{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:20:31Z","timestamp":1777897231299,"version":"3.51.4"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.molmet.2026.102364","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:41:08Z","timestamp":1775666468000},"page":"102364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Epigenetic modulation of the gut\u2013muscle axis in pompe disease: Microbiota fingerprints to cellular and molecular pathomechanisms"],"prefix":"10.1016","volume":"107","author":[{"given":"Marika","family":"Venezia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Colomba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Zizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Vinci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela M.","family":"Marsana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"D'Errico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Giacalone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Duro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2119-7988","authenticated-orcid":false,"given":"Marta","family":"Moschetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.molmet.2026.102364_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/biom14050573","article-title":"Failure of autophagy in pompe disease","volume":"14","author":"Do","year":"2024","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.molmet.2026.102364_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s13317-014-0063-1","article-title":"Assessment of patients with idiopathic inflammatory myopathies and isolated creatin-kinase elevation","volume":"5","author":"Iaccarino","year":"2014","journal-title":"Auto Immun Highlights"},{"issue":"11","key":"10.1016\/j.molmet.2026.102364_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25115589","article-title":"Exploring the gut Microbiota-Muscle axis in Duchenne Muscular Dystrophy","volume":"25","author":"Mostosi","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"502","key":"10.1016\/j.molmet.2026.102364_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan5662","article-title":"The gut microbiota influences skeletal muscle mass and function in mice","volume":"11","author":"Lahiri","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.molmet.2026.102364_bib5","article-title":"Mechanisms involved in gut Microbiota regulation of skeletal muscle","volume":"2022","author":"Li","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.molmet.2026.102364_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114985","article-title":"Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: a review","volume":"164","author":"Zhao","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.molmet.2026.102364_bib7","article-title":"Short chain fatty acids (SCFAs)-Mediated Gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.molmet.2026.102364_bib8","doi-asserted-by":"crossref","first-page":"762","DOI":"10.12659\/MSM.889068","article-title":"The role of oxidants and reactive nitrogen species in irritable bowel syndrome: a potential etiological explanation","volume":"19","author":"Mete","year":"2013","journal-title":"Med Sci Monit"},{"issue":"11","key":"10.1016\/j.molmet.2026.102364_bib9","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.molmed.2020.06.006","article-title":"Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease","volume":"26","author":"Bourgonje","year":"2020","journal-title":"Trends Mol Med"},{"issue":"1","key":"10.1016\/j.molmet.2026.102364_bib10","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-019-1380-z","article-title":"Celiac disease: a comprehensive current review","volume":"17","author":"Caio","year":"2019","journal-title":"BMC Med"},{"issue":"6566","key":"10.1016\/j.molmet.2026.102364_bib11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1126\/science.abc6108","article-title":"Identification of a choroid plexus vascular barrier closing during intestinal inflammation","volume":"374","author":"Carloni","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.molmet.2026.102364_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2019.00034","article-title":"Systematic review of Gut Microbiota and major depression","volume":"10","author":"Cheung","year":"2019","journal-title":"Front Psychiatr"},{"key":"10.1016\/j.molmet.2026.102364_bib13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuroscience.2016.03.013","article-title":"The microbiota-gut-brain axis and its potential therapeutic role in autism spectrum disorder","volume":"324","author":"Li","year":"2016","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.molmet.2026.102364_bib14","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.cell.2019.05.004","article-title":"Human gut Microbiota from autism spectrum disorder promote behavioral symptoms in mice","volume":"177","author":"Sharon","year":"2019","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.molmet.2026.102364_bib15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.tins.2013.01.005","article-title":"Gut-brain axis: how the microbiome influences anxiety and depression","volume":"36","author":"Foster","year":"2013","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.molmet.2026.102364_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpr.2020.101943","article-title":"The gut microbiota in anxiety and depression - a systematic review","volume":"83","author":"Simpson","year":"2021","journal-title":"Clin Psychol Rev"},{"issue":"4","key":"10.1016\/j.molmet.2026.102364_bib17","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1007\/s13311-018-0655-y","article-title":"Pompe disease: from basic science to therapy","volume":"15","author":"Kohler","year":"2018","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.molmet.2026.102364_bib18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.omtm.2020.05.026","article-title":"Enzyme replacement therapy can reverse pathogenic Cascade in pompe disease","volume":"18","author":"Meena","year":"2020","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"5","key":"10.1016\/j.molmet.2026.102364_bib19","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/emmm.201202176","article-title":"Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease","volume":"5","author":"Spampanato","year":"2013","journal-title":"EMBO Mol Med"},{"issue":"3","key":"10.1016\/j.molmet.2026.102364_bib20","doi-asserted-by":"crossref","first-page":"353","DOI":"10.15252\/emmm.201606547","article-title":"Modulation of mTOR signaling as a strategy for the treatment of Pompe disease","volume":"9","author":"Lim","year":"2017","journal-title":"EMBO Mol Med"},{"issue":"7","key":"10.1016\/j.molmet.2026.102364_bib21","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.ymthe.2018.04.025","article-title":"Therapeutic benefit of autophagy modulation in pompe disease","volume":"26","author":"Lim","year":"2018","journal-title":"Mol Ther"},{"issue":"21","key":"10.1016\/j.molmet.2026.102364_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115924","article-title":"Late-Onset pompe disease with normal creatine kinase levels: the importance of rheumatological suspicion","volume":"24","author":"Marotto","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.molmet.2026.102364_bib23","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.nmd.2018.03.011","article-title":"Targeted gene panel screening is an effective tool to identify undiagnosed late onset Pompe disease","volume":"28","author":"Savarese","year":"2018","journal-title":"Neuromuscul Disord"},{"issue":"3","key":"10.1016\/j.molmet.2026.102364_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ymgme.2023.107526","article-title":"Transcriptomic characterization of clinical skeletal muscle biopsy from late-onset Pompe patients","volume":"138","author":"Kinton","year":"2023","journal-title":"Mol Genet Metabol"},{"issue":"1","key":"10.1016\/j.molmet.2026.102364_bib25","article-title":"Analyzing immune cell infiltrates in skeletal muscle of infantile-onset Pompe disease using bioinformatics and machine learning","volume":"14","author":"Zhang","year":"2024","journal-title":"Sci Rep"},{"issue":"21","key":"10.1016\/j.molmet.2026.102364_bib26","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1113\/JP281788","article-title":"Dysbiosis of the gut microbiome impairs mouse skeletal muscle adaptation to exercise","volume":"599","author":"Valentino","year":"2021","journal-title":"J Physiol"},{"issue":"9","key":"10.1016\/j.molmet.2026.102364_bib27","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1113\/EP091063","article-title":"Microbes, metabolites and muscle: is the gut-muscle axis a plausible therapeutic target in Duchenne muscular dystrophy?","volume":"108","author":"Marullo","year":"2023","journal-title":"Exp Physiol"},{"issue":"6","key":"10.1016\/j.molmet.2026.102364_bib28","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s11914-022-00752-9","article-title":"Role of the gut microbiome in skeletal muscle physiology and pathophysiology","volume":"20","author":"Lefevre","year":"2022","journal-title":"Curr Osteoporos Rep"},{"issue":"1","key":"10.1016\/j.molmet.2026.102364_bib29","doi-asserted-by":"crossref","first-page":"E158","DOI":"10.1152\/ajpendo.00521.2018","article-title":"Gut bacteria are critical for optimal muscle function: a potential link with glucose homeostasis","volume":"317","author":"Nay","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.molmet.2026.102364_bib30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3390\/nu12010065","article-title":"Gut microbial, inflammatory and metabolic signatures in older people with physical frailty and sarcopenia: results from the BIOSPHERE Study","volume":"12","author":"Picca","year":"2019","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.molmet.2026.102364_bib31","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.cger.2015.04.005","article-title":"Sarcopenia as the biological substrate of physical frailty","volume":"31","author":"Landi","year":"2015","journal-title":"Clin Geriatr Med"},{"key":"10.1016\/j.molmet.2026.102364_bib32","doi-asserted-by":"crossref","DOI":"10.1177\/1178638820980490","article-title":"Interactions between gut microbiota and skeletal muscle","volume":"13","author":"Gizard","year":"2020","journal-title":"Nutr Metab Insights"},{"issue":"3","key":"10.1016\/j.molmet.2026.102364_bib33","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/jcsm.12964","article-title":"Gut microbes and muscle function: can probiotics make our muscles stronger?","volume":"13","author":"Giron","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"7","key":"10.1016\/j.molmet.2026.102364_bib34","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2217\/fmb.14.47","article-title":"Identifying and analyzing bacteriophages in human fecal samples: what could we discover?","volume":"9","author":"Muniesa","year":"2014","journal-title":"Future Microbiol"},{"issue":"23","key":"10.1016\/j.molmet.2026.102364_bib35","doi-asserted-by":"crossref","first-page":"28926","DOI":"10.1007\/s11356-021-13862-1","article-title":"The link among microbiota, epigenetics, and disease development","volume":"28","author":"El-Sayed","year":"2021","journal-title":"Environ Sci Pollut Res Int"},{"key":"10.1016\/j.molmet.2026.102364_bib36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev-genom-090711-163814","article-title":"The human microbiome: our second genome","volume":"13","author":"Grice","year":"2012","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"10","key":"10.1016\/j.molmet.2026.102364_bib37","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrmicro3344","article-title":"The gut microbiota, bacterial metabolites and colorectal cancer","volume":"12","author":"Louis","year":"2014","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"10.1016\/j.molmet.2026.102364_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00535-016-1242-9","article-title":"Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases","volume":"52","author":"Sun","year":"2017","journal-title":"J Gastroenterol"},{"issue":"1","key":"10.1016\/j.molmet.2026.102364_bib39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S0029665120006916","article-title":"SCFA: mechanisms and functional importance in the gut","volume":"80","author":"Martin-Gallausiaux","year":"2021","journal-title":"Proc Nutr Soc"},{"issue":"4","key":"10.1016\/j.molmet.2026.102364_bib40","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1128\/AEM.66.4.1654-1661.2000","article-title":"Phylogenetic relationships of butyrate-producing bacteria from the human gut","volume":"66","author":"Barcenilla","year":"2000","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"10.1016\/j.molmet.2026.102364_bib41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1574-6968.2002.tb11467.x","article-title":"The microbiology of butyrate formation in the human colon","volume":"217","author":"Pryde","year":"2002","journal-title":"FEMS Microbiol Lett"},{"issue":"1","key":"10.1016\/j.molmet.2026.102364_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11734-8","article-title":"Butyrate-producing bacteria supplemented in vitro to Crohn's disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity","volume":"7","author":"Geirnaert","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.molmet.2026.102364_bib43","doi-asserted-by":"crossref","DOI":"10.3332\/ecancer.2018.865","article-title":"Colorectal carcinogenesis: an archetype of gut microbiota-host interaction","volume":"12","author":"Alexander","year":"2018","journal-title":"ecancermedicalscience"},{"issue":"4","key":"10.1016\/j.molmet.2026.102364_bib44","article-title":"Irritable bowel syndrome and neurological deficiencies: is there A relationship? The possible relevance of the oxidative stress status","volume":"56","author":"Balmus","year":"2020","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.molmet.2026.102364_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6685581","article-title":"A concise review of ketogenic dietary interventions in the management of rare diseases","volume":"2021","author":"Hettiarachchi","year":"2021","journal-title":"J Nutr Metab"},{"issue":"4","key":"10.1016\/j.molmet.2026.102364_bib46","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1017\/cjn.2016.37","article-title":"Pompe disease: Diagnosis and Management. Evidence-Based Guidelines from a Canadian expert Panel","volume":"43","author":"Tarnopolsky","year":"2016","journal-title":"Can J Neurol Sci"},{"issue":"13","key":"10.1016\/j.molmet.2026.102364_bib47","doi-asserted-by":"crossref","DOI":"10.21037\/atm.2019.05.52","article-title":"Nutrition and exercise in Pompe disease","volume":"7","author":"Tarnopolsky","year":"2019","journal-title":"Ann Transl Med"},{"issue":"1","key":"10.1016\/j.molmet.2026.102364_bib48","doi-asserted-by":"crossref","DOI":"10.1186\/s13023-020-01416-6","article-title":"Exercise training alone or in combination with high-protein diet in patients with late onset Pompe disease: results of a cross over study","volume":"15","author":"Sechi","year":"2020","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"10.1016\/j.molmet.2026.102364_bib49","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/mus.20665","article-title":"Modification of the natural history of adult-onset acid maltase deficiency by nutrition and exercise therapy","volume":"35","author":"Slonim","year":"2007","journal-title":"Muscle Nerve"},{"issue":"1","key":"10.1016\/j.molmet.2026.102364_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56166-8","article-title":"Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in mice","volume":"9","author":"Nakao","year":"2019","journal-title":"Sci Rep"},{"issue":"27","key":"10.1016\/j.molmet.2026.102364_bib51","doi-asserted-by":"crossref","first-page":"25864","DOI":"10.1074\/jbc.M502456200","article-title":"Ketone bodies stimulate chaperone-mediated autophagy","volume":"280","author":"Finn","year":"2005","journal-title":"J Biol Chem"},{"issue":"6116","key":"10.1016\/j.molmet.2026.102364_bib52","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1126\/science.1227166","article-title":"Suppression of oxidative stress by \u03b2-hydroxybutyrate, an endogenous histone deacetylase inhibitor","volume":"339","author":"Shimazu","year":"2013","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.molmet.2026.102364_bib53","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm.3804","article-title":"The ketone metabolite \u03b2-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease","volume":"21","author":"Youm","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.molmet.2026.102364_bib54","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-nutr-071816-064916","article-title":"\u03b2-Hydroxybutyrate: a signaling metabolite","volume":"37","author":"Newman","year":"2017","journal-title":"Annu Rev Nutr"},{"issue":"7","key":"10.1016\/j.molmet.2026.102364_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/nu13072197","article-title":"Beneficial effects of exogenous ketogenic supplements on aging processes and age-related neurodegenerative diseases","volume":"13","author":"Kov\u00e1cs","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.molmet.2026.102364_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101395","article-title":"Ketone bodies, stress response, and redox homeostasis","volume":"29","author":"Rojas-Morales","year":"2020","journal-title":"Redox Biol"},{"issue":"3","key":"10.1016\/j.molmet.2026.102364_bib57","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s11357-020-00277-y","article-title":"From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience","volume":"43","author":"Stubbs","year":"2021","journal-title":"GeroScience"},{"issue":"4","key":"10.1016\/j.molmet.2026.102364_bib58","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/ajcn\/nqy170","article-title":"Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during LPS-induced inflammation in humans: anticatabolic impact of ketone bodies","volume":"108","author":"Thomsen","year":"2018","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"10.1016\/j.molmet.2026.102364_bib59","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1074\/jbc.M115.676510","article-title":"Acetoacetate accelerates muscle regeneration and ameliorates muscular dystrophy in mice","volume":"291","author":"Zou","year":"2016","journal-title":"J Biol Chem"},{"issue":"Suppl 2","key":"10.1016\/j.molmet.2026.102364_bib60","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/ajag.12853","article-title":"Effects of protein supplementation on muscle wasting disorders: a brief update of the evidence","volume":"39","author":"Kirk","year":"2020","journal-title":"Australas J Ageing"},{"issue":"10","key":"10.1016\/j.molmet.2026.102364_bib61","doi-asserted-by":"crossref","first-page":"R1251","DOI":"10.1152\/ajpregu.00212.2014","article-title":"Suppression of mTORC1 activation in acid-\u03b1-glucosidase-deficient cells and mice is ameliorated by leucine supplementation","volume":"307","author":"Shemesh","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"10.1016\/j.molmet.2026.102364_bib62","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","article-title":"The impact of the gut microbiota on human health: an integrative view","volume":"148","author":"Clemente","year":"2012","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.molmet.2026.102364_bib63","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1111\/jcmm.16448","article-title":"FGF19 protects skeletal muscle against obesity-induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK\/SIRT-1\/PGC-\u03b1 pathway","volume":"25","author":"Guo","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.molmet.2026.102364_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148537","article-title":"Fndc5\/irisin deficiency leads to dysbiosis of gut microbiota contributing to the depressive-like behaviors in mice","volume":"1819","author":"Liu","year":"2023","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.molmet.2026.102364_bib65","doi-asserted-by":"crossref","DOI":"10.1186\/s13256-018-1659-2","article-title":"Clostridium difficile cure with fecal microbiota transplantation in a child with Pompe disease: a case report","volume":"12","author":"Dow","year":"2018","journal-title":"J Med Case Rep"},{"issue":"5","key":"10.1016\/j.molmet.2026.102364_bib66","article-title":"Gigantic stomach: a rare manifestation of Duchenne Muscular Dystrophy","volume":"11","author":"Dhaliwal","year":"2019","journal-title":"Cureus"},{"issue":"14","key":"10.1016\/j.molmet.2026.102364_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411811","article-title":"mTOR signaling pathway and Gut Microbiota in various disorders: mechanisms and potential drugs in pharmacotherapy","volume":"24","author":"Gao","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10.1016\/j.molmet.2026.102364_bib68","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nri3535","article-title":"Microbiota-mediated colonization resistance against intestinal pathogens","volume":"13","author":"Buffie","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.molmet.2026.102364_bib69","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120238","article-title":"Microbiota-mediated inflammation and antimicrobial defense in the intestine","volume":"33","author":"Caballero","year":"2015","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"10.1016\/j.molmet.2026.102364_bib70","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/nrmicro2265","article-title":"Molecular mechanisms of Escherichia coli pathogenicity","volume":"8","author":"Croxen","year":"2010","journal-title":"Nat Rev Microbiol"},{"issue":"2","key":"10.1016\/j.molmet.2026.102364_bib71","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrmicro818","article-title":"Pathogenic Escherichia coli","volume":"2","author":"Kaper","year":"2004","journal-title":"Nat Rev Microbiol"},{"issue":"6086","key":"10.1016\/j.molmet.2026.102364_bib72","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1126\/science.1222195","article-title":"Regulated virulence controls the ability of a pathogen to compete with the gut microbiota","volume":"336","author":"Kamada","year":"2012","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.molmet.2026.102364_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026988","article-title":"Altering host resistance to infections through microbial transplantation","volume":"6","author":"Willing","year":"2011","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.molmet.2026.102364_bib74","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nrmicro3315","article-title":"Citrobacter rodentium: infection, inflammation and the microbiota","volume":"12","author":"Collins","year":"2014","journal-title":"Nat Rev Microbiol"},{"issue":"11","key":"10.1016\/j.molmet.2026.102364_bib75","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41579-019-0252-z","article-title":"Citrobacter rodentium-host-microbiota interactions: immunity, bioenergetics and metabolism","volume":"17","author":"Mullineaux-Sanders","year":"2019","journal-title":"Nat Rev Microbiol"},{"issue":"2","key":"10.1016\/j.molmet.2026.102364_bib76","doi-asserted-by":"crossref","first-page":"C616","DOI":"10.1152\/ajpcell.00425.2005","article-title":"Green tea extract and its major polyphenol (-)-epigallocatechin gallate improve muscle function in a mouse model for Duchenne muscular dystrophy","volume":"290","author":"Dorchies","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"issue":"6","key":"10.1016\/j.molmet.2026.102364_bib77","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00418-012-0926-3","article-title":"Quantitative evaluation of the beneficial effects in the mdx mouse of epigallocatechin gallate, an antioxidant polyphenol from green tea","volume":"137","author":"Nakae","year":"2012","journal-title":"Histochem Cell Biol"},{"issue":"24","key":"10.1016\/j.molmet.2026.102364_bib78","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1111\/febs.13098","article-title":"(-)-Epicatechin improves mitochondrial-related protein levels and ameliorates oxidative stress in dystrophic \u03b4-sarcoglycan null mouse striated muscle","volume":"281","author":"Ramirez-Sanchez","year":"2014","journal-title":"FEBS J"},{"issue":"2","key":"10.1016\/j.molmet.2026.102364_bib79","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1039\/D4FO04341C","article-title":"Differential effects of EPA and DHA on aging-related sarcopenia in mice and possible mechanisms involved","volume":"16","author":"Wu","year":"2025","journal-title":"Food Funct"},{"issue":"5","key":"10.1016\/j.molmet.2026.102364_bib80","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.bbalip.2017.02.010","article-title":"Omega-3 polyunsaturated fatty acids suppress the inflammatory responses of lipopolysaccharide-stimulated mouse microglia by activating SIRT1 pathways","volume":"1862","author":"Inoue","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"2","key":"10.1016\/j.molmet.2026.102364_bib81","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8020021","article-title":"Circulating MyomiRs as potential biomarkers to monitor response to Nusinersen in pediatric SMA patients","volume":"8","author":"Bonanno","year":"2020","journal-title":"Biomedicines"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877826000487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877826000487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:51:55Z","timestamp":1777625515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877826000487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":81,"alternative-id":["S2212877826000487"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2026.102364","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic modulation of the gut\u2013muscle axis in pompe disease: Microbiota fingerprints to cellular and molecular pathomechanisms","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2026.102364","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102364"}}