{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T23:57:29Z","timestamp":1775606249989,"version":"3.50.1"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.molmet.2025.102310","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:12:37Z","timestamp":1766189557000},"page":"102310","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Impaired hepatic metabolism in Hereditary Fructose Intolerance confers fructose-independent risk for steatosis and hypertriglyceridemia"],"prefix":"10.1016","volume":"104","author":[{"given":"Melissa A.","family":"Fulham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie A.","family":"Daurio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle F.","family":"Clasquin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa R.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig L.","family":"Hyde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott P.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magalie","family":"Boucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Poskanzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramya","family":"Gamini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evanthia","family":"Pashos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josh","family":"Fienman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendra K.","family":"Bence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4658-5908","authenticated-orcid":false,"given":"Gregory J.","family":"Tesz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2025.102310_bib1","series-title":"Biochemistry","author":"Voet","year":"2011"},{"issue":"1","key":"10.1016\/j.molmet.2025.102310_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1021\/bi00829a016","article-title":"Distribution of fructose diphosphate aldolase variants in biological systems","volume":"8","author":"Lebherz","year":"1969","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.molmet.2025.102310_bib3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0021-9258(18)62494-9","article-title":"Catalytic and immunochemical properties of homomeric and heteromeric combinations of aldolase subunits","volume":"246","author":"Penhoet","year":"1971","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molmet.2025.102310_bib4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3891\/acta.chem.scand.17s-0226","article-title":"Enzymic homology - structural and catalytic differentiation of fructose diphosphate aldolase","volume":"17","author":"Rutter","year":"1963","journal-title":"Acta Chem Scand"},{"issue":"8","key":"10.1016\/j.molmet.2025.102310_bib5","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1172\/JCI105872","article-title":"Enzymes of fructose metabolism in human liver","volume":"47","author":"Heinz","year":"1968","journal-title":"J Clin Investig"},{"issue":"10","key":"10.1016\/j.molmet.2025.102310_bib6","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1136\/jmg.33.10.837","article-title":"Neonatal screening for hereditary fructose intolerance: frequency of the most common mutant aldolase B allele (A149P) in the British population","volume":"33","author":"James","year":"1996","journal-title":"J Med Genet"},{"issue":"1","key":"10.1016\/j.molmet.2025.102310_bib7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1096\/fasebj.8.1.8299892","article-title":"Aldolase B and fructose intolerance","volume":"8","author":"Cox","year":"1994","journal-title":"FASEB J"},{"issue":"6","key":"10.1016\/j.molmet.2025.102310_bib8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrg815","article-title":"The genetic consequences of our sweet tooth","volume":"3","author":"Cox","year":"2002","journal-title":"Nat Rev Genet"},{"issue":"6","key":"10.1016\/j.molmet.2025.102310_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1001\/archpedi.1978.02120310069014","article-title":"Hereditary fructose intolerance in childhood. Diagnosis, management, and course in 55 patients","volume":"132","author":"Odievre","year":"1978","journal-title":"Am J Dis Child"},{"issue":"3","key":"10.1016\/j.molmet.2025.102310_bib10","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/MLR.0000000000000640","article-title":"Utilization of positive and negative controls to examine comorbid associations in observational database studies","volume":"55","author":"Desai","year":"2016","journal-title":"Med Care"},{"issue":"6938","key":"10.1016\/j.molmet.2025.102310_bib11","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0140-6736(56)92196-1","article-title":"Idiosyncrasy to fructose","volume":"271","author":"Chambers","year":"1956","journal-title":"Lancet"},{"issue":"13","key":"10.1016\/j.molmet.2025.102310_bib12","doi-asserted-by":"crossref","first-page":"E1796","DOI":"10.1073\/pnas.1520686113","article-title":"Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats","volume":"113","author":"Harriman","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.molmet.2025.102310_bib13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1210\/en.2012-1725","article-title":"The role of the carbohydrate response element-binding protein in male fructose-fed rats","volume":"154","author":"Erion","year":"2013","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.molmet.2025.102310_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.molmet.2025.102310_bib15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat Methods"},{"issue":"12","key":"10.1016\/j.molmet.2025.102310_bib16","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"W1","key":"10.1016\/j.molmet.2025.102310_bib17","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res"},{"issue":"Web Server issue","key":"10.1016\/j.molmet.2025.102310_bib18","doi-asserted-by":"crossref","first-page":"W652","DOI":"10.1093\/nar\/gkp356","article-title":"MetaboAnalyst: a web server for metabolomic data analysis and interpretation","volume":"37","author":"Xia","year":"2009","journal-title":"Nucleic Acids Res"},{"issue":"18","key":"10.1016\/j.molmet.2025.102310_bib19","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1021\/acs.jmedchem.7b00947","article-title":"Discovery of fragment-derived small molecules for in vivo inhibition of ketohexokinase (KHK)","volume":"60","author":"Huard","year":"2017","journal-title":"J Med Chem"},{"key":"10.1016\/j.molmet.2025.102310_bib20","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1056\/NEJM196312122692401","article-title":"Hereditary fructose intolerance","volume":"269","author":"Cornblath","year":"1963","journal-title":"N Engl J Med"},{"key":"10.1016\/j.molmet.2025.102310_bib21","series-title":"GeneReviews((R)): seattle (WA)","article-title":"Hereditary fructose intolerance","author":"Gaughan","year":"1993"},{"issue":"13","key":"10.1016\/j.molmet.2025.102310_bib22","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1056\/NEJM198309293091305","article-title":"Chronic fructose intoxication after infancy in children with hereditary fructose intolerance. A cause of growth retardation","volume":"309","author":"Mock","year":"1983","journal-title":"N Engl J Med"},{"key":"10.1016\/j.molmet.2025.102310_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101196","article-title":"Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction","volume":"48","author":"Gutierrez","year":"2021","journal-title":"Mol Metabol"},{"issue":"6037","key":"10.1016\/j.molmet.2025.102310_bib24","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.1204265","article-title":"Human fatty liver disease: old questions and new insights","volume":"332","author":"Cohen","year":"2011","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.molmet.2025.102310_bib25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","article-title":"Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics","volume":"25","author":"Puchalska","year":"2017","journal-title":"Cell Metab"},{"issue":"11","key":"10.1016\/j.molmet.2025.102310_bib26","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1210\/jc.2018-02795","article-title":"Patients with aldolase B deficiency are characterized by increased intrahepatic triglyceride content","volume":"104","author":"Simons","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"19","key":"10.1016\/j.molmet.2025.102310_bib27","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1073\/pnas.0401516101","article-title":"Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis","volume":"101","author":"Iizuka","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"10.1016\/j.molmet.2025.102310_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/nu10111699","article-title":"ChREBP reciprocally regulates liver and plasma triacylglycerol levels in different manners","volume":"10","author":"Iizuka","year":"2018","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.molmet.2025.102310_bib29","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1194\/jlr.M081836","article-title":"Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice","volume":"59","author":"Linden","year":"2018","journal-title":"J Lipid Res"},{"issue":"9","key":"10.1016\/j.molmet.2025.102310_bib30","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J Clin Investig"},{"issue":"21","key":"10.1016\/j.molmet.2025.102310_bib31","doi-asserted-by":"crossref","first-page":"12027","DOI":"10.1073\/pnas.1534923100","article-title":"Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes","volume":"100","author":"Horton","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.molmet.2025.102310_bib32","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cmet.2017.07.004","article-title":"Sweet sixteenth for ChREBP: established roles and future goals","volume":"26","author":"Abdul-Wahed","year":"2017","journal-title":"Cell Metab"},{"issue":"4","key":"10.1016\/j.molmet.2025.102310_bib33","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molmet.2014.02.002","article-title":"Integrated physiology and systems biology of PPARalpha","volume":"3","author":"Kersten","year":"2014","journal-title":"Mol Metabol"},{"issue":"1","key":"10.1016\/j.molmet.2025.102310_bib34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1172\/JCI108764","article-title":"A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis","volume":"60","author":"McGarry","year":"1977","journal-title":"J Clin Investig"},{"key":"10.1016\/j.molmet.2025.102310_bib35","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.nutr.28.061807.155434","article-title":"Malonyl-CoA, a key signaling molecule in mammalian cells","volume":"28","author":"Saggerson","year":"2008","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.molmet.2025.102310_bib36","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1016\/S0021-9258(18)60223-6","article-title":"Studies on the mechanism of fatty acid synthesis. XII. Acetyl coenzyme A carboxylase","volume":"237","author":"Waite","year":"1962","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.molmet.2025.102310_bib37","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ymgme.2015.01.001","article-title":"Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans","volume":"114","author":"Oppelt","year":"2015","journal-title":"Mol Genet Metabol"},{"issue":"6","key":"10.1016\/j.molmet.2025.102310_bib38","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1172\/JCI94427","article-title":"Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice","volume":"128","author":"Lanaspa","year":"2018","journal-title":"J Clin Investig"},{"issue":"10","key":"10.1016\/j.molmet.2025.102310_bib39","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1016\/S0021-9258(19)43971-9","article-title":"Influence of glucagon on the metabolism of xylitol and dihydroxyacetone in the isolated perfused rat liver","volume":"248","author":"Blair","year":"1973","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.molmet.2025.102310_bib40","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.clnu.2019.02.019","article-title":"Non-alcoholic fatty liver in hereditary fructose intolerance","volume":"39","author":"Aldamiz-Echevarria","year":"2020","journal-title":"Clin Nutr"},{"issue":"9","key":"10.1016\/j.molmet.2025.102310_bib41","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s00018-019-03348-2","article-title":"Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease","volume":"77","author":"Buziau","year":"2020","journal-title":"Cell Mol Life Sci"},{"issue":"10","key":"10.1016\/j.molmet.2025.102310_bib42","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1038\/s41591-021-01489-1","article-title":"ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials","volume":"27","author":"Calle","year":"2021","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.molmet.2025.102310_bib43","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.cmet.2017.08.011","article-title":"Acetyl CoA carboxylase inhibition reduces hepatic steatosis but elevates plasma triglycerides in mice and humans: a bedside to bench investigation","volume":"26","author":"Kim","year":"2017","journal-title":"Cell Metab"},{"issue":"520","key":"10.1016\/j.molmet.2025.102310_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav9701","article-title":"Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis","volume":"11","author":"Amin","year":"2019","journal-title":"Sci Transl Med"},{"issue":"31","key":"10.1016\/j.molmet.2025.102310_bib45","doi-asserted-by":"crossref","first-page":"22678","DOI":"10.1074\/jbc.M704213200","article-title":"Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance","volume":"282","author":"Choi","year":"2007","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.molmet.2025.102310_bib46","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/hep.20783","article-title":"Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice","volume":"42","author":"Yu","year":"2005","journal-title":"Hepatology"},{"issue":"20","key":"10.1016\/j.molmet.2025.102310_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/nu15204376","article-title":"Endogenous fructose production and metabolism drive metabolic dysregulation and liver disease in mice with hereditary fructose intolerance","volume":"15","author":"Andres-Hernando","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.molmet.2025.102310_bib48","series-title":"2023 medicinal chemistry reviews","first-page":"135","article-title":"Recent ADVANCES in small-molecule inhibitors of ketohexokinase (KHK)","author":"Ebner","year":"2023"},{"issue":"1","key":"10.1016\/j.molmet.2025.102310_bib49","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1432-1033.1989.tb14538.x","article-title":"A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6-phosphate and fructose 1-phosphate","volume":"179","author":"Van Schaftingen","year":"1989","journal-title":"Eur J Biochem"},{"issue":"10","key":"10.1016\/j.molmet.2025.102310_bib50","doi-asserted-by":"crossref","first-page":"8466","DOI":"10.1074\/jbc.M105984200","article-title":"Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase","volume":"277","author":"Veiga-da-Cunha","year":"2002","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.molmet.2025.102310_bib51","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J Clin Investig"},{"issue":"12","key":"10.1016\/j.molmet.2025.102310_bib52","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/j.cgh.2018.04.042","article-title":"Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis","volume":"16","author":"Lawitz","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"492","key":"10.1016\/j.molmet.2025.102310_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau8465","article-title":"Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition","volume":"11","author":"Esler","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.molmet.2025.102310_bib54","first-page":"509","article-title":"[studies of glycide metabolism in galactosemia and fructosemia]","volume":"7","author":"Dubois","year":"1962","journal-title":"Rev Fr Etud Clin Biol"},{"key":"10.1016\/j.molmet.2025.102310_bib55","first-page":"90","article-title":"[Study of a case of functional hypoglycemia caused by intolerance to fructose]","volume":"16","author":"Dubois","year":"1961","journal-title":"Helv Paediatr Acta"},{"issue":"3","key":"10.1016\/j.molmet.2025.102310_bib56","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41575-022-00707-6","article-title":"Intestinal gluconeogenesis: metabolic benefits make sense in the light of evolution","volume":"20","author":"Gautier-Stein","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"23","key":"10.1016\/j.molmet.2025.102310_bib57","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018889","article-title":"Glucose metabolism in the kidney: neurohormonal activation and heart failure development","volume":"9","author":"Gronda","year":"2020","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.molmet.2025.102310_bib58","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1432-1033.1984.tb08265.x","article-title":"Expression of aldolase isozyme mRNAs in fetal rat liver","volume":"142","author":"Numazaki","year":"1984","journal-title":"Eur J Biochem"},{"issue":"19","key":"10.1016\/j.molmet.2025.102310_bib59","doi-asserted-by":"crossref","first-page":"20314","DOI":"10.1074\/jbc.M312475200","article-title":"Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression","volume":"279","author":"Dentin","year":"2004","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.molmet.2025.102310_bib60","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1172\/JCI41636","article-title":"The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans","volume":"122","author":"Benhamed","year":"2012","journal-title":"J Clin Investig"},{"issue":"4","key":"10.1016\/j.molmet.2025.102310_bib61","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1128\/MCB.01576-12","article-title":"Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter","volume":"33","author":"Petrie","year":"2013","journal-title":"Mol Cell Biol"},{"issue":"9","key":"10.1016\/j.molmet.2025.102310_bib62","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1073\/pnas.0730817100","article-title":"Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver","volume":"100","author":"Kabashima","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.molmet.2025.102310_bib63","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jhep.2011.07.019","article-title":"Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver","volume":"56","author":"Dentin","year":"2012","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.molmet.2025.102310_bib64","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cmet.2023.11.010","article-title":"ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits","volume":"36","author":"Singh","year":"2024","journal-title":"Cell Metab"},{"issue":"10","key":"10.1016\/j.molmet.2025.102310_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/nu11102397","article-title":"Daily fructose traces intake and liver injury in children with hereditary fructose intolerance","volume":"11","author":"Di Dato","year":"2019","journal-title":"Nutrients"},{"issue":"17","key":"10.1016\/j.molmet.2025.102310_bib66","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1128\/MCB.20.17.6508-6517.2000","article-title":"Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism","volume":"20","author":"She","year":"2000","journal-title":"Mol Cell Biol"},{"issue":"47","key":"10.1016\/j.molmet.2025.102310_bib67","doi-asserted-by":"crossref","first-page":"48941","DOI":"10.1074\/jbc.M407120200","article-title":"Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase","volume":"279","author":"Burgess","year":"2004","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.molmet.2025.102310_bib68","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1016\/j.cmet.2024.10.001","article-title":"Amino acid is a major carbon source for hepatic lipogenesis","volume":"36","author":"Liao","year":"2024","journal-title":"Cell Metab"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877825002170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877825002170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T23:24:22Z","timestamp":1775604262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877825002170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":68,"alternative-id":["S2212877825002170"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2025.102310","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired hepatic metabolism in Hereditary Fructose Intolerance confers fructose-independent risk for steatosis and hypertriglyceridemia","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2025.102310","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102310"}}