{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:21:40Z","timestamp":1792707700355,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI23\/00669"],"award-info":[{"award-number":["PI23\/00669"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00375"],"award-info":[{"award-number":["PI20\/00375"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00487"],"award-info":[{"award-number":["PI20\/00487"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI23\/00119"],"award-info":[{"award-number":["PI23\/00119"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023731","name":"Regional Government of Andalusia Ministry of Health and Consumer Affairs","doi-asserted-by":"publisher","award":["PIGE-0052-2020"],"award-info":[{"award-number":["PIGE-0052-2020"]}],"id":[{"id":"10.13039\/501100023731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013941","name":"CIBERDEM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013941","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009473","name":"Universidad de M\u00e1laga","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009473","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008679","name":"Universidad de C\u00f3rdoba","doi-asserted-by":"publisher","award":["BIO-276"],"award-info":[{"award-number":["BIO-276"]}],"id":[{"id":"10.13039\/501100008679","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["FJC2021-047493-I"],"award-info":[{"award-number":["FJC2021-047493-I"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["RYC-2017-22369"],"award-info":[{"award-number":["RYC-2017-22369"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2024-160888OB-I00"],"award-info":[{"award-number":["PID2024-160888OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2021-126280OB-I00"],"award-info":[{"award-number":["PID2021-126280OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.molmet.2026.102348","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T16:38:27Z","timestamp":1772728707000},"page":"102348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Loss of energy homeostasis contributes to hepatic damage development in sickle cell disease"],"prefix":"10.1016","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-2886","authenticated-orcid":false,"given":"Luc\u00eda","family":"Beltr\u00e1n-Camacho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Vallejo-Mudarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Pozuelo-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Garc\u00eda-Caballero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rojas-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iolanda","family":"Lazaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleix","family":"Sala-Vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Valent\u00edn-Arag\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Caballero-Villarraso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3586-3319","authenticated-orcid":false,"given":"Lucas","family":"Opazo-Rios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Leiva-Cepas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Mas-Fontao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Egido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Villalba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma Carmen","family":"Dur\u00e1n-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.molmet.2026.102348_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3949\/ccjm.87a.18051","article-title":"Sickle cell disease: a primary care update","volume":"87","author":"Onimoe","year":"2020","journal-title":"Cleve Clin J Med"},{"issue":"4","key":"10.1016\/j.molmet.2026.102348_bib2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/ejh.13212","article-title":"Insight into the complex pathophysiology of sickle cell anaemia and possible treatment","volume":"102","author":"Piccin","year":"2019","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.molmet.2026.102348_bib3","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1100\/tsw.2008.157","article-title":"Sickle cell anemia, the first molecular disease: overview of molecular etiology, pathophysiology, and therapeutic approaches","volume":"8","author":"Steinberg","year":"2008","journal-title":"Sci World J"},{"issue":"8","key":"10.1016\/j.molmet.2026.102348_bib4","doi-asserted-by":"crossref","first-page":"e585","DOI":"10.1016\/S2352-3026(23)00118-7","article-title":"Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000-2021: a systematic analysis from the global burden of disease study 2021","volume":"10","author":"Collaborators","year":"2023","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.molmet.2026.102348_bib5","doi-asserted-by":"crossref","first-page":"100868","DOI":"10.1016\/j.blre.2021.100868","article-title":"Allogeneic hematopoietic stem cell transplant for sickle cell disease: the why, who, and what","volume":"50","author":"Cimpeanu","year":"2021","journal-title":"Blood Rev"},{"issue":"1","key":"10.1016\/j.molmet.2026.102348_bib6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13045-022-01237-z","article-title":"Advances in the diagnosis and treatment of sickle cell disease","volume":"15","author":"Brandow","year":"2022","journal-title":"J Hematol Oncol"},{"issue":"12","key":"10.1016\/j.molmet.2026.102348_bib7","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.tig.2022.07.003","article-title":"Effective therapies for sickle cell disease: are we there yet?","volume":"38","author":"Crossley","year":"2022","journal-title":"Trends Genet"},{"issue":"34","key":"10.1016\/j.molmet.2026.102348_bib8","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.3748\/wjg.v18.i34.4651","article-title":"Interactions between hepatic iron and lipid metabolism with possible relevance to steatohepatitis","volume":"18","author":"Ahmed","year":"2012","journal-title":"World J Gastroenterol"},{"issue":"2","key":"10.1016\/j.molmet.2026.102348_bib9","doi-asserted-by":"crossref","first-page":"C494","DOI":"10.1152\/ajpcell.00175.2022","article-title":"Molecular mechanisms of hepatic dysfunction in sickle cell disease: lessons from townes mouse model","volume":"323","author":"Pradhan-Sundd","year":"2022","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.molmet.2026.102348_bib10","article-title":"The enigma of sickle cell hepatopathy: pathophysiology, clinical manifestations and therapy","author":"Rizvi","year":"2024","journal-title":"Br J Haematol"},{"issue":"7","key":"10.1016\/j.molmet.2026.102348_bib11","article-title":"Etiology based sickle cell disease hepatopathy","volume":"10","author":"Hassan Al-Jafar","year":"2020","journal-title":"Open J Gastroenterol"},{"issue":"1","key":"10.1016\/j.molmet.2026.102348_bib12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jceh.2020.08.003","article-title":"Sickle hepatopathy","volume":"11","author":"Praharaj","year":"2021","journal-title":"J Clin Exp Hepatol"},{"issue":"1","key":"10.1016\/j.molmet.2026.102348_bib13","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1182\/hematology.2019000037","article-title":"Management of liver complications in sickle cell disease","volume":"2019","author":"Suddle","year":"2019","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"1","key":"10.1016\/j.molmet.2026.102348_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12929-024-01059-w","article-title":"Unraveling the differential mechanisms of revascularization promoted by MSCs & ECFCs from adipose tissue or umbilical cord in a murine model of critical limb-threatening ischemia","volume":"31","author":"Rojas-Torres","year":"2024","journal-title":"J Biomed Sci"},{"issue":"9","key":"10.1016\/j.molmet.2026.102348_bib15","doi-asserted-by":"crossref","first-page":"100279","DOI":"10.1016\/j.mcpro.2022.100279","article-title":"Rapid and In-Depth coverage of the (Phospho-)Proteome with deep libraries and optimal window design for dia-PASEF","volume":"21","author":"Skowronek","year":"2022","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.molmet.2026.102348_bib16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2023.07.012","article-title":"Sex-specific metabolic adaptations in transgenic mice overexpressing cytochrome b(5) reductase-3","volume":"207","author":"Sanchez-Mendoza","year":"2023","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"10.1016\/j.molmet.2026.102348_bib17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/path.6161","article-title":"Intravascular hemolysis triggers NAFLD characterized by a deregulation of lipid metabolism and lipophagy blockade","volume":"261","author":"Rayego-Mateos","year":"2023","journal-title":"J Pathol"},{"issue":"12","key":"10.1016\/j.molmet.2026.102348_bib18","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/S0022-2275(20)41345-8","article-title":"Rapid separation of serum lipids for fatty acid analysis by a single aminopropyl column","volume":"33","author":"Agren","year":"1992","journal-title":"J Lipid Res"},{"issue":"23","key":"10.1016\/j.molmet.2026.102348_bib19","doi-asserted-by":"crossref","first-page":"8896","DOI":"10.1021\/jf051468u","article-title":"A gas chromatography\/electron ionization-mass spectrometry-selected ion monitoring method for determining the fatty acid pattern in food after formation of fatty acid methyl esters","volume":"53","author":"Thurnhofer","year":"2005","journal-title":"J Agric Food Chem"},{"issue":"3","key":"10.1016\/j.molmet.2026.102348_bib20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/cvr\/cvae005","article-title":"Perilipin 1: a systematic review on its functions on lipid metabolism and atherosclerosis in mice and humans","volume":"120","author":"Desgrouas","year":"2024","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.molmet.2026.102348_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jbiomech.2016.11.022","article-title":"Biomechanics and biorheology of red blood cells in sickle cell anemia","volume":"50","author":"Li","year":"2017","journal-title":"J Biomech"},{"issue":"2","key":"10.1016\/j.molmet.2026.102348_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cld.2018.12.002","article-title":"The liver in sickle cell disease","volume":"23","author":"Theocharidou","year":"2019","journal-title":"Clin Liver Dis"},{"issue":"19","key":"10.1016\/j.molmet.2026.102348_bib23","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1182\/blood.2020009779","article-title":"P-selectin deficiency promotes liver senescence in sickle cell disease mice","volume":"137","author":"Vats","year":"2021","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.molmet.2026.102348_bib24","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1002\/hep.31239","article-title":"Impaired bile secretion promotes hepatobiliary injury in sickle cell disease","volume":"72","author":"Vats","year":"2020","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.molmet.2026.102348_bib25","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1186\/s12967-021-03074-z","article-title":"Vaso-occlusive crisis in sickle cell disease: a vicious cycle of secondary events","volume":"19","author":"Jang","year":"2021","journal-title":"J Transl Med"},{"issue":"6","key":"10.1016\/j.molmet.2026.102348_bib26","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1074\/jbc.M208916200","article-title":"Nitric oxide-dependent generation of reactive species in sickle cell disease. Actin tyrosine induces defective cytoskeletal polymerization","volume":"278","author":"Aslan","year":"2003","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.molmet.2026.102348_bib27","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1182\/bloodadvances.2018017574","article-title":"Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice","volume":"3","author":"Keleku-Lukwete","year":"2019","journal-title":"Blood Adv"},{"issue":"9","key":"10.1016\/j.molmet.2026.102348_bib28","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1182\/blood.V88.9.3583.bloodjournal8893583","article-title":"Immunohistochemical localization of hepatic nitric oxide synthase in normal and transgenic sickle cell mice: the effect of hypoxia","volume":"88","author":"Osei","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.molmet.2026.102348_bib29","doi-asserted-by":"crossref","first-page":"18010","DOI":"10.1038\/nrdp.2018.10","article-title":"Sickle cell disease","volume":"4","author":"Kato","year":"2018","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"10.1016\/j.molmet.2026.102348_bib30","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202201628","article-title":"A novel approach to measure complex V ATP hydrolysis in frozen cell lysates and tissue homogenates","volume":"6","author":"Fernandez-Del-Rio","year":"2023","journal-title":"Life Sci Alliance"},{"issue":"4","key":"10.1016\/j.molmet.2026.102348_bib31","doi-asserted-by":"crossref","first-page":"H1747","DOI":"10.1152\/ajpheart.01019.2003","article-title":"Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity","volume":"287","author":"Grover","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.molmet.2026.102348_bib32","doi-asserted-by":"crossref","first-page":"100181","DOI":"10.1016\/j.crtox.2024.100181","article-title":"Ferroptosis as an emerging target in sickle cell disease","volume":"7","author":"Fortuna","year":"2024","journal-title":"Curr Res Toxicol"},{"issue":"1","key":"10.1016\/j.molmet.2026.102348_bib33","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1046\/j.1523-1755.1998.00731.x","article-title":"Intracellular targets in heme protein-induced renal injury","volume":"53","author":"Nath","year":"1998","journal-title":"Kidney Int"},{"key":"10.1016\/j.molmet.2026.102348_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1436897","article-title":"Heme (dys)homeostasis and liver disease","volume":"15","author":"Duarte","year":"2024","journal-title":"Front Physiol"},{"key":"10.1016\/j.molmet.2026.102348_bib35","doi-asserted-by":"crossref","first-page":"122230","DOI":"10.1016\/j.biomaterials.2023.122230","article-title":"Inhibition of free heme-catalyzed Fenton-like reaction prevents non-alcoholic fatty liver disease by hepatocyte-targeted hydrogen delivery","volume":"301","author":"Zhao","year":"2023","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.molmet.2026.102348_bib36","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s42003-024-06243-0","article-title":"Activation of Nrf2\/HO-1 signaling pathway exacerbates cholestatic liver injury","volume":"7","author":"Wang","year":"2024","journal-title":"Commun Biol"},{"issue":"6","key":"10.1016\/j.molmet.2026.102348_bib37","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/hep4.1356","article-title":"Liver macrophages: old dogmas and new insights","volume":"3","author":"Guillot","year":"2019","journal-title":"Hepatol Commun"},{"issue":"8","key":"10.1016\/j.molmet.2026.102348_bib38","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/nm.4146","article-title":"On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver","volume":"22","author":"Theurl","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.molmet.2026.102348_bib39","doi-asserted-by":"crossref","first-page":"680855","DOI":"10.3389\/fimmu.2021.680855","article-title":"Acute hemolysis and heme suppress Anti-CD40 antibody-induced necro-inflammatory liver disease","volume":"12","author":"Pfefferl\u00e9","year":"2021","journal-title":"Front Immunol"},{"issue":"10","key":"10.1016\/j.molmet.2026.102348_bib40","doi-asserted-by":"crossref","first-page":"5576","DOI":"10.1172\/JCI137282","article-title":"Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes","volume":"130","author":"Pfefferl\u00e9","year":"2020","journal-title":"J Clin Investig"},{"issue":"5","key":"10.1016\/j.molmet.2026.102348_bib41","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1021\/pr101230y","article-title":"Extracellular hemoglobin polarizes the macrophage proteome toward Hb-clearance, enhanced antioxidant capacity and suppressed HLA class 2 expression","volume":"10","author":"Kaempfer","year":"2011","journal-title":"J Proteome Res May"},{"issue":"3","key":"10.1016\/j.molmet.2026.102348_bib42","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.2353\/ajpath.2009.080431","article-title":"Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype","volume":"174","author":"Boyle","year":"2009","journal-title":"Am J Pathol"},{"issue":"2","key":"10.1016\/j.molmet.2026.102348_bib43","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jacc.2011.10.852","article-title":"Hemoglobin directs macrophage differentiation and prevents foam cell formation in human atherosclerotic plaques","volume":"59","author":"Finn","year":"2012","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.molmet.2026.102348_bib44","doi-asserted-by":"crossref","first-page":"C423","DOI":"10.1152\/ajpcell.00386.2023","article-title":"Hemoglobin scavenger receptor CD163 as a potential biomarker of hemolysis-induced hepatobiliary injury in sickle cell disease","volume":"327","author":"Kaminski","year":"2024","journal-title":"Am J Physiol Cell Physiol"},{"issue":"10","key":"10.1016\/j.molmet.2026.102348_bib45","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/s41423-024-01199-x","article-title":"Lipid droplet accumulation mediates macrophage survival and treg recruitment via the CCL20\/CCR6 axis in human hepatocellular carcinoma","volume":"21","author":"Wang","year":"2024","journal-title":"Cell Mol Immunol"},{"issue":"17","key":"10.1016\/j.molmet.2026.102348_bib46","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1089\/ars.2012.4605","article-title":"Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption","volume":"18","author":"Etzerodt","year":"2013","journal-title":"Antioxid Redox Signal"},{"issue":"6","key":"10.1016\/j.molmet.2026.102348_bib47","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211314","article-title":"CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate","volume":"219","author":"Chen","year":"2022","journal-title":"J Exp Med"},{"key":"10.1016\/j.molmet.2026.102348_bib48","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.101221.2","article-title":"FABP4-mediated lipid accumulation and lipolysis in tumor-associated macrophages promote breast cancer metastasis","volume":"13","author":"Yorek","year":"2024","journal-title":"eLife"},{"issue":"4","key":"10.1016\/j.molmet.2026.102348_bib49","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jhep.2015.05.030","article-title":"Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia\/reperfusion injury","volume":"63","author":"Hu","year":"2015","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.molmet.2026.102348_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10010197","article-title":"Unveiling the role of the fatty acid binding protein 4 in the metabolic-associated fatty liver disease","volume":"10","author":"Moreno-Vedia","year":"2022","journal-title":"Biomedicines"},{"issue":"8","key":"10.1016\/j.molmet.2026.102348_bib51","doi-asserted-by":"crossref","first-page":"100590","DOI":"10.1016\/j.jlr.2024.100590","article-title":"Peridroplet mitochondria are associated with the severity of MASLD and the prevention of MASLD by diethyldithiocarbamate","volume":"65","author":"Sun","year":"2024","journal-title":"J Lipid Res"},{"key":"10.1016\/j.molmet.2026.102348_bib52","doi-asserted-by":"crossref","first-page":"106130","DOI":"10.1016\/j.nbd.2023.106130","article-title":"Targeting foam cell formation to improve recovery from ischemic stroke","volume":"181","author":"Zbesko","year":"2023","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.molmet.2026.102348_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.732929","article-title":"Liver zonation - revisiting old questions with new technologies","volume":"12","author":"Cunningham","year":"2021","journal-title":"Front Physiol"},{"issue":"2","key":"10.1016\/j.molmet.2026.102348_bib54","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.hoc.2013.11.001","article-title":"Therapeutic strategies to alter the oxygen affinity of sickle hemoglobin","volume":"28","author":"Safo","year":"2014","journal-title":"Hematol Oncol Clin North Am"},{"issue":"6","key":"10.1016\/j.molmet.2026.102348_bib55","doi-asserted-by":"crossref","first-page":"100725","DOI":"10.1016\/j.jhepr.2023.100725","article-title":"Characterisation of hepatic lipid signature distributed across the liver zonation using mass spectrometry imaging","volume":"5","author":"Seubnooch","year":"2023","journal-title":"JHEP Rep"},{"issue":"2","key":"10.1016\/j.molmet.2026.102348_bib56","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/ars.2009.2822","article-title":"Heme degradation and vascular injury","volume":"12","author":"Belcher","year":"2010","journal-title":"Antioxid Redox Signal"},{"issue":"10","key":"10.1016\/j.molmet.2026.102348_bib57","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1007\/s00277-021-04575-z","article-title":"Concise review: how do red blood cells born, live, and die?","volume":"100","author":"Corrons","year":"2021","journal-title":"Ann Hematol"},{"key":"10.1016\/j.molmet.2026.102348_bib58","doi-asserted-by":"crossref","first-page":"104787","DOI":"10.1016\/j.exphem.2025.104787","article-title":"Patterns of hemolysis, erythropoiesis, and iron distribution define unique disease trajectories in three mouse models of genetic anemia","volume":"147","author":"Dubach","year":"2025","journal-title":"Exp Hematol"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877826000323?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877826000323?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:24:29Z","timestamp":1778851469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877826000323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":58,"alternative-id":["S2212877826000323"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2026.102348","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of energy homeostasis contributes to hepatic damage development in sickle cell disease","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2026.102348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102348"}}