{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:33:35Z","timestamp":1793691215031,"version":"4.5.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["APP210102943"],"award-info":[{"award-number":["APP210102943"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["NS300"],"award-info":[{"award-number":["NS300"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.molmet.2025.102180","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T11:37:11Z","timestamp":1749209831000},"page":"102180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Gut microbiota-derived extracellular vesicles exhibit diurnal regulation and activate hepatic gluconeogenesis"],"prefix":"10.1016","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1359-1797","authenticated-orcid":false,"given":"Jian","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemma Justine","family":"Taitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Potier-Villette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Pinget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Pulpitel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Stanley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Nanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Macia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.molmet.2025.102180_bib4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1101\/gad.290379.116","article-title":"Pancreatic \u03b1- and \u03b2-cellular clocks have distinct molecular properties and impact on islet hormone secretion and gene expression","volume":"31","author":"Petrenko","year":"2017","journal-title":"Gene Dev"},{"issue":"11","key":"10.1016\/j.molmet.2025.102180_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0020377","article-title":"BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis","volume":"2","author":"Rudic","year":"2004","journal-title":"PLoS Biol"},{"issue":"1","key":"10.1016\/j.molmet.2025.102180_bib6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat Rev Microbiol"},{"issue":"3","key":"10.1016\/j.molmet.2025.102180_bib7","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cmet.2020.01.012","article-title":"Dissociation of adaptive thermogenesis from glucose homeostasis in microbiome-deficient mice","volume":"31","author":"Krisko","year":"2020","journal-title":"Cell Metab"},{"issue":"3","key":"10.1016\/j.molmet.2025.102180_bib8","first-page":"1677","article-title":"Butyrate stimulates hepatic gluconeogenesis in mouse primary hepatocytes","volume":"17","author":"Ji","year":"2019","journal-title":"Exp Ther Med"},{"issue":"17","key":"10.1016\/j.molmet.2025.102180_bib9","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.3390\/ijms21176275","article-title":"Pathophysiology of type 2 diabetes mellitus","volume":"21","author":"Galicia-Garcia","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.molmet.2025.102180_bib10","doi-asserted-by":"crossref","first-page":"112183","DOI":"10.1016\/j.biopha.2021.112183","article-title":"Gestational diabetes mellitus - a metabolic and reproductive disorder","volume":"143","author":"Choudhury","year":"2021","journal-title":"Biomed; Pharmacothe = Biomed; Pharmacotherapie"},{"issue":"2","key":"10.1016\/j.molmet.2025.102180_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jaci.2022.11.007","article-title":"Dietary fiber and SCFAs in the regulation of mucosal immunity","volume":"151","author":"Tan","year":"2023","journal-title":"J Allergy Clin Immunol"},{"issue":"20","key":"10.1016\/j.molmet.2025.102180_bib12","doi-asserted-by":"crossref","first-page":"15256","DOI":"10.3390\/ijms242015256","article-title":"Dysbiotic gut microbiota-derived metabolites and their role in non-communicable diseases","volume":"24","author":"Tan","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.molmet.2025.102180_bib13","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/hr.2016.12","article-title":"A role for circadian clock in metabolic disease","volume":"39","author":"Shimizu","year":"2016","journal-title":"Hypertens Res: Off J Japanese Soc Hypertension"},{"issue":"14","key":"10.1016\/j.molmet.2025.102180_bib14","doi-asserted-by":"crossref","DOI":"10.1172\/JCI170998","article-title":"Circadian disruption, clock genes, and metabolic health","volume":"134","author":"Schrader","year":"2024","journal-title":"J Clin Investig"},{"key":"10.1016\/j.molmet.2025.102180_bib15","article-title":"Metabolic consequences of sleep and circadian disruption during pregnancy and postpartum","author":"Kishman","year":"2024","journal-title":"Trends Endocrinol Metabol: TEM (Trends Endocrinol Metab)"},{"issue":"1","key":"10.1016\/j.molmet.2025.102180_bib16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/ijms21010107","article-title":"Host- and microbiota-derived extracellular vesicles, immune function, and disease development","volume":"21","author":"Macia","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.molmet.2025.102180_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250163","article-title":"Diet, commensal microbiota-derived extracellular vesicles, and host immunity","volume":"53","author":"Taitz","year":"2023","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.molmet.2025.102180_bib18","doi-asserted-by":"crossref","unstructured":"Liang, X., Dai, N., Sheng, K., Lu, H., Wang, J., Chen, L., et al., n.d. Gut bacterial extracellular vesicles: important players in regulating intestinal microenvironment. Gut Microbes 14(1): 2134689, Doi: 10.1080\/19490976.2022.2134689.","DOI":"10.1080\/19490976.2022.2134689"},{"key":"10.1016\/j.molmet.2025.102180_bib19","doi-asserted-by":"crossref","first-page":"15878","DOI":"10.1038\/srep15878","article-title":"Gut microbe-derived extracellular vesicles induce insulin resistance, thereby impairing glucose metabolism in skeletal muscle","volume":"5","author":"Choi","year":"2015","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.molmet.2025.102180_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.282","article-title":"Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp Mol Med"},{"issue":"9","key":"10.1016\/j.molmet.2025.102180_bib21","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1016\/j.cell.2023.03.014","article-title":"Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease","volume":"186","author":"Wang","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.molmet.2025.102180_bib22","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1038\/s41467-022-31761-y","article-title":"Dietary protein increases T-cell-independent sIgA production through changes in gut microbiota-derived extracellular vesicles","volume":"13","author":"Tan","year":"2022","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.molmet.2025.102180_bib23","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1210\/me.2012-1413","article-title":"Activation of basal gluconeogenesis by coactivator p300 maintains hepatic glycogen storage","volume":"27","author":"He","year":"2013","journal-title":"Mol Endocrinol"},{"issue":"1","key":"10.1016\/j.molmet.2025.102180_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41467-017-00163-w","article-title":"Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity","volume":"8","author":"Cao","year":"2017","journal-title":"Nat Commun"},{"issue":"39","key":"10.1016\/j.molmet.2025.102180_bib25","doi-asserted-by":"crossref","first-page":"15172","DOI":"10.1073\/pnas.0806717105","article-title":"Physiological significance of a peripheral tissue circadian clock","volume":"105","author":"Lamia","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"10.1016\/j.molmet.2025.102180_bib26","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1093\/ajcn\/79.6.1078","article-title":"Energy requirements during pregnancy based on total energy expenditure and energy deposition","volume":"79","author":"Butte","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"7","key":"10.1016\/j.molmet.2025.102180_bib27","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1172\/JCI119704","article-title":"Glucose turnover and gluconeogenesis in human pregnancy","volume":"100","author":"Kalhan","year":"1997","journal-title":"J Clin Investig"},{"issue":"3","key":"10.1016\/j.molmet.2025.102180_bib28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the Mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat Rev Genet"},{"issue":"3","key":"10.1016\/j.molmet.2025.102180_bib29","first-page":"183","article-title":"Intestinal gluconeogenesis: metabolic benefits make sense in the light of evolution. Nature reviews","volume":"20","author":"Gautier-Stein","year":"2023","journal-title":"Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.molmet.2025.102180_bib30","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.3390\/nu12051474","article-title":"The Firmicutes\/Bacteroidetes ratio: a relevant marker of gut dysbiosis in Obese patients?","volume":"12","author":"Magne","year":"2020","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.molmet.2025.102180_bib31","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3945\/ajcn.2009.27834","article-title":"Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet","volume":"90","author":"Veldhorst","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1016\/j.molmet.2025.102180_bib32","doi-asserted-by":"crossref","first-page":"21066","DOI":"10.1038\/s41598-020-78121-8","article-title":"Significant increase in the secretion of extracellular vesicles and antibiotics resistance from methicillin-resistant Staphylococcus aureus induced by ampicillin stress","volume":"10","author":"Kim","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.molmet.2025.102180_bib33","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.cell.2017.03.001","article-title":"Selective chemical inhibition of PGC-1\u03b1 gluconeogenic activity ameliorates type 2 diabetes","volume":"169","author":"Sharabi","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.molmet.2025.102180_bib34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-Seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1016\/j.molmet.2025.102180_bib35","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-Seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"43","key":"10.1016\/j.molmet.2025.102180_bib36","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"10.1016\/j.molmet.2025.102180_bib37","doi-asserted-by":"crossref","first-page":"111191","DOI":"10.1016\/j.celrep.2022.111191","article-title":"Dysbiosis in imiquimod-induced psoriasis alters gut immunity and exacerbates colitis development","volume":"40","author":"Pinget","year":"2022","journal-title":"Cell Rep"},{"issue":"4","key":"10.1016\/j.molmet.2025.102180_bib38","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jhep.2007.07.006","article-title":"Grading and staging systems for inflammation and fibrosis in chronic liver diseases","volume":"47","author":"Goodman","year":"2007","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.molmet.2025.102180_bib39","doi-asserted-by":"crossref","first-page":"101943","DOI":"10.1016\/j.xpro.2022.101943","article-title":"Screening self-peptides for recognition by mouse alloreactive CD8+ T cells using direct ex vivo multimer staining","volume":"4","author":"Son","year":"2023","journal-title":"STAR Protocols"},{"issue":"8","key":"10.1016\/j.molmet.2025.102180_bib40","doi-asserted-by":"crossref","first-page":"102835","DOI":"10.1016\/j.isci.2021.102835","article-title":"Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function","volume":"24","author":"Tan","year":"2021","journal-title":"iScience"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877825000870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877825000870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:24:11Z","timestamp":1778851451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877825000870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":37,"alternative-id":["S2212877825000870"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2025.102180","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut microbiota-derived extracellular vesicles exhibit diurnal regulation and activate hepatic gluconeogenesis","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2025.102180","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102180"}}