{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:09:13Z","timestamp":1778854153276,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2023-AdG 1011420930"],"award-info":[{"award-number":["ERC-2023-AdG 1011420930"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF14OC0011493"],"award-info":[{"award-number":["NNF14OC0011493"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF23SA0084103"],"award-info":[{"award-number":["NNF23SA0084103"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF18CC0034900"],"award-info":[{"award-number":["NNF18CC0034900"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2015-00165"],"award-info":[{"award-number":["2015-00165"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","award":["2023.0312"],"award-info":[{"award-number":["2023.0312"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.molmet.2025.102116","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T11:33:19Z","timestamp":1740223999000},"page":"102116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Enhanced metabolic adaptations following late dark phase wheel running in high-fat diet-fed mice"],"prefix":"10.1016","volume":"95","author":[{"given":"Stephen P.","family":"Ashcroft","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy M.","family":"Ehrlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Burek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Logan A.","family":"Pendergrast","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caio Y.","family":"Yonamine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas T.","family":"Treebak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6891-7497","authenticated-orcid":false,"given":"Juleen R.","family":"Zierath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.molmet.2025.102116_bib1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1210\/er.2015-1007","article-title":"Circadian metabolism in the light of evolution","volume":"36","author":"Gerhart-Hines","year":"2015","journal-title":"Endocr Rev"},{"issue":"5503","key":"10.1016\/j.molmet.2025.102116_bib2","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.291.5503.490","article-title":"Entrainment of the circadian clock in the liver by feeding","volume":"291","author":"Stokkan","year":"2001","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.molmet.2025.102116_bib3","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1249\/MSS.0b013e318255cf4c","article-title":"Scheduled exercise phase shifts the circadian clock in skeletal muscle","volume":"44","author":"Wolff","year":"2012","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"10.1016\/j.molmet.2025.102116_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/aje\/kwj355","article-title":"Work characteristics and incidence of type 2 diabetes in women","volume":"165","author":"Kroenke","year":"2007","journal-title":"Am J Epidemiol"},{"issue":"12","key":"10.1016\/j.molmet.2025.102116_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001141","article-title":"Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women","volume":"8","author":"Pan","year":"2011","journal-title":"PLoS Med"},{"issue":"5","key":"10.1016\/j.molmet.2025.102116_bib6","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1080\/07420520903044422","article-title":"Shiftwork and impaired glucose metabolism: a 14-year cohort study on 7104 male workers","volume":"26","author":"Suwazono","year":"2009","journal-title":"Chronobiol Int"},{"issue":"30","key":"10.1016\/j.molmet.2025.102116_bib7","doi-asserted-by":"crossref","first-page":"7789","DOI":"10.1073\/pnas.1722295115","article-title":"Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle","volume":"115","author":"Wefers","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.molmet.2025.102116_bib8","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1210\/jc.2014-3911","article-title":"Subchronic sleep restriction causes tissue-specific insulin resistance","volume":"100","author":"Rao","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.molmet.2025.102116_bib9","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1073\/pnas.0808180106","article-title":"Adverse metabolic and cardiovascular consequences of circadian misalignment","volume":"106","author":"Scheer","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.molmet.2025.102116_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2005886","article-title":"Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock","volume":"16","author":"Dyar","year":"2018","journal-title":"PLoS Biol"},{"issue":"5724","key":"10.1016\/j.molmet.2025.102116_bib11","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.1108750","article-title":"Obesity and metabolic syndrome in circadian Clock mutant mice","volume":"308","author":"Turek","year":"2005","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.molmet.2025.102116_bib12","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cub.2013.01.048","article-title":"Circadian\u00a0disruption leads to insulin resistance and obesity","volume":"23","author":"Shi","year":"2013","journal-title":"Curr Biol"},{"issue":"4","key":"10.1016\/j.molmet.2025.102116_bib13","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cmet.2015.08.006","article-title":"Hepatic Bmal1 regulates rhythmic mitochondrial dynamics and promotes metabolic fitness","volume":"22","author":"Jacobi","year":"2015","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.molmet.2025.102116_bib14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molmet.2013.10.005","article-title":"Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock","volume":"3","author":"Dyar","year":"2014","journal-title":"Mol Metabol"},{"issue":"12","key":"10.1016\/j.molmet.2025.102116_bib15","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1038\/nm.2979","article-title":"Obesity in mice with adipocyte-specific deletion of clock component Arntl","volume":"18","author":"Paschos","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.molmet.2025.102116_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101202","article-title":"Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice","volume":"49","author":"Hasan","year":"2021","journal-title":"Mol Metabol"},{"issue":"1","key":"10.1016\/j.molmet.2025.102116_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116476","article-title":"Free access to a running-wheel advances the phase of behavioral and physiological circadian rhythms and peripheral molecular clocks in mice","volume":"10","author":"Yasumoto","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.molmet.2025.102116_bib18","doi-asserted-by":"crossref","first-page":"E165","DOI":"10.1152\/ajpendo.00266.2017","article-title":"Exercise training reduces intrahepatic lipid content in people with and people without nonalcoholic fatty liver","volume":"314","author":"Brouwers","year":"2018","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.molmet.2025.102116_bib19","doi-asserted-by":"crossref","first-page":"572","DOI":"10.2337\/db09-1322","article-title":"Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity","volume":"59","author":"Meex","year":"2010","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.molmet.2025.102116_bib20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41574-018-0150-x","article-title":"Circadian rhythms and exercise - re-setting the clock in metabolic disease","volume":"15","author":"Gabriel","year":"2019","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"10.1016\/j.molmet.2025.102116_bib21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cmet.2019.03.012","article-title":"Physiological and molecular dissection of daily variance in exercise capacity","volume":"30","author":"Ezagouri","year":"2019","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.molmet.2025.102116_bib22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cmet.2019.03.013","article-title":"Time of exercise specifies the impact on muscle metabolic pathways and systemic energy homeostasis","volume":"30","author":"Sato","year":"2019","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.molmet.2025.102116_bib23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cmet.2021.12.016","article-title":"Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis","volume":"34","author":"Sato","year":"2022","journal-title":"Cell Metab"},{"issue":"4","key":"10.1016\/j.molmet.2025.102116_bib24","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1152\/japplphysiol.00737.2018","article-title":"Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action","volume":"126","author":"Dalbram","year":"2019","journal-title":"J\u00a0Appl Physiol"},{"issue":"1","key":"10.1016\/j.molmet.2025.102116_bib25","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201304R","article-title":"Time to run: late rather than early exercise training in mice remodels the gut microbiome and reduces atherosclerosis development","volume":"37","author":"Schonke","year":"2023","journal-title":"FASEB J"},{"issue":"9","key":"10.1016\/j.molmet.2025.102116_bib26","doi-asserted-by":"crossref","first-page":"959","DOI":"10.3109\/07420528.2014.935785","article-title":"Combination of meal and exercise timing with a high-fat diet influences energy expenditure and obesity in mice","volume":"31","author":"Sasaki","year":"2014","journal-title":"Chronobiol Int"},{"issue":"10","key":"10.1016\/j.molmet.2025.102116_bib27","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/j.cmet.2023.08.005","article-title":"Seasonal light hours modulate peripheral clocks and energy metabolism in mice","volume":"35","author":"Small","year":"2023","journal-title":"Cell Metab"},{"key":"10.1016\/j.molmet.2025.102116_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101440","article-title":"Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice","volume":"57","author":"Small","year":"2022","journal-title":"Mol Metabol"},{"issue":"14","key":"10.1016\/j.molmet.2025.102116_bib29","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2220102120","article-title":"NAMPT-dependent NAD(+) biosynthesis controls circadian metabolism in\u00a0a\u00a0tissue-specific manner","volume":"120","author":"Basse","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.molmet.2025.102116_bib30","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.2337\/db14-0704","article-title":"A\u00a0novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis","volume":"64","author":"Stanford","year":"2015","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.molmet.2025.102116_bib31","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.cmet.2012.04.019","article-title":"Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet","volume":"15","author":"Hatori","year":"2012","journal-title":"Cell Metab"},{"issue":"11","key":"10.1016\/j.molmet.2025.102116_bib32","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/oby.2009.264","article-title":"Circadian timing of food intake contributes to weight gain","volume":"17","author":"Arble","year":"2009","journal-title":"Obesity"},{"issue":"6","key":"10.1016\/j.molmet.2025.102116_bib33","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.cmet.2014.11.008","article-title":"Diet and feeding pattern affect\u00a0the\u00a0diurnal dynamics of the gut microbiome","volume":"20","author":"Zarrinpar","year":"2014","journal-title":"Cell Metab"},{"issue":"5","key":"10.1016\/j.molmet.2025.102116_bib34","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2362.2010.02278.x","article-title":"Regulation of adipokine production in human adipose tissue by propionic acid","volume":"40","author":"Al-Lahham","year":"2010","journal-title":"Eur J Clin Invest"},{"issue":"1","key":"10.1016\/j.molmet.2025.102116_bib35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nmeth.1806","article-title":"A\u00a0guide to analysis of mouse energy metabolism","volume":"9","author":"Tsch\u00f6p","year":"2012","journal-title":"Nat Methods"},{"issue":"6","key":"10.1016\/j.molmet.2025.102116_bib36","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1042\/bst0311143","article-title":"Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation","volume":"31","author":"Holness","year":"2003","journal-title":"Biochem Soc Trans"},{"issue":"7","key":"10.1016\/j.molmet.2025.102116_bib37","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1210\/en.2003-0097","article-title":"Effects of long-term voluntary exercise on the mouse hypothalamic-pituitary-adrenocortical axis","volume":"144","author":"Droste","year":"2003","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.molmet.2025.102116_bib38","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1172\/JCI110517","article-title":"Muscle glucose metabolism following exercise in the rat: increased sensitivity to insulin","volume":"69","author":"Richter","year":"1982","journal-title":"J\u00a0Clin Investig"},{"issue":"3 Pt 1","key":"10.1016\/j.molmet.2025.102116_bib39","first-page":"E248","article-title":"Effect of physical exercise on sensitivity and responsiveness to insulin in humans","volume":"254","author":"Mikines","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1016\/j.molmet.2025.102116_bib40","article-title":"A\u00a0comparative study of the metabolic and skeletal response of C57BL\/6J and C57BL\/6N mice in a diet-induced model of type 2 diabetes","volume":"2015","author":"Rendina-Ruedy","year":"2015","journal-title":"J\u00a0Nutr Metab"},{"issue":"4","key":"10.1016\/j.molmet.2025.102116_bib41","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.molmet.2013.07.009","article-title":"Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis","volume":"2","author":"Kahle","year":"2013","journal-title":"Mol Metabol"},{"issue":"7","key":"10.1016\/j.molmet.2025.102116_bib42","doi-asserted-by":"crossref","first-page":"872","DOI":"10.2337\/db22-0746","article-title":"Age and diet modulate the insulin-sensitizing effects of exercise: a tracer-based oral glucose tolerance test","volume":"72","author":"Vieira-Lara","year":"2023","journal-title":"Diabetes"},{"issue":"24","key":"10.1016\/j.molmet.2025.102116_bib43","article-title":"Exercise training elicits superior metabolic effects when performed in the afternoon compared to morning in metabolically compromised humans","volume":"8","author":"Mancilla","year":"2021","journal-title":"Phys Rep"},{"issue":"3","key":"10.1016\/j.molmet.2025.102116_bib44","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00125-022-05813-3","article-title":"Timing of physical activity in relation to liver fat content and insulin resistance","volume":"66","author":"van der Velde","year":"2023","journal-title":"Diabetologia"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877825000237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877825000237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:23:33Z","timestamp":1778851413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877825000237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":44,"alternative-id":["S2212877825000237"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2025.102116","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced metabolic adaptations following late dark phase wheel running in high-fat diet-fed mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2025.102116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102116"}}