{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:05:49Z","timestamp":1793689549605,"version":"4.5.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260639"],"award-info":[{"award-number":["82260639"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1R01DK113409"],"award-info":[{"award-number":["1R01DK113409"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.molmet.2026.102397","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:46:58Z","timestamp":1781279218000},"page":"102397","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A UFMylation-COPII axis orchestrates lipid transport in intestinal enterocytes and regulates systemic lipid balance"],"prefix":"10.1016","volume":"110","author":[{"given":"Yaqun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3604-0982","authenticated-orcid":false,"given":"Honglin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.molmet.2026.102397_bib1","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114742","article-title":"When fat meets the gut-focus on intestinal lipid handling in metabolic health and disease","volume":"14","author":"Wit","year":"2022","journal-title":"EMBO Mol Med"},{"issue":"3","key":"10.1016\/j.molmet.2026.102397_bib2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/MOL.0000000000000084","article-title":"Intestinal lipid absorption and lipoprotein formation","volume":"25","author":"Hussain","year":"2014","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.molmet.2026.102397_bib3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-nutr-071714-034338","article-title":"New insights into the regulation of chylomicron production","volume":"35","author":"Dash","year":"2015","journal-title":"Annu Rev Nutr"},{"issue":"3","key":"10.1016\/j.molmet.2026.102397_bib4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41575-019-0250-7","article-title":"Regulation of intestinal lipid metabolism: current concepts and relevance to disease","volume":"17","author":"Ko","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.molmet.2026.102397_bib5","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041260","article-title":"Cargo receptor-mediated ER export in lipoprotein secretion and lipid homeostasis","volume":"15","author":"Wang","year":"2023","journal-title":"Cold Spring Harbor Perspect Biol"},{"issue":"3","key":"10.1016\/j.molmet.2026.102397_bib6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/MOL.0000000000000983","article-title":"The intracellular chylomicron highway: novel insights into chylomicron biosynthesis, trafficking, and secretion","volume":"36","author":"Visser","year":"2025","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.molmet.2026.102397_bib7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev-physiol-021909-135801","article-title":"The biogenesis of chylomicrons","volume":"72","author":"Mansbach","year":"2010","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"10.1016\/j.molmet.2026.102397_bib8","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.molcel.2023.11.034","article-title":"The UFM1 system: working principles, cellular functions, and pathophysiology","volume":"84","author":"Komatsu","year":"2024","journal-title":"Mol Cell"},{"issue":"9","key":"10.1016\/j.molmet.2026.102397_bib9","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1038\/sj.emboj.7600205","article-title":"A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier","volume":"23","author":"Komatsu","year":"2004","journal-title":"EMBO J"},{"issue":"8","key":"10.1016\/j.molmet.2026.102397_bib10","doi-asserted-by":"crossref","first-page":"5417","DOI":"10.1074\/jbc.M109.036814","article-title":"A novel type of E3 ligase for the Ufm1 conjugation system","volume":"285","author":"Tatsumi","year":"2010","journal-title":"J Biol Chem"},{"issue":"20","key":"10.1016\/j.molmet.2026.102397_bib11","doi-asserted-by":"crossref","first-page":"15126","DOI":"10.1074\/jbc.M110.110619","article-title":"A novel C53\/LZAP-interacting protein regulates stability of C53\/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling","volume":"285","author":"Wu","year":"2010","journal-title":"J Biol Chem"},{"issue":"14","key":"10.1016\/j.molmet.2026.102397_bib12","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1038\/emboj.2010.116","article-title":"Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity","volume":"29","author":"Shiwaku","year":"2010","journal-title":"EMBO J"},{"issue":"16","key":"10.1016\/j.molmet.2026.102397_bib13","doi-asserted-by":"crossref","first-page":"12232","DOI":"10.1074\/jbc.M109.065920","article-title":"A novel LZAP-binding protein, NLBP, inhibits cell invasion","volume":"285","author":"Kwon","year":"2010","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.molmet.2026.102397_bib14","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.bbagen.2009.12.004","article-title":"Cloning and molecular characterization of Dashurin encoded by C20orf116, a PCI-domain containing protein","volume":"1800","author":"Neziri","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"10.1016\/j.molmet.2026.102397_bib15","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1038\/cdd.2015.51","article-title":"RCAD\/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis","volume":"22","author":"Zhang","year":"2015","journal-title":"Cell Death Differ"},{"issue":"11","key":"10.1016\/j.molmet.2026.102397_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005643","article-title":"UFBP1, a key component of the Ufm1 conjugation System, is essential for ufmylation-mediated regulation of erythroid development","volume":"11","author":"Cai","year":"2015","journal-title":"PLoS Genet"},{"issue":"1","key":"10.1016\/j.molmet.2026.102397_bib17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41421-018-0070-x","article-title":"Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation","volume":"5","author":"Cai","year":"2019","journal-title":"Cell Discov"},{"issue":"1","key":"10.1016\/j.molmet.2026.102397_bib18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13046-023-02681-6","article-title":"Loss of Ufl1\/Ufbp1 in hepatocytes promotes liver pathological damage and carcinogenesis through activating mTOR signaling","volume":"42","author":"Chen","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"issue":"9","key":"10.1016\/j.molmet.2026.102397_bib19","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/s41419-023-06095-2","article-title":"Ufmylation on UFBP1 alleviates non-alcoholic fatty liver disease by modulating hepatic endoplasmic reticulum stress","volume":"14","author":"Mao","year":"2023","journal-title":"Cell Death Dis"},{"issue":"7","key":"10.1016\/j.molmet.2026.102397_bib20","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/emboj.2011.52","article-title":"The unfolded protein response transducer IRE1alpha prevents ER stress-induced hepatic steatosis","volume":"30","author":"Zhang","year":"2011","journal-title":"EMBO J"},{"issue":"11","key":"10.1016\/j.molmet.2026.102397_bib21","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1128\/MCB.22.11.3864-3874.2002","article-title":"The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas","volume":"22","author":"Zhang","year":"2002","journal-title":"Mol Cell Biol"},{"issue":"3","key":"10.1016\/j.molmet.2026.102397_bib22","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/gene.20042","article-title":"Tissue-specific and inducible Cre-mediated recombination in the gut epithelium","volume":"39","author":"el Marjou","year":"2004","journal-title":"Genesis"},{"issue":"3","key":"10.1016\/j.molmet.2026.102397_bib23","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1194\/jlr.RA119000259","article-title":"Model systems for studying the assembly, trafficking, and secretion of apoB lipoproteins using fluorescent fusion proteins","volume":"61","author":"Walsh","year":"2020","journal-title":"J Lipid Res"},{"issue":"16","key":"10.1016\/j.molmet.2026.102397_bib24","doi-asserted-by":"crossref","first-page":"11019","DOI":"10.1074\/jbc.M512823200","article-title":"Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteins","volume":"281","author":"Rava","year":"2006","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.molmet.2026.102397_bib25","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0022-2275(20)37620-3","article-title":"Fatty acid uptake by Caco-2 human intestinal cells","volume":"37","author":"Trotter","year":"1996","journal-title":"J Lipid Res"},{"issue":"7","key":"10.1016\/j.molmet.2026.102397_bib26","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1074\/jbc.M113.479980","article-title":"The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis","volume":"289","author":"Fryer","year":"2014","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.molmet.2026.102397_bib27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00041433-200404000-00012","article-title":"The intracellular transport of chylomicrons requires the small GTPase, Sar1b","volume":"15","author":"Shoulders","year":"2004","journal-title":"Curr Opin Lipidol"},{"issue":"24","key":"10.1016\/j.molmet.2026.102397_bib28","doi-asserted-by":"crossref","first-page":"11776","DOI":"10.1073\/pnas.1814480116","article-title":"Coupling of COPII vesicle trafficking to nutrient availability by the IRE1alpha-XBP1s axis","volume":"116","author":"Liu","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.molmet.2026.102397_bib29","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1073\/pnas.1816202116","article-title":"Ribosomal protein RPL26 is the principal target of UFMylation","volume":"116","author":"Walczak","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.molmet.2026.102397_bib30","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41422-019-0236-6","article-title":"UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis","volume":"30","author":"Wang","year":"2020","journal-title":"Cell Res"},{"issue":"1","key":"10.1016\/j.molmet.2026.102397_bib31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ng1145","article-title":"Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders","volume":"34","author":"Jones","year":"2003","journal-title":"Nat Genet"},{"issue":"8","key":"10.1016\/j.molmet.2026.102397_bib32","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0962-8924(00)89054-6","article-title":"Microsomal triglyceride transfer protein: a protein complex required for the assembly of lipoprotein particles","volume":"5","author":"Gordon","year":"1995","journal-title":"Trends Cell Biol"},{"issue":"1","key":"10.1016\/j.molmet.2026.102397_bib33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1194\/jlr.R200014-JLR200","article-title":"Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly","volume":"44","author":"Hussain","year":"2003","journal-title":"J Lipid Res"},{"issue":"7","key":"10.1016\/j.molmet.2026.102397_bib34","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1074\/jbc.M510622200","article-title":"Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency","volume":"281","author":"Xie","year":"2006","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.molmet.2026.102397_bib35","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1002\/hep.29021","article-title":"TM6SF2 rs58542926 impacts lipid processing in liver and small intestine","volume":"65","author":"O\u2019Hare","year":"2017","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.molmet.2026.102397_bib36","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.cmet.2020.10.020","article-title":"Receptor-Mediated ER export of lipoproteins controls lipid homeostasis in mice and humans","volume":"33","author":"Wang","year":"2021","journal-title":"Cell Metab"},{"issue":"4","key":"10.1016\/j.molmet.2026.102397_bib37","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1161\/ATVBAHA.123.318980","article-title":"Surf4 (Surfeit locus protein 4) deficiency reduces intestinal lipid absorption and secretion and decreases metabolism in mice","volume":"43","author":"Tao","year":"2023","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.molmet.2026.102397_bib38","doi-asserted-by":"crossref","first-page":"101847","DOI":"10.1016\/j.molmet.2023.101847","article-title":"Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion","volume":"79","author":"Guo","year":"2024","journal-title":"Mol Metabol"},{"key":"10.1016\/j.molmet.2026.102397_bib39","doi-asserted-by":"crossref","first-page":"100052","DOI":"10.1074\/jbc.RA120.015002","article-title":"PRAP1 is a novel lipid-binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport","volume":"296","author":"Peng","year":"2021","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.molmet.2026.102397_bib40","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1038\/s41467-024-46102-4","article-title":"Pla2g12b drives expansion of triglyceride-rich lipoproteins","volume":"15","author":"Thierer","year":"2024","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.molmet.2026.102397_bib41","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1194\/jlr.M046482","article-title":"Cideb facilitates the lipidation of chylomicrons in the small intestine","volume":"55","author":"Zhang","year":"2014","journal-title":"J Lipid Res"},{"issue":"15","key":"10.1016\/j.molmet.2026.102397_bib42","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.7150\/ijbs.74348","article-title":"Small intestine-specific knockout of CIDEC improves obesity and hepatic steatosis by inhibiting synthesis of phosphatidic acid","volume":"18","author":"Huang","year":"2022","journal-title":"Int J Biol Sci"},{"issue":"Pt 2","key":"10.1016\/j.molmet.2026.102397_bib43","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1242\/jcs.00215","article-title":"COPII proteins are required for Golgi fusion but not for endoplasmic reticulum budding of the pre-chylomicron transport vesicle","volume":"116","author":"Siddiqi","year":"2003","journal-title":"J Cell Sci"},{"issue":"5","key":"10.1016\/j.molmet.2026.102397_bib44","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1194\/jlr.M002758","article-title":"Sec24C is required for docking the prechylomicron transport vesicle with the Golgi","volume":"51","author":"Siddiqi","year":"2010","journal-title":"J Lipid Res"},{"issue":"5","key":"10.1016\/j.molmet.2026.102397_bib45","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1194\/jlr.R052415","article-title":"Insights from human congenital disorders of intestinal lipid metabolism","volume":"56","author":"Levy","year":"2015","journal-title":"J Lipid Res"},{"issue":"2","key":"10.1016\/j.molmet.2026.102397_bib46","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/MOL.0000000000000578","article-title":"Chylomicron retention disease: genetics, biochemistry, and clinical spectrum","volume":"30","author":"Levy","year":"2019","journal-title":"Curr Opin Lipidol"},{"issue":"5","key":"10.1016\/j.molmet.2026.102397_bib47","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/hep.21369","article-title":"Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice","volume":"44","author":"Newberry","year":"2006","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.molmet.2026.102397_bib48","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41419-021-03401-8","article-title":"Cdk5rap3 is essential for intestinal Paneth cell development and maintenance","volume":"12","author":"Quintero","year":"2021","journal-title":"Cell Death Dis"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877826000815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877826000815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:48:17Z","timestamp":1785887297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877826000815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":48,"alternative-id":["S2212877826000815"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2026.102397","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A UFMylation-COPII axis orchestrates lipid transport in intestinal enterocytes and regulates systemic lipid balance","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2026.102397","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102397"}}