{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:12:23Z","timestamp":1791576743780,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T00:00:00Z","timestamp":1321574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["NSFC81072228"],"award-info":[{"award-number":["NSFC81072228"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Natural Science Foundation","doi-asserted-by":"crossref","award":["10151008901000093"],"award-info":[{"award-number":["10151008901000093"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Natural Science Foundation","doi-asserted-by":"crossref","award":["S2011020002325"],"award-info":[{"award-number":["S2011020002325"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Cooperative Project of Science and Technology of Guangdong Province","award":["1011420600001"],"award-info":[{"award-number":["1011420600001"]}]},{"name":"NIH PHS","award":["CA139596"],"award-info":[{"award-number":["CA139596"]}]},{"name":"T32 training grant","award":["T32DE018381"],"award-info":[{"award-number":["T32DE018381"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>Microtubule\u2010associated tumor suppressor gene (MTUS1, also known as mitochondrial tumor suppressor) is a recently identified tumor suppressor gene that has been implicated in several cancer types. The expression of MTUS1 gene leads to 5 known transcript variants and codes for 5 isoforms of Angiotensin II AT2 receptor interacting protein (ATIP). In this study, we first confirmed that the down\u2010regulation of MTUS1\/ATIP was a frequent event in oral tongue squamous cell carcinoma (OTSCC) and the premalignant lesion (leukoplakia). We further demonstrated that the down\u2010regulation of MTUS1\/ATIP was correlated with poor differentiation and enhanced proliferation (Ki67 proliferation index). Statistical analysis suggests that the down\u2010regulation of MTUS1\/ATIP was associated with reduced overall survival. Isoform specific quantitative RT\u2010PCR assays revealed that ATIP1, ATIP3a and ATIP3b were the major isoforms of the MTUS1 gene products in oral tongue epithelial cells. Significant down\u2010regulations were observed for all 3 ATIP isoforms in OTSCC as compared to matching normal tissues. In\u00a0vitro functional study showed that the restoration of ATIP1 expression led to G1 arrest, apoptosis and reduction of cell proliferation in OTSCC cell lines. These ATIP1\u2010induced cellular changes were accompanied by reduced phosphorylation of ERK1\/2 and up\u2010regulation of p53. Taken together, these data suggest that MTUS1 plays major roles in the progression of OTSCC, and may serve as a biomarker or therapeutic target for patients with OTSCC.<\/jats:p>","DOI":"10.1016\/j.molonc.2011.11.002","type":"journal-article","created":{"date-parts":[[2011,11,19]],"date-time":"2011-11-19T08:50:45Z","timestamp":1321692645000},"page":"73-80","source":"Crossref","is-referenced-by-count":51,"title":["Down\u2010regulation of tumor suppressor MTUS1\/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma"],"prefix":"10.1002","volume":"6","author":[{"given":"Xueqiang","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushen","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoxu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anxun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2010.100098"},{"key":"e_1_2_7_3_1","first-page":"919","article-title":"p53 regulates the expression of human angiotensin II AT2 receptor interacting protein (ATIP1) gene","volume":"2","author":"Chen Z.","year":"2011","journal-title":"Oncol. 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