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Many progression markers both in tissues and serum, including circulating tumor cells, have been studied and new molecular markers are awaited from high\u2010throughput screenings to discriminate between clinical stages and predict disease progression.<\/jats:p><jats:p>The present review focuses on human tyrosinase related protein 1 also known as gp75 glycoprotein (Tyrp1\/gp75), a melanosomal protein involved in the pigmentary machinery of the melanocyte and often used as differentiation marker, with a special emphasis on its emerging roles in the malignant melanocyte and melanoma progression.<\/jats:p>","DOI":"10.1016\/j.molonc.2011.01.006","type":"journal-article","created":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T09:15:50Z","timestamp":1296810950000},"page":"150-155","source":"Crossref","is-referenced-by-count":93,"title":["Tyrosinase related protein 1 (TYRP1\/gp75) in human cutaneous melanoma"],"prefix":"10.1002","volume":"5","author":[{"given":"Ghanem","family":"Ghanem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Journ\u00e9","family":"Fabrice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,3]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00005.x"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2770393"},{"issue":"6","key":"e_1_2_3_4_1","first-page":"293","article-title":"The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas","volume":"5","author":"Bolander A.","year":"2008","journal-title":"Cancer Genomics Proteomics"},{"issue":"6","key":"e_1_2_3_5_1","first-page":"1145","article-title":"Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: a new subtype of albinism classified as \"OCA3","volume":"58","author":"Boissy R.E.","year":"1996","journal-title":"Am. 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