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The aim of our study has been to investigate the microRNAs (miRNAs or miRs) regulated by the HMGA1 proteins in the process of cell transformation analyzing the miRNA expression profile of v\u2010ras\u2010Ki oncogene\u2010transformed thyroid cells expressing or not HMGA1 proteins. We demonstrate that, among the miRNAs regulated by cell transformation, there are miR\u201010b, miR\u201021, miR\u2010125b, miR\u2010221 and miR\u2010222 that are positively and miR\u201034a and miR\u2010603 that are negatively regulated by HMGA1 expression. Then, we focused our attention on the miR\u201010b and miR\u2010603 whose expression was dependent on the presence of HMGA1 also in other cell systems. We found that miR\u201010b is able to target the PTEN gene, whereas miR\u2010603 targets the CCND1 and CCND2 genes coding for the cyclin D1 and cyclin D2 proteins, respectively. Moreover, functional studies showed that miR\u201010b and miR\u2010603 regulate positively and negatively, respectively, cell proliferation and migration suggesting a role of their dysregulation in thyroid cell transformation.<\/jats:p>","DOI":"10.1016\/j.molonc.2013.01.002","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T07:16:38Z","timestamp":1358406998000},"page":"531-542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["The High Mobility Group A proteins contribute to thyroid cell transformation by regulating miR\u2010603 and miR\u201010b expression"],"prefix":"10.1002","volume":"7","author":[{"given":"Paula","family":"Mussnich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"D'Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenza","family":"Leone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Maria","family":"Croce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Fusco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.2.487"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.556"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M000564200"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.141224998"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.7.2225-2238.2003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010656"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10275"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.3.1545"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205368"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203633"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3482"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e318164145e"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205428"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208501"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1889"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.04.024"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2009.11.007"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.09.045"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2637"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.7.9.3365"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2271"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652412798376170"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02461.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3037"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318228280a"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.6.6.15874"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/371175a0"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5308.1943"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.5.21.3428"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603654"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0597-64"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403293101"},{"key":"e_1_2_8_35_1","first-page":"1553","article-title":"miR-10b promotes cell invasion through RhoC-AKT signaling pathway by targeting HOXD10 in gastric cancer","volume":"40","author":"Liu Z.","year":"2012","journal-title":"Int. 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