{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:01:31Z","timestamp":1784635291674,"version":"3.55.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006474","name":"Columbia University","doi-asserted-by":"publisher","award":["P30DK063608"],"award-info":[{"award-number":["P30DK063608"]}],"id":[{"id":"10.13039\/100006474","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006474","name":"Columbia University","doi-asserted-by":"publisher","award":["P30DK132710"],"award-info":[{"award-number":["P30DK132710"]}],"id":[{"id":"10.13039\/100006474","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK103818"],"award-info":[{"award-number":["DK103818"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK119767"],"award-info":[{"award-number":["DK119767"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.molmet.2026.102389","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T23:34:08Z","timestamp":1780356848000},"page":"102389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["TGF\u03b2 activity stabilizes ACC1 to increase de novo lipogenesis in metabolic liver disease"],"prefix":"10.1016","volume":"110","author":[{"given":"Brent","family":"Mayfield","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Yagashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinku","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Mira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Kendall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Meincke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenick","family":"Raphael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison","family":"Cullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stryder M.","family":"Meadows","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke E.","family":"Berchowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Carrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Fallowfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Schwabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Valenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5991-2723","authenticated-orcid":false,"given":"Utpal B.","family":"Pajvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2026.102389_bib1","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1002\/hep.24268","article-title":"Pathologic criteria for nonalcoholic steatohepatitis: interprotocol agreement and ability to predict liver-related mortality","volume":"53","author":"Younossi","year":"2011","journal-title":"Hepatology"},{"issue":"468","key":"10.1016\/j.molmet.2026.102389_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat0344","article-title":"Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis","volume":"10","author":"Zhu","year":"2018","journal-title":"Sci Transl Med"},{"issue":"3","key":"10.1016\/j.molmet.2026.102389_bib3","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.165369","article-title":"Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis","volume":"8","author":"Kang","year":"2023","journal-title":"JCI Insight"},{"issue":"599","key":"10.1016\/j.molmet.2026.102389_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe1692","article-title":"Hepatocyte TLR4 triggers inter-hepatocyte Jagged1\/Notch signaling to determine NASH-induced fibrosis","volume":"13","author":"Yu","year":"2021","journal-title":"Sci Transl Med"},{"issue":"2","key":"10.1016\/j.molmet.2026.102389_bib5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.immuni.2024.01.009","article-title":"Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis","volume":"57","author":"Savage","year":"2024","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.molmet.2026.102389_bib6","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1053\/j.gastro.2013.11.049","article-title":"Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease","volume":"146","author":"Lambert","year":"2014","journal-title":"Gastroenterology Mar"},{"issue":"15","key":"10.1016\/j.molmet.2026.102389_bib7","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1016\/j.cell.2024.06.029","article-title":"Diabetes mellitus\u2014Progress and opportunities in the evolving epidemic","volume":"187","author":"Abel","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2026.102389_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/iep.12008","article-title":"An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis","volume":"94","author":"Matsumoto","year":"2013","journal-title":"Int J Exp Pathol"},{"issue":"12","key":"10.1016\/j.molmet.2026.102389_bib9","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.2337\/db13-0769","article-title":"Hepatic notch signaling correlates with insulin resistance and non-alcoholic fatty liver disease","volume":"62","author":"Valenti","year":"2013","journal-title":"Diabetes"},{"issue":"682","key":"10.1016\/j.molmet.2026.102389_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adc9653","article-title":"Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis","volume":"15","author":"Xiao","year":"2023","journal-title":"Sci Transl Med"},{"issue":"3","key":"10.1016\/j.molmet.2026.102389_bib11","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jhep.2020.09.032","article-title":"Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features","volume":"74","author":"Zhu","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.molmet.2026.102389_bib12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-213X-13-15","article-title":"A bright single-cell resolution live imaging reporter of Notch signaling in the mouse","volume":"13","author":"Nowotschin","year":"2013","journal-title":"BMC Dev Biol"},{"key":"10.1016\/j.molmet.2026.102389_bib13","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1091\/mbc.11.8.2691","article-title":"Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta","volume":"11","author":"Saharinen","year":"2000","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.molmet.2026.102389_bib14","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1002\/jcp.22479","article-title":"Control of lung development by latent TGF-beta binding proteins","volume":"226","author":"Dabovic","year":"2011","journal-title":"J Cell Physiol"},{"issue":"12","key":"10.1016\/j.molmet.2026.102389_bib15","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1002\/jcp.24094","article-title":"Specificity of latent TGF-\u00df binding protein (LTBP) incorporation into matrix: role of fibrillins and fibronectin","volume":"227","author":"Zilberberg","year":"2012","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.molmet.2026.102389_bib16","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1038\/s41388-017-0075-1","article-title":"LTBP3 promotes early metastatic events during cancer cell dissemination","volume":"37","author":"Deryugina","year":"2018","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.molmet.2026.102389_bib17","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.3390\/nu12061650","article-title":"Heightened plasma levels of transforming growth factor beta (TGF-\u03b2) and increased degree of systemic biochemical perturbation characterizes hepatic steatosis in overweight pediatric patients: a cross-sectional study","volume":"12","author":"Barretto","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.molmet.2026.102389_bib18","doi-asserted-by":"crossref","first-page":"104733","DOI":"10.1016\/j.yexmp.2021.104733","article-title":"TGF-\u03b21 signaling can worsen NAFLD with liver fibrosis backdrop","volume":"124","author":"Ahmed","year":"2022","journal-title":"Exp Mol Pathol"},{"issue":"11","key":"10.1016\/j.molmet.2026.102389_bib19","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1038\/s41591-023-02602-2","article-title":"An integrated gene-to-outcome multimodal database for metabolic dysfunction-associated steatotic liver disease","volume":"29","author":"Kendall","year":"2023","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.molmet.2026.102389_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2024.101528","article-title":"Accurate prediction of all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease using electronic health records","volume":"29","author":"Drozdov","year":"2024","journal-title":"Ann Hepatol"},{"issue":"11","key":"10.1016\/j.molmet.2026.102389_bib21","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1093\/hmg\/ddv053","article-title":"Mutations in the latent TGF-beta binding protein 3 (LTBP3) gene cause brachyolmia with amelogenesis imperfecta","volume":"24","author":"Huckert","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"8","key":"10.1016\/j.molmet.2026.102389_bib22","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.ymthe.2020.06.015","article-title":"Delivery of oligonucleotides to the liver with GalNAc: from research to registered therapeutic drug","volume":"28","author":"Debacker","year":"2020","journal-title":"Mol Ther"},{"issue":"33","key":"10.1016\/j.molmet.2026.102389_bib23","doi-asserted-by":"crossref","first-page":"20533","DOI":"10.1016\/S0021-9258(17)30535-5","article-title":"Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms","volume":"265","author":"Cheifetz","year":"1990","journal-title":"J Biol Chem"},{"issue":"44","key":"10.1016\/j.molmet.2026.102389_bib24","doi-asserted-by":"crossref","first-page":"27678","DOI":"10.1074\/jbc.272.44.27678","article-title":"TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling","volume":"272","author":"Abdollah","year":"1997","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.molmet.2026.102389_bib25","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.bbrc.2008.10.145","article-title":"Study of interaction between Smad7 and DNA by single-molecule force spectroscopy","volume":"377","author":"Shi","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.molmet.2026.102389_bib26","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1172\/JCI118055","article-title":"Cell-specific expression of transforming growth factor-beta in rat liver: evidence for autocrine regulation of hepatocyte proliferation","volume":"96","author":"Bissell","year":"1995","journal-title":"J Clin Investig"},{"key":"10.1016\/j.molmet.2026.102389_bib49","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.molmet.2026.102389_bib27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cmet.2005.10.010","article-title":"A role of SMAD4 in iron metabolism through the positive regulation of Hepcidin expression","volume":"2","author":"Wang","year":"2005","journal-title":"Cell Metab Dec"},{"issue":"22","key":"10.1016\/j.molmet.2026.102389_bib28","doi-asserted-by":"crossref","first-page":"13123","DOI":"10.1074\/jbc.271.22.13123","article-title":"Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors","volume":"271","author":"Feng","year":"1996","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.molmet.2026.102389_bib29","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1053\/j.gastro.2006.02.040","article-title":"Ins and outs modulating hepatic triglyceride and development of nonalcoholic fatty liver disease","volume":"130","author":"Goldberg","year":"2006","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.molmet.2026.102389_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068693","article-title":"Transcriptome of extracellular vesicles released by hepatocytes","volume":"8","author":"Royo","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.molmet.2026.102389_bib31","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/hep.26698","article-title":"TGF-\u03b2 signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism","volume":"59","author":"Yang","year":"2013","journal-title":"Hepatology"},{"issue":"19","key":"10.1016\/j.molmet.2026.102389_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911696","article-title":"Hepatocyte-specific Smad4 deficiency alleviates liver fibrosis via the p38\/p65 pathway","volume":"23","author":"Wei","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.molmet.2026.102389_bib33","doi-asserted-by":"crossref","DOI":"10.1172\/JCI141529","article-title":"Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development","volume":"131","author":"Ito","year":"2021","journal-title":"J Clin Investig"},{"issue":"1","key":"10.1016\/j.molmet.2026.102389_bib34","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0168-8278(99)80010-5","article-title":"The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo","volume":"30","author":"Hellerbrand","year":"1999","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.molmet.2026.102389_bib35","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-011-1246-y","article-title":"TGF-\u03b2 in progression of liver disease","volume":"347","author":"Dooley","year":"2012","journal-title":"Cell Tissue Res"},{"issue":"119","key":"10.1016\/j.molmet.2026.102389_bib36","first-page":"29","article-title":"Role of LncRNA-activated by transforming growth factor beta in the progression of hepatitis C virus-related liver fibrosis","volume":"22","author":"Fu","year":"2016","journal-title":"Discov Med"},{"issue":"12","key":"10.1016\/j.molmet.2026.102389_bib37","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.3390\/ijms23126689","article-title":"Galunisertib exerts antifibrotic effects on TGF-\u03b2-induced fibroproliferative dermal fibroblasts","volume":"23","author":"Peterson","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.molmet.2026.102389_bib38","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41401-021-00630-7","article-title":"N-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice","volume":"43","author":"Shen","year":"2021","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.molmet.2026.102389_bib39","doi-asserted-by":"crossref","first-page":"114776","DOI":"10.1016\/j.intimp.2025.114776","article-title":"Corrigendum to \u2018Thiazole isomers as potential ALK5 inhibitors alleviate P2X7R-mediated inflammation during liver fibrosis\u2019 [International immunopharmacology 153 (24 April 2025) 114472]","volume":"157","author":"Jiang","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.molmet.2026.102389_bib40","first-page":"4479","article-title":"Clinical development of Galunisertib (LY2157299 Monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway","volume":"9","author":"Herbertz","year":"2015","journal-title":"Drug Des Dev Ther"},{"key":"10.1016\/j.molmet.2026.102389_bib41","doi-asserted-by":"crossref","first-page":"112441","DOI":"10.1016\/j.biopha.2021.112441","article-title":"SP-1154, a novel synthetic TGF-\u03b2 inhibitor, alleviates obesity and hepatic steatosis in high-fat diet-induced mice","volume":"145","author":"Pahk","year":"2022","journal-title":"Biomed Pharmacother Jan"},{"key":"10.1016\/j.molmet.2026.102389_bib42","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s42255-024-01043-6","article-title":"An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)","volume":"6","author":"Vacca","year":"2024","journal-title":"Nat Metab"},{"issue":"4","key":"10.1016\/j.molmet.2026.102389_bib43","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1056\/NEJMoa2401943","article-title":"Tirzepatide for metabolic dysfunction-associated steatohepatitis with liver fibrosis","volume":"391","author":"Loomba","year":"2024","journal-title":"N Engl J Med"},{"issue":"21","key":"10.1016\/j.molmet.2026.102389_bib44","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1056\/NEJMoa2413258","article-title":"Phase 3 trial of semaglutide in metabolic dysfunction-associated steatohepatitis","volume":"392","author":"Sanyal","year":"2025","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.molmet.2026.102389_bib45","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.molmet.2026.102389_bib46","first-page":"15545","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005"},{"issue":"8059","key":"10.1016\/j.molmet.2026.102389_bib47","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/s41586-025-08677-w","article-title":"Hepatic stellate cells control liver zonation, size and functions via R-Spondin 3","volume":"640","author":"Sugimoto","year":"2025","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.molmet.2026.102389_bib48","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/gene.10029","article-title":"Generation of Smad4\/Dpc4 conditional knockout mice","volume":"32","author":"Yang","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.molmet.2026.102389_bib50","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nm.2378","article-title":"Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner","volume":"17","author":"Pajvani","year":"2011","journal-title":"Nat Med"},{"issue":"8 Jan","key":"10.1016\/j.molmet.2026.102389_bib51","doi-asserted-by":"crossref","first-page":"10255","DOI":"10.1038\/ncomms10255","article-title":"mTORC1-Independent raptor prevents hepatic steatosis by stabilizing PHLPP2","volume":"7","author":"Kim","year":"2016","journal-title":"Nat Commun"},{"issue":"7931","key":"10.1016\/j.molmet.2026.102389_bib52","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41586-022-05289-6","article-title":"Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis","volume":"610","author":"Filliol","year":"2022","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.molmet.2026.102389_bib53","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877826000736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877826000736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:08:51Z","timestamp":1784632131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877826000736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":53,"alternative-id":["S2212877826000736"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2026.102389","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TGF\u03b2 activity stabilizes ACC1 to increase de novo lipogenesis in metabolic liver disease","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2026.102389","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102389"}}