{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:39:55Z","timestamp":1790138395257,"version":"4.0.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK136079"],"award-info":[{"award-number":["R01 DK136079"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK131717"],"award-info":[{"award-number":["DK131717"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.molmet.2025.102199","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T03:45:48Z","timestamp":1751427948000},"page":"102199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Dorsal raphe nucleus MC4R-GABAergic neurons regulate feeding and anxiety"],"prefix":"10.1016","volume":"99","author":[{"given":"Satoshi","family":"Yamagata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Copperi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin Thomas","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Dae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7921-2617","authenticated-orcid":false,"given":"Sabrina","family":"Diano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.molmet.2025.102199_bib1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/12506","article-title":"Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin","volume":"5","author":"Yaswen","year":"1999","journal-title":"Nat Med"},{"issue":"17","key":"10.1016\/j.molmet.2025.102199_bib2","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1093\/hmg\/11.17.1997","article-title":"A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism","volume":"11","author":"Challis","year":"2002","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.1016\/j.molmet.2025.102199_bib3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.cmet.2016.07.006","article-title":"Metabolic precision medicines: curing POMC deficiency","volume":"24","author":"M\u00fcller","year":"2016","journal-title":"Cell Metab"},{"issue":"7109","key":"10.1016\/j.molmet.2025.102199_bib4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nature05026","article-title":"Central nervous system control of food intake and body weight","volume":"443","author":"Morton","year":"2006","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.molmet.2025.102199_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/1096-9861(20000724)423:2<261::AID-CNE6>3.0.CO;2-6","article-title":"Chemical characterization of leptin-activated neurons in the rat brain","volume":"423","author":"Elias","year":"2000","journal-title":"J Comp Neurol"},{"issue":"6658","key":"10.1016\/j.molmet.2025.102199_bib6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/37016","article-title":"Melanocortin receptors in leptin effects","volume":"390","author":"Seeley","year":"1997","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.molmet.2025.102199_bib7","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nn1455","article-title":"Anatomy and regulation of the central melanocortin system","volume":"8","author":"Cone","year":"2005","journal-title":"Nat Neurosci"},{"issue":"3","key":"10.1016\/j.molmet.2025.102199_bib8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/cne.10454","article-title":"Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat","volume":"457","author":"Kishi","year":"2003","journal-title":"J Comp Neurol"},{"issue":"18","key":"10.1016\/j.molmet.2025.102199_bib9","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1523\/JNEUROSCI.23-18-07143.2003","article-title":"Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter","volume":"23","author":"Liu","year":"2003","journal-title":"J Neurosci"},{"issue":"10","key":"10.1016\/j.molmet.2025.102199_bib10","first-page":"1298","article-title":"Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain","volume":"8","author":"Mountjoy","year":"1994","journal-title":"Mol Endocrinol"},{"issue":"12","key":"10.1016\/j.molmet.2025.102199_bib11","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1056\/NEJMoa022050","article-title":"Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene","volume":"348","author":"Farooqi","year":"2003","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.molmet.2025.102199_bib12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1096\/fasebj.8.8.8181666","article-title":"Obesity, diabetes, and neoplasia in yellow A(vy)\/- mice: ectopic expression of the agouti gene","volume":"8","author":"Yen","year":"1994","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.molmet.2025.102199_bib13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0092-8674(00)81865-6","article-title":"Targeted disruption of the melanocortin-4 receptor results in obesity in mice","volume":"88","author":"Huszar","year":"1997","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.molmet.2025.102199_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/79254","article-title":"Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass","volume":"26","author":"Chen","year":"2000","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.molmet.2025.102199_bib15","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1210\/endo.141.9.7791","article-title":"A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse","volume":"141","author":"Butler","year":"2000","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.molmet.2025.102199_bib16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0361-9230(81)90077-0","article-title":"Mutual connections of the raphe system and hypothalamus in relation to fever","volume":"7","author":"Petrovick\u00fd","year":"1981","journal-title":"Brain Res Bull"},{"issue":"5","key":"10.1016\/j.molmet.2025.102199_bib17","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/cne.22237","article-title":"Vesicular glutamate transporter 3-expressing nonserotonergic projection neurons constitute a subregion in the rat midbrain raphe nuclei","volume":"518","author":"Hioki","year":"2010","journal-title":"J Comp Neurol"},{"issue":"3","key":"10.1016\/j.molmet.2025.102199_bib18","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cell.2017.06.045","article-title":"Identification of a brainstem circuit controlling feeding","volume":"170","author":"Nectow","year":"2017","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.molmet.2025.102199_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108267","article-title":"MC4R signaling in dorsal raphe nucleus controls feeding, anxiety, and depression","volume":"33","author":"Bruschetta","year":"2020","journal-title":"Cell Rep"},{"issue":"12","key":"10.1016\/j.molmet.2025.102199_bib20","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1172\/JCI70338","article-title":"Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis","volume":"123","author":"Berglund","year":"2013","journal-title":"J Clin Investig"},{"issue":"3","key":"10.1016\/j.molmet.2025.102199_bib21","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.cell.2019.05.048","article-title":"Regulation of energy expenditure by brainstem GABA neurons","volume":"178","author":"Schneeberger","year":"2019","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.molmet.2025.102199_bib22","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.cell.2025.01.018","article-title":"Brainstem neuropeptidergic neurons link a neurohumoral axis to satiation","volume":"188","author":"Chowdhury","year":"2025","journal-title":"Cell"},{"issue":"39","key":"10.1016\/j.molmet.2025.102199_bib23","doi-asserted-by":"crossref","first-page":"15800","DOI":"10.1073\/pnas.1304505110","article-title":"Presynaptic gating of excitation in the dorsal raphe nucleus by GABA","volume":"110","author":"Soiza-Reilly","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.molmet.2025.102199_bib24","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.neuron.2014.06.024","article-title":"Presynaptic partners of dorsal raphe serotonergic and GABAergic neurons","volume":"83","author":"Weissbourd","year":"2014","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.molmet.2025.102199_bib25","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.cell.2025.01.018","article-title":"Brainstem neuropeptidergic neurons link a neurohumoral axis to satiation","volume":"188","author":"Chowdhury","year":"2025","journal-title":"Cell"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877825001061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877825001061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T15:14:23Z","timestamp":1755098063000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877825001061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":25,"alternative-id":["S2212877825001061"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2025.102199","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dorsal raphe nucleus MC4R-GABAergic neurons regulate feeding and anxiety","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2025.102199","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102199"}}