{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:39:13Z","timestamp":1790858353358,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30160038"],"award-info":[{"award-number":["30160038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.mrfmmm.2004.03.008","type":"journal-article","created":{"date-parts":[[2004,6,16]],"date-time":"2004-06-16T07:57:17Z","timestamp":1087372637000},"page":"167-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Folate deficiency induces aneuploidy in human lymphocytes in vitro\u2014evidence using cytokinesis-blocked cells and probes specific for chromosomes 17 and 21"],"prefix":"10.1016","volume":"551","author":[{"given":"Xu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglun","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fenech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB1","doi-asserted-by":"crossref","unstructured":"I. Eto, C.L. Krumdieck, Role of Vitamin B-12 and folate deficiencies in carcinogenesis, in: L.A. Poirier, P.M. Newberne, M.W. Pariza (Eds.), Essential Nutrients in Carcinogenesis, Plenum Press, New York, 1986, pp. 313\u2013331.","DOI":"10.1007\/978-1-4613-1835-4_23"},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB2","first-page":"56","article-title":"The role of folic acid and Vitamin B12 in genomic stability of human cells","volume":"475","author":"Fenech","year":"2001","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0950-3536(05)80216-1","article-title":"DNA damage in folate deficiency","volume":"8","author":"Blount","year":"1995","journal-title":"Bailleres Clin. Haematol."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB4","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1073\/pnas.94.7.3290","article-title":"Folate deficiency causes uracil midincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage","volume":"94","author":"Blount","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB5","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/carcin\/18.5.869","article-title":"Genetic epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis","volume":"18","author":"Zingg","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB6","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/carcin\/18.7.1329","article-title":"Folate, Vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of old men","volume":"18","author":"Fenech","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB7","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/carcin\/19.7.1163","article-title":"Folate, Vitamin B12, homocysteine status and DNA damage in young Australian adults","volume":"19","author":"Fenech","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB8","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/carcin\/22.7.1019","article-title":"MTHFR C677T polymorphism dose not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro","volume":"22","author":"Crott","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB9","first-page":"1089","article-title":"The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytesin vitro","volume":"10","author":"Crott","year":"2001","journal-title":"Cancer Epidemiol. Biomark. Prevent."},{"issue":"1","key":"10.1016\/j.mrfmmm.2004.03.008_BIB10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/jn\/134.1.48","article-title":"MTHFR C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes","volume":"134","author":"Kimura","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00008469-199411000-00004","article-title":"DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation","volume":"3","author":"Cravo","year":"1994","journal-title":"Eur. J. Cancer. Prev."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB12","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/jn\/128.7.1204","article-title":"Moderate folate depletion increases plasma homocysteine and decreases lymphocytes DNA methylation in post-menopausal women","volume":"128","author":"Jacob","year":"1998","journal-title":"J. Nutr."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB13","first-page":"901","article-title":"Hypomethylation in cervical tissue\u2014is there correlation with folate status","volume":"7","author":"Fowler","year":"1998","journal-title":"Cancer Epi. Biom. Prev."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB14","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1073\/pnas.97.7.3236","article-title":"Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidy","volume":"97","author":"Li","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB15","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/ajcn\/70.4.495","article-title":"Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome","volume":"70","author":"James","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/excr.1994.1068","article-title":"Exclusion of specific human chromosomes into micronuclei by 5-azacytidine treatment of lymphocyte cultures","volume":"211","author":"Guttenbach","year":"1994","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000015389","article-title":"Preferential occurrence of chromosome 21 mal-segregation in peripheral blood lymphocytes of Alzheimer disease patients","volume":"87","author":"Migliore","year":"1999","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB18","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1001\/jama.281.17.1632","article-title":"A prospective study of folate intake and the risk of breast cancer","volume":"281","author":"Zhang","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB19","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S1072-7515(00)00252-0","article-title":"Incidence of chromosomes 1 and 17 aneusomy in breast cancer and adjacent tissue: an interphase cytogenetic study","volume":"190","author":"Botti","year":"2000","journal-title":"J. Amer Coll Surg."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/modpathol.3880505","article-title":"Aneusomy 17 in breast cancer:its role in HER-2\/neu protein expression and implication for clinical assessment of HER-2\/neu status","volume":"15","author":"Wang","year":"2002","journal-title":"Mod. Pathol."},{"issue":"9297","key":"10.1016\/j.mrfmmm.2004.03.008_BIB21","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1016\/S0140-6736(01)06959-8","article-title":"Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study","volume":"358","author":"Thompson","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1034\/j.1600-0609.2002.00547.x","article-title":"Spectral karyotyping and interphase FISH reveal abnormalities not detected by conventional G-banding. Implications for treatment stratification of childhood acute lymphoblastic leukaemia: detailed analyses of 70 cases","volume":"68","author":"Nordgren","year":"2002","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0027-5107(00)00065-8","article-title":"The in vitro micronucleus technique","volume":"455","author":"Fenech","year":"2000","journal-title":"Mutat. Res."},{"issue":"22","key":"10.1016\/j.mrfmmm.2004.03.008_BIB24","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S1359-6446(02)02502-3","article-title":"Chromosomal biomarkers of genomic instability relevant to cancer","volume":"7","author":"Fenech","year":"2002","journal-title":"Drug Discov. Today"},{"issue":"1","key":"10.1016\/j.mrfmmm.2004.03.008_BIB25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/mutage\/18.1.81","article-title":"A comparison of folic acid and 5-methyl tetrahydrofolate for prevention of DNA damage and cell death in human lymphocytes in vitro","volume":"18","author":"Wang","year":"2003","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/BF00215682","article-title":"Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction","volume":"88","author":"Dunham","year":"1992","journal-title":"Hum. Genet."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB27","first-page":"29","article-title":"Incidence of mosaic cell lines in vivo and malsegregation of chromosome 21 in lymphocytes in vitro of trisomy 21 patients: detection by fluorescence in situ hybridization on binucleated lymphocytes","volume":"106","author":"Shi","year":"2000","journal-title":"Hum. Genet."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0165-1161(90)90041-L","article-title":"Detection of aneuploidy and aneuploidy-inducing agents in human lymphocytes using fluorescence in situ hybridization with chromosome-specific DNA probes","volume":"234","author":"Eastmond","year":"1990","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB29","doi-asserted-by":"crossref","first-page":"9138","DOI":"10.1073\/pnas.85.23.9138","article-title":"Fluorescence in situ hybridization with human chromosome specific libraries: detection of trisomy 21 and translocations of chromosome 4","volume":"85","author":"Pinkel","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.mrfmmm.2004.03.008_BIB30","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/mutage\/14.5.491","article-title":"Analysis of chromosome loss and non-disjunction in cytokinesis-blocked lymphocytes of 24 male subjects","volume":"14","author":"Carere","year":"1999","journal-title":"Mutagenesis"},{"issue":"3","key":"10.1016\/j.mrfmmm.2004.03.008_BIB31","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/ajmg.a.20234","article-title":"Methionine synthase (MTR) 2756 (A \u2192 G) polymorphism, double heterozygosity methionine synthase 2756 AG\/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome","volume":"121A","author":"Bosco","year":"2003","journal-title":"Am. J. Med. Genet."},{"issue":"2","key":"10.1016\/j.mrfmmm.2004.03.008_BIB32","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0027-5107(96)00143-1","article-title":"Fluorescence in situ hybridisation with chromosome-specific centromeric probes:a sensitive method to detect aneuploidy","volume":"372","author":"Marshall","year":"1996","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB33","doi-asserted-by":"crossref","unstructured":"E. Engel, S.E. Antonarkis, Genomic Imprinting and Uniparental Disomy in Medicine: Clinical and Molecular Aspects, Wiley-Liss Inc., 2002, pp. 25\u201348.","DOI":"10.1002\/0471221937"},{"issue":"2","key":"10.1016\/j.mrfmmm.2004.03.008_BIB34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0888-7543(92)90242-K","article-title":"Uniparental isodisomy due to duplication of chromosome 21 occurring in somatic cells monosomic for chromosome 21","volume":"13","author":"Petersen","year":"1992","journal-title":"Genomics"},{"issue":"1\u20132","key":"10.1016\/j.mrfmmm.2004.03.008_BIB35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0027-5107(02)00088-X","article-title":"Aneuploidy, centrosome activity and chromosome instability in cells deficient in homologous recombination repair","volume":"504","author":"Griffin","year":"2002","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2004.03.008_BIB36","first-page":"383","article-title":"Centrosome abnormalities and genomic instability induced by human papillomavirus oncoproteins","volume":"5","author":"Duensing","year":"2003","journal-title":"Prog. Cell Cycle Res."},{"issue":"5","key":"10.1016\/j.mrfmmm.2004.03.008_BIB37","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1091\/mbc.e02-08-0510","article-title":"Centrosomes split in the presence of impaired DNA integrity during mitosis","volume":"14","author":"Hut","year":"2003","journal-title":"Mol. Biol. Cell"}],"container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510704001514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510704001514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T13:26:09Z","timestamp":1764595569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0027510704001514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":37,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0027510704001514"],"URL":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2004.03.008","relation":{},"ISSN":["1386-1964"],"issn-type":[{"value":"1386-1964","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Folate deficiency induces aneuploidy in human lymphocytes in vitro\u2014evidence using cytokinesis-blocked cells and probes specific for chromosomes 17 and 21","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2004.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}