{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:46:48Z","timestamp":1794048408331,"version":"4.8.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.molp.2020.01.006","type":"journal-article","created":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T11:34:45Z","timestamp":1579347285000},"page":"634-649","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":148,"title":["bHLH121 Functions as a Direct Link that Facilitates the Activation of FIT by bHLH IVc Transcription Factors for Maintaining Fe Homeostasis in Arabidopsis"],"prefix":"10.1016","volume":"13","author":[{"given":"Rihua","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuerong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengna","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengkai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0622-4043","authenticated-orcid":false,"given":"Gang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molp.2020.01.006_bib1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev-arplant-050213-035759","article-title":"Iron cofactor assembly in plants","volume":"65","author":"Balk","year":"2014","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.molp.2020.01.006_bib2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1471-2164-10-147","article-title":"Early iron-deficiency-induced transcriptional changes in Arabidopsis roots as revealed by microarray analyses","volume":"10","author":"Buckhout","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.molp.2020.01.006_bib3","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1038\/srep02854","article-title":"A new protein-protein interaction sensor based on tripartite split-GFP association","volume":"3","author":"Cabantous","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molp.2020.01.006_bib4","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1111\/pce.13321","article-title":"A FIT-binding protein is involved in modulating iron and zinc homeostasis in Arabidopsis","volume":"41","author":"Chen","year":"2018","journal-title":"Plant Cell Environ."},{"key":"10.1016\/j.molp.2020.01.006_bib5","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1105\/tpc.104.024315","article-title":"The essential basic helix-loop-helix protein FIT1 is required for the iron deficiency response","volume":"16","author":"Colangelo","year":"2004","journal-title":"Plant Cell"},{"key":"10.1016\/j.molp.2020.01.006_bib6","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.molp.2018.06.005","article-title":"Four IVa bHLH transcription factors are novel interactors of FIT and mediate JA inhibition of iron uptake in Arabidopsis","volume":"11","author":"Cui","year":"2018","journal-title":"Mol. Plant"},{"key":"10.1016\/j.molp.2020.01.006_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.arplant.54.031902.135018","article-title":"Iron transport and signaling in plants","volume":"54","author":"Curie","year":"2003","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.molp.2020.01.006_bib8","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1126\/science.1153795","article-title":"Cell identity mediates the response of Arabidopsis roots to abiotic stress","volume":"320","author":"Dinneny","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.molp.2020.01.006_bib9","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1073\/pnas.93.11.5624","article-title":"A novel iron-regulated metal transporter from plants identified by functional expression in yeast","volume":"93","author":"Eide","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.molp.2020.01.006_bib10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/nph.12471","article-title":"Involvement of the ABCG37 transporter in secretion of scopoletin and derivatives by Arabidopsis roots in response to iron deficiency","volume":"201","author":"Fourcroy","year":"2014","journal-title":"New Phytol."},{"key":"10.1016\/j.molp.2020.01.006_bib66","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1105\/tpc.19.00541","article-title":"The transcription factor bHLH121 interacts with bHLH105 (ILR3) and its closest homologs to regulate iron homeostasis in Arabidopsis","volume":"32","author":"Gao","year":"2020","journal-title":"Plant Cell."},{"key":"10.1016\/j.molp.2020.01.006_bib11","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1093\/jxb\/erq203","article-title":"Ethylene and nitric oxide involvement in the up-regulation of key genes related to iron acquisition and homeostasis in Arabidopsis","volume":"61","author":"Garcia","year":"2010","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.molp.2020.01.006_bib12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s12870-014-0231-5","article-title":"Functional characterisation of Arabidopsis SPL7 conserved protein domains suggests novel regulatory mechanisms in the Cu deficiency response","volume":"14","author":"Garcia-Molina","year":"2014","journal-title":"BMC Plant Biol."},{"key":"10.1016\/j.molp.2020.01.006_bib13","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.devcel.2019.01.006","article-title":"CIPK11-Dependent phosphorylation modulates FIT activity to promote Arabidopsis iron acquisition in response to calcium signaling","volume":"48","author":"Gratz","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.molp.2020.01.006_bib14","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/nph.16168","article-title":"Phospho-mutant activity assays provide evidence for alternative phospho-regulation pathways of the transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR","volume":"225","author":"Gratz","year":"2020","journal-title":"New Phytol."},{"key":"10.1016\/j.molp.2020.01.006_bib15","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/s41477-018-0266-y","article-title":"IRON MAN is a ubiquitous family of peptides that control iron transport in plants","volume":"4","author":"Grillet","year":"2018","journal-title":"Nat. Plants"},{"key":"10.1016\/j.molp.2020.01.006_bib16","doi-asserted-by":"crossref","first-page":"13296","DOI":"10.1073\/pnas.192412899","article-title":"Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors","volume":"99","author":"Guan","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.molp.2020.01.006_bib17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.pbi.2009.05.006","article-title":"Physiological functions of mineral micronutrients (Cu, Zn, Mn, Fe, Ni, Mo, B, Cl)","volume":"12","author":"H\u00e4nsch","year":"2009","journal-title":"Curr. Opin. Plant Biol."},{"key":"10.1016\/j.molp.2020.01.006_bib18","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/molbev\/msg088","article-title":"The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity","volume":"20","author":"Heim","year":"2003","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.molp.2020.01.006_bib19","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.febslet.2004.10.062","article-title":"FRU (BHLH029) is required for induction of iron mobilization genes in Arabidopsis thaliana","volume":"577","author":"Jakoby","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.molp.2020.01.006_bib20","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1111\/pce.13192","article-title":"Changes in iron availability in Arabidopsis are rapidly sensed in the leaf vasculature and impaired sensing leads to opposite transcriptional programs in leaves and roots","volume":"41","author":"Khan","year":"2018","journal-title":"Plant Cell Environ."},{"key":"10.1016\/j.molp.2020.01.006_bib67","doi-asserted-by":"crossref","first-page":"24933","DOI":"10.1073\/pnas.1916892116","article-title":"The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI","volume":"116","author":"Kim","year":"2019","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1016\/j.molp.2020.01.006_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plantsci.2013.04.006","article-title":"Arabidopsis thaliana nicotianamine synthase 4 is required for proper response to iron deficiency and to cadmium exposure","volume":"209","author":"Koen","year":"2013","journal-title":"Plant Sci."},{"key":"10.1016\/j.molp.2020.01.006_bib22","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1104\/pp.15.01589","article-title":"ZINC FINGER OF ARABIDOPSIS THALIANA12 (ZAT12) interacts with FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT) linking iron deficiency and oxidative stress responses","volume":"170","author":"Le","year":"2016","journal-title":"Plant Physiol."},{"key":"10.1016\/j.molp.2020.01.006_bib23","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1104\/pp.15.01827","article-title":"Two bHLH transcription factors, bHLH34 and bHLH104, regulate iron homeostasis in Arabidopsis thaliana","volume":"170","author":"Li","year":"2016","journal-title":"Plant Physiol."},{"key":"10.1016\/j.molp.2020.01.006_bib24","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1093\/jxb\/eru179","article-title":"MYB82 functions in regulation of trichome development in Arabidopsis","volume":"65","author":"Liang","year":"2014","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.molp.2020.01.006_bib25","doi-asserted-by":"crossref","first-page":"21451","DOI":"10.1038\/srep21451","article-title":"Selection of highly efficient sgRNAs for CRISPR\/Cas9-based plant genome editing","volume":"6","author":"Liang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molp.2020.01.006_bib26","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/jxb\/erx043","article-title":"bHLH transcription factor bHLH115 regulates iron homeostasis in Arabidopsis thaliana","volume":"68","author":"Liang","year":"2017","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.molp.2020.01.006_bib27","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1105\/tpc.111.084715","article-title":"Interaction between the bHLH transcription factor FIT and ETHYLENE INSENSITIVE3\/ETHYLENE INSENSITIVE3-LIKE1 reveals molecular linkage between the regulation of iron acquisition and ethylene signaling in Arabidopsis","volume":"23","author":"Lingam","year":"2011","journal-title":"Plant Cell"},{"key":"10.1016\/j.molp.2020.01.006_bib28","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/tpj.13874","article-title":"Detection of membrane protein-protein interaction in planta based on dual-intein-coupled tripartite split-GFP association","volume":"94","author":"Liu","year":"2018","journal-title":"Plant J."},{"key":"10.1016\/j.molp.2020.01.006_bib29","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1105\/tpc.110.074096","article-title":"The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots","volume":"22","author":"Long","year":"2010","journal-title":"Plant Cell"},{"key":"10.1016\/j.molp.2020.01.006_bib30","series-title":"Mineral Nutrition of Higher Plants","author":"Marschner","year":"1995"},{"key":"10.1016\/j.molp.2020.01.006_bib31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/pcp\/pct160","article-title":"Gibberellin-induced expression of Fe uptake-related genes in Arabidopsis","volume":"55","author":"Matsuoka","year":"2014","journal-title":"Plant Cell Physiol."},{"key":"10.1016\/j.molp.2020.01.006_bib32","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1104\/pp.111.183285","article-title":"Posttranslational regulation of the iron deficiency basic helix-loop-helix transcription factor FIT is affected by iron and nitric oxide","volume":"157","author":"Meiser","year":"2011","journal-title":"Plant Physiol."},{"key":"10.1016\/j.molp.2020.01.006_bib33","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S1369-5266(99)80043-0","article-title":"Iron acquisition by plants","volume":"2","author":"Mori","year":"1999","journal-title":"Curr. Opin. Plant Biol."},{"key":"10.1016\/j.molp.2020.01.006_bib34","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1021\/cr900112r","article-title":"Iron uptake and transport in plants: the good, the bad, and the ionome","volume":"109","author":"Morrissey","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.molp.2020.01.006_bib35","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1038\/s41598-017-11171-7","article-title":"Dissection of iron signaling and iron accumulation by overexpression of subgroup Ib bHLH039 protein","volume":"7","author":"Naranjo-Arcos","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.molp.2020.01.006_bib36","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1365-313X.2007.03212.x","article-title":"A multicolored set of in\u00a0vivo organelle markers for co-localization studies in Arabidopsis and other plants","volume":"51","author":"Nelson","year":"2007","journal-title":"Plant J."},{"key":"10.1016\/j.molp.2020.01.006_bib37","doi-asserted-by":"crossref","first-page":"e1003953","DOI":"10.1371\/journal.pgen.1003953","article-title":"MYB10 and MYB72 are required for growth under iron-limiting conditions","volume":"9","author":"Palmer","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.molp.2020.01.006_bib38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1104\/pp.80.1.175","article-title":"Evidence for a specific uptake system for iron phytosiderophores in roots of grasses","volume":"80","author":"R\u00f6mheld","year":"1986","journal-title":"Plant Physiol."},{"key":"10.1016\/j.molp.2020.01.006_bib39","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/17800","article-title":"A ferric-chelate reductase for iron uptake from soils","volume":"397","author":"Robinson","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.molp.2020.01.006_bib40","doi-asserted-by":"crossref","first-page":"e26116","DOI":"10.4161\/psb.26116","article-title":"Reduction-based iron uptake revisited: on the role of secreted iron-binding compounds","volume":"8","author":"Rodriguez-Celma","year":"2013","journal-title":"Plant Signal. Behav."},{"key":"10.1016\/j.molp.2020.01.006_bib41","doi-asserted-by":"crossref","first-page":"17584","DOI":"10.1073\/pnas.1907971116","article-title":"Arabidopsis BRUTUS-LIKE E3 ligases negatively regulate iron uptake by targeting transcription factor FIT for recycling","volume":"116","author":"Rodriguez-Celma","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.molp.2020.01.006_bib42","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nprot.2008.66","article-title":"An efficient chromatin immunoprecipitation (ChIP) protocol for studying histone modifications in Arabidopsis plants","volume":"3","author":"Saleh","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.molp.2020.01.006_bib43","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1104\/pp.113.228544","article-title":"Feruloyl-CoA 6'-hydroxylase1-dependent coumarins mediate iron acquisition from alkaline substrates in Arabidopsis","volume":"164","author":"Schmid","year":"2014","journal-title":"Plant Physiol."},{"key":"10.1016\/j.molp.2020.01.006_bib44","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1046\/j.1365-3040.2003.00967.x","article-title":"Proton pumping by tomato roots. Effect of Fe deficiency and hormones on the activity and distribution of plasma membrane H+-ATPase in rhizodermal cells","volume":"26","author":"Schmidt","year":"2003","journal-title":"Plant Cell Environ."},{"key":"10.1016\/j.molp.2020.01.006_bib45","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1104\/pp.114.250837","article-title":"Iron-binding E3 ligase mediates iron response in plants by targeting basic helix-loop-helix transcription factors","volume":"167","author":"Selote","year":"2015","journal-title":"Plant Physiol."},{"key":"10.1016\/j.molp.2020.01.006_bib68","article-title":"The dual benefit of a dominant mutation in Arabidopsis IRON DEFICIENCY TOLERANT1 for iron biofortification and heavy metal phytoremediation","author":"Sharma","year":"2019","journal-title":"Plant Biotechnol J."},{"key":"10.1016\/j.molp.2020.01.006_bib46","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/j.1365-313X.2011.04565.x","article-title":"Proteasome-mediated turnover of the transcriptional activator FIT is required for plant iron-deficiency responses","volume":"66","author":"Sivitz","year":"2011","journal-title":"Plant J."},{"key":"10.1016\/j.molp.2020.01.006_bib48","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1093\/jxb\/ery005","article-title":"Scopoletin 8-hydroxylase: a novel enzyme involved in coumarin biosynthesis and iron-deficiency responses in Arabidopsis","volume":"69","author":"Siwinska","year":"2018","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.molp.2020.01.006_bib49","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10265-018-1068-z","article-title":"The basic helix-loop-helix transcription factor, bHLH11 functions in the iron-uptake system in Arabidopsis thaliana","volume":"132","author":"Tanabe","year":"2019","journal-title":"J. Plant Res."},{"key":"10.1016\/j.molp.2020.01.006_bib50","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1111\/nph.15753","article-title":"Transcriptional integration of the responses to iron availability in Arabidopsis by the bHLH factor ILR3","author":"Tissot","year":"2019","journal-title":"New Phytol."},{"key":"10.1016\/j.molp.2020.01.006_bib51","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1104\/pp.18.00178","article-title":"Scopoletin 8-hydroxylase-mediated Fraxetin production is crucial for iron mobilization","volume":"177","author":"Tsai","year":"2018","journal-title":"Plant Physiol."},{"key":"10.1016\/j.molp.2020.01.006_bib52","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1105\/tpc.001388","article-title":"IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth","volume":"14","author":"Vert","year":"2002","journal-title":"Plant Cell"},{"key":"10.1016\/j.molp.2020.01.006_bib53","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.pbi.2008.06.013","article-title":"Time to pump iron: iron-deficiency-signaling mechanisms of higher plants","volume":"11","author":"Walker","year":"2008","journal-title":"Curr. Opin. Plant Biol."},{"key":"10.1016\/j.molp.2020.01.006_bib54","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00425-007-0535-x","article-title":"Iron deficiency-mediated stress regulation of four subgroup Ib BHLH genes in Arabidopsis thaliana","volume":"226","author":"Wang","year":"2007","journal-title":"Planta"},{"key":"10.1016\/j.molp.2020.01.006_bib55","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/mp\/sss089","article-title":"Requirement and functional redundancy of Ib subgroup bHLH proteins for iron deficiency responses and uptake in Arabidopsis thaliana","volume":"6","author":"Wang","year":"2013","journal-title":"Mol. Plant"},{"key":"10.1016\/j.molp.2020.01.006_bib56","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.devcel.2016.03.022","article-title":"Tissue-specific regulation of gibberellin signaling fine-tunes Arabidopsis iron-deficiency responses","volume":"37","author":"Wild","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.molp.2020.01.006_bib57","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1746-4811-5-16","article-title":"Tape-Arabidopsis Sandwich - a simpler Arabidopsis protoplast isolation method","volume":"5","author":"Wu","year":"2009","journal-title":"Plant Methods"},{"key":"10.1016\/j.molp.2020.01.006_bib58","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.molp.2017.06.004","article-title":"CRISPR-GE: a convenient software toolkit for CRISPR-based genome editing","volume":"10","author":"Xie","year":"2017","journal-title":"Mol. Plant"},{"key":"10.1016\/j.molp.2020.01.006_bib59","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/nph.12057","article-title":"The 14-3-3 protein GENERAL REGULATORY FACTOR11 (GRF11) acts downstream of nitric oxide to regulate iron acquisition in Arabidopsis thaliana","volume":"197","author":"Yang","year":"2013","journal-title":"New Phytol."},{"key":"10.1016\/j.molp.2020.01.006_bib60","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1046\/j.1365-313X.1996.10050835.x","article-title":"Genetic evidence that induction of root Fe(III) chelate reductase activity is necessary for iron uptake under iron deficiency","volume":"10","author":"Yi","year":"1996","journal-title":"Plant J."},{"key":"10.1016\/j.molp.2020.01.006_bib61","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/sj.cr.7290331","article-title":"AtbHLH29 of Arabidopsis thaliana is a functional ortholog of tomato FER involved in controlling iron acquisition in strategy I plants","volume":"15","author":"Yuan","year":"2005","journal-title":"Cell Res."},{"key":"10.1016\/j.molp.2020.01.006_bib62","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/cr.2008.26","article-title":"FIT interacts with AtbHLH38 and AtbHLH39 in regulating iron uptake gene expression for iron homeostasis in Arabidopsis","volume":"18","author":"Yuan","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.molp.2020.01.006_bib63","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1105\/tpc.114.123737","article-title":"OPT3 is a Phloem-specific iron transporter that is essential for systemic iron signaling and redistribution of iron and cadmium in Arabidopsis","volume":"26","author":"Zhai","year":"2014","journal-title":"Plant Cell"},{"key":"10.1016\/j.molp.2020.01.006_bib64","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1105\/tpc.114.132704","article-title":"The bHLH transcription factor bHLH104 interacts with IAA-LEUCINE RESISTANT3 and modulates iron homeostasis in Arabidopsis","volume":"27","author":"Zhang","year":"2015","journal-title":"Plant Cell"},{"key":"10.1016\/j.molp.2020.01.006_bib65","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1046\/j.1365-313x.2000.00868.x","article-title":"Technical advance: an estrogen receptor-based transactivator XVE mediates highly inducible gene expression in transgenic plants","volume":"24","author":"Zuo","year":"2000","journal-title":"Plant J."}],"container-title":["Molecular Plant"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S167420522030006X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S167420522030006X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T12:02:14Z","timestamp":1761652934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S167420522030006X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S167420522030006X"],"URL":"https:\/\/doi.org\/10.1016\/j.molp.2020.01.006","relation":{},"ISSN":["1674-2052"],"issn-type":[{"value":"1674-2052","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"bHLH121 Functions as a Direct Link that Facilitates the Activation of FIT by bHLH IVc Transcription Factors for Maintaining Fe Homeostasis in Arabidopsis","name":"articletitle","label":"Article Title"},{"value":"Molecular Plant","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molp.2020.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 The Author 2020","name":"copyright","label":"Copyright"}]}}