{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:55:27Z","timestamp":1793850927285,"version":"4.6.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P400PM_191043"],"award-info":[{"award-number":["P400PM_191043"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["101390"],"award-info":[{"award-number":["101390"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["125132"],"award-info":[{"award-number":["125132"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["177225"],"award-info":[{"award-number":["177225"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32CA272303-03"],"award-info":[{"award-number":["5T32CA272303-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.molmet.2025.102283","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:48:26Z","timestamp":1763538506000},"page":"102283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Myokine IL-6 activity enhances post-exercise fatty acid accumulation in skeletal muscle but does not affect glycogen resynthesis"],"prefix":"10.1016","volume":"103","author":[{"given":"Timothy M.","family":"Kistner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beckey","family":"Trinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Mfeketo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit","family":"van Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente K.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Lieberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9105-5247","authenticated-orcid":false,"given":"Helga","family":"Ellingsgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2025.102283_bib1","first-page":"6","article-title":"Interleukin-6 in acute exercise and training: what is the biological relevance?","volume":"12","author":"Fischer","year":"2006","journal-title":"Exerc Immunol Rev"},{"key":"10.1016\/j.molmet.2025.102283_bib2","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1152\/japplphysiol.00080.2007","article-title":"Role of myokines in exercise and metabolism","volume":"103","author":"Pedersen","year":"2007","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.molmet.2025.102283_bib3","first-page":"884","article-title":"Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans","volume":"17","author":"Starkie","year":"2003","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"key":"10.1016\/j.molmet.2025.102283_bib4","doi-asserted-by":"crossref","first-page":"E433","DOI":"10.1152\/ajpendo.00074.2003","article-title":"IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans","volume":"285","author":"Steensberg","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.molmet.2025.102283_bib5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s42255-022-00538-4","article-title":"Interleukin 6 as an energy allocator in muscle tissue","volume":"4","author":"Kistner","year":"2022","journal-title":"Nat Metab"},{"key":"10.1016\/j.molmet.2025.102283_bib6","doi-asserted-by":"crossref","first-page":"E543","DOI":"10.1152\/ajpendo.00232.2016","article-title":"Liver glycogen metabolism during and after prolonged endurance-type exercise","volume":"311","author":"Gonzalez","year":"2016","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.molmet.2025.102283_bib7","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S1043-2760(03)00143-7","article-title":"Fatty acid mobilization from adipose tissue during exercise","volume":"14","author":"Horowitz","year":"2003","journal-title":"Trends Endocrinol Metab TEM"},{"key":"10.1016\/j.molmet.2025.102283_bib8","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.2337\/diabetes.48.5.1192","article-title":"Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes","volume":"48","author":"Kennedy","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2025.102283_bib9","doi-asserted-by":"crossref","first-page":"E183","DOI":"10.1152\/ajpendo.00254.2011","article-title":"Acute endurance exercise increases plasma membrane fatty acid transport proteins in rat and human skeletal muscle","volume":"302","author":"Bradley","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.molmet.2025.102283_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2015.00027","article-title":"Post-exercise skeletal muscle glycogen related to plasma cytokines and muscle IL-6 protein content, but not muscle cytokine mRNA expression","volume":"2","author":"Nieman","year":"2015","journal-title":"Front Nutr"},{"key":"10.1016\/j.molmet.2025.102283_bib11","article-title":"Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men","volume":"2","author":"Trinh","year":"2021","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.molmet.2025.102283_bib12","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.2337\/diabetes.53.7.1643","article-title":"Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction","volume":"53","author":"Febbraio","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2025.102283_bib13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3390\/nu12020280","article-title":"The importance of fatty acids as nutrients during post-exercise recovery","volume":"12","author":"Lundsgaard","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.molmet.2025.102283_bib14","volume":"34","author":"Richter","year":"1985"},{"key":"10.1016\/j.molmet.2025.102283_bib15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1152\/physrev.00003.2009","article-title":"Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease","volume":"90","author":"Glatz","year":"2010","journal-title":"Physiol Rev"},{"key":"10.1016\/j.molmet.2025.102283_bib16","doi-asserted-by":"crossref","first-page":"E180","DOI":"10.1152\/ajpendo.00073.2010","article-title":"Exercise training increases sarcolemmal and mitochondrial fatty acid transport proteins in human skeletal muscle","volume":"299","author":"Talanian","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.molmet.2025.102283_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029391","article-title":"Enhanced fatty acid oxidation and FATP4 protein expression after endurance exercise training in human skeletal muscle","volume":"7","author":"Jeppesen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.molmet.2025.102283_bib18","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1172\/JCI133572","article-title":"Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts","volume":"130","author":"Chowdhury","year":"2020","journal-title":"J Clin Investig"},{"key":"10.1016\/j.molmet.2025.102283_bib19","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s11745-012-3678-x","article-title":"A single bout of exercise increases the expression of glucose but not fatty acid transporters in skeletal muscle of IL-6 KO mice","volume":"47","author":"\u0141ukaszuk","year":"2012","journal-title":"Lipids"},{"key":"10.1016\/j.molmet.2025.102283_bib20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1249\/JES.0000000000000224","article-title":"Exercise and GLUT4","volume":"48","author":"Flores-Opazo","year":"2020","journal-title":"Exerc Sport Sci Rev"},{"key":"10.1016\/j.molmet.2025.102283_bib21","doi-asserted-by":"crossref","first-page":"E251","DOI":"10.1152\/ajpendo.00448.2004","article-title":"Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt","volume":"289","author":"Weigert","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.molmet.2025.102283_bib22","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/dom.12299","article-title":"Interleukin-6 in combination with the interleukin-6 receptor stimulates glucose uptake in resting human skeletal muscle independently of insulin action","volume":"16","author":"Saini","year":"2014","journal-title":"Diabetes Obes Metabol"},{"key":"10.1016\/j.molmet.2025.102283_bib23","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1113\/jphysiol.2002.019380","article-title":"Interleukin-6 production in human subcutaneous abdominal adipose tissue: the effect of exercise","volume":"543","author":"Lyngs\u00f8","year":"2002","journal-title":"J Physiol"},{"key":"10.1016\/j.molmet.2025.102283_bib24","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3390\/nu10030298","article-title":"Regulation of muscle glycogen metabolism during exercise: implications for endurance performance and training adaptations","volume":"10","author":"Hearris","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.molmet.2025.102283_bib25","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1194\/jlr.M900021-JLR200","article-title":"Relationship between postabsorptive respiratory exchange ratio and plasma free fatty acid concentrations","volume":"50","author":"Jensen","year":"2009","journal-title":"J Lipid Res"},{"key":"10.1016\/j.molmet.2025.102283_bib26","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cmet.2018.04.008","article-title":"Interleukin-6 delays gastric emptying in humans with direct effects on glycemic control","volume":"27","author":"Lang Lehrskov","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/j.molmet.2025.102283_bib27","doi-asserted-by":"crossref","first-page":"848","DOI":"10.2337\/dbi18-0042","article-title":"Exercise and muscle lipid content, composition, and localization: influence on muscle insulin sensitivity","volume":"69","author":"Bergman","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2025.102283_bib28","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1113\/jphysiol.2003.052431","article-title":"Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance-trained males in a fasted state","volume":"553","author":"Van Loon","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.molmet.2025.102283_bib29","doi-asserted-by":"crossref","first-page":"E332","DOI":"10.1152\/ajpendo.1998.275.2.E332","article-title":"Utilization of skeletal muscle triacylglycerol during postexercise recovery in humans","volume":"275","author":"Kiens","year":"1998","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.molmet.2025.102283_bib30","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1113\/jphysiol.2002.031179","article-title":"Skeletal muscle fat and carbohydrate metabolism during recovery from glycogen-depleting exercise in humans","volume":"548","author":"Kimber","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.molmet.2025.102283_bib31","doi-asserted-by":"crossref","first-page":"E832","DOI":"10.1152\/ajpendo.00328.2010","article-title":"IL-6 selectively stimulates fat metabolism in human skeletal muscle","volume":"299","author":"Wolsk","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.molmet.2025.102283_bib32","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/eci.12781","article-title":"Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease","volume":"47","author":"Pedersen","year":"2017","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.molmet.2025.102283_bib33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0165-5728(00)00205-8","article-title":"Catecholamines trigger IL-10 release in acute systemic stress reaction by direct stimulation of its promoter\/enhancer activity in monocytic cells","volume":"105","author":"Platzer","year":"2000","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.molmet.2025.102283_bib34","series-title":"ACSM's guidelines for exercise testing and prescription","year":"2014"},{"key":"10.1016\/j.molmet.2025.102283_bib35","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1113\/jphysiol.2002.022392","article-title":"Regional fat metabolism in human splanchnic and adipose tissues; the effect of exercise","volume":"543","author":"Van Hall","year":"2002","journal-title":"J Physiol"},{"key":"10.1016\/j.molmet.2025.102283_bib36","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/jms.3407","article-title":"Glucose and glycerol concentrations and their tracer enrichment measurements using liquid chromatography tandem mass spectrometry","volume":"49","author":"Born\u00f8","year":"2014","journal-title":"J Mass Spectrom JMS"},{"key":"10.1016\/j.molmet.2025.102283_bib37","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3109\/00365517509095787","article-title":"Percutaneous needle biopsy of skeletal muscle in physiological and clinical research","volume":"35","author":"Bergstrom","year":"1975","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.molmet.2025.102283_bib38","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1476-5381.1973.tb08339.x","article-title":"The dependence of paracetamol absorption on the rate of gastric emptying","volume":"47","author":"Heading","year":"1973","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.molmet.2025.102283_bib39","first-page":"23","article-title":"Table of nonprotein respiratory quotient: an update","volume":"16","author":"P\u00e9ronnet","year":"1991","journal-title":"Can J Sport Sci J Can Sci Sport"},{"key":"10.1016\/j.molmet.2025.102283_bib40","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1152\/jappl.1983.55.2.628","article-title":"Calculation of substrate oxidation rates in vivo from gaseous exchange","volume":"55","author":"Frayn","year":"1983","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.molmet.2025.102283_bib41","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1749-6632.1959.tb44923.x","article-title":"Influences of glucose loading and of injected insulin on hepatic glucose output","volume":"82","author":"Steele","year":"1959","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.molmet.2025.102283_bib42","series-title":"Radioactive and stable isotope tracers in biomedicine : principles and practice of kinetic analysis","author":"Wolfe","year":"1992"},{"key":"10.1016\/j.molmet.2025.102283_bib43","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0022-2275(20)42613-6","article-title":"Mechanism of free fatty acid re-esterification in human adipocytes in vitro","volume":"31","author":"Edens","year":"1990","journal-title":"J Lipid Res"},{"key":"10.1016\/j.molmet.2025.102283_bib44","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1113\/jphysiol.2004.075135","article-title":"High triacylglycerol turnover rate in human skeletal muscle","volume":"561","author":"Sacchetti","year":"2004","journal-title":"J Physiol"},{"key":"10.1016\/j.molmet.2025.102283_bib45","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1113\/jphysiol.2002.023796","article-title":"Human skeletal muscle fatty acid and glycerol metabolism during rest, exercise and recovery","volume":"543","author":"Van Hall","year":"2002","journal-title":"J Physiol"},{"key":"10.1016\/j.molmet.2025.102283_bib46","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.2337\/diabetes.52.7.1641","article-title":"What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean?","volume":"52","author":"Mittendorfer","year":"2003","journal-title":"Diabetes"},{"issue":"Pt 1","key":"10.1016\/j.molmet.2025.102283_bib47","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1469-7793.1998.215by.x","article-title":"Validation of the [1,2-13C] acetate recovery factor for correction of [U-13C]palmitate oxidation rates in humans","volume":"513","author":"Schrauwen","year":"1998","journal-title":"J Physiol"},{"key":"10.1016\/j.molmet.2025.102283_bib48","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2001.014340","article-title":"Whole body and leg acetate kinetics at rest, during exercise and recovery in humans","volume":"542","author":"Van Hall","year":"2002","journal-title":"J Physiol"},{"key":"10.1016\/j.molmet.2025.102283_bib49","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.1074\/jbc.R117.802843","article-title":"The dynamic life of the glycogen granule","volume":"293","author":"Prats","year":"2018","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molmet.2025.102283_bib50","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1210\/jc.2007-2223","article-title":"Interleukin-6 markedly decreases skeletal muscle protein turnover and increases nonmuscle amino acid utilization in healthy individuals","volume":"93","author":"Van Hall","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.molmet.2025.102283_bib51","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1007\/s00125-013-3003-0","article-title":"Effects of gastric bypass surgery on glucose absorption and metabolism during a mixed meal in glucose-tolerant individuals","volume":"56","author":"Jacobsen","year":"2013","journal-title":"Diabetologia"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877825001905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877825001905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:25:09Z","timestamp":1778851509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877825001905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":51,"alternative-id":["S2212877825001905"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2025.102283","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myokine IL-6 activity enhances post-exercise fatty acid accumulation in skeletal muscle but does not affect glycogen resynthesis","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2025.102283","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102283"}}