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The validity of this assumption is demonstrated by the development of specific inhibitors or antibodies that eliminate tumoral cells by targeting some of these changes. Imatinib, an inhibitor of the tyrosine kinase ABL, the prototype of these targeting drugs, is yielding complete remissions in most CML patients. Knowledge of chromosomal abnormalities is becoming an essential contribution to the diagnosis and prognosis of cancers but also for monitoring minimal residual disease or relapse. The concept of the \u201ccytogenetic uniqueness\u201d of each cancer has resulted in personalized treatment. This investigation will expound upon, besides the recurrent genomic alterations, the numerous products of perverted Darwinian selection at the cellular level.<\/jats:p>","DOI":"10.1016\/j.molonc.2010.06.003","type":"journal-article","created":{"date-parts":[[2010,6,12]],"date-time":"2010-06-12T08:53:27Z","timestamp":1276332807000},"page":"309-322","source":"Crossref","is-referenced-by-count":26,"title":["Cytogenomics of cancers: From chromosome to sequence"],"prefix":"10.1002","volume":"4","author":[{"given":"Alain","family":"Bernheim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,11]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1215"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1791"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206686"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/35094086"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1980.tb07179.x"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(81)90039-X"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(81)90005-9"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08822"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6522707"},{"key":"e_1_2_17_11_1","unstructured":"1914 Gustav Fisher Jena T. 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