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The study of patients with BRCA mutation has been of particular value, in as much as the examination of prophylactic salpingo\u2010oophorectomies will reveal an early cancer in approximately 5% of individuals. Recently studies have shown that about 80% of these early carcinomas originate in the distal fallopian tube. This review summarizes the recent data supporting the distal fallopian tube as an important site for serous carcinogenesis, stressing both the presence of a novel precursor (the p53 signature) and the application of this model to all women irrespective of BRCA status. The challenges and unmet needs unmasked by this paradigm shift in ovarian cancer research are discussed.<\/jats:p>","DOI":"10.1016\/j.molonc.2009.01.004","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T17:22:55Z","timestamp":1233768175000},"page":"165-170","source":"Crossref","is-referenced-by-count":135,"title":["Intercepting pelvic cancer in the distal fallopian tube: Theories and realities"],"prefix":"10.1002","volume":"3","author":[{"given":"Christopher P.","family":"Crum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"e_1_2_3_2_1","unstructured":"2007 American Cancer Society Cancer Facts and Figures"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90203-1"},{"key":"e_1_2_3_4_1","first-page":"49","article-title":"Early adenocarcinoma of the fallopian tubes. 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