{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:03:30Z","timestamp":1790409810595,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.mrfmmm.2004.07.010","type":"journal-article","created":{"date-parts":[[2004,9,25]],"date-time":"2004-09-25T11:07:18Z","timestamp":1096110438000},"page":"127-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Increased mutation in mice genetically predisposed to oxidative damage in the brain"],"prefix":"10.1016","volume":"556","author":[{"given":"James R.","family":"Stringer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon S.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared M.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saundra L.","family":"Stringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrfmmm.2004.07.010_bib1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/17135","article-title":"Molecular characterization of mitochondrial apoptosis-inducing factor","volume":"397","author":"Susin","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib2","first-page":"34","article-title":"Two new mutations","volume":"45","author":"Barber","year":"1971","journal-title":"Mouse News Lett."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature01034","article-title":"The harlequin mouse mutation downregulates apoptosis-inducing factor","volume":"419","author":"Klein","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib4","doi-asserted-by":"crossref","first-page":"16391","DOI":"10.1074\/jbc.M010498200","article-title":"NADH oxidase activity of mitochondrial apoptosis-inducing factor","volume":"276","author":"Miramar","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib5","first-page":"7444","article-title":"Oxidative stress increases frameshift mutations in human colorectal cancer cells","volume":"61","author":"Gasche","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S1476-5586(03)80027-1","article-title":"Induction of chromosomal instability by chronic oxidative stress","volume":"5","author":"Limoli","year":"2003","journal-title":"Neoplasia"},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1474-9728.2003.00066.x","article-title":"Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture","volume":"2","author":"Busuttil","year":"2003","journal-title":"Aging Cell"},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib8","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0891-5849(00)00172-6","article-title":"DNA damage, repair, and antioxidant systems in brain regions: a correlative study","volume":"28","author":"Cardozo-Pelaez","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib9","doi-asserted-by":"crossref","first-page":"12468","DOI":"10.1073\/pnas.95.21.12468","article-title":"Induction of microsatellite instability by oxidative DNA damage","volume":"95","author":"Jackson","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib10","first-page":"1837","article-title":"A novel signature mutation for oxidative damage resembles a mutational pattern found commonly in human cancers","volume":"59","author":"Turker","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0027-5107(98)00163-8","article-title":"In situ detection of frameshift mutations in mouse cells","volume":"421","author":"Cao","year":"1998","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/meth.1998.0644","article-title":"Use of human placental alkaline phosphatase transgenes to detect somatic mutation in mice in situ","volume":"16","author":"DePrimo","year":"1998","journal-title":"Methods"},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0027-5107(02)00120-3","article-title":"Visualization of mosaicism in tissues of normal and mismatch-repair-deficient mice carrying a microsatellite-containing transgene","volume":"505","author":"Hersh","year":"2002","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib14","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0168-9525(93)90089-Z","article-title":"Mutagenesis by 8-oxoguanine: an enemy within","volume":"9","author":"Grollman","year":"1993","journal-title":"Trends Genet."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib15","first-page":"187","article-title":"Microsatellite instability induced by hydrogen peroxide in Escherichia coli","volume":"447","author":"Jackson","year":"2000","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib16","first-page":"2447","article-title":"Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability","volume":"62","author":"Duval","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/jcp.52.1.5","article-title":"DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer?","volume":"52","author":"Iino","year":"1999","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib18","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1349-7006.2001.tb01134.x","article-title":"Frameshift mutations at mononucleotide repeats in RAD50 recombinational DNA repair gene in colorectal cancers with microsatellite instability","volume":"92","author":"Ikenoue","year":"2001","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib19","first-page":"2995","article-title":"Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype","volume":"59","author":"Schwartz","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib20","first-page":"4213","article-title":"Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability","volume":"59","author":"Duval","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib21","first-page":"297","article-title":"Microsatellite instability and frameshift mutations in genes involved in cell cycle progression or apoptosis in ovarian cancer","volume":"11","author":"Codegoni","year":"1999","journal-title":"Oncol. Res."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib22","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1038\/sj.onc.1202583","article-title":"Mutated gene-specific phenotypes of dinucleotide repeat instability in human colorectal carcinoma cell lines deficient in DNA mismatch repair","volume":"18","author":"Oki","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib23","first-page":"4420","article-title":"Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype","volume":"57","author":"Yamamoto","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib24","doi-asserted-by":"crossref","first-page":"22044","DOI":"10.1074\/jbc.270.37.22044","article-title":"Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells","volume":"270","author":"Wang","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/ng0997-79","article-title":"Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC","volume":"17","author":"Laken","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib26","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1126\/science.275.5302.967","article-title":"Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype","volume":"275","author":"Rampino","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib27","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.7761852","article-title":"Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability [see comments]","volume":"268","author":"Markowitz","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/ijc.1299","article-title":"Systematic identification of genes with coding microsatellites mutated in DNA mismatch repair-deficient cancer cells","volume":"93","author":"Woerner","year":"2001","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib29","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/BF01980211","article-title":"Human placental alkaline phosphatase as a histochemical marker of gene expression in transgenic mice","volume":"5","author":"DePrimo","year":"1996","journal-title":"Transgenic Res."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib30","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1242\/dev.128.19.3759","article-title":"In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain","volume":"128","author":"Wichterle","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib31","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1172\/JCI200318182","article-title":"Oxidative stress, cell cycle, and neurodegeneration","volume":"111","author":"Klein","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib32","series-title":"Atlas of the Mouse Brain and Spinal Cord","author":"Sidman","year":"1971"},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib33","series-title":"The Human Brain: An Introduction to its Functional Anatomy","author":"Nolte","year":"2002"},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib34","series-title":"Histology and Cell Biology: An Introduction to Pathology","author":"Kierszenbaum","year":"2002"},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib35","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/em.20004","article-title":"Spontaneous mutation in Big Blue mice from fetus to old age: tissue-specific time courses of mutation frequency but similar mutation types","volume":"43","author":"Hill","year":"2004","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib36","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0896-6273(04)00017-0","article-title":"Cell cycle activation linked to neuronal cell death initiated by DNA damage","volume":"41","author":"Kruman","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib37","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1523\/JNEUROSCI.21-08-02661.2001","article-title":"DNA replication precedes neuronal cell death in Alzheimer's disease","volume":"21","author":"Yang","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mrfmmm.2004.07.010_bib38","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0896-6273(04)00111-4","article-title":"For the long run: maintaining germinal niches in the adult brain","volume":"41","author":"Alvarez-Buylla","year":"2004","journal-title":"Neuron"}],"container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510704003112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510704003112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T14:05:36Z","timestamp":1764684336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0027510704003112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":38,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0027510704003112"],"URL":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2004.07.010","relation":{},"ISSN":["1386-1964"],"issn-type":[{"value":"1386-1964","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased mutation in mice genetically predisposed to oxidative damage in the brain","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2004.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}