{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:54:42Z","timestamp":1789206882459,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T00:00:00Z","timestamp":1379721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"South-Eastern Regional Health Authority"},{"name":"Holes foundation"},{"name":"Johs. I. Svanholms foundation"},{"name":"Gunnar Kristian Olsen and Randi Andresens foundation"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>The conventional first\u2010line chemotherapy for metastatic colorectal cancer (mCRC) consists of fluorouracil (5\u2010FU) in combination with either oxaliplatin or irinotecan. We have explored microRNAs (miRNAs) in plasma as potential predictive markers to oxaliplatin\u2010based chemotherapy. The expression of 742 miRNAs was examined in plasma samples from 24 mCRC patients (12 responders and 12 non\u2010responders) before onset and after four cycles of 5\u2010FU\/oxaliplatin. The top differentially expressed miRNAs between responders and non\u2010responders were selected for further analysis in a validation cohort of 150 patients. In the validation cohort, there was a significant overrepresentation of miRNAs with higher mean expression in the non\u2010responder group than in the responder group before treatment (p\u00a0&lt;\u00a00.002). Moreover, we found three miRNAs (miR\u2010106a, miR\u2010484, and miR\u2010130b) to be significantly differentially expressed before treatment (p\u00a0=\u00a00.008, 0.008, and 0.008, respectively). All three miRNAs were upregulated in non\u2010responders. High expression of miR\u201027b, miR\u2010148a, and miR\u2010326 were associated with decreased progression\u2010free survival (Hazard ratios (HR) of 1.4 (95% CI 1.1\u20131.8, p\u00a0=\u00a00.004), 1.3 (95% CI 1.1\u20131.6, p\u00a0=\u00a00.007), and 1.4 (95% CI 1.1\u20131.8, p\u00a0=\u00a00.008), respectively). miR\u2010326 was also associated with decreased overall survival (HR 1.5 (95% CI 1.1\u20132.0, p\u00a0=\u00a00.003)). There were no significantly differentially expressed miRNAs in association with clinical outcome after four cycles of chemotherapy. The present study demonstrates that plasma miRNAs analyzed before treatment may serve as non\u2010invasive markers predicting outcome in mCRC patients treated with 5\u2010FU and oxaliplatin\u2010based chemotherapy.<\/jats:p>","DOI":"10.1016\/j.molonc.2013.09.001","type":"journal-article","created":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T06:45:56Z","timestamp":1379745956000},"page":"59-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":129,"title":["Plasma microRNAs predicting clinical outcome in metastatic colorectal cancer patients receiving first\u2010line oxaliplatin\u2010based treatment"],"prefix":"10.1002","volume":"8","author":[{"given":"J.B.","family":"Kjersem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ikdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.C.","family":"Lingjaerde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Guren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.","family":"Tveit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.H.","family":"Kure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0496"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-374"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28043"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100048108"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2012.11.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.05.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-012-2003-z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017745"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-012-0089-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20580"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1798"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1840"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043452"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.172"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.12.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-83"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.12.018"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.121"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-012-0210-3"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0267"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601912448068"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23271"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.365"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0484-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.270561"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.10.017"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0027"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301122"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-6-r64"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804549105"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.81"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.167817"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013515"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2013.02.016"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603233"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.4.425"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1262"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046684"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707351104"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.205"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.113"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1403"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.0915"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-011-9435-3"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510565103"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.07.021"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02750.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.28"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24782"},{"key":"e_1_2_7_52_1","first-page":"121","article-title":"5-Fluorouracil and oxaliplatin modify the expression profiles of MicroRNAs in human colon cancer cells in\u00a0Vitro","volume":"23","author":"Zhou J.","year":"2010","journal-title":"Oncol. Rep."}],"container-title":["Molecular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.molonc.2013.09.001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.molonc.2013.09.001","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1574789113001257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1574789113001257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.molonc.2013.09.001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:01:11Z","timestamp":1695477671000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.molonc.2013.09.001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,21]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1016\/j.molonc.2013.09.001"],"URL":"https:\/\/doi.org\/10.1016\/j.molonc.2013.09.001","archive":["Portico"],"relation":{},"ISSN":["1574-7891","1878-0261"],"issn-type":[{"value":"1574-7891","type":"print"},{"value":"1878-0261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,21]]},"assertion":[{"value":"2013-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}