{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:46:02Z","timestamp":1791909962201,"version":"4.3.4"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Medical Center Asan Institute for Life Sciences","doi-asserted-by":"publisher","award":["2023IP0140"],"award-info":[{"award-number":["2023IP0140"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A2C20934489"],"award-info":[{"award-number":["2021R1A2C20934489"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1A2B5B02098524"],"award-info":[{"award-number":["2020R1A2B5B02098524"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\\u20132022R1A2C1004644"],"award-info":[{"award-number":["NRF\\u20132022R1A2C1004644"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2024-00438349"],"award-info":[{"award-number":["RS-2024-00438349"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Metabolism"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.molmet.2026.102440","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:31:59Z","timestamp":1789745519000},"page":"102440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["GNPAT-driven plasmalogen biosynthesis regulates macrophage polarization and protects against obesity-induced inflammation by suppressing PKC\u03b4\u2013STAT1 signaling"],"prefix":"10.1016","volume":"113","author":[{"given":"Ji-Young","family":"Yun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung Seok","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung Hwan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-4374","authenticated-orcid":false,"given":"Jaechan","family":"Leem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Ok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2617-444X","authenticated-orcid":false,"given":"Hyun Ju","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-kyung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0641-7208","authenticated-orcid":false,"given":"In-Jeoung","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Bum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Up","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hee","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molmet.2026.102440_bib1","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1053\/j.gastro.2007.03.059","article-title":"Obesity, inflammation, and insulin resistance","volume":"132","author":"Shoelson","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.molmet.2026.102440_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrendo.2015.189","article-title":"Regulation of metabolism by the innate immune system","volume":"12","author":"Lackey","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.molmet.2026.102440_bib3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cellimm.2017.03.001","article-title":"Role of immune cells in obesity induced low grade inflammation and insulin resistance","volume":"315","author":"Asghar","year":"2017","journal-title":"Cell Immunol"},{"key":"10.1016\/j.molmet.2026.102440_bib4","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1161\/CIRCRESAHA.115.306885","article-title":"Obesity-Induced changes in adipose tissue microenvironment and their impact on cardiovascular disease","volume":"118","author":"Fuster","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.molmet.2026.102440_bib5","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/s41467-017-01232-w","article-title":"Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation","volume":"8","author":"Shin","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.molmet.2026.102440_bib6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/imm.13002","article-title":"Properties and functions of adipose tissue macrophages in obesity","volume":"155","author":"Russo","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.molmet.2026.102440_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J Clin Investig"},{"key":"10.1016\/j.molmet.2026.102440_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mce.2017.01.005","article-title":"M2 macrophages infusion ameliorates obesity and insulin resistance by remodeling inflammatory\/macrophages' homeostasis in obese mice","volume":"443","author":"Zhang","year":"2017","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.molmet.2026.102440_bib9","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI57132","article-title":"Inflammatory links between obesity and metabolic disease","volume":"121","author":"Lumeng","year":"2011","journal-title":"J Clin Investig"},{"key":"10.1016\/j.molmet.2026.102440_bib10","doi-asserted-by":"crossref","first-page":"696","DOI":"10.3389\/fimmu.2018.00696","article-title":"Macrophage lamin A\/C regulates inflammation and the development of obesity-induced insulin resistance","volume":"9","author":"Kim","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.molmet.2026.102440_bib11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.molmet.2019.08.015","article-title":"MicroRNA-10a-5p regulates macrophage polarization and promotes therapeutic adipose tissue remodeling","volume":"29","author":"Cho","year":"2019","journal-title":"Mol Metabol"},{"key":"10.1016\/j.molmet.2026.102440_bib12","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.cmet.2014.01.002","article-title":"Peroxisomes: a nexus for lipid metabolism and cellular signaling","volume":"19","author":"Lodhi","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.molmet.2026.102440_bib13","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.bbadis.2012.05.008","article-title":"Functions of plasmalogen lipids in health and disease","volume":"1822","author":"Braverman","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.molmet.2026.102440_bib14","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0005-2760(90)90141-J","article-title":"Lipoproteins secreted by cultured rat hepatocytes contain the antioxidant 1-alk-1-enyl-2-acylglycerophosphoethanolamine","volume":"1045","author":"Vance","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.molmet.2026.102440_bib15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/306069a0","article-title":"Severe plasmalogen deficiency in tissues of infants without peroxisomes (Zellweger syndrome)","volume":"306","author":"Heymans","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.molmet.2026.102440_bib16","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.chemphyslip.2011.06.008","article-title":"Plasmalogens the neglected regulatory and scavenging lipid species","volume":"164","author":"Wallner","year":"2011","journal-title":"Chem Phys Lipids"},{"key":"10.1016\/j.molmet.2026.102440_bib17","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1084\/jem.20081800","article-title":"Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes","volume":"205","author":"Oresic","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.molmet.2026.102440_bib18","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/hep.29039","article-title":"Protective role of endogenous plasmalogens against hepatic steatosis and steatohepatitis in mice","volume":"66","author":"Jang","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.molmet.2026.102440_bib19","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1007\/s00125-011-2272-8","article-title":"LDL from obese patients with the metabolic syndrome show increased lipid peroxidation and activate platelets","volume":"54","author":"Colas","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.molmet.2026.102440_bib20","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.bbalip.2013.07.009","article-title":"Dyslipidemia, but not hyperglycemia and insulin resistance, is associated with marked alterations in the HDL lipidome in type 2 diabetic subjects in the DIWA cohort: impact on small HDL particles","volume":"1831","author":"Stahlman","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.molmet.2026.102440_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000623","article-title":"Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans","volume":"9","author":"Pietilainen","year":"2011","journal-title":"PLoS Biol"},{"key":"10.1016\/j.molmet.2026.102440_bib22","doi-asserted-by":"crossref","first-page":"E649","DOI":"10.1002\/oby.20508","article-title":"The effect of short-term overfeeding on serum lipids in healthy humans","volume":"21","author":"Heilbronn","year":"2013","journal-title":"Obesity"},{"key":"10.1016\/j.molmet.2026.102440_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028539","article-title":"Alkyl-glycerol rescues plasmalogen levels and pathology of ether-phospholipid deficient mice","volume":"6","author":"Brites","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.molmet.2026.102440_bib24","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1096\/fj.05-4661fje","article-title":"Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells","volume":"20","author":"Fecchi","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.molmet.2026.102440_bib25","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1194\/jlr.R085993","article-title":"Contributions of innate type 2 inflammation to adipose function","volume":"60","author":"Bolus","year":"2019","journal-title":"J Lipid Res"},{"key":"10.1016\/j.molmet.2026.102440_bib26","first-page":"129","article-title":"Adipocyte CD1d determines adipose inflammation and insulin resistance in obesity","volume":"7","author":"Huh","year":"2018","journal-title":"Adipocyte"},{"key":"10.1016\/j.molmet.2026.102440_bib27","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.3389\/fimmu.2018.01311","article-title":"Regulatory roles of invariant natural killer T cells in adipose tissue inflammation: defenders against obesity-induced metabolic complications","volume":"9","author":"Park","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.molmet.2026.102440_bib28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S1074-7613(00)80290-3","article-title":"CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4","volume":"6","author":"Mendiratta","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.molmet.2026.102440_bib29","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/ni.2245","article-title":"Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus","volume":"13","author":"Facciotti","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.molmet.2026.102440_bib30","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.molmet.2026.102440_bib31","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.molmet.2026.102440_bib32","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/B978-0-12-411619-1.00016-1","article-title":"Flow cytometry analyses of adipose tissue macrophages","volume":"537","author":"Cho","year":"2014","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.molmet.2026.102440_bib33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10545-014-9795-3","article-title":"Plasmalogens and fatty alcohols in rhizomelic chondrodysplasia punctata and Sjogren-Larsson syndrome","volume":"38","author":"Malheiro","year":"2015","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.molmet.2026.102440_bib34","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1189\/jlb.69.4.598","article-title":"Requirement for STAT1 in LPS-induced gene expression in macrophages","volume":"69","author":"Ohmori","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.molmet.2026.102440_bib35","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.3389\/fimmu.2018.01175","article-title":"Transcriptional regulation of macrophages polarization by MicroRNAs","volume":"9","author":"Li","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.molmet.2026.102440_bib36","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.2337\/db20-0384","article-title":"STAT1 dissociates adipose tissue inflammation from insulin sensitivity in obesity","volume":"69","author":"Cox","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.molmet.2026.102440_bib37","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/ni.3691","article-title":"Mechanisms and consequences of Jak-STAT signaling in the immune system","volume":"18","author":"Villarino","year":"2017","journal-title":"Nat Immunol"},{"key":"10.1016\/j.molmet.2026.102440_bib38","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.bbrc.2018.06.084","article-title":"Scallop-derived plasmalogens attenuate the activation of PKCdelta associated with the brain inflammation","volume":"503","author":"Sejimo","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.molmet.2026.102440_bib39","doi-asserted-by":"crossref","first-page":"45603","DOI":"10.1074\/jbc.M407448200","article-title":"Protein kinase Cdelta regulates apoptosis via activation of STAT1","volume":"279","author":"DeVries","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molmet.2026.102440_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/326580","article-title":"Insulin resistance, inflammation, and obesity: role of monocyte chemoattractant protein-1 (or CCL2) in the regulation of metabolism","volume":"2010","author":"Rull","year":"2010","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.molmet.2026.102440_bib41","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1136\/gutjnl-2020-322509","article-title":"Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis","volume":"70","author":"Koh","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.molmet.2026.102440_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2023.101234","article-title":"Systematic crosstalk in plasmalogen and diacyl lipid biosynthesis for their differential yet concerted molecular functions in the cell","volume":"91","author":"Kimura","year":"2023","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.molmet.2026.102440_bib43","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/s12276-024-01222-1","article-title":"Glycerol 3-phosphate dehydrogenases (1 and 2) in cancer and other diseases","volume":"56","author":"Oh","year":"2024","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.molmet.2026.102440_bib44","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.139946","article-title":"Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol\/PKCepsilon\/insulin receptor Thr1160 phosphorylation","volume":"6","author":"Lyu","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.molmet.2026.102440_bib45","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1172\/JCI120606","article-title":"Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission","volume":"129","author":"Park","year":"2019","journal-title":"J Clin Investig"},{"issue":"Pt 3","key":"10.1016\/j.molmet.2026.102440_bib46","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1042\/bj3230807","article-title":"Delayed oxidative degradation of polyunsaturated diacyl phospholipids in the presence of plasmalogen phospholipids in vitro","volume":"323","author":"Reiss","year":"1997","journal-title":"Biochem J"},{"key":"10.1016\/j.molmet.2026.102440_bib47","doi-asserted-by":"crossref","first-page":"7817","DOI":"10.1073\/pnas.0912059107","article-title":"Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes","volume":"107","author":"Ecker","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.molmet.2026.102440_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.730829","article-title":"Plasmalogens and chronic inflammatory diseases","volume":"12","author":"Bozelli","year":"2021","journal-title":"Front Physiol"},{"key":"10.1016\/j.molmet.2026.102440_bib49","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5762395","article-title":"Lipid-Induced mechanisms of Metabolic syndrome","volume":"2020","author":"Denisenko","year":"2020","journal-title":"J Obes"},{"key":"10.1016\/j.molmet.2026.102440_bib50","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.3389\/fimmu.2017.01251","article-title":"Essential role for ethanolamine plasmalogen hydrolysis in bacterial lipopolysaccharide priming of macrophages for enhanced arachidonic acid release","volume":"8","author":"Gil-de-Gomez","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.molmet.2026.102440_bib51","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.3389\/fimmu.2018.01723","article-title":"Regulation of phagocytosis in macrophages by membrane ethanolamine plasmalogens","volume":"9","author":"Rubio","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.molmet.2026.102440_bib52","doi-asserted-by":"crossref","first-page":"14408","DOI":"10.1074\/jbc.M109671200","article-title":"Protein kinase C-delta (PKC-delta) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727","volume":"277","author":"Uddin","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molmet.2026.102440_bib53","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s42255-023-00972-y","article-title":"A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism","volume":"6","author":"Tighanimine","year":"2024","journal-title":"Nat Metab"},{"key":"10.1016\/j.molmet.2026.102440_bib54","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.bbamcr.2010.03.013","article-title":"Be different--the diversity of peroxisomes in the animal kingdom","volume":"1803","author":"Islinger","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.molmet.2026.102440_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101577","article-title":"Peroxisomal regulation of energy homeostasis: effect on obesity and related metabolic disorders","volume":"65","author":"Kleiboeker","year":"2022","journal-title":"Mol Metabol"},{"key":"10.1016\/j.molmet.2026.102440_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252011237","article-title":"Regulation of mitochondrial and peroxisomal metabolism in female obesity and type 2 diabetes","volume":"25","author":"Antelo-Cea","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.molmet.2026.102440_bib57","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.plipres.2019.04.003","article-title":"Plasmalogens: a potential therapeutic target for neurodegenerative and cardiometabolic disease","volume":"74","author":"Paul","year":"2019","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.molmet.2026.102440_bib58","doi-asserted-by":"crossref","DOI":"10.1111\/cts.70195","article-title":"First-In-Human safety, tolerability, and pharmacokinetics of PPI-1011, a synthetic plasmalogen precursor","volume":"18","author":"Smith","year":"2025","journal-title":"Clin Transl Sci"},{"key":"10.1016\/j.molmet.2026.102440_bib59","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1038\/s41467-020-15963-w","article-title":"Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity","volume":"11","author":"Seo","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.molmet.2026.102440_bib60","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molmet.2026.102440_bib61","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.2337\/db15-1624","article-title":"Nitric oxide produced by macrophages inhibits adipocyte differentiation and promotes profibrogenic responses in preadipocytes to induce adipose tissue fibrosis","volume":"65","author":"Jang","year":"2016","journal-title":"Diabetes"}],"container-title":["Molecular Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877826001249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212877826001249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:50:50Z","timestamp":1791906650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212877826001249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":61,"alternative-id":["S2212877826001249"],"URL":"https:\/\/doi.org\/10.1016\/j.molmet.2026.102440","relation":{},"ISSN":["2212-8778"],"issn-type":[{"value":"2212-8778","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GNPAT-driven plasmalogen biosynthesis regulates macrophage polarization and protects against obesity-induced inflammation by suppressing PKC\u03b4\u2013STAT1 signaling","name":"articletitle","label":"Article Title"},{"value":"Molecular Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molmet.2026.102440","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"102440"}}