{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:33:26Z","timestamp":1761179606510,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"357","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Morphologie"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.morpho.2023.01.001","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T17:31:46Z","timestamp":1674667906000},"page":"259-263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Aging effects in the extracellular matrix of the clitoris: A scanning electron microscopic analysis"],"prefix":"10.1016","volume":"107","author":[{"given":"Lucas Alves Sarmento","family":"Pires","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique Silva Dias","family":"Babinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albino","family":"Fonseca Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Henrique Martins","family":"Manaia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio Antonio","family":"Babinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.morpho.2023.01.001_bib0180","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/aac2.12013","article-title":"A glitch in the matrix: Age-dependent changes in the extracellular matrix facilitate common sites of metastasis","volume":"1","author":"Marino","year":"2020","journal-title":"Aging and Cancer"},{"key":"10.1016\/j.morpho.2023.01.001_bib0185","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.mayocp.2019.01.009","article-title":"The international society for the study of women's sexual health process of care for the identification of sexual concerns and problems in women","volume":"94","author":"Parish","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.morpho.2023.01.001_bib0190","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/ca.22524","article-title":"Anatomy of the clitoris and the female sexual response","volume":"28","author":"Pauls","year":"2015","journal-title":"Clinical anatomy"},{"key":"10.1016\/j.morpho.2023.01.001_bib0195","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ogc.2015.10.011","article-title":"Anatomy of the vulva and the female sexual response. Obstetrics and gynecology clinics of North America","volume":"43","author":"Yeung","year":"2016","journal-title":"Obstet Gynecol Clin North Am"},{"key":"10.1016\/j.morpho.2023.01.001_bib0200","doi-asserted-by":"crossref","first-page":"e201900803","DOI":"10.1590\/s0102-865020190080000003","article-title":"Stereological analysis of elastic fibers of the corpus cavernosum of rats during the aging process","volume":"34","author":"Hota","year":"2019","journal-title":"Acta Cir Bras"},{"key":"10.1016\/j.morpho.2023.01.001_bib0205","first-page":"513","article-title":"Immunohistochemical study of the corpora cavernosa of the human clitoris","volume":"188","author":"Toesca","year":"1996","journal-title":"J Anat"},{"year":"2014","series-title":"Anatomic study of the clitoris and the bulbo-clitoral organ","author":"Di Marino","key":"10.1016\/j.morpho.2023.01.001_bib0210"},{"key":"10.1016\/j.morpho.2023.01.001_bib0215","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jsxm.2016.02.172","article-title":"The physiology of female sexual function and the pathophysiology of female sexual dysfunction (Committee 13A)","volume":"13","author":"Levin","year":"2016","journal-title":"J Sex Med"},{"key":"10.1016\/j.morpho.2023.01.001_bib0220","doi-asserted-by":"crossref","first-page":"101682","DOI":"10.1016\/j.tice.2021.101682","article-title":"Fibrous components of extracellular matrix and smooth muscle of the vaginal wall in young and postmenopausal women: Stereological analysis","volume":"74","author":"Babinski","year":"2021","journal-title":"Tissue Cell"},{"key":"10.1016\/j.morpho.2023.01.001_bib0225","first-page":"956","article-title":"Organization of the fibrous connective tissue of the fallopian tubes in fertile and climacteric periods: a scanning electron microscopic and stereologic study","volume":"14","author":"Souza","year":"2021","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.morpho.2023.01.001_bib0230","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1464-410X.2010.09944.x","article-title":"The penis in diabetes: structural analysis of connective tissue and smooth muscle alterations in a rabbit model","volume":"108","author":"Abidu-Figueiredo","year":"2011","journal-title":"BJU international"},{"key":"10.1016\/j.morpho.2023.01.001_bib0235","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jsxm.2019.01.003","article-title":"Ultrastructural study of clitoral cavernous tissue and clitoral blood flow from type 1 diabetic premenopausal women on phosphodiesterase-5 inhibitor","volume":"16","author":"Caruso","year":"2019","journal-title":"J Sex Med"},{"key":"10.1016\/j.morpho.2023.01.001_bib0240","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/sj.ijir.3900982","article-title":"Morphological modifications in clitoris and vagina in spontaneously hypertensive rats","volume":"15","author":"Bechara","year":"2003","journal-title":"Int J Impot"},{"key":"10.1016\/j.morpho.2023.01.001_bib0245","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/sj.ijir.3900514","article-title":"Atherosclerosis-induced chronic arterial insufficiency causes clitoral cavernosal fibrosis in the rabbit","volume":"12","author":"Park","year":"2000","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.morpho.2023.01.001_bib0250","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1111\/j.1464-410X.2011.10162.x","article-title":"Cavernous smooth muscle hyperplasia in a rat model of hyperlipidaemia-associated erectile dysfunction","volume":"108","author":"Qiu","year":"2011","journal-title":"BJU international"},{"key":"10.1016\/j.morpho.2023.01.001_bib0255","first-page":"379","article-title":"Effects of hypercholesterolemic diet by long-term on elastic system fibers penile tissue: volumetric density analysis of elastic system fibers","volume":"9","author":"Fonseca","year":"2016","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.morpho.2023.01.001_bib0260","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1111\/jsm.12103","article-title":"Clitoral changes, sexuality, and body image during the menstrual cycle: a pilot study","volume":"10","author":"Morotti","year":"2013","journal-title":"J Sex Med"},{"key":"10.1016\/j.morpho.2023.01.001_bib0265","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41443-018-0089-4","article-title":"Effects of a high energy density diet in the \u201ccorpus cavernosum\u201d of mice","volume":"31","author":"Alves-Pereira","year":"2019","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.morpho.2023.01.001_bib0270","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF00393302","article-title":"Scanning electron microscopy of the tunica albuginea of the corpora cavernosa in normal and impotent subjects","volume":"23","author":"Iacono","year":"1995","journal-title":"Urol Res"},{"key":"10.1016\/j.morpho.2023.01.001_bib0275","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF02550501","article-title":"Ultrastructual changes of corpora cavernosa in vascular erectile dysfunction","volume":"28","author":"Aydos","year":"1996","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.morpho.2023.01.001_bib0280","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1590\/S0102-86502013000500010","article-title":"Age-related changes in the concentration of elastic fibers in different regions of the rabbit penis","volume":"28","author":"Abidu-Figueiredo","year":"2013","journal-title":"Acta Cir Bras"},{"key":"10.1016\/j.morpho.2023.01.001_bib0285","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S0022-5347(01)61825-1","article-title":"Histomorphometric analysis of age-related structural changes in human clitoral cavernosal tissue","volume":"161","author":"Tarcan","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.morpho.2023.01.001_bib0290","first-page":"271","article-title":"Effect of aging on penile ultrastructure","volume":"3","author":"Shen","year":"2001","journal-title":"Asian J Androl"},{"key":"10.1016\/j.morpho.2023.01.001_bib0295","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.5114\/aoms\/143150","article-title":"Changes in the extracellular matrix of the clitoris caused by aging: a stereological and comparative study","volume":"17","author":"Pires","year":"2021","journal-title":"Arch Med Sci"},{"key":"10.1016\/j.morpho.2023.01.001_bib0300","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1679\/aohc.51.473","article-title":"Three-dimensional organization of the collagen fibrillar framework of the human and rat livers","volume":"51","author":"Ohtani","year":"1988","journal-title":"Arch Histol Cytol"},{"key":"10.1016\/j.morpho.2023.01.001_bib0305","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.diff.2019.07.006","article-title":"Clitoral development in the mouse and human","volume":"111","author":"Cunha","year":"2020","journal-title":"Differentiation; research in biological diversity"},{"key":"10.1016\/j.morpho.2023.01.001_bib0310","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0022-5347(17)40205-9","article-title":"Corpora cavernosa ultrastructure in vascular erectile dysfunction","volume":"143","author":"Vickers","year":"1990","journal-title":"J Urol"},{"key":"10.1016\/j.morpho.2023.01.001_bib0315","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.mcna.2019.02.008","article-title":"Female Sexual Dysfunction","volume":"103","author":"Clayton","year":"2019","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.morpho.2023.01.001_bib0320","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1161\/01.HYP.31.1.522","article-title":"17Beta-estradiol, its metabolites, and progesterone inhibit cardiac fibroblast growth","volume":"31","author":"Dubey","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.morpho.2023.01.001_bib0325","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/gerona\/gls068","article-title":"The role of androgens and estrogens on healthy aging and longevity","volume":"67","author":"Horstman","year":"2012","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.morpho.2023.01.001_bib0330","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1111\/jcmm.14199","article-title":"Local oestrogen therapy modulates extracellular matrix and immune response in the vaginal tissue of post-menopausal women with severe pelvic organ prolapse","volume":"23","author":"Tyagi","year":"2019","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.morpho.2023.01.001_bib0335","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.jsxm.2016.10.007","article-title":"Differential effects of testosterone and estradiol on clitoral function: an experimental study in rats","volume":"13","author":"Comeglio","year":"2016","journal-title":"J Sex Med"},{"key":"10.1016\/j.morpho.2023.01.001_bib0340","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1007\/s40618-021-01598-1","article-title":"Effects of testosterone treatment on clitoral haemodynamics in women with sexual dysfunction","volume":"44","author":"Cipriani","year":"2021","journal-title":"J Endocrinol Invest"},{"year":"2021","key":"10.1016\/j.morpho.2023.01.001_bib0345"},{"key":"10.1016\/j.morpho.2023.01.001_bib0350","article-title":"Pleasure, womanhood and the desire for reconstructive surgery after female genital cutting in Belgium","author":"O\u2019Neill","year":"2021","journal-title":"Anthropol Med"}],"container-title":["Morphologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286011523000012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1286011523000012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T13:58:38Z","timestamp":1761141518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1286011523000012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":35,"journal-issue":{"issue":"357","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S1286011523000012"],"URL":"https:\/\/doi.org\/10.1016\/j.morpho.2023.01.001","relation":{},"ISSN":["1286-0115"],"issn-type":[{"type":"print","value":"1286-0115"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aging effects in the extracellular matrix of the clitoris: A scanning electron microscopic analysis","name":"articletitle","label":"Article Title"},{"value":"Morphologie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.morpho.2023.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}