{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:14:10Z","timestamp":1778645650353,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004024","name":"Jinan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A151501636"],"award-info":[{"award-number":["2022A151501636"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["20241515013257"],"award-info":[{"award-number":["20241515013257"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.molpha.2025.100066","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T23:48:49Z","timestamp":1754437729000},"page":"100066","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heterogeneous nuclear ribonucleoprotein A\/B drives gastric cancer and epithelial-mesenchymal transition via the Akt-GSK3\u03b2-Wnt pathway"],"prefix":"10.1016","volume":"107","author":[{"given":"Luo","family":"Huiru","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aime Gael Yaya","family":"Traore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinshuang","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengzhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongxue","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10251","key":"10.1016\/j.molpha.2025.100066_bib1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.molpha.2025.100066_bib2","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"issue":"7","key":"10.1016\/j.molpha.2025.100066_bib3","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.ejca.2012.12.016","article-title":"Role of chemotherapy for advanced\/recurrent gastric cancer: an individual-patient-data meta-analysis","volume":"49","author":"GASTRIC (Global Advanced\/Adjuvant Stomach Tumor Research International Collaboration) Group","year":"2013","journal-title":"Eur J Cancer"},{"issue":"7634","key":"10.1016\/j.molpha.2025.100066_bib4","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nature20609","article-title":"Mechanism of early dissemination and metastasis in Her2+ mammary cancer","volume":"540","author":"Harper","year":"2016","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.molpha.2025.100066_bib5","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrc3793","article-title":"Mechanisms of disseminated cancer cell dormancy: an awakening field","volume":"14","author":"Sosa","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.molpha.2025.100066_bib6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.canlet.2017.03.013","article-title":"Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer","volume":"396","author":"K\u0119dzierska","year":"2017","journal-title":"Cancer Lett"},{"issue":"9","key":"10.1016\/j.molpha.2025.100066_bib7","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1261\/rna.057919.116","article-title":"Splicing-factor alterations in cancers","volume":"22","author":"Anczuk\u00f3w","year":"2016","journal-title":"RNA"},{"key":"10.1016\/j.molpha.2025.100066_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2020.100728","article-title":"The role of alternative splicing in cancer: from oncogenesis to drug resistance","volume":"53","author":"Sciarrillo","year":"2020","journal-title":"Drug Resist Updat"},{"issue":"5","key":"10.1016\/j.molpha.2025.100066_bib9","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.3390\/ijms21051551","article-title":"Roles of splicing factors in hormone-related cancer progression","volume":"21","author":"Takeiwa","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.molpha.2025.100066_bib10","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ebiom.2019.06.017","article-title":"HnRNP-F regulates EMT in bladder cancer by mediating the stabilization of Snail1 mRNA by binding to its 3\u2032 UTR","volume":"45","author":"Li","year":"2019","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.molpha.2025.100066_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.479","article-title":"Translational upregulation of Aurora-A by hnRNP Q1 contributes to cell proliferation and tumorigenesis in colorectal cancer","volume":"8","author":"Lai","year":"2017","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.molpha.2025.100066_bib12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.molcel.2015.09.005","article-title":"SRSF1-regulated alternative splicing in breast cancer","volume":"60","author":"Anczuk\u00f3w","year":"2015","journal-title":"Mol Cell"},{"key":"10.1016\/j.molpha.2025.100066_bib13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ebiom.2018.11.007","article-title":"SRSF1 modulates PTPMT1 alternative splicing to regulate lung cancer cell radioresistance","volume":"38","author":"Sheng","year":"2018","journal-title":"EBioMedicine"},{"issue":"2","key":"10.1016\/j.molpha.2025.100066_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0378-1119(92)90276-U","article-title":"A protein binding to CArG box motifs and to single-stranded DNA functions as a transcriptional repressor","volume":"119","author":"Kamada","year":"1992","journal-title":"Gene"},{"issue":"13","key":"10.1016\/j.molpha.2025.100066_bib15","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1093\/nar\/23.13.2389","article-title":"Cloning and characterisation of a nuclear, site specific ssDNA binding protein","volume":"23","author":"Smidt","year":"1995","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"10.1016\/j.molpha.2025.100066_bib16","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1074\/jbc.272.3.1452","article-title":"Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing","volume":"272","author":"Lau","year":"1997","journal-title":"J Biol Chem"},{"issue":"17","key":"10.1016\/j.molpha.2025.100066_bib17","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1093\/nar\/gkf506","article-title":"Distinct domains in the CArG-box binding factor A destabilize tetraplex forms of the fragile X expanded sequence d(CGG)n","volume":"30","author":"Weisman-Shomer","year":"2002","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"10.1016\/j.molpha.2025.100066_bib18","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1002\/eji.200535659","article-title":"CArG box-binding factor-A interacts with multiple motifs in immunoglobulin promoters and has a regulated subcellular distribution","volume":"36","author":"Aranburu","year":"2006","journal-title":"Eur J Immunol"},{"issue":"10","key":"10.1016\/j.molpha.2025.100066_bib19","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1158\/0008-5472.CAN-13-2509","article-title":"HNRNPAB induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by transcriptionally activating SNAIL","volume":"74","author":"Zhou","year":"2014","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.molpha.2025.100066_bib20","first-page":"452","article-title":"[High expression of hnRNPAB\/Kap1 together promote poor prognosis in HCC]","volume":"25","author":"Zhou","year":"2017","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"issue":"1","key":"10.1016\/j.molpha.2025.100066_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/ijc.32409","article-title":"HNRNPAB-regulated lncRNA-ELF209 inhibits the malignancy of hepatocellular carcinoma","volume":"146","author":"Yang","year":"2020","journal-title":"Int J Cancer"},{"issue":"6","key":"10.1016\/j.molpha.2025.100066_bib22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3892\/or.2023.8566","article-title":"Knockdown of hnRNPAB reduces the stem cell properties and enhances the chemosensitivity of human colorectal cancer stem cells","volume":"49","author":"Zhou","year":"2023","journal-title":"Oncol Rep"},{"issue":"6","key":"10.1016\/j.molpha.2025.100066_bib23","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2-catenin signaling and disease","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.molpha.2025.100066_bib24","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djt356","article-title":"Wnt signaling pathway in non-small cell lung cancer","volume":"106","author":"Stewart","year":"2014","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"10.1016\/j.molpha.2025.100066_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13046-018-0716-4","article-title":"CDK5RAP3 suppresses Wnt\/\u03b2-catenin signaling by inhibiting AKT phosphorylation in gastric cancer","volume":"37","author":"Zheng","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"issue":"11","key":"10.1016\/j.molpha.2025.100066_bib30","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1349-7006.2005.00113.x","article-title":"Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer","volume":"96","author":"Tsuchiya","year":"2005","journal-title":"Cancer Sci"},{"key":"10.1016\/j.molpha.2025.100066_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3750673","article-title":"Mining the prognostic value of HNRNPAB and its function in breast carcinoma","volume":"2020","author":"Cao","year":"2020","journal-title":"Int J Genomics"},{"issue":"6","key":"10.1016\/j.molpha.2025.100066_bib32","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1080\/15476286.2020.1822636","article-title":"Identification of spliceosome components pivotal to breast cancer survival","volume":"18","author":"An","year":"2021","journal-title":"RNA Biol"},{"issue":"3","key":"10.1016\/j.molpha.2025.100066_bib33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","article-title":"EMT transition states during tumor progression and metastasis","volume":"29","author":"Pastushenko","year":"2019","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.molpha.2025.100066_bib34","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-pathol-020117-043854","article-title":"Epithelial mesenchymal transition in tumor metastasis","volume":"13","author":"Mittal","year":"2018","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.molpha.2025.100066_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110909","article-title":"EMT, cancer stem cells and autophagy; the three main axes of metastasis","volume":"133","author":"Babaei","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10.1016\/j.molpha.2025.100066_bib36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41416-020-01150-7","article-title":"Metastasis: crosstalk between tissue mechanics and tumour cell plasticity","volume":"124","author":"Coban","year":"2021","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1016\/j.molpha.2025.100066_bib37","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/med.21596","article-title":"Small molecule inhibitors of epithelial-mesenchymal transition for the treatment of cancer and fibrosis","volume":"40","author":"Feng","year":"2020","journal-title":"Med Res Rev"},{"issue":"50","key":"10.1016\/j.molpha.2025.100066_bib38","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1038\/sj.onc.1209091","article-title":"Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase\/AKT pathways","volume":"24","author":"Larue","year":"2005","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.molpha.2025.100066_bib39","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1158\/0008-5472.CAN-18-2738","article-title":"AKT as a therapeutic target for cancer","volume":"79","author":"Song","year":"2019","journal-title":"Cancer Res"},{"issue":"6559","key":"10.1016\/j.molpha.2025.100066_bib40","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/378785a0","article-title":"Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B","volume":"378","author":"Cross","year":"1995","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.molpha.2025.100066_bib41","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrn2870","article-title":"GSK3 signalling in neural development","volume":"11","author":"Hur","year":"2010","journal-title":"Nat Rev Neurosci"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X25153261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X25153261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:50:47Z","timestamp":1778644247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X25153261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0026895X25153261"],"URL":"https:\/\/doi.org\/10.1016\/j.molpha.2025.100066","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heterogeneous nuclear ribonucleoprotein A\/B drives gastric cancer and epithelial-mesenchymal transition via the Akt-GSK3\u03b2-Wnt pathway","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molpha.2025.100066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100066"}}