{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:33:09Z","timestamp":1788492789709,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T00:00:00Z","timestamp":1298505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Netherlands Organization for Scientific Research"},{"name":"the Fondation Ren\u00e9 Touraine"},{"DOI":"10.13039\/501100000651","name":"Leukaemia and Lymphoma Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000651","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Julian Starmer-Smith Memorial Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>MicroRNAs (miRNAs) are small RNA species that regulate gene expression post\u2010transcriptionally and are aberrantly expressed in many malignancies including lymphoma. However, the role of miRNAs in the pathogenesis of T\u2010cell lymphoid malignancies is poorly understood. Previously we examined the miRNA profile of S\u00e9zary syndrome (Sz), a leukemia of skin\u2010homing memory T cells. In this study we determined the complete miRNome of mycosis fungoides (MF), the most common type of cutaneous T cell lymphoma. The miRNA profile of skin biopsies from 19 patients with tumor stage MF and 12 patients with benign inflammatory dermatoses (eczema and lichen planus) were compared by microarray analysis. We identified 49 miRNAs that are differentially expressed in tumor stage MF compared to benign inflammatory dermatoses using ANOVA analysis (P\u00a0&lt;\u00a00.05, Benjamini\u2013Hochberg corrected). The majority of the differentially expressed miRNAs (30\/49) were up\u2010regulated in tumor stage MF. The most significant differentially expressed were miR\u2010155 and miR\u201092a (both up\u2010regulated in tumor stage MF), while miR\u201093 showed the highest up\u2010regulation in tumor stage MF with a fold difference of 5.8. Differential expression of a selection of these miRNAs was validated by miRNA\u2010Q\u2010PCR on additional test groups (tumors and controls). None of the miRNAs up\u2010regulated in tumor stage MF was previously shown to be up\u2010regulated in Sz, and only 2 of the 19 miRNAs down\u2010regulated in tumor stage MF were also down\u2010regulated in Sz. Taken together this report is the first describing the miRNA signature of tumor stage MF.<\/jats:p>","DOI":"10.1016\/j.molonc.2011.02.003","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T12:47:33Z","timestamp":1298724453000},"page":"273-280","source":"Crossref","is-referenced-by-count":91,"title":["miRNA expression profiling of mycosis fungoides"],"prefix":"10.1002","volume":"5","author":[{"given":"Marloes S.","family":"van Kester","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Ballabio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marchina F.","family":"Benner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao H.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel J.","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"van der Fits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remco","family":"van Doorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten H.","family":"Vermeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rein","family":"Willemze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis P.","family":"Tensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles 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