{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:54:37Z","timestamp":1762214077090,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100020376","name":"Gout and Uric Acid Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015293","name":"Policy-Based Medical Services Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015293","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.molpha.2025.100028","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T11:54:31Z","timestamp":1741175671000},"page":"100028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural similarity-based search for glinides exhibiting cis- and trans-inhibitory activity toward uric acid transporter 1"],"prefix":"10.1016","volume":"107","author":[{"given":"Misa","family":"Sayama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshie","family":"Reien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8416-4605","authenticated-orcid":false,"given":"Seiji","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiko","family":"Anzai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itsuko","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.molpha.2025.100028_bib1","doi-asserted-by":"crossref","first-page":"45942","DOI":"10.1074\/jbc.M406724200","article-title":"The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus","volume":"279","author":"Anzai","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.molpha.2025.100028_bib2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0731-7085(02)00680-5","article-title":"Rapid and simple method for the analysis of nateglinide in human plasma using HPLC analysis with UV detection","volume":"31","author":"Bauer","year":"2003","journal-title":"J\u00a0Pharm Biomed Anal"},{"key":"10.1016\/j.molpha.2025.100028_bib3","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1021\/jm0208875","article-title":"Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K+ channel blockers","volume":"45","author":"Cavalli","year":"2002","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.molpha.2025.100028_bib4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0002-9343(57)90229-2","article-title":"Studies of hyperuricemia produced by pyrazinamide","volume":"23","author":"Cullen","year":"1957","journal-title":"Am J Med"},{"key":"10.1016\/j.molpha.2025.100028_bib5","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41422-024-01023-1","article-title":"Transport mechanism and structural pharmacology of human urate transporter URAT1","volume":"34","author":"Dai","year":"2024","journal-title":"Cell Res"},{"key":"10.1016\/j.molpha.2025.100028_bib6","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s40265-016-0591-2","article-title":"Impact of statin therapy on plasma uric acid concentrations: a systematic review and meta-analysis","volume":"76","author":"Derosa","year":"2016","journal-title":"Drugs"},{"key":"10.1016\/j.molpha.2025.100028_bib7","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nature742","article-title":"Molecular identification of a renal urate-anion exchanger that regulates blood urate levels","volume":"417","author":"Enomoto","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.molpha.2025.100028_bib8","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1124\/dmd.123.001412","article-title":"Potentiation of the uricosuric effect of dotinurad by trans-Inhibition of the uric acid reabsorptive transporter 1","volume":"50","author":"Fujita","year":"2023","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.molpha.2025.100028_bib9","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1681\/ASN.2007010106","article-title":"Torasemide transport by organic anion transporters contributes to hyperuricemia","volume":"18","author":"Hagos","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.molpha.2025.100028_bib10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1021\/jm0603365","article-title":"Comparison of shape-matching and docking as virtual screening tools","volume":"50","author":"Hawkins","year":"2007","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.molpha.2025.100028_bib11","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1021\/ci100031x","article-title":"Conformer generation with OMEGA: algorithm and validation using high quality structures from the protein databank and Cambridge structural database","volume":"50","author":"Hawkins","year":"2010","journal-title":"J\u00a0Chem Inf Model"},{"key":"10.1016\/j.molpha.2025.100028_bib12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1124\/jpet.106.112755","article-title":"Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter","volume":"320","author":"Iwanaga","year":"2007","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.molpha.2025.100028_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1021\/jm060379l","article-title":"Medicinal chemistry of hERG optimizations: highlights and hang-ups","volume":"49","author":"Jamieson","year":"2006","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.molpha.2025.100028_bib14","doi-asserted-by":"crossref","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","article-title":"PubChem 2023 update","volume":"51","author":"Kim","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.molpha.2025.100028_bib15","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.mayocp.2022.02.027","article-title":"Lowering and raising serum urate levels: off-label effects of commonly used medications","volume":"97","author":"Leung","year":"2022","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.molpha.2025.100028_bib16","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1021\/ci100436p","article-title":"FRED pose prediction and virtual screening accuracy","volume":"51","author":"McGann","year":"2011","journal-title":"J\u00a0Chem Inf Model"},{"key":"10.1016\/j.molpha.2025.100028_bib17","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s10822-012-9584-8","article-title":"FRED and HYBRID docking performance on standardized datasets","volume":"26","author":"McGann","year":"2012","journal-title":"J\u00a0Comput Aided Mol Des"},{"key":"10.1016\/j.molpha.2025.100028_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1620\/tjem.251.87","article-title":"Uric acid elevation by favipiravir, an antiviral drug","volume":"251","author":"Mishima","year":"2020","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.molpha.2025.100028_bib19","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.bbamem.2010.03.002","article-title":"Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter","volume":"1798","author":"Miyauchi","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.molpha.2025.100028_bib20","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/15257771003741323","article-title":"Effects of three strong statins (atorvastatin, pitavastatin, and rosuvastatin) on serum uric acid levels in dyslipidemic patients","volume":"29","author":"Ogata","year":"2010","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.molpha.2025.100028_bib21","first-page":"499","article-title":"Human renal transporter URAT1 mediates the transport of salicylate","volume":"52","author":"Ohtsu","year":"2010","journal-title":"Nihon Jinzo Gakkai Shi"},{"key":"10.1016\/j.molpha.2025.100028_bib22","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s12565-016-0369-3","article-title":"Roles of organic anion transporters (OATs) in renal proximal tubules and their localization","volume":"92","author":"Otani","year":"2017","journal-title":"Anat Sci Int"},{"key":"10.1016\/j.molpha.2025.100028_bib23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bmcl.2015.12.040","article-title":"Discovery of potent and orally bioavailable inhibitors of Human Uric Acid Transporter 1 (hURAT1) and binding mode prediction using homology model","volume":"26","author":"Peng","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.molpha.2025.100028_bib24","first-page":"679","article-title":"Drug-induced hyperuricaemia and gout","volume":"56","author":"Salem","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.molpha.2025.100028_bib25","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1529\/biophysj.106.093153","article-title":"Heterologous expression of Pharaonis halorhodopsin in Xenopus laevis oocytes and electrophysiological characterization of its light-driven Cl- pump activity","volume":"92","author":"Seki","year":"2007","journal-title":"Biophys J"},{"key":"10.1016\/j.molpha.2025.100028_bib26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.dmpk.2018.10.004","article-title":"Transport of 2,4-dichloro phenoxyacetic acid by human Na(+)-coupled monocarboxylate transporter 1 (hSMCT1, SLC5A8)","volume":"34","author":"Sugio","year":"2019","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1016\/j.molpha.2025.100028_bib27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.2042-7158.2011.01389.x","article-title":"Contribution of organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 to hepatic uptake of nateglinide, and the prediction of drug\u2013drug interactions via these transporters","volume":"64","author":"Takanohashi","year":"2012","journal-title":"J\u00a0Pharm Pharmacol"},{"key":"10.1016\/j.molpha.2025.100028_bib28","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/BF02849871","article-title":"Postmarketing surveillance study of nateglinide in Japan","volume":"22","author":"Taki","year":"2005","journal-title":"Adv Ther"},{"key":"10.1016\/j.molpha.2025.100028_bib29","first-page":"23","article-title":"Molecular mechanism of the urate-lowering effects of calcium channel blockers","volume":"43","author":"Tsuchiya","year":"2016","journal-title":"Dokkyo J Med Sci"},{"key":"10.1016\/j.molpha.2025.100028_bib30","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/1744-9987.12758","article-title":"Effects of uremic serum residue on OATP1B1- and OATP1B3-mediated pravastatin uptake in OATP-expressing HEK293 cells and human hepatocytes","volume":"23","author":"Uchiyama","year":"2019","journal-title":"Ther Apher Dial"},{"key":"10.1016\/j.molpha.2025.100028_bib31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2169\/internalmedicine.49.2597","article-title":"Effect of fenofibrate on uric acid metabolism and urate transporter 1","volume":"49","author":"Uetake","year":"2010","journal-title":"Intern Med"},{"key":"10.1016\/j.molpha.2025.100028_bib32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0014-2999(00)00324-1","article-title":"Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1","volume":"398","author":"Uwai","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.molpha.2025.100028_bib33","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3109\/13880209.2015.1034326","article-title":"Identification of natural products as modulators of OATP2B1 using LC-MS\/MS to quantify OATP-mediated uptake","volume":"54","author":"Wen","year":"2016","journal-title":"Pharm Biol"},{"key":"10.1016\/j.molpha.2025.100028_bib34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/2040622315596119","article-title":"The effect of angiotensin II receptor blockers on hyperuricemia","volume":"6","author":"Wolff","year":"2015","journal-title":"Ther Adv Chronic Dis"},{"key":"10.1016\/j.molpha.2025.100028_bib35","doi-asserted-by":"crossref","first-page":"9221","DOI":"10.3390\/ijms22179221","article-title":"Molecular biological and clinical understanding of the pathophysiology and treatments of hyperuricemia and its association with metabolic syndrome, cardiovascular diseases and chronic kidney disease","volume":"22","author":"Yanai","year":"2021","journal-title":"Int J Mol Sci"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X25152887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X25152887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:51:44Z","timestamp":1762213904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X25152887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0026895X25152887"],"URL":"https:\/\/doi.org\/10.1016\/j.molpha.2025.100028","relation":{},"ISSN":["0026-895X"],"issn-type":[{"type":"print","value":"0026-895X"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural similarity-based search for glinides exhibiting cis- and trans-inhibitory activity toward uric acid transporter 1","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molpha.2025.100028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100028"}}