{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:15:18Z","timestamp":1773868518403,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.molmet.2025.102287","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T17:09:09Z","timestamp":1763658549000},"page":"102287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Additive effects of GLY-200 (oral pharmacologic duodenal exclusion therapy) and GLP-1R agonist in obesity management"],"prefix":"10.1016","volume":"103","author":[{"given":"Taylor L.","family":"Carlson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Fineman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stace","family":"Kernodle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea R.","family":"Hutch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Colbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy J.","family":"Seeley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1222-598X","authenticated-orcid":false,"given":"Ashish","family":"Nimgaonkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.molmet.2025.102287_bib1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41392-024-01931-z","article-title":"Glucagon-like peptide-1 receptor: mechanisms and advances in therapy","volume":"9","author":"Zheng","year":"2024","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.molmet.2025.102287_bib2","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-076410","article-title":"Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis","volume":"384","author":"Yao","year":"2024","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.molmet.2025.102287_bib3","doi-asserted-by":"crossref","first-page":"E379","DOI":"10.1210\/jc.2010-1333","article-title":"Small intestinal alterations in severely Obese hyperglycemic subjects","volume":"96","author":"Verdam","year":"2011","journal-title":"J Clin Endocrinol Metabol"},{"issue":"3","key":"10.1016\/j.molmet.2025.102287_bib4","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJMra1514009","article-title":"Mechanisms, pathophysiology, and management of obesity","volume":"376","author":"Heymsfield","year":"2017","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.molmet.2025.102287_bib5","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2337\/dc16-0686","article-title":"Metabolic surgery for type 2 diabetes: changing the landscape of diabetes care","volume":"39","author":"Cefalu","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.molmet.2025.102287_bib6","article-title":"Glucagon-like peptide-1 receptor agonists for post-bariatric surgery weight regain and insufficient weight loss: a systematic review","volume":"46","author":"Pratama","year":"2024","journal-title":"Obes Med"},{"issue":"5","key":"10.1016\/j.molmet.2025.102287_bib7","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s11695-024-07178-5","article-title":"Combination therapy of endoscopic gastric remodeling with GLP-1RA for the treatment of MASLD","volume":"34","author":"Jirapinyo","year":"2024","journal-title":"Obes Surg"},{"issue":"22","key":"10.1016\/j.molmet.2025.102287_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adu1326","article-title":"Development of a targeted oral pharmacologic duodenal exclusion therapy for the treatment of metabolic diseases","volume":"11","author":"Carlson","year":"2025","journal-title":"Sci Adv"},{"issue":"9","key":"10.1016\/j.molmet.2025.102287_bib9","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1111\/dom.15066","article-title":"First-in-human study of a pharmacological duodenal exclusion therapy shows reduced postprandial glucose and insulin and increased bile acid and gut hormone concentrations","volume":"25","author":"Fineman","year":"2023","journal-title":"Diabetes Obes Metabol"},{"issue":"10","key":"10.1016\/j.molmet.2025.102287_bib10","doi-asserted-by":"crossref","first-page":"5996","DOI":"10.1111\/dom.16664","article-title":"GLY-200, an oral pharmacologic duodenal exclusion drug, resulted in positive effects on glucose, lipids and bodyweight in patients with type 2 diabetes: results of a randomized, double-blind placebo-controlled trial","volume":"27","author":"Bryant","year":"2025","journal-title":"Diabetes Obes Metabol"},{"issue":"6","key":"10.1016\/j.molmet.2025.102287_bib11","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.133429","article-title":"Semaglutide lowers body weight in rodents via distributed neural pathways","volume":"5","author":"Gabery","year":"2020","journal-title":"JCI Insight"},{"issue":"8","key":"10.1016\/j.molmet.2025.102287_bib12","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1089\/met.2018.0075","article-title":"Combination therapies for obesity","volume":"16","author":"Camilleri","year":"2018","journal-title":"Metab Syndr Relat Disord"},{"issue":"4","key":"10.1016\/j.molmet.2025.102287_bib13","doi-asserted-by":"crossref","first-page":"337","DOI":"10.7861\/clinmed.2023-0144","article-title":"Future therapies for obesity","volume":"23","author":"Melson","year":"2023","journal-title":"Clin Med"},{"issue":"4","key":"10.1016\/j.molmet.2025.102287_bib14","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cmet.2020.02.014","article-title":"Leveraging the gut to treat metabolic disease","volume":"31","author":"Gimeno","year":"2020","journal-title":"Cell Metab"},{"issue":"6","key":"10.1016\/j.molmet.2025.102287_bib15","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1172\/JCI72434","article-title":"Neuronal GLP1R mediates liraglutide\u2019s anorectic but not glucose-lowering effect","volume":"124","author":"Sisley","year":"2014","journal-title":"J Clin Investig"},{"key":"10.1016\/j.molmet.2025.102287_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101517","article-title":"Regulation of body weight: lessons learned from bariatric surgery","volume":"68","author":"Albaugh","year":"2023","journal-title":"Mol Metabol"},{"issue":"6","key":"10.1016\/j.molmet.2025.102287_bib17","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s11892-016-0747-1","article-title":"Longer-term physiological and metabolic effects of gastric bypass surgery","volume":"16","author":"Mosinski","year":"2016","journal-title":"Curr Diabetes Rep"},{"issue":"4","key":"10.1016\/j.molmet.2025.102287_bib18","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s12276-021-00677-w","article-title":"Role of the gut\u2013brain axis in energy and glucose metabolism","volume":"54","author":"Wachsmuth","year":"2022","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.molmet.2025.102287_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2020.170342","article-title":"Intestinal glucagon-like peptide-1 effects on food intake: physiological relevance and emerging mechanisms","volume":"131","author":"Krieger","year":"2020","journal-title":"Peptides"},{"issue":"8","key":"10.1016\/j.molmet.2025.102287_bib20","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1136\/gutjnl-2013-304583","article-title":"Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia","volume":"63","author":"Habegger","year":"2014","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.molmet.2025.102287_bib21","doi-asserted-by":"crossref","first-page":"R985","DOI":"10.1152\/ajpregu.00262.2012","article-title":"Isolated duodenal exclusion increases energy expenditure and improves glucose homeostasis in diet-induced obese rats","volume":"303","author":"Mu\u00f1oz","year":"2012","journal-title":"Am J Physiol Regulat Integr Compar Physiol"},{"key":"10.1016\/j.molmet.2025.102287_bib22","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3389\/fendo.2018.00530","article-title":"Weight-independent mechanisms of glucose control after Roux-en-Y gastric bypass","volume":"9","author":"Laferr\u00e8re","year":"2018","journal-title":"Front Endocrinol"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877825001942?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877825001942?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:09:13Z","timestamp":1773842953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877825001942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":22,"alternative-id":["S2212877825001942"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2025.102287","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Additive effects of GLY-200 (oral pharmacologic duodenal exclusion therapy) and GLP-1R agonist in obesity management","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2025.102287","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102287"}}