024.102063_bib64","first-page":"91","article-title":"Proteolytic degradation of heat shock protein A2 occurs in response to oxidative stress in male germ cells of the mouse","volume":"23","author":"Bromfield","year":"2017","journal-title":"Mol Hum Reprod"},{"issue":"5","key":"10.1016\/j.molmet.2024.102063_bib65","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/oxfordjournals.humrep.a137150","article-title":"The evaluation of morphological characteristics of human spermatozoa according to stricter criteria","volume":"5","author":"Menkveld","year":"1990","journal-title":"Hum Reprod"},{"issue":"8","key":"10.1016\/j.molmet.2024.102063_bib66","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/oxfordjournals.humrep.a137020","article-title":"Appropriate timing of the acrosome reaction is a major requirement for the fertilizing spermatozoon","volume":"4","author":"Tesarik","year":"1989","journal-title":"Hum Reprod"},{"issue":"1\u20132","key":"10.1016\/j.molmet.2024.102063_bib67","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0300-483X(99)00107-9","article-title":"Hydrogen peroxide induces premature acrosome reaction in rat sperm and reduces their penetration of the zona pellucida","volume":"139","author":"Hsu","year":"1999","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib68","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1530\/REP-14-0240","article-title":"Oxidative stress impairs function and increases redox protein modifications in human spermatozoa","volume":"149","author":"Morielli","year":"2015","journal-title":"Reproduction"},{"issue":"4","key":"10.1016\/j.molmet.2024.102063_bib69","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/rmb2.12052","article-title":"Reactive oxygen species measured in the unprocessed semen samples of 715 infertile patients","volume":"16","author":"Yumura","year":"2017","journal-title":"Reprod Med Biol"},{"issue":"4","key":"10.1016\/j.molmet.2024.102063_bib70","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.fertnstert.2006.02.111","article-title":"Reactive oxygen species as an independent marker of male factor infertility","volume":"86","author":"Agarwal","year":"2006","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.molmet.2024.102063_bib71","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.mrgentox.2013.06.017","article-title":"Proteomic analysis for testis of mice exposed to carbon ion radiation","volume":"755","author":"Li","year":"2013","journal-title":"Mutat Res"},{"issue":"14","key":"10.1016\/j.molmet.2024.102063_bib72","doi-asserted-by":"crossref","first-page":"13775","DOI":"10.1007\/s11356-018-1417-4","article-title":"Investigation on the origin of sperm morphological defects: oxidative attacks, chromatin immaturity, and DNA fragmentation","volume":"25","author":"Oumaima","year":"2018","journal-title":"Environ Sci Pollut Res Int"},{"issue":"6","key":"10.1016\/j.molmet.2024.102063_bib73","doi-asserted-by":"crossref","first-page":"F67","DOI":"10.1530\/REP-22-0200","article-title":"Oxidative stress and reproductive function: the protection of mammalian spermatozoa against oxidative stress","volume":"164","author":"O'Flaherty","year":"2022","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib74","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bbabio.2013.08.007","article-title":"ROS generation and multiple forms of mammalian mitochondrial glycerol-3-phosphate dehydrogenase","volume":"1837","author":"Mracek","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.molmet.2024.102063_bib75","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1146\/annurev.bi.46.070177.004001","article-title":"Glycerol utilization and its regulation in mammals","volume":"46","author":"Lin","year":"1977","journal-title":"Annu Rev Biochem"},{"issue":"3","key":"10.1016\/j.molmet.2024.102063_bib76","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1006\/geno.1999.5874","article-title":"Retrotransposition of glycerol kinase-related genes from the X chromosome to autosomes: functional and evolutionary aspects","volume":"59","author":"Pan","year":"1999","journal-title":"Genomics"},{"issue":"7","key":"10.1016\/j.molmet.2024.102063_bib77","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/pmic.200800519","article-title":"Tyrosine phosphoproteome of hamster spermatozoa: role of glycerol-3-phosphate dehydrogenase 2 in sperm capacitation","volume":"9","author":"Kota","year":"2009","journal-title":"Proteomics"},{"issue":"1","key":"10.1016\/j.molmet.2024.102063_bib78","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1530\/jrf.0.0610163","article-title":"Entry of glycerol into the rat epididymis and its utilization by epididymal spermatozoa","volume":"61","author":"Cooper","year":"1981","journal-title":"J\u00a0Reprod Fertil"},{"issue":"7","key":"10.1016\/j.molmet.2024.102063_bib79","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1074\/jbc.M114.614537","article-title":"New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity","volume":"290","author":"Ohshima","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.molmet.2024.102063_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2024.101321","article-title":"Physiological and pathological aspects of epididymal sperm maturation","volume":"100","author":"Weigel Munoz","year":"2024","journal-title":"Mol Aspect Med"},{"issue":"4","key":"10.1016\/j.molmet.2024.102063_bib81","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1095\/biolreprod65.4.1102","article-title":"Analysis of reactive oxygen species generating systems in rat epididymal spermatozoa","volume":"65","author":"Vernet","year":"2001","journal-title":"Biol Reprod"},{"issue":"5","key":"10.1016\/j.molmet.2024.102063_bib82","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/andr.12630","article-title":"Orchestrating the antioxidant defenses in the epididymis","volume":"7","author":"O'Flaherty","year":"2019","journal-title":"Andrology"},{"issue":"39","key":"10.1016\/j.molmet.2024.102063_bib83","doi-asserted-by":"crossref","first-page":"33048","DOI":"10.1074\/jbc.M112.366690","article-title":"Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase","volume":"287","author":"Aitken","year":"2012","journal-title":"J\u00a0Biol Chem"},{"issue":"8","key":"10.1016\/j.molmet.2024.102063_bib84","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1089\/ars.2019.8000","article-title":"Redox control of proteolysis during inactivity-induced skeletal muscle atrophy","volume":"33","author":"Powers","year":"2020","journal-title":"Antioxidants Redox Signal"},{"issue":"4","key":"10.1016\/j.molmet.2024.102063_bib85","first-page":"459","article-title":"A\u00a0review of the physical and chemical properties of human semen and the formulation of a semen simulant","volume":"26","author":"Owen","year":"2005","journal-title":"J\u00a0Androl"},{"key":"10.1016\/j.molmet.2024.102063_bib86","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1743-7075-10-32","article-title":"Fructose-induced stress signaling in the liver involves methylglyoxal","volume":"10","author":"Wei","year":"2013","journal-title":"Nutr Metab"},{"issue":"4","key":"10.1016\/j.molmet.2024.102063_bib87","doi-asserted-by":"crossref","first-page":"R304","DOI":"10.1152\/ajpregu.00468.2012","article-title":"Glycerol-3-phosphatase and not lipid recycling is the primary pathway in the accumulation of high concentrations of glycerol in rainbow smelt (Osmerus mordax)","volume":"304","author":"Ditlecadet","year":"2013","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"5 Pt 1","key":"10.1016\/j.molmet.2024.102063_bib88","first-page":"2073","article-title":"Localization of aquaporin-7 in human testis and ejaculated sperm: possible involvement in maintenance of sperm quality","volume":"172","author":"Saito","year":"2004","journal-title":"J\u00a0Urol"},{"issue":"19","key":"10.1016\/j.molmet.2024.102063_bib89","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911655","article-title":"Relative abundance of lipid metabolites in spermatozoa across three compartments","volume":"23","author":"Furse","year":"2022","journal-title":"Int J Mol Sci"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824001947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824001947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T22:10:44Z","timestamp":1739916644000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877824001947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":89,"alternative-id":["S2212877824001947"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2024.102063","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Essential role of germ cell glycerol-3-phosphate phosphatase for sperm health, oxidative stress control and male fertility in mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2024.102063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102063"}}