{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:24:45Z","timestamp":1773937485293,"version":"3.50.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL181098"],"award-info":[{"award-number":["R01 HL181098"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R35 HL144980"],"award-info":[{"award-number":["R35 HL144980"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL151223"],"award-info":[{"award-number":["R01 HL151223"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["F31 HL151125"],"award-info":[{"award-number":["F31 HL151125"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["F31 HL164064"],"award-info":[{"award-number":["F31 HL164064"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","award":["19SFRN34830019"],"award-info":[{"award-number":["19SFRN34830019"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","award":["24PRE1243081"],"award-info":[{"award-number":["24PRE1243081"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.molpha.2025.100086","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:57:22Z","timestamp":1761897442000},"page":"100086","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Introduction of a single carboxylic acid converts the cyclic oligomeric depsipeptide ent-verticilide from a ryanodine receptor 2 (RyR2) inhibitor to RyR2 activator"],"prefix":"10.1016","volume":"107","author":[{"given":"Tri Q.","family":"Do","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-1792","authenticated-orcid":false,"given":"Daniel J.","family":"Blackwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0921-1835","authenticated-orcid":false,"given":"Abigail N.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madelaine P.","family":"Thorpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3840-2286","authenticated-orcid":false,"given":"Robyn T.","family":"Rebbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek R.","family":"Laver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0885-636X","authenticated-orcid":false,"given":"Jeffrey N.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4956-9735","authenticated-orcid":false,"given":"Bj\u00f6rn C.","family":"Knollmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6868","key":"10.1016\/j.molpha.2025.100086_bib1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/415198a","article-title":"Cardiac excitation-contraction coupling","volume":"415","author":"Bers","year":"2002","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.molpha.2025.100086_bib2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.jelectrocard.2011.07.025","article-title":"Mechanism underlying catecholaminergic polymorphic ventricular tachycardia and approaches to therapy","volume":"44","author":"Watanabe","year":"2011","journal-title":"J Electrocardiol"},{"key":"10.1016\/j.molpha.2025.100086_bib3","first-page":"380","article-title":"Altered cardiac myocyte Ca regulation in heart failure","volume":"21","author":"Bers","year":"2006","journal-title":"Physiology (Bethesda)"},{"issue":"8","key":"10.1016\/j.molpha.2025.100086_bib4","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.3390\/biom12081030","article-title":"Molecular, subcellular, and arrhythmogenic mechanisms in genetic RyR2 disease","volume":"12","author":"Fowler","year":"2022","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.molpha.2025.100086_bib5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1161\/CIRCEP.110.959916","article-title":"Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia","volume":"4","author":"Hwang","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"6","key":"10.1016\/j.molpha.2025.100086_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131179","article-title":"Channel activity of cardiac ryanodine receptors (RyR2) determines potency and efficacy of flecainide and R-propafenone against arrhythmogenic calcium waves in ventricular cardiomyocytes","volume":"10","author":"Savio-Galimberti","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.molpha.2025.100086_bib7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.yjmcc.2009.10.005","article-title":"Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass","volume":"48","author":"Hilliard","year":"2010","journal-title":"J Mol Cell Cardiol"},{"issue":"4","key":"10.1016\/j.molpha.2025.100086_bib8","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nm.1942","article-title":"Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans","volume":"15","author":"Watanabe","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.molpha.2025.100086_bib9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.yjmcc.2023.05.009","article-title":"RyR2 inhibition with dantrolene is antiarrhythmic, prevents further pathological remodeling, and improves cardiac function in chronic ischemic heart disease","volume":"181","author":"Schmeckpeper","year":"2023","journal-title":"J Mol Cell Cardiol"},{"issue":"8","key":"10.1016\/j.molpha.2025.100086_bib10","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.202213277","article-title":"Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6","volume":"155","author":"Walweel","year":"2023","journal-title":"J Gen Physiol"},{"issue":"17","key":"10.1016\/j.molpha.2025.100086_bib11","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/0002-9149(91)90308-8","article-title":"Increased risk of death and cardiac arrest from encainide and flecainide in patients after non-Q-wave acute myocardial infarction in the Cardiac Arrhythmia Suppression Trial. CAST Investigators","volume":"68","author":"Akiyama","year":"1991","journal-title":"Am J Cardiol"},{"issue":"8","key":"10.1016\/j.molpha.2025.100086_bib12","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1161\/CIRCULATIONAHA.113.007657","article-title":"Dantrolene: from better bacon to a treatment for ventricular fibrillation","volume":"129","author":"Roden","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.molpha.2025.100086_bib13","series-title":"Goodman & Gilman\u2019s: The Pharmacological Basis of Therapeutics","first-page":"667","article-title":"Antiarrhythmic drugs","author":"Knollmann","year":"2023"},{"issue":"3","key":"10.1016\/j.molpha.2025.100086_bib14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1124\/jpet.122.001455","article-title":"In vivo pharmacokinetic and pharmacodynamic properties of the antiarrhythmic molecule ent-verticilide","volume":"385","author":"Blackwell","year":"2023","journal-title":"J Pharmacol Exp Ther"},{"issue":"11","key":"10.1016\/j.molpha.2025.100086_bib15","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.1073\/pnas.1816685116","article-title":"Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic","volume":"116","author":"Batiste","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.molpha.2025.100086_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ja.2009.126","article-title":"Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033","volume":"63","author":"Shiomi","year":"2010","journal-title":"J Antibiot (Tokyo)"},{"issue":"7","key":"10.1016\/j.molpha.2025.100086_bib17","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1021\/acs.jmedchem.7b00717","article-title":"Beyond the rule of 5: lessons learned from AbbVie\u2019s drugs and compound collection","volume":"61","author":"DeGoey","year":"2018","journal-title":"J Med Chem"},{"issue":"44","key":"10.1016\/j.molpha.2025.100086_bib18","doi-asserted-by":"crossref","first-page":"24035","DOI":"10.1021\/jacs.3c07145","article-title":"Validation of a new methodology to create oral drugs beyond the rule of 5 for intracellular tough targets","volume":"145","author":"Ohta","year":"2023","journal-title":"J Am Chem Soc"},{"issue":"11","key":"10.1016\/j.molpha.2025.100086_bib19","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1021\/acsmedchemlett.2c00377","article-title":"Structure-activity relationships for the N-Me- versus N-H-amide modification to macrocyclic ent-verticilide antiarrhythmics","volume":"13","author":"Smith","year":"2022","journal-title":"ACS Med Chem Lett"},{"issue":"14","key":"10.1016\/j.molpha.2025.100086_bib20","doi-asserted-by":"crossref","first-page":"12205","DOI":"10.1021\/acs.jmedchem.4c00923","article-title":"Backbone-determined antiarrhythmic structure-activity relationships for a mirror image, oligomeric depsipeptide natural product","volume":"67","author":"Thorpe","year":"2024","journal-title":"J Med Chem"},{"issue":"12","key":"10.1016\/j.molpha.2025.100086_bib21","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1021\/acsmedchemlett.1c00508","article-title":"Ring size as an independent variable in cyclooligomeric depsipeptide antiarrhythmic activity","volume":"12","author":"Smith","year":"2021","journal-title":"ACS Med Chem Lett"},{"issue":"579","key":"10.1016\/j.molpha.2025.100086_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aba7287","article-title":"Cardiac ryanodine receptor calcium release deficiency syndrome","volume":"13","author":"Sun","year":"2021","journal-title":"Sci Transl Med"},{"issue":"6","key":"10.1016\/j.molpha.2025.100086_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euad156","article-title":"RYR2-ryanodinopathies: from calcium overload to calcium deficiency","volume":"25","author":"Steinberg","year":"2023","journal-title":"Europace"},{"issue":"52","key":"10.1016\/j.molpha.2025.100086_bib24","doi-asserted-by":"crossref","first-page":"14893","DOI":"10.1073\/pnas.1616462114","article-title":"Rapid synthesis of cyclic oligomeric depsipeptides with positional, stereochemical, and macrocycle size distribution control","volume":"113","author":"Batiste","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.molpha.2025.100086_bib25","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1021\/acschembio.3c00376","article-title":"RyR2 binding of an antiarrhythmic cyclic depsipeptide mapped using confocal fluorescence lifetime detection of FRET","volume":"18","author":"\u0160eflov\u00e1","year":"2023","journal-title":"ACS Chem Biol"},{"issue":"Pt 2","key":"10.1016\/j.molpha.2025.100086_bib26","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1469-7793.2000.t01-1-00483.x","article-title":"Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin","volume":"525","author":"Knollmann","year":"2000","journal-title":"J Physiol"},{"issue":"36","key":"10.1016\/j.molpha.2025.100086_bib27","doi-asserted-by":"crossref","first-page":"14977","DOI":"10.1039\/D4SC02758B","article-title":"The backbone constitution drives passive permeability independent of side chains in depsipeptide and peptide macrocycles inspired by ent-verticilide","volume":"15","author":"Thorpe","year":"2024","journal-title":"Chem Sci"},{"issue":"6","key":"10.1016\/j.molpha.2025.100086_bib28","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1161\/CIRCRESAHA.123.322847","article-title":"SparkMaster 2: a new software for automatic analysis of calcium spark data","volume":"133","author":"Tomek","year":"2023","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.molpha.2025.100086_bib29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1124\/mol.108.051490","article-title":"Amitriptyline activates cardiac ryanodine channels and causes spontaneous sarcoplasmic reticulum calcium release","volume":"75","author":"Chopra","year":"2009","journal-title":"Mol Pharmacol"},{"issue":"3","key":"10.1016\/j.molpha.2025.100086_bib30","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/S0006-3495(03)74976-5","article-title":"Regulation of the calcium release channel from skeletal muscle by suramin and the disulfonated stilbene derivatives DIDS, DBDS, and DNDS","volume":"84","author":"O\u2019Neill","year":"2003","journal-title":"Biophys J"},{"issue":"9","key":"10.1016\/j.molpha.2025.100086_bib31","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1440-1681.2007.04708.x","article-title":"Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites","volume":"34","author":"Laver","year":"2007","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"8","key":"10.1016\/j.molpha.2025.100086_bib32","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.3390\/cells10082101","article-title":"Flecainide paradoxically activates cardiac ryanodine receptor channels under low activity conditions: a potential pro-arrhythmic action","volume":"10","author":"Salvage","year":"2021","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.molpha.2025.100086_bib33","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0006-3495(87)83298-8","article-title":"Data transformations for improved display and fitting of single-channel dwell time histograms","volume":"52","author":"Sigworth","year":"1987","journal-title":"Biophys J"},{"issue":"4","key":"10.1016\/j.molpha.2025.100086_bib34","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1021\/acsmedchemlett.5c00037","article-title":"End-to-end backbone cyclization enhances passive permeability of bRo5 oligomeric depsipeptides with nonlinear size dependence","volume":"16","author":"Thorpe","year":"2025","journal-title":"ACS Med Chem Lett"},{"issue":"5134","key":"10.1016\/j.molpha.2025.100086_bib35","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1126\/science.8235594","article-title":"Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle","volume":"262","author":"Cheng","year":"1993","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.molpha.2025.100086_bib36","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.bpj.2011.01.017","article-title":"Single ryanodine receptor channel basis of caffeine's action on Ca2+ sparks","volume":"100","author":"Porta","year":"2011","journal-title":"Biophys J"},{"issue":"14","key":"10.1016\/j.molpha.2025.100086_bib37","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1016\/S0021-9258(19)84563-5","article-title":"Ryanodine activation and inhibition of the Ca2+ release channel of sarcoplasmic reticulum","volume":"261","author":"Meissner","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molpha.2025.100086_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.molpha.2025.100086_bib39","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.3390\/pharmaceutics15112523","article-title":"Caco-2 cell line standardization with pharmaceutical requirements and in vitro model suitability for permeability assays","volume":"15","author":"Kus","year":"2023","journal-title":"Pharmaceutics"},{"issue":"2","key":"10.1016\/j.molpha.2025.100086_bib40","doi-asserted-by":"crossref","DOI":"10.1172\/JCI162891","article-title":"Targeting ryanodine receptors to treat human diseases","volume":"133","author":"Marks","year":"2023","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.molpha.2025.100086_bib41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1124\/mol.115.097691","article-title":"Essential role of calmodulin in RyR inhibition by dantrolene","volume":"88","author":"Oo","year":"2015","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.molpha.2025.100086_bib42","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.yjmcc.2019.03.018","article-title":"Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814","volume":"130","author":"Walweel","year":"2019","journal-title":"J Mol Cell Cardiol"},{"issue":"7","key":"10.1016\/j.molpha.2025.100086_bib43","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2174\/0929867003374723","article-title":"FK506, an immunosuppressant targeting calcineurin function","volume":"7","author":"Dumont","year":"2000","journal-title":"Curr Med Chem"},{"issue":"29","key":"10.1016\/j.molpha.2025.100086_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abo1272","article-title":"Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment","volume":"8","author":"Miotto","year":"2022","journal-title":"Sci Adv"},{"issue":"3","key":"10.1016\/j.molpha.2025.100086_bib45","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1042\/BJ20070135","article-title":"K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association","volume":"404","author":"Hunt","year":"2007","journal-title":"Biochem J"},{"issue":"6","key":"10.1016\/j.molpha.2025.100086_bib46","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.3390\/ijms24065409","article-title":"Molecular aspects implicated in dantrolene selectivity with respect to ryanodine receptor isoforms","volume":"24","author":"Gaburjakova","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"51","key":"10.1016\/j.molpha.2025.100086_bib47","doi-asserted-by":"crossref","first-page":"25575","DOI":"10.1073\/pnas.1914451116","article-title":"Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators","volume":"116","author":"Chi","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.molpha.2025.100086_bib48","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.str.2024.11.018","article-title":"Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM","volume":"33","author":"Iyer","year":"2025","journal-title":"Structure"},{"issue":"7","key":"10.1016\/j.molpha.2025.100086_bib49","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.str.2022.04.010","article-title":"A drug and ATP binding site in type 1 ryanodine receptor","volume":"30","author":"Melville","year":"2022","journal-title":"Structure"},{"issue":"7","key":"10.1016\/j.molpha.2025.100086_bib50","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrd1440","article-title":"Novel therapeutic approaches for heart failure by normalizing calcium cycling","volume":"3","author":"Wehrens","year":"2004","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"10.1016\/j.molpha.2025.100086_bib51","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1172\/JCI62834","article-title":"Calcium cycling proteins and heart failure: mechanisms and therapeutics","volume":"123","author":"Marks","year":"2013","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.molpha.2025.100086_bib52","doi-asserted-by":"crossref","first-page":"H953","DOI":"10.1152\/ajpheart.00936.2011","article-title":"Dantrolene prevents arrhythmogenic Ca2+ release in heart failure","volume":"302","author":"Maxwell","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.molpha.2025.100086_bib53","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.88638","article-title":"Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function, and prevents sudden arrhythmic death in failing hearts","volume":"12","author":"Joshi","year":"2023","journal-title":"Elife"},{"issue":"7","key":"10.1016\/j.molpha.2025.100086_bib54","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/01.RES.0000036914.12686.28","article-title":"Quantitative assessment of the SR Ca2+ leak-load relationship","volume":"91","author":"Shannon","year":"2002","journal-title":"Circ Res"},{"issue":"11","key":"10.1016\/j.molpha.2025.100086_bib55","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1161\/01.RES.0000192146.85173.4b","article-title":"Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death","volume":"97","author":"Jiang","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.molpha.2025.100086_bib56","article-title":"Tetracaine","author":"Stringer","year":"2024","journal-title":"StatPearls"},{"issue":"1","key":"10.1016\/j.molpha.2025.100086_bib57","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-pharmtox-061724-080739","article-title":"Inhibitors of intracellular RyR2 calcium release channels as therapeutic agents in arrhythmogenic heart diseases","volume":"65","author":"Do","year":"2025","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"1","key":"10.1016\/j.molpha.2025.100086_bib58","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ccep.2010.10.012","article-title":"Overview of basic mechanisms of cardiac arrhythmia","volume":"3","author":"Antzelevitch","year":"2011","journal-title":"Card Electrophysiol Clin"},{"issue":"3","key":"10.1016\/j.molpha.2025.100086_bib59","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1124\/molpharm.123.000752","article-title":"ent-Verticilide B1 inhibits type 2 ryanodine receptor channels and is antiarrhythmic in Casq2 -\/- mice","volume":"105","author":"Gochman","year":"2024","journal-title":"Mol Pharmacol"},{"issue":"1","key":"10.1016\/j.molpha.2025.100086_bib60","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s41467-023-36579-w","article-title":"A bivalent remipede toxin promotes calcium release via ryanodine receptor activation","volume":"14","author":"Maxwell","year":"2023","journal-title":"Nat Commun"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X25157465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X25157465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:46:47Z","timestamp":1773931607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X25157465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":60,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0026895X25157465"],"URL":"https:\/\/doi.org\/10.1016\/j.molpha.2025.100086","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Introduction of a single carboxylic acid converts the cyclic oligomeric depsipeptide ent-verticilide from a ryanodine receptor 2 (RyR2) inhibitor to RyR2 activator","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molpha.2025.100086","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of American Society for Pharmacology and Experimental Therapeutics.","name":"copyright","label":"Copyright"}],"article-number":"100086"}}