{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:05:53Z","timestamp":1793927153547,"version":"4.8.0"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004385","name":"Universiteit Gent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019139","name":"Life Sciences, University of California, Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.molmet.2025.102282","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:48:26Z","timestamp":1763538506000},"page":"102282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["NLRP3 inhibition by VTX3232 tempers inflammation resulting in reduced body weight, hyperglycemia, and hepatic steatosis in obese male mice"],"prefix":"10.1016","volume":"103","author":[{"given":"Jennyfer","family":"Bultinck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shendong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovico","family":"Cantuti-Castelvetri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lander","family":"Brosens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby","family":"Bracke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Goethals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Christianson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Nuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Ogilvie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.molmet.2025.102282_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bj.2023.100624","article-title":"Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease","volume":"46","author":"Cho","year":"2023","journal-title":"Biomed J"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41573-023-00822-2","article-title":"Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets","volume":"23","author":"Vande Walle","year":"2024","journal-title":"Nat Rev Drug Discov"},{"issue":"9","key":"10.1016\/j.molmet.2025.102282_bib3","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/s41590-025-02230-7","article-title":"The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets","volume":"26","author":"Weber","year":"2025","journal-title":"Nat Immunol"},{"key":"10.1016\/j.molmet.2025.102282_bib4","article-title":"New insights into the interplay among autophagy, the NLRP3 inflammasome and inflammation in adipose tissue","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.molmet.2025.102282_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155217","article-title":"A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on","volume":"133","author":"Boutari","year":"2022","journal-title":"Metabolism"},{"issue":"10481","key":"10.1016\/j.molmet.2025.102282_bib6","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(25)00355-1","article-title":"Global, regional, and national prevalence of adult overweight and obesity, 1990\u20132021, with forecasts to 2050: a forecasting study for the global burden of disease study 2021","volume":"405","author":"Ng","year":"2025","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib7","doi-asserted-by":"crossref","DOI":"10.1124\/pharmrev.123.001045","article-title":"Emerging pharmacotherapies for obesity: a systematic review","volume":"77","author":"Kokkorakis","year":"2025","journal-title":"Pharmacol Rev"},{"issue":"6","key":"10.1016\/j.molmet.2025.102282_bib8","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s42255-021-00408-5","article-title":"Central nervous system regulation of organismal energy and glucose homeostasis","volume":"3","author":"Myers","year":"2021","journal-title":"Nat Metab"},{"issue":"7640","key":"10.1016\/j.molmet.2025.102282_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature21363","article-title":"Inflammation, metaflammation and immunometabolic disorders","volume":"542","author":"Hotamisligil","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41574-024-01047-y","article-title":"Inflammation and resolution in obesity","volume":"21","author":"Sot\u00e1k","year":"2025","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"10.1016\/j.molmet.2025.102282_bib11","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/s42255-024-01079-8","article-title":"Obesity-induced inflammation: connecting the periphery to the brain","volume":"6","author":"Thuc","year":"2024","journal-title":"Nat Metab"},{"issue":"3","key":"10.1016\/j.molmet.2025.102282_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/nutd.2017.10","article-title":"Microglia activation due to obesity programs metabolic failure leading to type two diabetes","volume":"7","author":"Maldonado-Ruiz","year":"2017","journal-title":"Nutr Diabetes"},{"issue":"37","key":"10.1016\/j.molmet.2025.102282_bib13","doi-asserted-by":"crossref","first-page":"15324","DOI":"10.1073\/pnas.1100255108","article-title":"Inflammasome is a central player in the induction of obesity and insulin resistance","volume":"108","author":"Stienstra","year":"2011","journal-title":"Proc Natl Acad Sci"},{"issue":"2","key":"10.1016\/j.molmet.2025.102282_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.molmet.2025.102282_bib15","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ni.2022","article-title":"Fatty acid\u2013induced NLRP3-ASC inflammasome activation interferes with insulin signaling","volume":"12","author":"Wen","year":"2011","journal-title":"Nat Immunol"},{"issue":"2","key":"10.1016\/j.molmet.2025.102282_bib16","article-title":"NLRP3 deficiency in nonimmune cells averts obesity-induced fatty liver disease","volume":"104","author":"Grigg","year":"2024","journal-title":"Lab Invest"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76497-1","article-title":"NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet","volume":"10","author":"Sokolova","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.molmet.2025.102282_bib18","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.3389\/fimmu.2019.01621","article-title":"NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity","volume":"10","author":"Sokolova","year":"2019","journal-title":"Front Immunol"},{"issue":"19","key":"10.1016\/j.molmet.2025.102282_bib19","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1111\/bph.15532","article-title":"NLRP3 at the crossroads between immune\/inflammatory responses and enteric neuroplastic remodelling in a mouse model of diet-induced obesity","volume":"178","author":"Pellegrini","year":"2021","journal-title":"Br J Pharmacol"},{"issue":"59","key":"10.1016\/j.molmet.2025.102282_bib20","doi-asserted-by":"crossref","first-page":"99740","DOI":"10.18632\/oncotarget.20763","article-title":"NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction","volume":"8","author":"Pavillard","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.molmet.2025.102282_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117711","article-title":"The NLRP3-inflammasome inhibitor MCC950 improves cardiac function in a HFpEF mouse model","volume":"181","author":"Li","year":"2024","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"10.1016\/j.molmet.2025.102282_bib22","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1124\/jpet.123.002013","article-title":"Reversal of high fat diet-induced obesity, systemic inflammation, and astrogliosis by the NLRP3 inflammasome inhibitors NT-0249 and NT-0796","volume":"388","author":"Thornton","year":"2024","journal-title":"J Pharmacol Exp Therapeut"},{"key":"10.1016\/j.molmet.2025.102282_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/oby.24305","article-title":"The NLRP3 inhibitor NT-0796 enhances and sustains GLP-1R agonist-mediated weight loss in a murine diet-induced obesity model","author":"Thornton","year":"2025","journal-title":"Obesity"},{"key":"10.1016\/j.molmet.2025.102282_bib24","unstructured":"Bultinck, J., Embo 2024. VTX3232: a novel, brain-penetrant NLRP3 inhibitor for treating systemic and central inflammation."},{"issue":"6","key":"10.1016\/j.molmet.2025.102282_bib25","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.133429","article-title":"Semaglutide lowers body weight in rodents via distributed neural pathways","volume":"5","author":"Gabery","year":"2020","journal-title":"JCI Insight"},{"issue":"8","key":"10.1016\/j.molmet.2025.102282_bib26","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/dom.14725","article-title":"Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension","volume":"24","author":"Wilding","year":"2022","journal-title":"Diabetes Obes Metabol"},{"key":"10.1016\/j.molmet.2025.102282_bib27","article-title":"A dietary intervention following incretin analog treatment restores adipose tissue functions in diet-induced obese mice","author":"Seuntjens","year":"2025","journal-title":"bioRxiv"},{"issue":"8","key":"10.1016\/j.molmet.2025.102282_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe2480","article-title":"3D microscopy and deep learning reveal the heterogeneity of crown-like structure microenvironments in intact adipose tissue","volume":"7","author":"Geng","year":"2021","journal-title":"Sci Adv"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jnutbio.2009.11.009","article-title":"Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease","volume":"22","author":"Kirpich","year":"2011","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.molmet.2025.102282_bib30","series-title":"RNA Seq analysis of non-alcoholic fatty liver disease (NAFLD) induced by Metabolic syndrome in a mouse model","author":"Almanza","year":"2016"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tem.2012.11.003","article-title":"Neuroinflammation and neurodegeneration in overnutrition-induced diseases","volume":"24","author":"Cai","year":"2013","journal-title":"Trends Endocrinol Metabol"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib32","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J Clin Investig"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cmet.2017.05.015","article-title":"Microglial inflammatory signaling orchestrates the hypothalamic immune response to dietary excess and mediates obesity susceptibility","volume":"26","author":"Valdearcos","year":"2017","journal-title":"Cell Metab"},{"issue":"6","key":"10.1016\/j.molmet.2025.102282_bib34","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1016\/j.celrep.2014.11.018","article-title":"Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function","volume":"9","author":"Valdearcos","year":"2014","journal-title":"Cell Rep"},{"issue":"5","key":"10.1016\/j.molmet.2025.102282_bib35","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199602013340503","article-title":"Serum immunoreactive-leptin concentrations in normal-weight and Obese humans","volume":"334","author":"Considine","year":"1996","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.7150\/ijbs.73936","article-title":"Targeting FGF21 in cardiovascular and metabolic diseases: from mechanism to medicine","volume":"19","author":"Tan","year":"2023","journal-title":"Int J Biol Sci"},{"issue":"11","key":"10.1016\/j.molmet.2025.102282_bib37","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.2337\/db10-0193","article-title":"Obesity is a fibroblast growth factor 21 (FGF21)-resistant state","volume":"59","author":"Fisher","year":"2010","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.molmet.2025.102282_bib38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.tins.2016.12.003","article-title":"Current understanding of the hypothalamic ghrelin pathways inducing appetite and adiposity","volume":"40","author":"Massadi","year":"2017","journal-title":"Trends Neurosci"},{"issue":"0","key":"10.1016\/j.molmet.2025.102282_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/JIR.S229691","article-title":"Saturated fatty acids in obesity-associated inflammation","volume":"13","author":"Zhou","year":"2020","journal-title":"J Inflamm Res"},{"issue":"7081","key":"10.1016\/j.molmet.2025.102282_bib40","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2025.102282_bib41","first-page":"1","article-title":"Cholesterol crystals in the pathogenesis of atherosclerosis","author":"Baumer","year":"2024","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.molmet.2025.102282_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1214289","article-title":"Cell type-specific roles of NLRP3, inflammasome-dependent and -independent, in host defense, sterile necroinflammation, tissue repair, and fibrosis","volume":"14","author":"Honda","year":"2023","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.molmet.2025.102282_bib43","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1128\/IAI.67.11.5573-5578.1999","article-title":"Differentiation of monocytes to macrophages primes cells for lipopolysaccharide stimulation via accumulation of cytoplasmic nuclear factor \u03baB","volume":"67","author":"Takashiba","year":"1999","journal-title":"Infect Immun"},{"issue":"10","key":"10.1016\/j.molmet.2025.102282_bib44","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.ebiom.2015.09.004","article-title":"Circulating unsaturated fatty acids delineate the metabolic status of Obese individuals","volume":"2","author":"Ni","year":"2015","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/j.molmet.2025.102282_bib45","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1073\/pnas.0915018107","article-title":"Differential release of chromatin-bound IL-1\u03b1 discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation","volume":"107","author":"Cohen","year":"2010","journal-title":"Proc Natl Acad Sci"},{"issue":"8","key":"10.1016\/j.molmet.2025.102282_bib46","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00296-009-1089-y","article-title":"Differential effect of IL-1\u03b2 and TNF-\u03b1 on the production of IL-6, IL-8 and PGE2 in fibroblast-like synoviocytes and THP-1 macrophages","volume":"30","author":"Choi","year":"2010","journal-title":"Rheumatol Int"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib47","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1083\/jcb.200612131","article-title":"Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNF\u03b1","volume":"178","author":"Manderson","year":"2007","journal-title":"J Cell Biol"},{"issue":"9","key":"10.1016\/j.molmet.2025.102282_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1048","article-title":"Hepatic interleukin-1 receptor type 1 signalling regulates insulin sensitivity in the early phases of nonalcoholic fatty liver disease","volume":"12","author":"Gehrke","year":"2022","journal-title":"Clin Transl Med"},{"issue":"9","key":"10.1016\/j.molmet.2025.102282_bib49","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1210\/en.2010-0340","article-title":"Interleukin-1\u03b2 May mediate insulin resistance in liver-derived cells in response to adipocyte inflammation","volume":"151","author":"Nov","year":"2010","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.molmet.2025.102282_bib50","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1007\/s00125-006-0335-z","article-title":"Long-term treatment with interleukin-1\u03b2 induces insulin resistance in murine and human adipocytes","volume":"49","author":"Lagathu","year":"2006","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.molmet.2025.102282_bib51","doi-asserted-by":"crossref","first-page":"E289","DOI":"10.1152\/ajpendo.00430.2013","article-title":"Interleukin-1\u03b2 mediates macrophage-induced impairment of insulin signaling in human primary adipocytes","volume":"307","author":"Gao","year":"2014","journal-title":"Am J Physiol Endocrinol Metabol"},{"issue":"2","key":"10.1016\/j.molmet.2025.102282_bib52","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0014-5793(89)80476-4","article-title":"Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes","volume":"242","author":"Castell","year":"1989","journal-title":"FEBS (Fed Eur Biochem Soc) Lett"},{"issue":"9","key":"10.1016\/j.molmet.2025.102282_bib53","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.cellsig.2007.04.007","article-title":"Activation of NF-\u03baB by IL-1\u03b2 blocks IL-6-induced sustained STAT3 activation and STAT3-dependent gene expression of the human \u03b3-fibrinogen gene","volume":"19","author":"Albrecht","year":"2007","journal-title":"Cell Signal"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib54","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/hep.24706","article-title":"Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease","volume":"55","author":"Kowdley","year":"2012","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.molmet.2025.102282_bib55","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI23606","article-title":"FGF-21 as a novel metabolic regulator","volume":"115","author":"Kharitonenkov","year":"2005","journal-title":"J Clin Investig"},{"issue":"3","key":"10.1016\/j.molmet.2025.102282_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202103157","article-title":"Probing insulin sensitivity with metabolically competent human stem cell-derived White adipose tissue microphysiological systems","volume":"18","author":"Qi","year":"2022","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib57","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1172\/JCI88878","article-title":"Hypothalamic inflammation in obesity and metabolic disease","volume":"127","author":"Jais","year":"2017","journal-title":"J Clin Investig"},{"issue":"2","key":"10.1016\/j.molmet.2025.102282_bib58","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cmet.2011.12.013","article-title":"Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity","volume":"15","author":"Ryan","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.molmet.2025.102282_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.971745","article-title":"Interleukin-18 in metabolism: from mice physiology to human diseases","volume":"13","author":"Somm","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.molmet.2025.102282_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.123339","article-title":"GLP-1 and IL-6 regulates obesity in the gut and brain","volume":"362","author":"Yang","year":"2025","journal-title":"Life Sci"},{"key":"10.1016\/j.molmet.2025.102282_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102891","article-title":"TNF as a mediator of metabolic inflammation and body-brain interaction in obesity-driven neuroinflammation and neurodegeneration","volume":"112","author":"Lo","year":"2025","journal-title":"Ageing Res Rev"},{"issue":"5","key":"10.1016\/j.molmet.2025.102282_bib62","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/s42255-024-01023-w","article-title":"Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization","volume":"6","author":"Rohm","year":"2024","journal-title":"Nat Metab"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib63","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in obesity, diabetes, and related disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.molmet.2025.102282_bib64","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/s12276-024-01261-8","article-title":"NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders","volume":"56","author":"Ramachandran","year":"2024","journal-title":"Exp Mol Med"},{"issue":"10","key":"10.1016\/j.molmet.2025.102282_bib65","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/s42255-021-00470-z","article-title":"Metabolic messengers: tumour necrosis factor","volume":"3","author":"Sethi","year":"2021","journal-title":"Nat Metab"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib66","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1038\/s41467-022-33067-5","article-title":"Interferon gamma mediates the reduction of adipose tissue regulatory T cells in human obesity","volume":"13","author":"Bradley","year":"2022","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.molmet.2025.102282_bib67","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/sj.ijo.0803259","article-title":"Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters","volume":"30","author":"Kim","year":"2006","journal-title":"Int J Obes"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib68","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1042\/CS20210959","article-title":"Augmented CCL5\/CCR5 signaling in brown adipose tissue inhibits adaptive thermogenesis and worsens insulin resistance in obesity","volume":"136","author":"Chan","year":"2022","journal-title":"Clin Sci"},{"issue":"7","key":"10.1016\/j.molmet.2025.102282_bib69","first-page":"259","article-title":"Human resistin: found in translation from mouse to man","volume":"22","author":"Schwartz","year":"2011","journal-title":"Trends Endocrinol Metabol"},{"issue":"Suppl 3","key":"10.1016\/j.molmet.2025.102282_bib70","article-title":"Fatty acid-binding protein 4 (FABP4): pathophysiological insights and potent clinical biomarker of metabolic and cardiovascular diseases","volume":"8s3","author":"Furuhashi","year":"2014","journal-title":"Clin Med Insights Cardiol"},{"issue":"18","key":"10.1016\/j.molmet.2025.102282_bib71","doi-asserted-by":"crossref","first-page":"6022","DOI":"10.3390\/jcm12186022","article-title":"From innate immunity to metabolic disorder: a review of the NLRP3 inflammasome in diabetes mellitus","volume":"12","author":"Ni\u021bulescu","year":"2023","journal-title":"J Clin Med"},{"issue":"5","key":"10.1016\/j.molmet.2025.102282_bib72","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/labinvest.2012.45","article-title":"Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis","volume":"92","author":"Dixon","year":"2012","journal-title":"Lab Invest"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib73","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-69764-y","article-title":"NLRP3 inflammasome pathway involved in the pathogenesis of metabolic associated fatty liver disease","volume":"14","author":"Osman","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.molmet.2025.102282_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.108053","article-title":"Targeting the NLRP3 inflammasome in cardiovascular diseases","volume":"236","author":"Toldo","year":"2022","journal-title":"Pharmacol Therapeut"},{"key":"10.1016\/j.molmet.2025.102282_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1550226","article-title":"NLRP3 inflammasome in cardiovascular diseases: an update","volume":"16","author":"Mo","year":"2025","journal-title":"Front Immunol"},{"issue":"10","key":"10.1016\/j.molmet.2025.102282_bib76","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1681\/ASN.2010020143","article-title":"The NLRP3 inflammasome promotes renal inflammation and contributes to CKD","volume":"21","author":"Vilaysane","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.molmet.2025.102282_bib77","unstructured":"N.d. Promising preclinical obesity data at Halia Therapeutics. https:\/\/haliatx.com\/halia-promising-preclinical-obesity-data\/. [accessed May 9, 2025]."},{"key":"10.1016\/j.molmet.2025.102282_bib78","article-title":"CNS-penetrant NLRP3 inhibitor achieves durable weight loss and reverses hypothalamic inflammation in diet-induced obesity","author":"Guo","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.molmet.2025.102282_bib79","unstructured":"Neumora therapeutics announces class-leading weight loss demonstrated with NMRA-215 in preclinical diet-induced obesity model. https:\/\/ir.neumoratx.com\/node\/8006\/pdf. [accessed October 27, 2025]."},{"key":"10.1016\/j.molmet.2025.102282_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149225","article-title":"Principal components analysis on genes related to inflammasome complex and microglial activation in the hypothalamus of obese mice treated with semaglutide (GLP-1 analog)","volume":"1846","author":"Marinho","year":"2025","journal-title":"Brain Res"},{"key":"10.1016\/j.molmet.2025.102282_bib81","article-title":"Principal components analysis on genes related to inflammasome complex and microglial activation in the hypothalamus of obese mice treated with semaglutide (GLP-1 analog)","volume":"1846","author":"Fabiano","year":"2025","journal-title":"Brain Res"},{"key":"10.1016\/j.molmet.2025.102282_bib82","article-title":"Glucagon-like peptide-1 receptor agonist attenuates diabetic neuropathic pain via inhibition of NOD-like receptor protein 3 inflammasome in brain microglia","volume":"186","author":"Wong","year":"2023","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.molmet.2025.102282_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2022.109806","article-title":"Glucagon-like peptide-1 receptor agonist attenuates diabetic neuropathic pain via inhibition of NOD-like receptor protein 3 inflammasome in brain microglia","volume":"186","author":"Zhang","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib84","article-title":"Semaglutide ameliorates pressure overload-induced cardiac hypertrophy by improving cardiac mitophagy to suppress the activation of NLRP3 inflammasome","volume":"14","author":"He","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.molmet.2025.102282_bib85","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1530985","article-title":"The agony and the efficacy: central mechanisms of GLP-1 induced adverse events and their mitigation by GIP","volume":"16","author":"Douros","year":"2025","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.molmet.2025.102282_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.obpill.2024.100127","article-title":"Glucagon-like Receptor-1 agonists for obesity: weight loss outcomes, tolerability, side effects, and risks","volume":"12","author":"Ghusn","year":"2024","journal-title":"Obesity Pillars"},{"key":"10.1016\/j.molmet.2025.102282_bib87","unstructured":"Ventyx biosciences announces positive topline results from phase 2 Study of VTX3232 in participants with obesity and cardiovascular risk factors. https:\/\/ir.ventyxbio.com\/node\/9546\/pdf. [accessed October 22, 2025]."},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib88","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cmet.2010.06.001","article-title":"Assessment of feeding behavior in laboratory mice","volume":"12","author":"Ellacott","year":"2010","journal-title":"Cell Metab"},{"issue":"7124","key":"10.1016\/j.molmet.2025.102282_bib89","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2025.102282_bib90","series-title":"FastQC: a quality control tool for high throughput sequence data","year":"2010"},{"issue":"1","key":"10.1016\/j.molmet.2025.102282_bib91","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet Journal"},{"issue":"4","key":"10.1016\/j.molmet.2025.102282_bib92","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat Methods"},{"key":"10.1016\/j.molmet.2025.102282_bib93","unstructured":"Love, M., Anders, S., Huber, W., n.d. Differential analysis of count data \u2013 the DESeq2 package."},{"issue":"D1","key":"10.1016\/j.molmet.2025.102282_bib94","doi-asserted-by":"crossref","first-page":"D330","DOI":"10.1093\/nar\/gky1055","article-title":"The gene ontology resource: 20 years and still GOing strong","volume":"47","author":"Consortium","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"suppl_1","key":"10.1016\/j.molmet.2025.102282_bib95","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkm882","article-title":"KEGG for linking genomes to life and the environment","volume":"36","author":"Kanehisa","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"10.1016\/j.molmet.2025.102282_bib96","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS A J Integr Biol"},{"issue":"43","key":"10.1016\/j.molmet.2025.102282_bib97","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"10.1016\/j.molmet.2025.102282_bib98","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/bioinformatics\/btab711","article-title":"ImmuCellAI-mouse: a tool for comprehensive prediction of mouse immune cell abundance and immune microenvironment depiction","volume":"38","author":"Miao","year":"2021","journal-title":"Bioinformatics"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877825001899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877825001899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:43:17Z","timestamp":1768398197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877825001899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":98,"alternative-id":["S2212877825001899"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2025.102282","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NLRP3 inhibition by VTX3232 tempers inflammation resulting in reduced body weight, hyperglycemia, and hepatic steatosis in obese male mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2025.102282","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102282"}}