{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:31:58Z","timestamp":1787225518951,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T00:00:00Z","timestamp":1469750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health, National Cancer Institute, Center for Cancer Research","doi-asserted-by":"publisher","award":["ZIA BC011513"],"award-info":[{"award-number":["ZIA BC011513"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Near infrared photoimmunotherapy (NIR\u2010PIT) is a new, highly\u2010selective cancer theranostics that employs an antibody\u2010photo absorber conjugate (APC). NIR\u2010PIT has successfully treated preclinical tumor models with APCs and is now in the first\u2010in\u2010human phase 1 clinical trial for head and neck cancer patients against EGFR. CD20 is highly expressed in many B\u2010cell lymphomas and is emerging as a molecular target for this disease. Here, we describe the use of the anti\u2010CD20 monoclonal antibody (mAb), rituximab\u2010IR700 APC for NIR\u2010PIT of B\u2010cell lymphoma in two CD20\u2010expressing lymphoma mouse models. CD20 expressing B\u2010cell lymphoma cell lines (Daudi and Ramos) were used in this study. Rituximab\u2010IR700, rituximab conjugated with IRDye700DX, showed specific binding, and cell\u2010specific killing only after exposure of NIR light to both cells in\u00a0vitro. To evaluate effects of NIR\u2010PIT in\u00a0vivo, tumor\u2010bearing mice were separated into 4 groups: (1) control; (2) APC i.v. only; (3) NIR light exposure only; (4) APC and NIR light (NIR\u2010PIT). These were performed every week for up to 3 weeks. Rituximab\u2010IR700 showed high tumor accumulation and high target\u2010to\u2010background ratio in\u00a0vivo. Tumor growth was significantly inhibited by NIR\u2010PIT in comparison with the other groups (p\u00a0&lt;\u00a00.001 for both tumors), and survival was significantly prolonged in both tumors (p\u00a0&lt;\u00a00.001 for Daudi tumors and p\u00a0&lt;\u00a00.0001 for Ramos tumors vs other groups). More than half of tumors were cured with this single regimen of NIR\u2010PIT. In conclusion, anti\u2010CD20 rituximab\u2010IR700 works as a highly effective APC for NIR\u2010PIT against B\u2010cell lymphoma.<\/jats:p>","DOI":"10.1016\/j.molonc.2016.07.010","type":"journal-article","created":{"date-parts":[[2016,7,30]],"date-time":"2016-07-30T01:12:48Z","timestamp":1469841168000},"page":"1404-1414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Near infrared photoimmunotherapy of B\u2010cell lymphoma"],"prefix":"10.1002","volume":"10","author":[{"given":"Tadanobu","family":"Nagaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiko","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Choyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisataka","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200229"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21753"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052283"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00132"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.7193"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cji.0000203081.43235.d7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-199811000-00012"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3175"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc200648m"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2554"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61177-X"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.04.003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8025"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136829"},{"key":"e_1_2_9_16_1","unstructured":"2016 M. Ogawa Y. Tomita Y. Nakamura M.-J. Lee S. Lee S. Tomita T. Nagaya K. Sato T. Yamauchi H. Iwai A. Kumar T. Haystead H. Shroff P.L. Choyke J.B. Trepel H. Kobayashi Immunogenic Cancer Cell Death Selectively Induced by Near-infrared Photoimmunotherapy"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.2.435.435"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn305011p"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0633"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2014.01.006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.05.018"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90276-3"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040119"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt058"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.593274"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.149526"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620713514682"}],"container-title":["Molecular Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.molonc.2016.07.010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.molonc.2016.07.010","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1574789116300709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1574789116300709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.molonc.2016.07.010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:06:51Z","timestamp":1695499611000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.molonc.2016.07.010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,29]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1016\/j.molonc.2016.07.010"],"URL":"https:\/\/doi.org\/10.1016\/j.molonc.2016.07.010","archive":["Portico"],"relation":{},"ISSN":["1574-7891","1878-0261"],"issn-type":[{"value":"1574-7891","type":"print"},{"value":"1878-0261","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,29]]},"assertion":[{"value":"2016-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}