{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T19:08:13Z","timestamp":1778526493992,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010566","name":"Consejer\u00eda de Salud y Familias, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["RC-0008-2021"],"award-info":[{"award-number":["RC-0008-2021"]}],"id":[{"id":"10.13039\/501100010566","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15-01350"],"award-info":[{"award-number":["PI15-01350"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CP20\/00066"],"award-info":[{"award-number":["CP20\/00066"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI19\/00178"],"award-info":[{"award-number":["FI19\/00178"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.molmet.2024.102087","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T11:55:01Z","timestamp":1735041301000},"page":"102087","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pre-operative DNA methylation marks as predictors of weight loss outcomes after sleeve gastrectomy"],"prefix":"10.1016","volume":"92","author":[{"given":"Guillermo","family":"Paz-L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa M.","family":"Linares-Pineda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Gonz\u00e1lez-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Sancho-Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Oca\u00f1a-Wilhelmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Tinahones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6932-5637","authenticated-orcid":false,"given":"Sonsoles","family":"Morcillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5842-8873","authenticated-orcid":false,"given":"Carolina","family":"Guti\u00e9rrez-Repiso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.molmet.2024.102087_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Afshin","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.molmet.2024.102087_bib2","series-title":"World obesity atlas","year":"2022"},{"issue":"7","key":"10.1016\/j.molmet.2024.102087_bib3","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1210\/clinem\/dgab091","article-title":"Long-term weight loss strategies for obesity","volume":"106","author":"Kheniser","year":"2021","journal-title":"J\u00a0Clin Endocrinol Metabol"},{"issue":"8","key":"10.1016\/j.molmet.2024.102087_bib4","article-title":"Surgery for weight loss in adults","volume":"2014","author":"Colquitt","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.molmet.2024.102087_bib5","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.jviscsurg.2022.12.001","article-title":"Factors influencing bariatric surgery outcomes","volume":"160","author":"Crozet","year":"2023","journal-title":"Journal of Visceral Surgery"},{"key":"10.1016\/j.molmet.2024.102087_bib6","first-page":"1","article-title":"Towards precision medicine in bariatric surgery prescription","volume":"1","author":"Pereira","year":"2023","journal-title":"Rev Endocr Metab Disord"},{"issue":"3","key":"10.1016\/j.molmet.2024.102087_bib7","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/joim.13496","article-title":"The potential of DNA methylation as a biomarker for obesity and smoking","volume":"292","author":"Heikkinen","year":"2022","journal-title":"J\u00a0Intern Med"},{"issue":"5","key":"10.1016\/j.molmet.2024.102087_bib8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/15592294.2019.1595297","article-title":"DNA methylation markers in obesity, metabolic syndrome, and weight loss","volume":"14","author":"Samblas","year":"2019","journal-title":"Epigenetics"},{"key":"10.1016\/j.molmet.2024.102087_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2017.10.004","article-title":"Epigenetic reprogramming in metabolic disorders: nutritional factors and beyond","volume":"54","author":"Cheng","year":"2018","journal-title":"J\u00a0Nutr Biochem"},{"issue":"1","key":"10.1016\/j.molmet.2024.102087_bib10","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-022-01401-9","article-title":"Bariatric surgery-induced weight loss and associated genome-wide DNA-methylation alterations in obese individuals","volume":"14","author":"Talukdar","year":"2022","journal-title":"Clin Epigenet"},{"issue":"2","key":"10.1016\/j.molmet.2024.102087_bib11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s13304-021-01162-9","article-title":"Clinical epigenetics and restoring of metabolic health in severely obese patients undergoing batriatric and metabolic surgery","volume":"74","author":"Faenza","year":"2022","journal-title":"Updates in Surgery"},{"key":"10.1016\/j.molmet.2024.102087_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/srep46292","article-title":"Changes in SCD gene DNA methylation after bariatric surgery in morbidly obese patients are associated with free fatty acids","volume":"7","author":"Morcillo","year":"2017","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/j.molmet.2024.102087_bib13","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.soard.2018.06.011","article-title":"Decreased blood pressure is related to changes in NF-kB promoter methylation levels after bariatric surgery","volume":"14","author":"Mac\u00edas-Gonz\u00e1lez","year":"2018","journal-title":"Surg Obes Relat Dis: Official Journal of the American Society for Bariatric Surgery"},{"issue":"7635","key":"10.1016\/j.molmet.2024.102087_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature20784","article-title":"Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity","volume":"541","author":"Wahl","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.molmet.2024.102087_bib15","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-021-01162-x","article-title":"Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals","volume":"13","author":"Chen","year":"2021","journal-title":"Clin Epigenet"},{"issue":"3","key":"10.1016\/j.molmet.2024.102087_bib16","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/ijo.2017.245","article-title":"Subcutaneous adipose tissue gene expression and DNA methylation respond to both short- and long-term weight loss","volume":"42","author":"Bollepalli","year":"2018","journal-title":"Int J Obes"},{"issue":"1","key":"10.1016\/j.molmet.2024.102087_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s13073-020-00794-7","article-title":"DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial","volume":"12","author":"Keller","year":"2020","journal-title":"Genome Med"},{"issue":"1","key":"10.1016\/j.molmet.2024.102087_bib18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s40618-018-0881-5","article-title":"DNA methylation of genes regulating appetite and prediction of weight loss after bariatric surgery in obese individuals","volume":"42","author":"Copped\u00e8","year":"2019","journal-title":"J\u00a0Endocrinol Invest"},{"key":"10.1016\/j.molmet.2024.102087_bib19","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.2147\/DMSO.S402687","article-title":"Establishment of a nomogram based on inflammatory response-related methylation sites in intraoperative visceral adipose tissue to predict EWL% at one year after LSG","volume":"16","author":"Chen","year":"2023","journal-title":"Diabetes, Metab Syndrome Obes Targets Ther"},{"issue":"19","key":"10.1016\/j.molmet.2024.102087_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914778","article-title":"Epigenetic marks as predictors of metabolic response to bariatric surgery: validation from an epigenome wide association study","volume":"24","author":"Guti\u00e9rrez-Repiso","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.molmet.2024.102087_bib21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/ije\/dyr238","article-title":"Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies","volume":"41","author":"Jaffe","year":"2012","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.molmet.2024.102087_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1181002","article-title":"Implication of DNA methylation during lifestyle mediated weight loss","volume":"14","author":"Aurich","year":"2023","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.molmet.2024.102087_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105242","article-title":"Blood methylation pattern reflects epigenetic remodelling in adipose tissue after bariatric surgery","volume":"106","author":"M\u00fcller","year":"2024","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.molmet.2024.102087_bib24","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-023-01522-9","article-title":"DNA methylation is differentially associated with glycemic outcomes by different types of weight-loss interventions: an epigenome-wide association study","volume":"15","author":"Wen","year":"2023","journal-title":"Clin Epigenet"},{"issue":"24","key":"10.1016\/j.molmet.2024.102087_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/nu15245023","article-title":"A\u00a0predictive tool based on DNA methylation data for personalized weight loss through different dietary strategies: a pilot study","volume":"15","author":"Garc\u00eda-\u00c1lvarez","year":"2023","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.molmet.2024.102087_bib26","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3945\/ajcn.116.143164","article-title":"Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial","volume":"105","author":"Perfilyev","year":"2017","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"10.1016\/j.molmet.2024.102087_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/life12050633","article-title":"Relationship between the levels of lncRNA H19 in plasma and different adipose tissue depots with patients' response to bariatric surgery","volume":"12","author":"Artemyeva","year":"2022","journal-title":"Life"},{"issue":"11","key":"10.1016\/j.molmet.2024.102087_bib28","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/j.soard.2020.06.024","article-title":"Can genetics help predict efficacy of bariatric surgery? An analysis of microRNA profiles","volume":"16","author":"Doyon","year":"2020","journal-title":"Surg Obes Relat Dis"},{"key":"10.1016\/j.molmet.2024.102087_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.907148","article-title":"microRNA-140 regulates PDGFR\u03b1 and is involved in adipocyte differentiation","volume":"9","author":"Yan","year":"2022","journal-title":"Front Mol Biosci"},{"issue":"16","key":"10.1016\/j.molmet.2024.102087_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/cells12162090","article-title":"The transcription factor HOXA5: novel insights into metabolic diseases and adipose\u00a0tissue dysfunction","volume":"12","author":"Parrillo","year":"2023","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.molmet.2024.102087_bib31","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/hmg\/ddad024","article-title":"Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease","volume":"32","author":"R\u00f6nn","year":"2023","journal-title":"Hum Mol Genet"},{"issue":"6","key":"10.1016\/j.molmet.2024.102087_bib32","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ijo.2016.36","article-title":"Hoxa5 undergoes dynamic DNA methylation and transcriptional repression in the adipose tissue of mice exposed to high-fat diet","volume":"40","author":"Parrillo","year":"2016","journal-title":"Int J Obes"},{"issue":"6","key":"10.1016\/j.molmet.2024.102087_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011033","article-title":"Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss","volume":"5","author":"Dankel","year":"2010","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.molmet.2024.102087_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/cells11040728","article-title":"Epigenetic dysregulation of the homeobox A5 (HOXA5) gene associates with subcutaneous adipocyte hypertrophy in human obesity","volume":"11","author":"Parrillo","year":"2022","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.molmet.2024.102087_bib35","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41430-023-01316-5","article-title":"Mediation effect of JAK2 methylation on the association between sitting time and abdominal obesity in rural adults","volume":"77","author":"Chang","year":"2023","journal-title":"Eur J Clin Nutr"},{"issue":"12","key":"10.1016\/j.molmet.2024.102087_bib36","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1016\/j.numecd.2021.08.046","article-title":"Janus kinase 2 (JAK2) methylation and obesity: a Mendelian randomization study","volume":"31","author":"Tu","year":"2021","journal-title":"Nutr Metabol Cardiovasc Dis : Nutr Metabol Cardiovasc Dis"},{"issue":"4","key":"10.1016\/j.molmet.2024.102087_bib37","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1139\/bcb-2021-0558","article-title":"Hoxa5 inhibits adipocyte proliferation through transcriptional regulation of Ccne1 and blocking JAK2\/STAT3 signaling pathway in mice","volume":"100","author":"Pan","year":"2022","journal-title":"Biochemistry and Cell Biology\u00a0= Biochimie et Biologie Cellulaire"},{"issue":"2","key":"10.1016\/j.molmet.2024.102087_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/ccs3.12039","article-title":"The signaling pathways in obesity-related complications","volume":"18","author":"Chandrasekaran","year":"2024","journal-title":"Journal of Cell Communication and Signaling"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824002187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877824002187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:12:16Z","timestamp":1778523136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877824002187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":38,"alternative-id":["S2212877824002187"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2024.102087","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre-operative DNA methylation marks as predictors of weight loss outcomes after sleeve gastrectomy","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2024.102087","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102087"}}