{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:06:22Z","timestamp":1791421582209,"version":"4.3.3"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T00:00:00Z","timestamp":1441756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research Fund of Science and Technology office","award":["2008225008-10"],"award-info":[{"award-number":["2008225008-10"]}]},{"name":"Scientific Research Fund of Science and Technology office","award":["2011225019"],"award-info":[{"award-number":["2011225019"]}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer, it remains a huge challenge to understand the cellular and molecular mechanisms of the aggressive behavior of EOC cells. Here we investigated the role of an immunomodulatory cytokine IL\u201033 and its receptor ST2 in mediating the growth and metastasis of EOC. Our data show that both IL\u201033 and ST2 were highly up\u2010regulated in EOC tumors compared with normal ovary and ovarian benign tumors, and the expression levels were further increased in tumor tissues at the metastatic site. The expression levels of IL\u201033 and ST2 were positively correlated with the Ki\u201067 expression, and negatively correlated with the patient survival time. Using EOC cell lines, we observed that cells knocked down of IL\u201033 gene by siRNA had reduced migratory and invasive potential, while full length human IL\u201033 (fl\u2010hIL\u201033) promoted the invasive, migratory and proliferative capacity of EOC cells and this process could be inhibited by IL\u201033 decoy receptor sST2. Signaling pathway analysis suggested that IL\u201033 increased the phosphorylation of ERK and JNK which was blocked by sST2. Fl\u2010hIL\u201033\u2010induced increases in EOC cell migration, invasive potential and proliferation were specifically abrogated by treatment with the ERK inhibitor U0126 while JNK inhibitor SP600125 only disrupted IL\u201033\u2010induced enhancement of cell viability. Taken together, our data suggest that IL\u201033\/ST2 axis closely associates with poor prognosis of EOC patients, and it promotes ovarian cancer growth and metastasis through regulating ERK and JNK signaling pathways. Thus IL\u201033\/ST2 might be potential prognosis markers and therapeutic targets for EOC patients.<\/jats:p>","DOI":"10.1016\/j.molonc.2015.06.004","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T21:16:26Z","timestamp":1441746986000},"page":"113-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Interleukin\u201033 predicts poor prognosis and promotes ovarian cancer cell growth and metastasis through regulating ERK and JNK signaling pathways"],"prefix":"10.1002","volume":"10","author":[{"given":"Xiaoguang","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Barbour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kezuo","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingli","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Rong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.7-suppl_5-20"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63631-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444671"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800306"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1593\/tlo.12418"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041033"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4226"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-203372"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not234"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.03.002"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401344"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001115)89:10<2068::AID-CNCR6>3.0.CO;2-Z"},{"key":"e_1_2_9_14_1","first-page":"1","article-title":"Old and new immunohistochemical markers for the diagnosis of gastrointestinal stromal tumors","volume":"33","author":"Gonzalez-Campora R.","year":"2011","journal-title":"Anal. 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