{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:38:08Z","timestamp":1790660288276,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Suppressor of cytokine signaling (SOCS) 1 is an inducible negative regulator of cytokine signaling but its role in human cancer is not completely established. Here we report that, while SOCS1 is expressed in normal colonic epithelium and colon adenocarcinomas, its level decreases during progression of colon adenocarcinomas, the lowest level being found in the most aggressive stage and least differentiated carcinomas. Forced expression of SOCS1 in metastatic colorectal SW620 cells reverses many characteristics of Epithelial\u2013Mesenchymal Transition (EMT), as highlighted by the disappearance of the transcription factor ZEB1 and the mesenchymal form of p120ctn and the re\u2010expression of E\u2010cadherin. Furthermore, miRNA profiling indicated that SOCS1 also up\u2010regulates the expression of the mir\u2010200 family of miRNAs, which can promote the mesenchymal\u2013epithelial transition and reduce tumor cell migration. Accordingly, overexpression of SOCS1 induced cell morphology changes and dramatically reduced tumor cell invasion <jats:italic>in\u00a0vitro<\/jats:italic>. When injected in nude mice, SOCS1\u2010expressing SW620 cells induced metastases in a smaller number of animals than parental SW620 cells, and did not generate any adrenal gland or bone metastasis. Overall, our results suggest that SOCS1 controls metastatic progression of colorectal tumors by preventing the mesenchymal\u2013epithelial transition (MET), including E\u2010cadherin expression. This pathway may be associated with survival to colorectal cancer by reducing the capacity of generating metastases.<\/jats:p>","DOI":"10.1016\/j.molonc.2014.03.014","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T05:46:35Z","timestamp":1395726395000},"page":"942-955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Suppressor of cytokine signaling 1 modulates invasion and metastatic potential of colorectal cancer cells"],"prefix":"10.1002","volume":"8","author":[{"given":"Muriel","family":"David","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Naudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Letourneur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Polrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack-Michel","family":"Renoir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Lazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Dessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Roche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Bertoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane","family":"Pierre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2013.35"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80047-1"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.8.1319"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1942"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2008.74"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605078"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200307111"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2922"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24543"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.12.2591"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208429"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.10.3547-3557.2001"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1262-0"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060436"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1429"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.442"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301846"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1058"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00020.x"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200205115"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120812"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105575200"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1252404"},{"key":"e_1_2_13_25_1","first-page":"4562","article-title":"Classification of human colorectal adenocarcinoma cell lines","volume":"36","author":"Leibovitz A.","year":"1976","journal-title":"Cancer Res."},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.05.004"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23408.x"},{"key":"e_1_2_13_28_1","first-page":"341","article-title":"Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features","volume":"11","author":"Lin S.Y.","year":"2004","journal-title":"Oncol. Rep."},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-4-9"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706987200"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-9-103"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.12.3587"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.10.5691"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5259.263"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.2.375"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063695"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01275-08"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704652104"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210543"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.21841"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5682"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.007"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403223200"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.12.017"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2009.03.002"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1834"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-010-0030-2"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.5.1309"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031675"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0501-29"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.2071"}],"container-title":["Molecular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.molonc.2014.03.014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.molonc.2014.03.014","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1574789114000623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1574789114000623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.molonc.2014.03.014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:12:59Z","timestamp":1695514379000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.molonc.2014.03.014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,25]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1016\/j.molonc.2014.03.014"],"URL":"https:\/\/doi.org\/10.1016\/j.molonc.2014.03.014","archive":["Portico"],"relation":{},"ISSN":["1574-7891","1878-0261"],"issn-type":[{"value":"1574-7891","type":"print"},{"value":"1878-0261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,25]]},"assertion":[{"value":"2013-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}