{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:58:35Z","timestamp":1790639915485,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.molmet.2026.102413","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:08:57Z","timestamp":1783350537000},"page":"102413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pik3ip1 mediates thyroid hormone-dependent regulation of the PI3K\/Akt\/mTOR axis in muscle atrophy"],"prefix":"10.1016","volume":"111","author":[{"given":"Annarita","family":"Nappi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Sagliocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Restolfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Miro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Acampora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Giuseppina","family":"Altobelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9977-3761","authenticated-orcid":false,"given":"Monica","family":"Dentice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annunziata Gaetana","family":"Cicatiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.molmet.2026.102413_bib1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.tem.2011.11.002","article-title":"Thyroid hormone metabolism in skeletal development and adult bone maintenance","volume":"23","author":"Waung","year":"2012","journal-title":"Trends Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.molmet.2026.102413_bib2","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s42255-024-00986-0","article-title":"Metabolic messengers: Thyroid hormones","volume":"6","author":"Sinha","year":"2024","journal-title":"Nat Metab"},{"issue":"4","key":"10.1016\/j.molmet.2026.102413_bib3","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrendo.2013.238","article-title":"Thyroid hormones and skeletal muscle--new insights and potential implications","volume":"10","author":"Salvatore","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.molmet.2026.102413_bib4","doi-asserted-by":"crossref","first-page":"474","DOI":"10.3389\/fendo.2018.00474","article-title":"Metabolic effects of the intracellular regulation of thyroid hormone: old players, new concepts","volume":"9","author":"Cicatiello","year":"2018","journal-title":"Front Endocrinol"},{"issue":"12","key":"10.1016\/j.molmet.2026.102413_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110562","article-title":"Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2","volume":"38","author":"Cicatiello","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.molmet.2026.102413_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101228","article-title":"The thyroid hormone activating enzyme, type 2 deiodinase, induces myogenic differentiation by regulating mitochondrial metabolism and reducing oxidative stress","volume":"24","author":"Sagliocchi","year":"2019","journal-title":"Redox Biol"},{"issue":"4\u20135","key":"10.1016\/j.molmet.2026.102413_bib7","first-page":"231","article-title":"The key roles of thyroid hormone in mitochondrial regulation, at interface of human health and disease","volume":"35","author":"Sagliocchi","year":"2024","journal-title":"J Basic Clin Physiol Pharmacol"},{"issue":"6","key":"10.1016\/j.molmet.2026.102413_bib8","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1093\/nar\/gkt065","article-title":"Epigenetic control of type 2 and 3 deiodinases in myogenesis: role of Lysine-specific Demethylase enzyme and FoxO3","volume":"41","author":"Ambrosio","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"10.1016\/j.molmet.2026.102413_bib9","doi-asserted-by":"crossref","first-page":"E818","DOI":"10.1152\/ajpendo.00292.2011","article-title":"Type II iodothyronine deiodinase provides intracellular 3,5,3\u2019-triiodothyronine to normal and regenerating mouse skeletal muscle","volume":"301","author":"Marsili","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"13","key":"10.1016\/j.molmet.2026.102413_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22137175","article-title":"Selective inhibition of genomic and non-genomic effects of thyroid hormone regulates muscle cell differentiation and metabolic behavior","volume":"22","author":"Nappi","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.molmet.2026.102413_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12050405","article-title":"Thyroid hormone receptor isoforms alpha and beta play convergent roles in muscle physiology and metabolic regulation","volume":"12","author":"Nappi","year":"2022","journal-title":"Metabolites"},{"issue":"11","key":"10.1016\/j.molmet.2026.102413_bib12","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1172\/JCI43670","article-title":"The FoxO3\/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration","volume":"120","author":"Dentice","year":"2010","journal-title":"J Clin Investig"},{"issue":"6","key":"10.1016\/j.molmet.2026.102413_bib13","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.cmet.2014.10.009","article-title":"Intracellular inactivation of thyroid hormone is a survival mechanism for muscle stem cell proliferation and lineage progression","volume":"20","author":"Dentice","year":"2014","journal-title":"Cell Metab"},{"issue":"5","key":"10.1016\/j.molmet.2026.102413_bib14","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1210\/en.2019-00088","article-title":"A global loss of Dio2 leads to unexpected changes in function and fiber types of slow skeletal muscle in Male mice","volume":"160","author":"Carmody","year":"2019","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.molmet.2026.102413_bib15","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1210\/en.2010-0631","article-title":"Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism","volume":"151","author":"Marsili","year":"2010","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.molmet.2026.102413_bib16","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1016\/j.bbagen.2012.05.007","article-title":"The deiodinases and the control of intracellular thyroid hormone signaling during cellular differentiation","volume":"1830","author":"Dentice","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"10.1016\/j.molmet.2026.102413_bib17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1530\/JOE-10-0448","article-title":"Deiodinases: the balance of thyroid hormone: local control of thyroid hormone action: role of type 2 deiodinase","volume":"209","author":"Williams","year":"2011","journal-title":"J Endocrinol"},{"issue":"8","key":"10.1016\/j.molmet.2026.102413_bib18","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41574-019-0218-2","article-title":"Deiodinases and their intricate role in thyroid hormone homeostasis","volume":"15","author":"Luongo","year":"2019","journal-title":"Nat Rev Endocrinol"},{"issue":"10","key":"10.1016\/j.molmet.2026.102413_bib19","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1172\/JCI29812","article-title":"Deiodinases: implications of the local control of thyroid hormone action","volume":"116","author":"Bianco","year":"2006","journal-title":"J Clin Investig"},{"issue":"4","key":"10.1016\/j.molmet.2026.102413_bib20","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000343922","article-title":"The role of the iodothyronine deiodinases in the physiology and pathophysiology of thyroid hormone action","volume":"1","author":"Larsen","year":"2012","journal-title":"Eur Thyroid J"},{"key":"10.1016\/j.molmet.2026.102413_bib21","doi-asserted-by":"crossref","first-page":"1882438","DOI":"10.3389\/fphys.2026.1882438","article-title":"Thyroid hormones and metabolic flexibility: tissue-specific control of energy homeostasis","volume":"17","author":"Cicatiello","year":"2026","journal-title":"Front Physiol"},{"issue":"4","key":"10.1016\/j.molmet.2026.102413_bib22","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1002\/jcsm.13023","article-title":"Decoding the transcriptome of denervated muscle at single-nucleus resolution","volume":"13","author":"Lin","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"17","key":"10.1016\/j.molmet.2026.102413_bib23","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1111\/febs.12253","article-title":"Mechanisms regulating skeletal muscle growth and atrophy","volume":"280","author":"Schiaffino","year":"2013","journal-title":"FEBS J"},{"issue":"7","key":"10.1016\/j.molmet.2026.102413_bib24","doi-asserted-by":"crossref","first-page":"E907","DOI":"10.1152\/ajpendo.00380.2013","article-title":"SA, et al. Skeletal muscle denervation causes skeletal muscle atrophy through a pathway that involves both Gadd45a and HDAC4","volume":"305","author":"Bongers","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.molmet.2026.102413_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11080517","article-title":"Metabolic remodeling in skeletal muscle atrophy as a therapeutic target","volume":"11","author":"Renzini","year":"2021","journal-title":"Metabolites"},{"issue":"1","key":"10.1016\/j.molmet.2026.102413_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13395-025-00397-z","article-title":"Signaling networks governing skeletal muscle growth, atrophy, and cachexia","volume":"15","author":"Joshi","year":"2025","journal-title":"Skelet Muscle"},{"issue":"1","key":"10.1016\/j.molmet.2026.102413_bib27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2044-5040-1-4","article-title":"Regulation of skeletal muscle growth by the IGF1-Akt\/PKB pathway: insights from genetic models","volume":"1","author":"Schiaffino","year":"2011","journal-title":"Skelet Muscle"},{"issue":"6","key":"10.1016\/j.molmet.2026.102413_bib28","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cmet.2007.11.004","article-title":"FoxO3 coordinately activates protein degradation by the autophagic\/lysosomal and proteasomal pathways in atrophying muscle cells","volume":"6","author":"Zhao","year":"2007","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.molmet.2026.102413_bib29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbrc.2007.04.096","article-title":"PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein","volume":"358","author":"Zhu","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.molmet.2026.102413_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122251","article-title":"Pik3ip1 modulates cardiac hypertrophy by inhibiting PI3K pathway","volume":"10","author":"Song","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.molmet.2026.102413_bib31","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1002\/eji.201141653","article-title":"Inhibition of T-cell activation by PIK3IP1","volume":"42","author":"DeFrances","year":"2012","journal-title":"Eur J Immunol"},{"issue":"14","key":"10.1016\/j.molmet.2026.102413_bib32","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1158\/0008-5472.CAN-08-0025","article-title":"PIK3IP1, a negative regulator of PI3K, suppresses the development of hepatocellular carcinoma","volume":"68","author":"He","year":"2008","journal-title":"Cancer Res"},{"issue":"11","key":"10.1016\/j.molmet.2026.102413_bib33","doi-asserted-by":"crossref","first-page":"21211","DOI":"10.1002\/jcp.28727","article-title":"GRP94 promotes muscle differentiation by inhibiting the PI3K\/AKT\/mTOR signaling pathway","volume":"234","author":"Li","year":"2019","journal-title":"J Cell Physiol"},{"issue":"6","key":"10.1016\/j.molmet.2026.102413_bib34","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1515\/jbcpp-2025-0160","article-title":"Thyroid hormone imbalance, malnutrition, and sarcopenia: a triad of muscle health challenges","volume":"36","author":"Nappi","year":"2025","journal-title":"J Basic Clin Physiol Pharmacol"},{"issue":"2","key":"10.1016\/j.molmet.2026.102413_bib35","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<165::AID-GENE22>3.0.CO;2-F","article-title":"Selective expression of Cre recombinase in skeletal muscle fibers","volume":"26","author":"Bothe","year":"2000","journal-title":"Genesis"},{"issue":"12","key":"10.1016\/j.molmet.2026.102413_bib36","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1002\/j.1460-2075.1996.tb00664.x","article-title":"Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function","volume":"15","author":"Forrest","year":"1996","journal-title":"EMBO J"},{"issue":"2","key":"10.1016\/j.molmet.2026.102413_bib37","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/emboj\/17.2.455","article-title":"Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1","volume":"17","author":"Wikstrom","year":"1998","journal-title":"EMBO J"},{"issue":"2","key":"10.1016\/j.molmet.2026.102413_bib38","first-page":"69","article-title":"Muscle biopsy--technical and diagnostic aspects","volume":"6","author":"Dubowitz","year":"1974","journal-title":"Ann Clin Res"},{"issue":"5","key":"10.1016\/j.molmet.2026.102413_bib39","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s40618-024-02526-9","article-title":"The thyroid hormone activating enzyme, DIO2, is a potential pan-cancer biomarker and immunotherapy target","volume":"48","author":"Nappi","year":"2025","journal-title":"J Endocrinol Investig"},{"key":"10.1016\/j.molmet.2026.102413_bib40","doi-asserted-by":"crossref","first-page":"100454","DOI":"10.1016\/j.jlb.2025.100454","article-title":"Cell-free RNA profiling uncovers non-canonical circulating D2 transcript elevation in bladder cancer plasma","volume":"11","author":"Nappi","year":"2026","journal-title":"J Liq Biopsy"},{"key":"10.1016\/j.molmet.2026.102413_bib41","doi-asserted-by":"crossref","DOI":"10.1113\/JP291418","article-title":"Voltage-gated potassium channels mediate thyroid hormone control of skeletal muscle excitability","author":"Nappi","year":"2026","journal-title":"J Physiol"},{"key":"10.1016\/j.molmet.2026.102413_bib42","doi-asserted-by":"crossref","first-page":"106685","DOI":"10.1016\/j.phrs.2023.106685","article-title":"Repositioning of Cefuroxime as novel selective inhibitor of the thyroid hormone activating enzyme type 2 deiodinase","volume":"189","author":"Sagliocchi","year":"2023","journal-title":"Pharmacol Res"},{"issue":"12","key":"10.1016\/j.molmet.2026.102413_bib43","doi-asserted-by":"crossref","first-page":"7637","DOI":"10.1128\/AAC.01746-15","article-title":"Fitness cost of rifampin resistance in Neisseria meningitidis: in vitro Study of mechanisms associated with rpoB H553Y mutation","volume":"59","author":"Colicchio","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.molmet.2026.102413_bib44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.molmet.2026.102413_bib45","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"issue":"43","key":"10.1016\/j.molmet.2026.102413_bib46","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.molmet.2026.102413_bib47","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1002\/1878-0261.13782","article-title":"Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1","volume":"19","author":"Torabinejad","year":"2025","journal-title":"Mol Oncol"},{"issue":"1","key":"10.1016\/j.molmet.2026.102413_bib48","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/s41467-023-36755-y","article-title":"Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage","volume":"14","author":"Nappi","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.molmet.2026.102413_bib49","doi-asserted-by":"crossref","first-page":"115326","DOI":"10.1016\/j.biopha.2023.115326","article-title":"SIRT6 pharmacological inhibition delays skin cancer progression in the squamous cell carcinoma","volume":"166","author":"Abbotto","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10.1016\/j.molmet.2026.102413_bib50","doi-asserted-by":"crossref","first-page":"26113","DOI":"10.31083\/FBL26113","article-title":"Thyroid hormone activation regulates the crosstalk between breast cancer and mesenchymal stem cells","volume":"30","author":"Nappi","year":"2025","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10.1016\/j.molmet.2026.102413_bib51","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.abb.2019.01.009","article-title":"Identification of potential target genes associated with the reversion of androgen-dependent skeletal muscle atrophy","volume":"663","author":"de","year":"2019","journal-title":"Arch Biochem Biophys"},{"issue":"6","key":"10.1016\/j.molmet.2026.102413_bib52","doi-asserted-by":"crossref","first-page":"E469","DOI":"10.1152\/ajpendo.00204.2014","article-title":"Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx\/atrogin-1","volume":"307","author":"Bodine","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.molmet.2026.102413_bib53","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1038\/s41467-018-06583-6","article-title":"Myogenin promotes myocyte fusion to balance fibre number and size","volume":"9","author":"Ganassi","year":"2018","journal-title":"Nat Commun"},{"issue":"51","key":"10.1016\/j.molmet.2026.102413_bib54","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc4062","article-title":"Human myotube formation is determined by MyoD-Myomixer\/Myomaker axis","volume":"6","author":"Zhang","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.molmet.2026.102413_bib55","doi-asserted-by":"crossref","first-page":"174835","DOI":"10.1016\/j.ejphar.2022.174835","article-title":"The basic functions of phosphoglycerate kinase 1 and its roles in cancer and other diseases","volume":"920","author":"Liu","year":"2022","journal-title":"Eur J Pharmacol"},{"issue":"9","key":"10.1016\/j.molmet.2026.102413_bib56","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.chembiol.2019.05.006","article-title":"6-Phosphogluconate dehydrogenase links cytosolic carbohydrate metabolism to protein secretion via modulation of glutathione levels","volume":"26","author":"Li","year":"2019","journal-title":"Cell Chem Biol"},{"issue":"1","key":"10.1016\/j.molmet.2026.102413_bib57","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1186\/s12967-025-07253-0","article-title":"A novel palmitoylation-based molecular signature reveals COX6A1 as a key regulator in metabolic dysfunction-associated steatotic liver disease","volume":"23","author":"Yu","year":"2025","journal-title":"J Transl Med"},{"issue":"1","key":"10.1016\/j.molmet.2026.102413_bib58","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13148-020-00976-5","article-title":"Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes","volume":"12","author":"A","year":"2020","journal-title":"Clin Epigenetics"},{"issue":"128","key":"10.1016\/j.molmet.2026.102413_bib59","doi-asserted-by":"crossref","first-page":"ra49","DOI":"10.1126\/scisignal.2000803","article-title":"Evolution of the TSC1\/TSC2-TOR signaling pathway","volume":"3","author":"Serfontein","year":"2010","journal-title":"Sci Signal"},{"issue":"15","key":"10.1016\/j.molmet.2026.102413_bib60","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1111\/febs.16370","article-title":"Protein phosphatase 2A catalytic subunit beta suppresses PMA\/ionomycin-induced T-cell activation by negatively regulating PI3K\/Akt signaling","volume":"289","author":"Gao","year":"2022","journal-title":"FEBS J"},{"key":"10.1016\/j.molmet.2026.102413_bib61","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1242\/jeb.111.1.13","article-title":"Hormonal control of muscle atrophy and degeneration in the moth Antheraea polyphemus","volume":"111","author":"Schwartz","year":"1984","journal-title":"J Exp Biol"},{"key":"10.1016\/j.molmet.2026.102413_bib62","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-981-13-1435-3_9","article-title":"Hormones and muscle atrophy","volume":"1088","author":"Martin","year":"2018","journal-title":"Adv Exp Med Biol"},{"issue":"4\u20135","key":"10.1016\/j.molmet.2026.102413_bib63","first-page":"253","article-title":"Effects of thyroid hormones in skeletal muscle protein turnover","volume":"35","author":"Nappi","year":"2024","journal-title":"J Basic Clin Physiol Pharmacol"},{"issue":"5","key":"10.1016\/j.molmet.2026.102413_bib64","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1515\/jbcpp-2023-0179","article-title":"The intricate role of glutamine in pathophysiological contexts","volume":"34","author":"Nappi","year":"2023","journal-title":"J Basic Clin Physiol Pharmacol"},{"issue":"6","key":"10.1016\/j.molmet.2026.102413_bib65","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1073\/pnas.0510849103","article-title":"Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone beta receptor","volume":"103","author":"Furuya","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.molmet.2026.102413_bib66","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1089\/thy.2013.0054","article-title":"Inhibition of tumorigenesis by the thyroid hormone receptor beta in xenograft models","volume":"24","author":"Kim","year":"2014","journal-title":"Thyroid"},{"issue":"8","key":"10.1016\/j.molmet.2026.102413_bib67","doi-asserted-by":"crossref","first-page":"bvab102","DOI":"10.1210\/jendso\/bvab102","article-title":"Thyroid hormone receptor beta inhibits PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer via genomic mechanisms","volume":"5","author":"Davidson","year":"2021","journal-title":"J Endocr Soc"},{"issue":"1","key":"10.1016\/j.molmet.2026.102413_bib68","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1096\/fj.03-0610com","article-title":"Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression","volume":"18","author":"Lecker","year":"2004","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.molmet.2026.102413_bib69","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41467-020-20123-1","article-title":"Mechanisms of muscle atrophy and hypertrophy: implications in health and disease","volume":"12","author":"Sartori","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.molmet.2026.102413_bib70","doi-asserted-by":"crossref","first-page":"104498","DOI":"10.1016\/j.jprot.2022.104498","article-title":"Urine proteomics as a non-invasive approach to monitor exertional rhabdomyolysis during military training","volume":"258","author":"Carneiro","year":"2022","journal-title":"J Proteomics"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877826000979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877826000979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:03:36Z","timestamp":1790636616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877826000979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":70,"alternative-id":["S2212877826000979"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2026.102413","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pik3ip1 mediates thyroid hormone-dependent regulation of the PI3K\/Akt\/mTOR axis in muscle atrophy","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2026.102413","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102413"}}