{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:03:19Z","timestamp":1785322999125,"version":"3.55.0"},"reference-count":79,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH141461"],"award-info":[{"award-number":["MH141461"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007737","name":"St. Jude Children's Research Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH124671"],"award-info":[{"award-number":["MH124671"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS031373"],"award-info":[{"award-number":["NS031373"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS132060"],"award-info":[{"award-number":["NS132060"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["molpharm.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Pharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.molpha.2026.100133","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:24:30Z","timestamp":1780719870000},"page":"100133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Molecular pharmacology of mGlu7\/8 heterodimers reveals unique properties of orthosteric agonists and positive allosteric modulators"],"prefix":"10.1016","volume":"108","author":[{"given":"Anthony S.","family":"Ferranti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhyun","family":"Noh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3195-7190","authenticated-orcid":false,"given":"Xia","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Bungard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley B.","family":"Asher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-2967","authenticated-orcid":false,"given":"Jonathan A.","family":"Javitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6009-8212","authenticated-orcid":false,"given":"Colleen M.","family":"Niswender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.molpha.2026.100133_bib1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.pharmtox.011008.145533","article-title":"Metabotropic glutamate receptors: physiology, pharmacology, and disease","volume":"50","author":"Niswender","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.molpha.2026.100133_bib2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.coph.2016.10.007","article-title":"Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation","volume":"32","author":"Hellyer","year":"2017","journal-title":"Curr Opin Pharmacol"},{"issue":"3","key":"10.1016\/j.molpha.2026.100133_bib3","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1124\/pharmrev.121.000540","article-title":"Allosteric modulators of metabotropic glutamate receptors as novel therapeutics for neuropsychiatric disease","volume":"74","author":"Luessen","year":"2022","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.molpha.2026.100133_bib4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuroscience.2024.06.013","article-title":"Heterodimers revolutionize the field of metabotropic glutamate receptors","volume":"578","author":"Belkacemi","year":"2025","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.molpha.2026.100133_bib5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1096\/fj.10-163147","article-title":"A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors","volume":"25","author":"Doumazane","year":"2011","journal-title":"FASEB J"},{"issue":"10","key":"10.1016\/j.molpha.2026.100133_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102458","article-title":"Differential activity of mGlu7 allosteric modulators provides evidence for mGlu7\/8 heterodimers at hippocampal Schaffer collateral-CA1 synapses","volume":"298","author":"Lin","year":"2022","journal-title":"J Biol Chem"},{"key":"10.1016\/j.molpha.2026.100133_bib7","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.26985","article-title":"Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer","volume":"6","author":"Liu","year":"2017","journal-title":"eLife"},{"issue":"8","key":"10.1016\/j.molpha.2026.100133_bib8","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/s41589-022-01050-2","article-title":"Nanobody-based sensors reveal a high proportion of mGlu heterodimers in the brain","volume":"18","author":"Meng","year":"2022","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.molpha.2026.100133_bib9","doi-asserted-by":"crossref","unstructured":"Moreno Delgado D, M\u00f8ller TC, Ster J, et al. Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells. eLife. 6:e25233. https:\/\/doi.org\/10.7554\/eLife.25233.","DOI":"10.7554\/eLife.25233"},{"key":"10.1016\/j.molpha.2026.100133_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108426","article-title":"Symmetric signal transduction and negative allosteric modulation of heterodimeric mGlu1\/5 receptors","volume":"190","author":"Werthmann","year":"2021","journal-title":"Neuropharmacology"},{"issue":"677","key":"10.1016\/j.molpha.2026.100133_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abd2319","article-title":"Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu2\/mGlu4 receptor heterodimers","volume":"14","author":"Xiang","year":"2021","journal-title":"Sci Signal"},{"issue":"1","key":"10.1016\/j.molpha.2026.100133_bib12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1523\/JNEUROSCI.1129-13.2014","article-title":"Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS","volume":"34","author":"Yin","year":"2014","journal-title":"J Neurosci"},{"issue":"9","key":"10.1016\/j.molpha.2026.100133_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.molpha.2025.100063","article-title":"Metabotropic glutamate receptor homo- and heterodimers exhibit distinct responses to orthosteric and allosteric ligands","volume":"107","author":"McCullock","year":"2025","journal-title":"Mol Pharmacol"},{"issue":"6","key":"10.1016\/j.molpha.2026.100133_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101418","article-title":"The mGluR6 ligand-binding domain, but not the C-terminal domain, is required for synaptic localization in retinal ON-bipolar cells","volume":"297","author":"Agosto","year":"2021","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"10.1016\/j.molpha.2026.100133_bib15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0304-3940(94)90602-5","article-title":"Expression of mRNAs of L-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina","volume":"171","author":"Akazawa","year":"1994","journal-title":"Neurosci Lett"},{"issue":"4","key":"10.1016\/j.molpha.2026.100133_bib16","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1523\/JNEUROSCI.15-04-03075.1995","article-title":"A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb","volume":"15","author":"Duvoisin","year":"1995","journal-title":"J Neurosci"},{"issue":"16","key":"10.1016\/j.molpha.2026.100133_bib17","doi-asserted-by":"crossref","first-page":"11868","DOI":"10.1016\/S0021-9258(19)50280-0","article-title":"Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate","volume":"268","author":"Nakajima","year":"1993","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.molpha.2026.100133_bib18","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0092-8674(94)90151-1","article-title":"Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells","volume":"77","author":"Nomura","year":"1994","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.molpha.2026.100133_bib19","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/ajmg.b.32253","article-title":"Glutamatergic copy number variants and their role in attention-deficit\/hyperactivity disorder","volume":"165","author":"Akutagava-Martins","year":"2014","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"1","key":"10.1016\/j.molpha.2026.100133_bib20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/ng.1013","article-title":"Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder","volume":"44","author":"Elia","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.molpha.2026.100133_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2023.173546","article-title":"GRM7 gene mutations and consequences for neurodevelopment","volume":"225","author":"Freitas","year":"2023","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"10.1016\/j.molpha.2026.100133_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s11689-023-09483-z","article-title":"Rare recurrent copy number variations in metabotropic glutamate receptor interacting genes in children with neurodevelopmental disorders","volume":"15","author":"Glessner","year":"2023","journal-title":"J Neurodev Disord"},{"issue":"12","key":"10.1016\/j.molpha.2026.100133_bib23","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.biopsych.2006.06.026","article-title":"Attention-deficit\/hyperactivity disorder and comorbid disruptive behavior disorders: evidence of pleiotropy and new susceptibility loci","volume":"61","author":"Jain","year":"2007","journal-title":"Biol Psychiatry"},{"issue":"7","key":"10.1016\/j.molpha.2026.100133_bib24","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1007\/s11011-023-01272-w","article-title":"A pilot study on glutamate receptor and carrier gene variants and risk of childhood autism spectrum","volume":"38","author":"Liu","year":"2023","journal-title":"Metab Brain Dis"},{"issue":"21","key":"10.1016\/j.molpha.2026.100133_bib25","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1177\/15353702211018970","article-title":"Deep learning prediction of attention-deficit hyperactivity disorder in African Americans by copy number variation","volume":"246","author":"Liu","year":"2021","journal-title":"Exp Biol Med"},{"issue":"8","key":"10.1016\/j.molpha.2026.100133_bib26","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/ajmg.b.30865","article-title":"Genome-wide association study of response to methylphenidate in 187 children with attention-deficit\/hyperactivity disorder","volume":"147B","author":"Mick","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.molpha.2026.100133_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1744-9081-9-1","article-title":"Association between the GRM7 rs3792452 polymorphism and attention deficit hyperactivity disorder in a Korean sample","volume":"9","author":"Park","year":"2013","journal-title":"Behav Brain Funct BBF"},{"key":"10.1016\/j.molpha.2026.100133_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jpsychires.2020.09.035","article-title":"Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit\/hyperactivity disorder and functional exploration of risk loci","volume":"132","author":"Zhang","year":"2021","journal-title":"J Psychiatr Res"},{"issue":"1","key":"10.1016\/j.molpha.2026.100133_bib29","article-title":"Altered short-term synaptic plasticity in mice lacking the metabotropic glutamate receptor mGlu7","volume":"2","author":"Bushell","year":"2002","journal-title":"Sci World J"},{"issue":"7","key":"10.1016\/j.molpha.2026.100133_bib30","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12654","article-title":"Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders","volume":"19","author":"Fisher","year":"2020","journal-title":"Genes Brain Behav"},{"issue":"22","key":"10.1016\/j.molpha.2026.100133_bib31","doi-asserted-by":"crossref","first-page":"8734","DOI":"10.1523\/JNEUROSCI.21-22-08734.2001","article-title":"Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7","volume":"21","author":"Sansig","year":"2001","journal-title":"J Neurosci"},{"issue":"2","key":"10.1016\/j.molpha.2026.100133_bib32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1460-9568.2005.04210.x","article-title":"Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8","volume":"22","author":"Duvoisin","year":"2005","journal-title":"Eur J Neurosci"},{"issue":"1","key":"10.1016\/j.molpha.2026.100133_bib33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1601-183X.2009.00532.x","article-title":"The effect of mGlu8 deficiency in animal models of psychiatric diseases","volume":"9","author":"Fendt","year":"2010","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.molpha.2026.100133_bib34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neuropharm.2013.04.052","article-title":"Differential roles of mGlu7 and mGlu8 in amygdala-dependent behavior and physiology","volume":"72","author":"Fendt","year":"2013","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.molpha.2026.100133_bib35","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0028-3908(02)00078-3","article-title":"Performance deficits of mGluR8 knockout mice in learning tasks: the effects of null mutation and the background genotype","volume":"43","author":"Gerlai","year":"2002","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.molpha.2026.100133_bib36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0028-3908(02)00079-5","article-title":"Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor","volume":"43","author":"Linden","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.molpha.2026.100133_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.901309","article-title":"Loss-of-function models of the metabotropic glutamate receptor genes Grm8a and Grm8b display distinct behavioral phenotypes in zebrafish larvae (Danio rerio)","volume":"15","author":"L\u00fcffe","year":"2022","journal-title":"Front Mol Neurosci"},{"issue":"31","key":"10.1016\/j.molpha.2026.100133_bib38","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0119-24.2024","article-title":"Thalamocortical mGlu8 modulates dorsal thalamus excitatory transmission and sensorimotor activity","volume":"44","author":"Nabit","year":"2024","journal-title":"J Neurosci"},{"issue":"403","key":"10.1016\/j.molpha.2026.100133_bib39","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aai7459","article-title":"mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome","volume":"9","author":"Gogliotti","year":"2017","journal-title":"Sci Transl Med"},{"issue":"10","key":"10.1016\/j.molpha.2026.100133_bib40","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1021\/acsmedchemlett.7b00317","article-title":"Discovery of VU6005649, a CNS penetrant mGlu7\/8 receptor PAM derived from a series of pyrazolo[1,5-a]pyrimidines","volume":"8","author":"Abe","year":"2017","journal-title":"ACS Med Chem Lett"},{"issue":"45","key":"10.1016\/j.molpha.2026.100133_bib41","doi-asserted-by":"crossref","first-page":"33000","DOI":"10.1074\/jbc.M702542200","article-title":"Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement","volume":"282","author":"Brock","year":"2007","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.molpha.2026.100133_bib42","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/sj.emboj.7600557","article-title":"Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR","volume":"24","author":"Hlavackova","year":"2005","journal-title":"EMBO J"},{"issue":"37","key":"10.1016\/j.molpha.2026.100133_bib43","doi-asserted-by":"crossref","first-page":"15480","DOI":"10.1073\/pnas.1107775108","article-title":"Interdomain movements in metabotropic glutamate receptor activation","volume":"108","author":"Huang","year":"2011","journal-title":"Proc Natl Acad Sci"},{"issue":"9","key":"10.1016\/j.molpha.2026.100133_bib44","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/nchembio.623","article-title":"CODA-RET reveals functional selectivity as a result of GPCR heteromerization","volume":"7","author":"Urizar","year":"2011","journal-title":"Nat Chem Biol"},{"issue":"1","key":"10.1016\/j.molpha.2026.100133_bib45","doi-asserted-by":"crossref","first-page":"8552","DOI":"10.1038\/s41467-024-52822-4","article-title":"Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer","volume":"15","author":"Lin","year":"2024","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.molpha.2026.100133_bib46","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1021\/cn500153z","article-title":"Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7","volume":"5","author":"Jalan-Sakrikar","year":"2014","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.molpha.2026.100133_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.129106","article-title":"Persistent challenges in the development of an mGlu7 PAM in vivo tool compound: the discovery of VU6046980","volume":"80","author":"Kalbfleisch","year":"2023","journal-title":"Bioorg Med Chem Lett"},{"issue":"9","key":"10.1016\/j.molpha.2026.100133_bib48","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1021\/acsmedchemlett.0c00432","article-title":"Discovery of VU6027459: a first-in-class selective and CNS penetrant mGlu7 positive allosteric modulator tool compound","volume":"11","author":"Reed","year":"2020","journal-title":"ACS Med Chem Lett"},{"issue":"10","key":"10.1016\/j.molpha.2026.100133_bib49","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1261\/rna.078729.121","article-title":"Regulation and functional consequences of mGlu4 RNA editing","volume":"27","author":"Hofmann","year":"2021","journal-title":"RNA"},{"issue":"1","key":"10.1016\/j.molpha.2026.100133_bib50","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1124\/molpharm.123.000678","article-title":"Differential activity of orthosteric agonists and allosteric modulators at metabotropic glutamate receptor 7","volume":"104","author":"Lei","year":"2023","journal-title":"Mol Pharmacol"},{"issue":"10","key":"10.1016\/j.molpha.2026.100133_bib51","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.1073\/pnas.1031748100","article-title":"Membrane receptor trafficking: evidence of proximal and distal zones conferred by two independent endoplasmic reticulum localization signals","volume":"100","author":"Shikano","year":"2003","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"10.1016\/j.molpha.2026.100133_bib52","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0026-895X(25)09394-0","article-title":"Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q\/i proteins: characterization of new antagonists","volume":"50","author":"Gomeza","year":"1996","journal-title":"Mol Pharmacol"},{"issue":"15","key":"10.1016\/j.molpha.2026.100133_bib53","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.1523\/JNEUROSCI.20-15-05663.2000","article-title":"cAMP-dependent protein kinase inhibits mGluR2 coupling to G-proteins by direct receptor phosphorylation","volume":"20","author":"Schaffhauser","year":"2000","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.molpha.2026.100133_bib54","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1124\/mol.107.041053","article-title":"A novel assay of Gi\/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors","volume":"73","author":"Niswender","year":"2008","journal-title":"Mol Pharmacol"},{"issue":"19","key":"10.1016\/j.molpha.2026.100133_bib55","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1074\/jbc.RA118.001975","article-title":"Mini G protein probes for active G protein\u2013coupled receptors (GPCRs) in live cells","volume":"293","author":"Wan","year":"2018","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.molpha.2026.100133_bib56","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1124\/mol.110.067207","article-title":"Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity","volume":"78","author":"Rodriguez","year":"2010","journal-title":"Mol Pharmacol"},{"issue":"3","key":"10.1016\/j.molpha.2026.100133_bib57","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0028-3908(00)00169-6","article-title":"(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord","volume":"40","author":"Thomas","year":"2001","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.molpha.2026.100133_bib58","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00407-012-0098-5","article-title":"The Hill equation and the origin of quantitative pharmacology","volume":"66","author":"Gesztelyi","year":"2012","journal-title":"Arch Hist Exact Sci"},{"issue":"3","key":"10.1016\/j.molpha.2026.100133_bib59","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1124\/jpet.108.140350","article-title":"Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats","volume":"327","author":"Brady","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"issue":"41","key":"10.1016\/j.molpha.2026.100133_bib60","doi-asserted-by":"crossref","first-page":"10422","DOI":"10.1523\/JNEUROSCI.1850-08.2008","article-title":"Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats","volume":"28","author":"Jones","year":"2008","journal-title":"J Neurosci"},{"issue":"19","key":"10.1016\/j.molpha.2026.100133_bib61","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.1523\/JNEUROSCI.16-19-05979.1996","article-title":"Metabotropic glutamate receptors activate G-protein-coupled inwardly rectifying potassium channels in Xenopus oocytes","volume":"16","author":"Saugstad","year":"1996","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.molpha.2026.100133_bib62","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1085\/jgp.109.4.477","article-title":"Positive and negative coupling of the metabotropic glutamate receptors to a G protein\u2013activated K+ channel, GIRK, in Xenopus oocytes","volume":"109","author":"Sharon","year":"1997","journal-title":"J Gen Physiol"},{"issue":"5","key":"10.1016\/j.molpha.2026.100133_bib63","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.neuropharm.2007.12.009","article-title":"Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated","volume":"54","author":"Ayala","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.molpha.2026.100133_bib64","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.eplepsyres.2017.12.002","article-title":"Bidirectional shift of group III metabotropic glutamate receptor-mediated synaptic depression in the epileptic hippocampus","volume":"139","author":"Dammann","year":"2018","journal-title":"Epilepsy Res"},{"issue":"7864","key":"10.1016\/j.molpha.2026.100133_bib65","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41586-021-03641-w","article-title":"Structures of human mGlu2 and mGlu7 homo- and heterodimers","volume":"594","author":"Du","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.molpha.2026.100133_bib66","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neuron.2016.08.036","article-title":"Mechanism of assembly and cooperativity of homomeric and heteromeric metabotropic glutamate receptors","volume":"92","author":"Levitz","year":"2016","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.molpha.2026.100133_bib67","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0028-3908(03)00200-4","article-title":"Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice","volume":"45","author":"Linden","year":"2003","journal-title":"Neuropharmacology"},{"issue":"12","key":"10.1016\/j.molpha.2026.100133_bib68","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.tips.2007.09.011","article-title":"Why the Schild method is better than Schild realised","volume":"28","author":"Colquhoun","year":"2007","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.molpha.2026.100133_bib69","series-title":"Drug Receptors: A Symposium","first-page":"29","article-title":"Receptor classification with special reference to \u03b2-adrenergic receptors","author":"Schild","year":"1973"},{"issue":"3","key":"10.1016\/j.molpha.2026.100133_bib70","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1139\/y82-036","article-title":"The Schild regression in the process of receptor classification","volume":"60","author":"Kenakin","year":"1982","journal-title":"Can J Physiol Pharmacol"},{"issue":"2","key":"10.1016\/j.molpha.2026.100133_bib71","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00177709","article-title":"The effects on Schild regressions of antagonist removal from the receptor compartment by a saturable process","volume":"335","author":"Kenakin","year":"1987","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"10.1016\/j.molpha.2026.100133_bib72","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0006-8993(89)90969-4","article-title":"Schild plot analysis of glycine and kynurenic acid at the N-methyl-D-aspartate excitatory amino acid receptor","volume":"497","author":"Pullan","year":"1989","journal-title":"Brain Res"},{"issue":"22","key":"10.1016\/j.molpha.2026.100133_bib73","doi-asserted-by":"crossref","first-page":"10040","DOI":"10.1021\/acs.jmedchem.8b01120","article-title":"Structural basis for (S)-3,4-dicarboxyphenylglycine (DCPG) as a potent and subtype selective agonist of the mGlu8 receptor","volume":"61","author":"Chen","year":"2018","journal-title":"J Med Chem"},{"issue":"18","key":"10.1016\/j.molpha.2026.100133_bib74","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1016\/j.molcel.2025.08.019","article-title":"Structural characterization of five functional states of metabotropic glutamate receptor 8","volume":"85","author":"Zhao","year":"2025","journal-title":"Mol Cell"},{"issue":"1","key":"10.1016\/j.molpha.2026.100133_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-023-44013-4","article-title":"Homo- and hetero-dimeric subunit interactions set affinity and efficacy in metabotropic glutamate receptors","volume":"14","author":"Habrian","year":"2023","journal-title":"Nat Commun"},{"issue":"49","key":"10.1016\/j.molpha.2026.100133_bib76","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adi8076","article-title":"Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers","volume":"9","author":"Lee","year":"2023","journal-title":"Sci Adv"},{"issue":"2","key":"10.1016\/j.molpha.2026.100133_bib77","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0021-9258(17)42247-2","article-title":"Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction","volume":"269","author":"Okamoto","year":"1994","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.molpha.2026.100133_bib78","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejphar.2009.08.047","article-title":"Effects of a novel metabotropic glutamate receptor 7 negative allosteric modulator, 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo[4,5-c]pyridin-4(5H)-one (MMPIP), on the central nervous system in rodents","volume":"639","author":"Hikichi","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.molpha.2026.100133_bib79","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fncir.2016.00031","article-title":"Phasic and tonic mGlu7 receptor activity modulates the thalamocortical network","volume":"10","author":"Tassin","year":"2016","journal-title":"Front Neural Circuits"}],"container-title":["Molecular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X26000337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026895X26000337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:27:50Z","timestamp":1785320870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026895X26000337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":79,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0026895X26000337"],"URL":"https:\/\/doi.org\/10.1016\/j.molpha.2026.100133","relation":{},"ISSN":["0026-895X"],"issn-type":[{"value":"0026-895X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular pharmacology of mGlu7\/8 heterodimers reveals unique properties of orthosteric agonists and positive allosteric modulators","name":"articletitle","label":"Article Title"},{"value":"Molecular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.molpha.2026.100133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Pharmacology and Experimental Therapeutics.","name":"copyright","label":"Copyright"}],"article-number":"100133"}}