{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:32:59Z","timestamp":1782300779295,"version":"3.54.5"},"reference-count":55,"publisher":"Elsevier BV","issue":"354","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Morphologie"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.morpho.2021.04.004","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T08:33:11Z","timestamp":1621413191000},"page":"145-154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Role of pomegranate extract in restoring endometrial androgen receptor expression, proliferation, and pinopodes in a rat model of polycystic ovary syndrome"],"prefix":"10.1016","volume":"106","author":[{"given":"M.A.A.","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"Sadek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.E.M.","family":"Sharaf Eldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.morpho.2021.04.004_bib0280","first-page":"47","article-title":"Changes of the uterine tissue in rats with polycystic ovary syndrome induced by estradiol valerate","volume":"11","author":"Mirabolghasemi","year":"2017","journal-title":"Int J Fertil Steril"},{"key":"10.1016\/j.morpho.2021.04.004_bib0285","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.repbio.2020.01.001","article-title":"Investigation of the effects of vitamin D treatment on the ovarian AMH receptors in a polycystic ovary syndrome experimental model: an ultrastructural and immunohistochemical study","volume":"20","author":"Kuyucu","year":"2020","journal-title":"Reprod Biol"},{"key":"10.1016\/j.morpho.2021.04.004_bib0290","first-page":"291","article-title":"Features of polycystic ovary syndrome in adolescence","volume":"8","author":"Tsikouras","year":"2015","journal-title":"J Med Life"},{"key":"10.1016\/j.morpho.2021.04.004_bib0295","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1089\/jwh.2016.5792","article-title":"Lifestyle and behavioral management of polycystic ovary syndrome","volume":"26","author":"Brennan","year":"2017","journal-title":"J Womens Health (Larchmt)"},{"key":"10.1016\/j.morpho.2021.04.004_bib0300","doi-asserted-by":"crossref","first-page":"2965821","DOI":"10.1155\/2019\/2965821","article-title":"Phyllanthus muellerianus (Euphorbiaceae) restores ovarian functions in letrozole-induced polycystic ovarian syndrome in rats","volume":"2019","author":"Ndeingang","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.morpho.2021.04.004_bib0305","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ebiom.2017.03.023","article-title":"Metformin ameliorates uterine defects in a rat model of polycystic ovary syndrome","volume":"18","author":"Zhang","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.morpho.2021.04.004_bib0310","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1038\/ijo.2016.154","article-title":"Proinflammatory environment and role of TNF-\u03b1 in endometrial function of obese women having polycystic ovarian syndrome","volume":"40","author":"Or\u00f3stica","year":"2016","journal-title":"Int J Obes"},{"key":"10.1016\/j.morpho.2021.04.004_bib0315","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.repbio.2018.01.002","article-title":"Investigation of the uterine structural changes in the experimental model with polycystic ovary syndrome and effects of vitamin D treatment: an ultrastructural and immunohistochemical study","volume":"18","author":"Kuyucu","year":"2018","journal-title":"Reprod Biol"},{"key":"10.1016\/j.morpho.2021.04.004_bib0320","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1080\/13880209.2018.1510973","article-title":"Wenshen Yangxue decoction improves endometrial receptivity recovery and promotes endometrial angiogenesis in a rat model","volume":"56","author":"Xin","year":"2018","journal-title":"Pharm Biol"},{"key":"10.1016\/j.morpho.2021.04.004_bib0325","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/humupd\/dmq037","article-title":"Implantation failure: molecular mechanisms and clinical treatment","volume":"17","author":"Cakmak","year":"2011","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.morpho.2021.04.004_bib0330","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/GMIT.GMIT_112_18","article-title":"Evaluation of endometrial receptivity by measuring HOXA-10, HOXA-11, and leukemia inhibitory factor expression in patients with polycystic ovary syndrome","volume":"8","author":"Kara","year":"2019","journal-title":"Gynecol Minim Invasive Ther"},{"key":"10.1016\/j.morpho.2021.04.004_bib0335","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.3390\/nu10101430","article-title":"Welsh onion root (allium fistulosum) restores ovarian functions from letrozole induced-polycystic ovary syndrome","volume":"10","author":"Lee","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.morpho.2021.04.004_bib0340","first-page":"1077","article-title":"Clinical utility of letrozole in the treatment of breast cancer: a Chinese perspective","volume":"9","author":"He","year":"2016","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.morpho.2021.04.004_bib0345","article-title":"A rat model of polycystic ovary syndrome with insulin resistance induced by letrozole combined with high fat diet","volume":"26","author":"Wang","year":"2020","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.morpho.2021.04.004_bib0350","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.foodchem.2009.04.123","article-title":"Anti-inflammatory effects of Punica granatum Linne in vitro and in vivo","volume":"118","author":"Lee","year":"2010","journal-title":"Food Chem"},{"key":"10.1016\/j.morpho.2021.04.004_bib0355","doi-asserted-by":"crossref","first-page":"329","DOI":"10.21603\/2308-4057-2020-2-329-336","article-title":"Antioxidant and anti-diabetic activity of pomegranate (Punica granatum L.) leaves extracts","volume":"8","author":"Cheurfa","year":"2020","journal-title":"Foods Raw Mater"},{"key":"10.1016\/j.morpho.2021.04.004_bib0360","doi-asserted-by":"crossref","first-page":"2732958","DOI":"10.1155\/2020\/2732958","article-title":"Pomegranate seeds extract possesses a protective effect against tramadol-induced testicular toxicity in experimental rats","volume":"2020","author":"Minisy","year":"2020","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.morpho.2021.04.004_bib0365","first-page":"1262","article-title":"Potential therapeutic effect of pomegranate seed oil on ovarian ischemia\/reperfusion injury in rats","volume":"21","author":"Yayla","year":"2018","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.morpho.2021.04.004_bib0370","first-page":"35","article-title":"The effect of concentrated pomegranate juice consumption on risk factors of cardiovascular diseases in women with polycystic ovary syndrome: a randomized controlled trial","author":"Abedini","year":"2020","journal-title":"Phyther Res"},{"key":"10.1016\/j.morpho.2021.04.004_bib0375","doi-asserted-by":"crossref","first-page":"971","DOI":"10.13005\/bpj\/849","article-title":"The effect of pomegranate juice extract on hormonal changes of female wistar rats caused by polycystic ovarian syndrome","volume":"8","author":"Hossein","year":"2015","journal-title":"Biomed Pharmacol J"},{"key":"10.1016\/j.morpho.2021.04.004_bib0380","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J Basic Clin Pharm"},{"key":"10.1016\/j.morpho.2021.04.004_bib0385","doi-asserted-by":"crossref","first-page":"2152749","DOI":"10.1155\/2017\/2152749","article-title":"In vitro antibacterial activity of pomegranate juice and peel extracts on cariogenic bacteria","volume":"2017","author":"Ferrazzano","year":"2017","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.morpho.2021.04.004_bib0390","first-page":"1","article-title":"Proximate composition, phytochemical analysis and in vivo antioxidant activity of pomegranate seeds (Punica granatum) in female albino mice","volume":"7","author":"Abiola","year":"2018","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.morpho.2021.04.004_bib0395","article-title":"Effects of electro-acupuncture on ovarian P450arom, P450c17\u03b1 and mRNA expression induced by letrozole in PCOS rats","volume":"8","author":"Sun","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.morpho.2021.04.004_bib0400","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40738-020-00074-3","article-title":"Staging of the estrous cycle and induction of estrus in experimental rodents: an update","volume":"6","author":"Ajayi","year":"2020","journal-title":"Fertil Res Pract"},{"key":"10.1016\/j.morpho.2021.04.004_bib0405","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1439-0264.2006.00743.x","article-title":"Determination of oestrous cycle of the rats by direct examination: how reliable?","volume":"36","author":"Yener","year":"2007","journal-title":"Anat Histol Embryol"},{"key":"10.1016\/j.morpho.2021.04.004_bib0410","series-title":"Anesth. Analg. Lab. Anim","first-page":"239","article-title":"Anesthesia and analgesia for laboratory rodents","author":"Gaertner","year":"2008"},{"key":"10.1016\/j.morpho.2021.04.004_bib0415","series-title":"Theory Pract. Histol. Tech","first-page":"121","article-title":"The hematoxylins and eosin","author":"Gamble","year":"2008"},{"key":"10.1016\/j.morpho.2021.04.004_bib0420","series-title":"Theory Pract. Histol. Tech","first-page":"135","article-title":"Connective Tissues and Stains","author":"Jones","year":"2008"},{"key":"10.1016\/j.morpho.2021.04.004_bib0425","series-title":"Working with antibodies. immunohistochem. basics methods","first-page":"31","author":"Buchwalow","year":"2010"},{"key":"10.1016\/j.morpho.2021.04.004_bib0430","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1023\/A:1011336726819","article-title":"Comparative analysis of scanning electron microscopy techniques for semiconductors: electron-beam-induced potential method, single-contact electron-beam-induced current method, and thermoacoustic detection","volume":"30","author":"Rau","year":"2001","journal-title":"Russ Microelectron"},{"key":"10.1016\/j.morpho.2021.04.004_bib0435","series-title":"Basic & clinical biostatistics. Basic Clin. Biostat","first-page":"162","author":"Dawson","year":"2004"},{"key":"10.1016\/j.morpho.2021.04.004_bib0440","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.7150\/ijbs.13109","article-title":"Regulation of androgen receptor expression alters AMPK phosphorylation in the endometrium: in vivo and in vitro studies in women with polycystic ovary syndrome","volume":"11","author":"Li","year":"2015","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.morpho.2021.04.004_bib0445","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/09513590.2018.1529158","article-title":"Effect of irisin on endometrial receptivity of rats with polycystic ovary syndrome","volume":"35","author":"Li","year":"2019","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.morpho.2021.04.004_bib0450","first-page":"5575","article-title":"Correlation between endometrial receptivity with expressions of IL-1 and VEGF in rats with polycystic ovary syndrome","volume":"23","author":"Zhao","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.morpho.2021.04.004_bib0455","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.sjbs.2019.02.007","article-title":"Effects of dodder total flavone on polycystic ovary syndrome rat models induced by DHEA combined HCG","volume":"26","author":"Miao","year":"2019","journal-title":"Saudi J Biol Sci"},{"key":"10.1016\/j.morpho.2021.04.004_bib0460","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1177\/1933719118783881","article-title":"Hyperandrogenism induces histo-architectural changes in the rat uterus","volume":"26","author":"Bracho","year":"2018","journal-title":"Reprod Sci"},{"key":"10.1016\/j.morpho.2021.04.004_bib0465","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ygyno.2006.09.003","article-title":"Deregulation of tissue homeostasis in endometria from patients with polycystic ovarian syndrome with and without endometrial hyperplasia","volume":"104","author":"Villavicencio","year":"2007","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.morpho.2021.04.004_bib0470","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1158\/2159-8290.CD-16-0733","article-title":"Tissue force programs cell fate and tumor aggression","volume":"7","author":"Northey","year":"2017","journal-title":"Cancer Discov"},{"key":"10.1016\/j.morpho.2021.04.004_bib0475","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/jcp.20494","article-title":"Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells","volume":"206","author":"Bullwinkel","year":"2005","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.morpho.2021.04.004_bib0480","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2164\/jandrol.109.009266","article-title":"Roles of androgen receptor in male and female reproduction: lessons from global and cell-specific androgen receptor knockout (ARKO) mice","volume":"31","author":"Zhou","year":"2009","journal-title":"J Androl"},{"key":"10.1016\/j.morpho.2021.04.004_bib0485","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.mce.2011.06.031","article-title":"The role of androgens and the androgen receptor in cycling endometrium","volume":"358","author":"Cloke","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.morpho.2021.04.004_bib0490","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/rda.13489","article-title":"Expression of oestrogen receptor, androgen receptor and progesterone nuclear receptor in sheep uterus during the oestrous cycle","volume":"54","author":"Duan","year":"2019","journal-title":"Reprod Domest Anim"},{"key":"10.1016\/j.morpho.2021.04.004_bib0495","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.3390\/ijerph17072293","article-title":"Testosterone decreases the number of implanting embryos, expression of pinopode and L-selectin ligand (MECA-79) in the endometrium of early pregnant rats","volume":"17","author":"Mokhtar","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.morpho.2021.04.004_bib0500","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jmau.2015.10.002","article-title":"Ultrastructural features of eutopic endometrium in a rat model of endometriosis","volume":"4","author":"Elgamal","year":"2016","journal-title":"J Microsc Ultrastruct"},{"key":"10.1016\/j.morpho.2021.04.004_bib0505","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/humupd\/dmn052","article-title":"Pinopodes: a questionable role in endometrial receptivity","volume":"15","author":"Quinn","year":"2009","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.morpho.2021.04.004_bib0510","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/01.EHX.0000446582.73701.1b","article-title":"Arsenic-induced toxicity in the endometrium of adult albino rat and the possible role of human chorionic gonadotropin hormone","volume":"37","author":"Elshawarby","year":"2014","journal-title":"Egypt J Histol"},{"key":"10.1016\/j.morpho.2021.04.004_bib0515","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1093\/biolre\/iox101","article-title":"Adrenomedullin improves fertility and promotes pinopodes and cell junctions in the peri-implantation endometrium","volume":"97","author":"Matson","year":"2017","journal-title":"Biol Reprod"},{"key":"10.1016\/j.morpho.2021.04.004_bib0520","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.numecd.2018.07.002","article-title":"Effect of synbiotic pomegranate juice on glycemic, sex hormone profile and anthropometric indices in PCOS: a randomized, triple blind, controlled trial","volume":"29","author":"Esmaeilinezhad","year":"2019","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.morpho.2021.04.004_bib0525","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/2277-9175.129371","article-title":"Potent health effects of pomegranate","volume":"3","author":"Zarfeshany","year":"2014","journal-title":"Adv Biomed Res"},{"key":"10.1016\/j.morpho.2021.04.004_bib0530","first-page":"789764","article-title":"Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents","author":"Viladomiu","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.morpho.2021.04.004_bib0535","first-page":"345","article-title":"Punica granatum (Pomegranate) activity in health promotion and cancer prevention","volume":"12","author":"Bassiri-Jahromi","year":"2018","journal-title":"Oncol Rev"},{"key":"10.1016\/j.morpho.2021.04.004_bib0540","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jff.2016.08.024","article-title":"The anti-proliferative and anti-androgenic activity of different pomegranate accessions","volume":"26","author":"Orgil","year":"2016","journal-title":"J Funct Foods"},{"key":"10.1016\/j.morpho.2021.04.004_bib0545","doi-asserted-by":"crossref","first-page":"76","DOI":"10.17795\/jjnpp-8821","article-title":"Preventive effects of pomegranate seed extract on bleomycin-induced pulmonary fibrosis in rat","volume":"8","author":"Hemmati","year":"2013","journal-title":"Jundishapur J Nat Pharm Prod"},{"key":"10.1016\/j.morpho.2021.04.004_bib0550","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jnutbio.2007.11.006","article-title":"Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor","volume":"19","author":"Hong","year":"2008","journal-title":"J Nutr Biochem"}],"container-title":["Morphologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286011521000679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286011521000679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T13:58:23Z","timestamp":1761141503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286011521000679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":55,"journal-issue":{"issue":"354","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S1286011521000679"],"URL":"https:\/\/doi.org\/10.1016\/j.morpho.2021.04.004","relation":{},"ISSN":["1286-0115"],"issn-type":[{"value":"1286-0115","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of pomegranate extract in restoring endometrial androgen receptor expression, proliferation, and pinopodes in a rat model of polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"Morphologie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.morpho.2021.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}