{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:19:17Z","timestamp":1786994357627,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T00:00:00Z","timestamp":1387843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Several biomarkers have been proposed as useful parameters to better specify the prognosis or to delineate new target therapy strategies for glioblastoma patients. MicroRNAs could represent putative target molecules, considering their role in tumorigenesis, cancer progression and their specific tissue expression. Although several studies have tried to identify microRNA signature for glioblastoma, a microRNA profile is still far from being well\u2010defined.<\/jats:p>\n                  <jats:p>In this work the expression of 19 microRNAs (miR\u20107, miR\u20109, miR\u20109\u2217, miR\u201010a, miR\u201010b, miR\u201017, miR\u201020a, miR\u201021, miR\u201026a, miR\u201027a, miR\u201031, miR\u201034a, miR\u2010101, miR\u2010137, miR\u2010182, miR\u2010221, miR\u2010222, miR\u2010330, miR\u2010519d) was evaluated in sixty formalin\u2010fixed and paraffin\u2010embedded glioblastoma samples using a locked nucleic acid real\u2010time PCR. Moreover, a comparison of miRNA expressions was performed between primary brain neoplasias of different grades (grades IV\u2013I).<\/jats:p>\n                  <jats:p>The analysis of 14 validated miRNA expression in the 60 glioblastomas, using three different non\u2010neoplastic references as controls, revealed a putative miRNA signature: mir\u201010b and miR\u201021 were up\u2010regulated, while miR\u20107, miR\u201031, miR\u2010101, miR\u2010137, miR\u2010222 and miR\u2010330 were down\u2010regulated in glioblastomas. Comparing miRNA expression between glioblastoma group and gliomas of grades I\u2013III, 3 miRNAs (miR\u201010b, mir\u201034a and miR\u2010101) showed different regulation statuses between high\u2010grade and low\u2010grade tumors. miR\u201010b was up\u2010regulated in high grade and significantly down\u2010regulated in low\u2010grade gliomas, suggesting that could be a candidate for a GBM target therapy.<\/jats:p>\n                  <jats:p>This study provides further data for the identification of a miRNA profile for glioblastoma and suggests that different\u2010grade neoplasia could be characterized by different expression of specific miRNAs.<\/jats:p>","DOI":"10.1016\/j.molonc.2013.12.010","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T17:30:25Z","timestamp":1387906225000},"page":"417-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Expression of 19 microRNAs in glioblastoma and comparison with other brain neoplasia of grades I\u2013III"],"prefix":"10.1002","volume":"8","author":[{"given":"Michela","family":"Visani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"de Biase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Marucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serenella","family":"Cerasoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evandro","family":"Nigrisoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Bacchi Reggiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorenzo","family":"Albani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Baruzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Pession","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the PERNO study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.4969"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/597915"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0137"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.06.034"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(00)02065-5"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.07.030"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-9797-4"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808788200"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035596"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5385-07.2008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-4-163"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2011.05.002"},{"key":"e_1_2_10_15_1","first-page":"1100","article-title":"Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival","volume":"8","author":"Ermoian R.P.","year":"2002","journal-title":"Clin. 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