{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:02:18Z","timestamp":1789516938771,"version":"build-2803163510"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K16796"],"award-info":[{"award-number":["23K16796"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H00548"],"award-info":[{"award-number":["20H00548"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["108726\/Z\/15\/Z"],"award-info":[{"award-number":["108726\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["108926\/Z\/15\/Z"],"award-info":[{"award-number":["108926\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["208363\/Z\/17\/Z"],"award-info":[{"award-number":["208363\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214286\/Z\/18\/Z"],"award-info":[{"award-number":["214286\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/S011552\/1"],"award-info":[{"award-number":["MR\/S011552\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022690","name":"JDRF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019619","name":"International Diabetes Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013322","name":"European Federation of Pharmaceutical Industries and Associations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["777460"],"award-info":[{"award-number":["777460"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","award":["22\/0006401"],"award-info":[{"award-number":["22\/0006401"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.molmet.2026.102428","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T23:43:36Z","timestamp":1786059816000},"page":"102428","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Adaptive oligodendrogenesis regulates blood-hypothalamus barrier permeability, hypothalamic glucose sensing and systemic glucose homeostasis in male mice"],"prefix":"10.1016","volume":"112","author":[{"given":"Sophie","family":"Buller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily O.","family":"Staricoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Riches","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Giavara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masa","family":"Josipovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Ikemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Opoku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikumi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Hirohata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Stenzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart G.","family":"Nayar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ramos Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Hecksher-S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Timmler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina K.C.","family":"Dowsett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian Y.H.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giles S.H.","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly M.","family":"Alonge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1752-1270","authenticated-orcid":false,"given":"Clemence","family":"Blouet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2026.102428_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.4","article-title":"Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism","volume":"48","author":"Roh","year":"2016","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.molmet.2026.102428_bib2","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.2337\/db23-0139","article-title":"Identification of hypothalamic glucoregulatory neurons that sense and respond to changes in glycemia","volume":"72","author":"Deem","year":"2023","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2026.102428_bib3","doi-asserted-by":"crossref","first-page":"E2073","DOI":"10.1073\/pnas.1521160113","article-title":"Functional identification of a neurocircuit regulating blood glucose","volume":"113","author":"Meek","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.molmet.2026.102428_bib4","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1172\/JCI134135","article-title":"Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin","volume":"130","author":"Flak","year":"2020","journal-title":"J Clin Investig"},{"key":"10.1016\/j.molmet.2026.102428_bib5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cmet.2013.03.004","article-title":"Tanycytic VEGF-A boosts blood\u2013hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting","volume":"17","author":"Langlet","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/j.molmet.2026.102428_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111698","article-title":"Acute changes in systemic glycemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis","volume":"41","author":"Bakker","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.molmet.2026.102428_bib7","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S1044-7431(03)00210-0","article-title":"NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS","volume":"24","author":"Dawson","year":"2003","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.molmet.2026.102428_bib8","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/nn.2220","article-title":"PDGFRA\/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice","volume":"11","author":"Rivers","year":"2008","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.molmet.2026.102428_bib9","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.neuron.2010.09.009","article-title":"NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration","volume":"68","author":"Kang","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.molmet.2026.102428_bib10","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.neuron.2013.01.006","article-title":"Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling","volume":"77","author":"Young","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.molmet.2026.102428_bib11","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41593-018-0121-5","article-title":"Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex","volume":"21","author":"Hughes","year":"2018","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.molmet.2026.102428_bib12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1126\/science.1254960","article-title":"Motor skill learning requires active central myelination","volume":"346","author":"McKenzie","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.molmet.2026.102428_bib13","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/nn.4351","article-title":"Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning","volume":"19","author":"Xiao","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.molmet.2026.102428_bib14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41593-019-0582-1","article-title":"Preservation of a remote fear memory requires new myelin formation","volume":"23","author":"Pan","year":"2020","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.molmet.2026.102428_bib15","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.neuron.2019.10.013","article-title":"Disruption of oligodendrogenesis impairs memory consolidation in adult mice","volume":"105","author":"Steadman","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.molmet.2026.102428_bib16","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41593-020-0637-3","article-title":"Motor learning promotes remyelination via new and surviving oligodendrocytes","volume":"23","author":"Bacmeister","year":"2020","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.molmet.2026.102428_bib17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1126\/science.1115360","article-title":"Neurogenesis in the hypothalamus of adult mice: potential role in energy balance","volume":"310","author":"Kokoeva","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.molmet.2026.102428_bib18","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1038\/ncomms3049","article-title":"\u03b1-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors","volume":"4","author":"Robins","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.molmet.2026.102428_bib19","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cmet.2016.04.013","article-title":"Adult NG2-glia are required for median eminence-mediated leptin sensing and body weight control","volume":"23","author":"Djogo","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.molmet.2026.102428_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109362","article-title":"Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence","volume":"36","author":"Kohnke","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.molmet.2026.102428_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101690","article-title":"Median eminence myelin continuously turns over in adult mice","volume":"69","author":"Buller","year":"2023","journal-title":"Mol Metabol"},{"key":"10.1016\/j.molmet.2026.102428_bib22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.cell.2009.04.031","article-title":"Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination","volume":"138","author":"Emery","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2026.102428_bib23","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/s41467-022-28720-y","article-title":"White matter integrity in mice requires continuous myelin synthesis at the inner tongue","volume":"13","author":"Meschkat","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.molmet.2026.102428_bib24","series-title":"The mouse brain in stereotaxic coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.molmet.2026.102428_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2022.101304","article-title":"Transmission electron microscopic analysis of myelination in the murine central nervous system","volume":"3","author":"Wang","year":"2022","journal-title":"STAR Protoc"},{"key":"10.1016\/j.molmet.2026.102428_bib26","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2014.10.010","article-title":"iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging","volume":"159","author":"Renier","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2026.102428_bib27","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s12021-020-09490-8","article-title":"An optimized mouse brain atlas for automated mapping and quantification of neuronal activity using iDISCO+ and light sheet fluorescence microscopy","volume":"19","author":"Perens","year":"2021","journal-title":"Neuroinformatics"},{"key":"10.1016\/j.molmet.2026.102428_bib28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature13186","article-title":"A mesoscale connectome of the mouse brain","volume":"508","author":"Oh","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2026.102428_bib29","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1109\/TMI.2009.2035616","article-title":"Elastix: a toolbox for intensity-based medical image registration","volume":"29","author":"Klein","year":"2010","journal-title":"IEEE Trans Med Imag"},{"key":"10.1016\/j.molmet.2026.102428_bib30","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2026.102428_bib31","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/nprot.2006.224","article-title":"BrdU assay for neurogenesis in rodents","volume":"1","author":"Wojtowicz","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.molmet.2026.102428_bib32","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/s42255-022-00657-y","article-title":"HypoMap\u2014a unified single-cell gene expression atlas of the murine hypothalamus","volume":"4","author":"Steuernagel","year":"2022","journal-title":"Nat Metab"},{"key":"10.1016\/j.molmet.2026.102428_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aam7816","article-title":"BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions","volume":"9","author":"Fard","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.molmet.2026.102428_bib34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2337\/dc22-1445","article-title":"Brain glucose sensing and the problem of relative hypoglycemia","volume":"46","author":"Schwartz","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.molmet.2026.102428_bib35","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1749-6632.2010.05820.x","article-title":"Neuroendocrine responses to hypoglycemia","volume":"1212","author":"Tesfaye","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.molmet.2026.102428_bib36","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.72919","article-title":"Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes","volume":"10","author":"Kim","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.molmet.2026.102428_bib37","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1002\/cne.23355","article-title":"Tanycyte-like cells form a blood\u2013cerebrospinal fluid barrier in the circumventricular organs of the mouse brain","volume":"521","author":"Langlet","year":"2013","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.molmet.2026.102428_bib38","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1038\/s41467-024-50798-9","article-title":"A plastic aggrecan barrier modulated by peripheral energy state gates metabolic signal access to arcuate neurons","volume":"15","author":"Kuczynski-Noyau","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.molmet.2026.102428_bib39","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/s41586-024-07922-y","article-title":"Pathogenic hypothalamic extracellular matrix promotes metabolic disease","volume":"633","author":"Beddows","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2026.102428_bib40","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nn.4495","article-title":"A molecular census of arcuate hypothalamus and median eminence cell types","volume":"20","author":"Campbell","year":"2017","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.molmet.2026.102428_bib41","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.aaf6463","article-title":"Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system","volume":"352","author":"Marques","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.molmet.2026.102428_bib42","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1002\/glia.23207","article-title":"ADAMTS-4 in oligodendrocytes contributes to myelination with an impact on motor function","volume":"65","author":"Pruvost","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.molmet.2026.102428_bib43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13059-015-0676-3","article-title":"The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family","volume":"16","author":"Kelwick","year":"2015","journal-title":"Genome Biol"},{"key":"10.1016\/j.molmet.2026.102428_bib44","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/biom12010012","article-title":"ADAMTS proteins and vascular remodeling in aortic aneurysms","volume":"12","author":"Mougin","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.molmet.2026.102428_bib45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/mps4010023","article-title":"Validity and efficacy of methods to define blood brain barrier integrity in experimental ischemic strokes: a comparison of albumin Western blot, IgG Western blot and albumin immunofluorescence","volume":"4","author":"Franke","year":"2021","journal-title":"Methods Protoc"},{"key":"10.1016\/j.molmet.2026.102428_bib46","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1038\/s42255-025-01386-8","article-title":"Oligodendrocyte precursor cell-specific blocking of low-glucose-induced activation of AMPK ensures myelination and remyelination","volume":"7","author":"Sun","year":"2025","journal-title":"Nat Metab"},{"key":"10.1016\/j.molmet.2026.102428_bib47","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1038\/s41593-026-02263-7","article-title":"Glucose-dependent spatial and temporal modulation of oligodendrocyte progenitor cell proliferation via ACLY-regulated histone acetylation","volume":"29","author":"Sauma","year":"2026","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.molmet.2026.102428_bib48","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41586-023-06358-0","article-title":"Neural basis for fasting activation of the hypothalamic-pituitary-adrenal axis","volume":"620","author":"Douglass","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2026.102428_bib49","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.cmet.2023.03.019","article-title":"Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation","volume":"35","author":"Chen","year":"2023","journal-title":"Cell Metab"},{"key":"10.1016\/j.molmet.2026.102428_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.990803","article-title":"A subpopulation of agouti-related peptide neurons exciting corticotropin-releasing hormone axon terminals in median eminence led to hypothalamic-pituitary-adrenal axis activation in response to food restriction","volume":"15","author":"Yesmin","year":"2022","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.molmet.2026.102428_bib51","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1365-2613.2011.00802.x","article-title":"Anti-angiogenic properties of ADAMTS-4 in vitro","volume":"93","author":"Hsu","year":"2012","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.molmet.2026.102428_bib52","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0945-053X(02)00069-0","article-title":"Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4)","volume":"21","author":"Tortorella","year":"2002","journal-title":"Matrix Biol"},{"key":"10.1016\/j.molmet.2026.102428_bib53","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s42255-018-0029-0","article-title":"Perineuronal net formation during the critical period for neuronal maturation in the hypothalamic arcuate nucleus","volume":"1","author":"Mirzadeh","year":"2019","journal-title":"Nat Metab"},{"key":"10.1016\/j.molmet.2026.102428_bib54","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.cmet.2022.03.011","article-title":"Evaluating human genetic support for hypothesized metabolic disease genes","volume":"34","author":"Dornbos","year":"2022","journal-title":"Cell Metab"},{"key":"10.1016\/j.molmet.2026.102428_bib55","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/art.39561","article-title":"Suppressive effects of insulin on tumor necrosis factor-dependent early osteoarthritic changes associated with obesity and type 2 diabetes mellitus","volume":"68","author":"Hamada","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.molmet.2026.102428_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2023.108552","article-title":"Diabetes-related perturbations in the integrity of physiologic barriers","volume":"37","author":"Mooradian","year":"2023","journal-title":"J Diabet Complicat"},{"key":"10.1016\/j.molmet.2026.102428_bib57","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1002\/1873-3468.13240","article-title":"Short-term tamoxifen treatment has long-term effects on metabolism in high-fat diet-fed mice with involvement of Nmnat2 in POMC neurons","volume":"592","author":"Liu","year":"2018","journal-title":"FEBS Lett"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877826001122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877826001122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:10:27Z","timestamp":1789513827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877826001122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":57,"alternative-id":["S2212877826001122"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2026.102428","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adaptive oligodendrogenesis regulates blood-hypothalamus barrier permeability, hypothalamic glucose sensing and systemic glucose homeostasis in male mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2026.102428","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102428"}}