{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:02:49Z","timestamp":1792670569151,"version":"4.5.0"},"reference-count":105,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:00:00Z","timestamp":1234224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p>Germline mutations of the BRCA1 and BRCA2 genes confer a high life\u2010time risk of ovarian cancer. They represent the most significant and well characterised genetic risk factors so far identified for the disease. The frequency with which BRCA1\/2 mutations occur in families containing multiple cases of ovarian cancer or breast and ovarian cancer, and in population\u2010based ovarian cancer series varies geographically and between different ethnic groups. There are differences in the frequency of common mutations and in the presence of specific founder mutations in different populations. BRCA1 and BRCA2 are responsible for half of all families containing two or more ovarian cancer cases. In population\u2010based studies, BRCA1 and BRCA2 mutations are present in 5\u201315% of all ovarian cancer cases. Often, individuals in which mutations are identified in unselected cases have no family history of either ovarian or breast cancer. The ability to identify BRCA1\/2 mutations has been one of the few major success stories over the last few years in the clinical management of ovarian cancer. Currently, unaffected individuals can be screened for mutations if they have a family history of the disease. If a mutation is identified in the family, and if an individual is found be a mutation carrier, they can be offered clinical intervention strategies that can dramatically reduce their ovarian cancer risks. In some populations with frequent founder mutations screening may not be dependant on whether a mutation is identified in an affected relative.<\/jats:p>","DOI":"10.1016\/j.molonc.2009.02.001","type":"journal-article","created":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T22:40:41Z","timestamp":1234392041000},"page":"138-150","source":"Crossref","is-referenced-by-count":214,"title":["The Contribution of\n                    <i>BRCA1<\/i>\n                    and\n                    <i>BRCA2<\/i>\n                    to Ovarian Cancer"],"prefix":"10.1002","volume":"3","author":[{"given":"Susan J.","family":"Ramus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Gayther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00110-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/375033"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.024133"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.056556"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.2.463"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5270"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-004-5812-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.6.361"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22817"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602199"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.17.2260"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.1.9034168"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.1066"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1670"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.6905"},{"key":"e_1_2_6_18_1","first-page":"1673","article-title":"Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13","volume":"10","author":"Collins N.","year":"1995","journal-title":"Oncogene"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/BD-2007-27102"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10260"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00050-7"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1414.020"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05887"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.90"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-006-9101-0"},{"key":"e_1_2_6_26_1","first-page":"115","article-title":"Epidemiology of ovarian cancer","author":"Elmasry K.","year":"2007","journal-title":"Cancer of the Ovary"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1750"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2008.00974.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm234"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/301749"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.6.1480"},{"key":"e_1_2_6_32_1","first-page":"60","article-title":"BRCA1 and BRCA2 pathways and the risk of cancers other than breast or ovarian","volume":"7","author":"Friedenson B.","year":"2005","journal-title":"MedGenMed"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-428"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-103"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1086\/302583"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209874"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.89"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.019430"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20162"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00568.x"},{"key":"e_1_2_6_41_1","first-page":"90","article-title":"BRCA1 wild-type allele modifies risk of ovarian cancer in carriers of BRCA1 germ-line mutations","volume":"12","author":"Ginolhac S.M.","year":"2003","journal-title":"Cancer Epidemiol. 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