{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:38:00Z","timestamp":1792010280262,"version":"4.4.0"},"reference-count":136,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA 46523"],"award-info":[{"award-number":["CA 46523"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01 CA105345"],"award-info":[{"award-number":["U01 CA105345"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["5 P30 ES07784"],"award-info":[{"award-number":["5 P30 ES07784"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["CA 16672"],"award-info":[{"award-number":["CA 16672"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.mrfmmm.2004.11.015","type":"journal-article","created":{"date-parts":[[2005,2,10]],"date-time":"2005-02-10T23:35:31Z","timestamp":1108078531000},"page":"91-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":288,"title":["Cellular and molecular events leading to the development of skin cancer"],"prefix":"10.1016","volume":"571","author":[{"given":"Vladislava O.","family":"Melnikova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honnavara N.","family":"Ananthaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrfmmm.2004.11.015_bib1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/372773a0","article-title":"Sunburn and p53 in the onset of skin cancer","volume":"372","author":"Ziegler","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib2","first-page":"136","article-title":"Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion","volume":"1","author":"Brash","year":"1996","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib3","doi-asserted-by":"crossref","first-page":"12255","DOI":"10.1073\/pnas.94.23.12255","article-title":"p53-mediated protective responses to UV irradiation","volume":"94","author":"Smith","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib4","doi-asserted-by":"crossref","first-page":"10124","DOI":"10.1073\/pnas.88.22.10124","article-title":"A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma","volume":"88","author":"Brash","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib5","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/scientificamerican0796-52","article-title":"Sunlight and skin cancer","volume":"275","author":"Leffell","year":"1996","journal-title":"Sci. Am."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib6","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nm0597-510","article-title":"Sunlight and skin cancer: inhibition of p53 mutations in UV-irradiated mouse skin by sunscreens","volume":"3","author":"Ananthaswamy","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib7","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1038\/sj.onc.1202789","article-title":"p53 protects against skin cancer induction by UV-B radiation","volume":"18","author":"Jiang","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib8","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0002-9440(10)64836-5","article-title":"Loss of Fas-ligand expression in mouse keratinocytes during UV carcinogenesis","volume":"157","author":"Ouhtit","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0022-2836(66)80105-5","article-title":"Pyrimidine dimers in ultraviolet-irradiated DNA's","volume":"17","author":"Setlow","year":"1966","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1751-1097.1988.tb02785.x","article-title":"The relative cytotoxicity of (6-4) photoproducts and cyclobutane dimers in mammalian cells","volume":"48","author":"Mitchell","year":"1988","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib11","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1751-1097.1989.tb05578.x","article-title":"The biology of the 6-4 photoproduct","volume":"49","author":"Mitchell","year":"1989","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1751-1097.1993.tb02273.x","article-title":"Disribution and repair of photolesions in DNA: genetic consequences and the role of sequence context","volume":"57","author":"Sage","year":"1993","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1751-1097.1988.tb02786.x","article-title":"UV mutagenic photoproducts in Escherichia coli and human cells: a molecular genetics perspective on human skin cancer","volume":"49","author":"Brash","year":"1988","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/nar\/20.2.225","article-title":"Sequence specificity of cyclobutane pyrimidine dimers in DNA treated with solar (ultraviolet B) radiation","volume":"20","author":"Mitchell","year":"1992","journal-title":"Nucleic Acid Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/1011-1344(93)87101-R","article-title":"Properties and biological functions of the NIH and FPG proteins in Escherichia coli: two DNA glycolylases that repair oxidative damage in DNA","volume":"19","author":"Boiteux","year":"1993","journal-title":"J. Photochem. Photobiol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib16","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1073\/pnas.88.11.4690","article-title":"8-Oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity","volume":"88","author":"Tchou","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib17","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1021\/bi00116a016","article-title":"Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine\u2013DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization","volume":"31","author":"Boiteux","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/351453a0","article-title":"The p53 tumour suppressor gene","volume":"351","author":"Levine","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib19","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0092-8674(92)90421-8","article-title":"p53 function and dysfunction","volume":"70","author":"Vogelstein","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib20","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/jnci\/88.20.1442","article-title":"Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies","volume":"88","author":"Harris","year":"1996","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib21","doi-asserted-by":"crossref","first-page":"7491","DOI":"10.1073\/pnas.89.16.7491","article-title":"Wild-type p53 is a cell cycle checkpoint determinant following irradiation","volume":"89","author":"Kuerbitz","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib22","first-page":"4242","article-title":"Induction of cellular p53 activity by DNA-damaging agents and growth arrest","volume":"13","author":"Zahn","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib23","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/352345a0","article-title":"Wild type p53 induces apoptosis of myeloid leukemic cells that is inhibited by IL-6","volume":"352","author":"Yonish-Roauch","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib24","first-page":"1053","article-title":"Involvement of the p53 tumor suppressor in repair of UV-type DNA damage","volume":"10","author":"Smith","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib25","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/ng0695-188","article-title":"p53 modulation of TFIIH-associated nucleotide excision repair activity","volume":"10","author":"Wang","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib26","first-page":"1113","article-title":"Decreased DNA repair but normal apoptosis in ultraviolet-irradiated skin of p53-transgenic mice","volume":"148","author":"Li","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib27","first-page":"1457","article-title":"Differentiation-dependent p53 regulation of nucleotide excision repair in keratinocytes","volume":"150","author":"Li","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib28","first-page":"1689","article-title":"UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells","volume":"4","author":"Maltzman","year":"1984","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib29","series-title":"Comprehensive Toxicology","first-page":"255","article-title":"Ultraviolet light as a carcinogen","volume":"vol. 12","author":"Ananthaswamy","year":"1997"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib30","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0002-9440(10)64720-7","article-title":"Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin","volume":"156","author":"Ouhtit","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib31","first-page":"1815","article-title":"DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response","volume":"14","author":"Nelson","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib32","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1101\/gad.11.24.3471","article-title":"DNA damage induces phosphorylation of the amino terminus of p53","volume":"11","author":"Siliciano","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib33","doi-asserted-by":"crossref","first-page":"13777","DOI":"10.1073\/pnas.96.24.13777","article-title":"Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage","volume":"96","author":"Chehab","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib34","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1073\/pnas.95.6.2834","article-title":"Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation","volume":"95","author":"Kapoor","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib35","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/sj.onc.1203300","article-title":"Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation","volume":"19","author":"Kapoor","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib36","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1126\/science.281.5383.1674","article-title":"Enhanced phosphorylation of p53 by ATM in response to DNA damage","volume":"281","author":"Bannin","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib37","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1101\/gad.13.2.152","article-title":"A role for ATR in the DNA damage-induced phosphorylation of p53","volume":"13","author":"Tibbetts","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib38","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1074\/jbc.270.10.5511","article-title":"p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1","volume":"270","author":"Milne","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib39","doi-asserted-by":"crossref","first-page":"20444","DOI":"10.1074\/jbc.M001020200","article-title":"ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation","volume":"275","author":"She","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib40","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0092-8674(93)90499-G","article-title":"The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases","volume":"75","author":"Harper","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib41","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(93)90500-P","article-title":"WAF1, a potential mediator of p53 tumor suppression","volume":"75","author":"El-Deiry","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib42","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/0092-8674(94)90379-4","article-title":"p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest","volume":"76","author":"Dulic","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib43","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1038\/sj.onc.1201004","article-title":"Role of p21Waf1\/Cip1\/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells","volume":"14","author":"Sheikh","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib44","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1073\/pnas.96.2.424","article-title":"Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair","volume":"96","author":"Hwang","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4161\/cbt.59","article-title":"A nucleotide excision repair master-switch: p53 regulated coordinate induction of global genomic repair genes","volume":"1","author":"Amundson","year":"2002","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib46","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1128\/MCB.19.3.1673","article-title":"Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin","volume":"19","author":"Carrier","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib47","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/mutage\/17.2.149","article-title":"p53 regulation of DNA excision repair pathways","volume":"17","author":"Smith","year":"2002","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib48","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/emboj\/20.4.914","article-title":"A role for p53 in base excision repair","volume":"20","author":"Zhou","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib49","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0092-8674(95)90412-3","article-title":"Tumor suppressor p53 is a direct transcriptional activator of the human bax gene","volume":"80","author":"Miyashita","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib50","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1097-2765(01)00214-3","article-title":"PUMA, a novel proapoptotic gene, is induced by p53","volume":"7","author":"Nakano","year":"2001","journal-title":"Mol. Cells"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib51","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0092-8674(00)00073-8","article-title":"p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53","volume":"102","author":"Oda","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib52","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1084\/jem.188.11.2033","article-title":"p53 activates the CD95 (APO1\/Fas) gene in response to DNA damage by anticancer drugs","volume":"188","author":"Muller","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib53","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1126\/science.282.5387.290","article-title":"Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis","volume":"282","author":"Bennet","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib54","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1126\/science.288.5468.1053","article-title":"Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis","volume":"288","author":"Oda","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib55","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ng1097-141","article-title":"KILLER\/DR5 is a DNA damage-inducible p53-regulated death receptor gene","volume":"17","author":"Wu","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib56","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/79102","article-title":"Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis","volume":"26","author":"Lin","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib57","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1084\/jem.189.8.1285","article-title":"A critical role for Fas ligand in the active suppression of systemic immune responses by ultraviolet radiation","volume":"189","author":"Hill","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib58","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1128\/MCB.15.6.3032","article-title":"Wild-type human p53 and a temperature-sensitive mutant induce Fas\/APO-1expression","volume":"15","author":"Owen-Schaub","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib59","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1083\/jcb.140.1.171","article-title":"Ultraviolet light induces apoptosis via direct activation of CD95 (Fas\/APO-1) independently of its ligand CD95L","volume":"140","author":"Aragane","year":"1998","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib60","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1126\/science.285.5429.898","article-title":"Fas ligand: a sensor for DNA damage critical in skin cancer etiology","volume":"285","author":"Hill","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib61","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/1523-1747.ep12606202","article-title":"Ultraviolet-B-induced apoptosis of keratinocytes: evidence for partial involvement of tumor necrosis factor-alpha in the formation of sunburn cells","volume":"104","author":"Schwarz","year":"1995","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0625.1997.tb00138.x","article-title":"Pentoxifylline reduces the formation of sunburn cells","volume":"6","author":"Schwarz","year":"1997","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib63","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1126\/science.274.5290.1194","article-title":"Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors","volume":"274","author":"Rosette","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1011-1344(96)07459-3","article-title":"UV-induced signal transduction","volume":"37","author":"Bender","year":"1997","journal-title":"J. Photochem. Photobiol. B: Biol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib65","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/(SICI)1097-0215(19990129)80:3<431::AID-IJC16>3.0.CO;2-5","article-title":"Activation of the insulin-like growth factor-a receptor promotes the survival of human keratinocytes following ultraviolet B irradiation","volume":"80","author":"Kuhn","year":"1999","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib66","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1562\/0031-8655(2000)072<0135:UIEGFR>2.0.CO;2","article-title":"UVB-induced epidermal growth factor receptor phosphorylation is critical for downstream signaling and keratinocyte survival","volume":"72","author":"Peus","year":"2000","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib67","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1083\/jcb.133.1.211","article-title":"UV activates growth factor receptors via reactive oxygen intermediates","volume":"133","author":"Huang","year":"1996","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib68","first-page":"505","article-title":"The EGF-receptor\u2014an essential regulator of multiple epidermal functions","volume":"10","author":"Jost","year":"2000","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib69","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0065-2571(94)90024-8","article-title":"The mammalian UV response: mechanism of DNA damage induced gene expression","volume":"34","author":"Herrlich","year":"1994","journal-title":"Adv. Enzyme Regul."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib70","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/j.1460-2075.1993.tb05741.x","article-title":"UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase","volume":"12","author":"Radler-Pohl","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib71","first-page":"2804","article-title":"Rapid and preferential activation of the c-jun gene during the mammalian UV response","volume":"11","author":"Devary","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib72","first-page":"1947","article-title":"Differential effects of UV-B and UV-C components of solar radiation on MAP kinase signal transduction pathways in epidermal keratinocytes","volume":"11","author":"Dhanwada","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib73","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0092-8674(00)00116-1","article-title":"Signal transduction by the JNK group of MAP kinases","volume":"103","author":"Davis","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib74","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1007\/s000180050369","article-title":"The stress-activated protein kinase pathways","volume":"55","author":"Tibbles","year":"1999","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib75","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1023\/A:1010975124110","article-title":"Signaling by the JNK group of MAP kinases. c-jun N-terminal kinase","volume":"21","author":"Dong","year":"2001","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib76","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1038\/sj.onc.1204382","article-title":"Signal transduction by MAP kinases in T lymphocytes","volume":"20","author":"Rincon","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib77","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1038\/sj.onc.1202647","article-title":"Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells","volume":"18","author":"Balmanno","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib78","doi-asserted-by":"crossref","first-page":"E250","DOI":"10.1038\/ncb1101-e250","article-title":"A family outing: small GTPases cyclin\u2019 through G1","volume":"3","author":"Coleman","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib79","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/1521-1878(200009)22:9<818::AID-BIES7>3.0.CO;2-6","article-title":"Integrating the MAP kinase signal into the G1 phase cell cycle machinery","volume":"22","author":"Roovers","year":"2000","journal-title":"Bioessays"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib80","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1242\/jcs.114.14.2553","article-title":"Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways","volume":"114","author":"Schwartz","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib81","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/bj3260061","article-title":"Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase","volume":"326","author":"Weber","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib82","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1128\/MCB.22.15.5380-5394.2002","article-title":"The UV (ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor","volume":"22","author":"Iordanov","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib83","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1101\/gad.13.22.2905","article-title":"Cellular survival: a play in three Akts","volume":"13","author":"Datta","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib84","first-page":"561","article-title":"UV activation of receptor tyrosine kinase activity","volume":"11","author":"Coffer","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib85","doi-asserted-by":"crossref","first-page":"45737","DOI":"10.1074\/jbc.M300574200","article-title":"Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase\/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes","volume":"278","author":"Wang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib86","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1034\/j.1600-0625.2003.00101.x","article-title":"Involvement of EGF receptor activation in the induction of cyclooxygenase-2 in HaCaT keratinocytes after UVB","volume":"12","author":"Ashida","year":"2003","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib87","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.0906-6705.2004.00102.x","article-title":"Solar-simulated irradiation evokes a persistent and biphasic IL-1alpha response","volume":"13","author":"Luo","year":"2004","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib88","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/1523-1747.ep12388914","article-title":"Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes","volume":"103","author":"Pincelli","year":"1994","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib89","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1046\/j.1523-1747.1999.00773.x","article-title":"Nerve growth factor protects human keratinocytes from ultraviolet-B-induced apoptosis","volume":"113","author":"Marconi","year":"1999","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib90","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1073\/pnas.95.2.565","article-title":"UVB-induced association of tumor necrosis factor (TNF) receptor 1\/TNF receptor-associated factor-2 mediates activation of Rel proteins","volume":"95","author":"Tobin","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib91","first-page":"3299","article-title":"Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel\/nuclear factor-kappaB signaling","volume":"59","author":"van Hogerlinden","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib92","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/ncb1001","article-title":"Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice","volume":"5","author":"Wikonkal","year":"2003","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib93","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1073\/pnas.91.1.360","article-title":"UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement","volume":"91","author":"Nakazawa","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib94","first-page":"765","article-title":"Human epidermal cancer and accompanying precursors have identical p53 mutations different from p53 mutations in adjacent areas of clonally expanded non-neoplastic keratinocytes","volume":"12","author":"Ren","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib95","doi-asserted-by":"crossref","first-page":"14025","DOI":"10.1073\/pnas.93.24.14025","article-title":"Frequent clones of p53-mutated keratinocytes in normal human skin","volume":"93","author":"Jonason","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib96","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0304-3835(94)90234-8","article-title":"Analysis of p53 gene in human precancerous actinic keratosis lesions and squamous cell cancers","volume":"85","author":"Nelson","year":"1994","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib97","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/1523-1747.ep12475717","article-title":"p53 mutations are common and early events that precede tumor invasion in squamous cell neoplasia of the skin","volume":"100","author":"Campbell","year":"1993","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib98","first-page":"3604","article-title":"p53 mutations in non-melanoma skin cancer of head and neck: molecular evidence for field cancerization","volume":"55","author":"Kanjilal","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib99","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/1523-1747.ep12321051","article-title":"High prevalence of mutations in the p53 gene in poorly differentiated squamous cell carcinomas in xeroderma pigmentosum patients","volume":"105","author":"Matsumura","year":"1995","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib100","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1073\/pnas.93.1.274","article-title":"Early p53 alterations in mouse skin carcinogenesis by UVB radiation: Immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells","volume":"93","author":"Berg","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib101","first-page":"2961","article-title":"High frequency of p53 mutations in ultraviolet radiation-induced murine skin tumors: evidence for strand bias and tumor heterogeneity","volume":"53","author":"Kanjilal","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib102","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1046\/j.0022-202x.2001.01380.x","article-title":"Erb Ultraviolet light downregulates CD95 ligand and TRAIL receptor expression facilitating actinic keratosis and squamous cell carcinoma formation","volume":"117","author":"Bachmann","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib103","doi-asserted-by":"crossref","first-page":"13948","DOI":"10.1073\/pnas.241353198","article-title":"Escaping the stem cell compartment: sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations","volume":"98","author":"Zhang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib104","first-page":"977","article-title":"Early p53-postitive foci as indicator of tumor risk in ultraviolet-exposed hairless mice: kinetics of induction, effects of DNA repair deficiency, and p53 heterozygosity","volume":"61","author":"Rebel","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib105","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1523-1747.2003.12320.x","article-title":"Ultraviolet B irradiation induces expansion of intraepithelial tumor cells in a tissue model of early cancer progression","volume":"121","author":"Mudgil","year":"2003","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib106","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0002-9440(10)65600-3","article-title":"p53-regulated apoptosis is differentiation dependent in ultraviolet B-irradiated mouse keratinocytes","volume":"153","author":"Tron","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib107","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1038\/sj.onc.1206657","article-title":"Antigen-specific immunity does not mediate acute regression of UVB-induced p53-mutant clones","volume":"22","author":"Remenyik","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib108","first-page":"979","article-title":"Development of skin tumors in hairless mice after discontinuation of ultraviolet irradiation","volume":"51","author":"de Gruijl","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib109","first-page":"3804","article-title":"p53 mutations in basal cell carcinomas","volume":"52","author":"Rady","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib110","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1073\/pnas.90.9.4216","article-title":"Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers","volume":"90","author":"Ziegler","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib111","first-page":"228","article-title":"p53 mutations in human aggressive and nonaggressive basal and squamous cell carcinomas","volume":"9","author":"Bolshakov","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib112","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/mc.2940040606","article-title":"Mutations in p53 tumor suppressor gene in human cutaneous squamous cell carcinomas","volume":"4","author":"Pierceall","year":"1991","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib113","first-page":"583","article-title":"p53 gene mutations in human epithelial skin cancers","volume":"8","author":"Moles","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib114","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.1073\/pnas.90.22.10529","article-title":"Specific UV-induced mutation spectrum in the p53 gene of skin tumors in DNA repair deficient xeroderma pigmentosum patients","volume":"90","author":"Dumaz","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib115","first-page":"2944","article-title":"Ultraviolet-specific mutations in the p53 gene in skin tumors in xeroderma pigmentosum patients","volume":"53","author":"Sato","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib116","first-page":"25","article-title":"Progression of basal cell carcinoma through loss of chromosome 9q and inactivation of a single p53 allele","volume":"54","author":"Van der Riet","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib117","first-page":"6400","article-title":"Carcinogen-specific mutational pattern in the p53 gene in ultraviolet B radiation-induced squamous cell carcinomas of mouse skin","volume":"52","author":"Kress","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib118","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1073\/pnas.0401141101","article-title":"The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: a role for UVA in human skin carcinogenesis","volume":"101","author":"Agar","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib119","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1146\/annurev.bi.56.070187.004023","article-title":"Ras genes","volume":"56","author":"Barbacid","year":"1987","journal-title":"Ann. Rev. Biochem."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib120","first-page":"4682","article-title":"Ras oncogenes in human cancer: review","volume":"49","author":"Bos","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib121","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.1751-1097.1990.tb08452.x","article-title":"Molecular mechanisms of ultraviolet radiation carcinogenesis","volume":"52","author":"Ananthaswamy","year":"1990","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib122","first-page":"3341","article-title":"Detection and identification of activated oncogenes in human skin cancers occurring on sun-exposed body sites","volume":"48","author":"Ananthaswamy","year":"1988","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib123","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/jcb.240360205","article-title":"Simultaneous transfer of tumorigenic and metastatic phenotypes by transfection with genomic DNA from a human cutaneous squamous cell carcinoma","volume":"36","author":"Ananthaswamy","year":"1988","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib124","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF01753682","article-title":"Correlation between Ha-ras gene amplification and spontaneous metastasis in NIH 3T3 cells transfected with genomic DNA from human skin cancers","volume":"7","author":"Ananthaswamy","year":"1989","journal-title":"Clin. Exp. Met."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib125","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/mc.2940040306","article-title":"Ras gene mutation and amplification in human nonmelanoma skin cancers","volume":"4","author":"Pierceall","year":"1991","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib126","first-page":"3946","article-title":"N-ras mutation in ultraviolet radiation-induced murine skin cancers","volume":"52","author":"Pierceall","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib127","first-page":"9","article-title":"Activation of N-ras induced by ultraviolet irradiation in vitro","volume":"3","author":"van der Lubbe","year":"1988","journal-title":"Oncogene Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib128","first-page":"2085","article-title":"Transformation of NIH 3T3 cells by transfection with UV-irradiated human c-Ha-ras-1 proto-oncogene DNA","volume":"6","author":"Pierceall","year":"1991","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib129","first-page":"201","article-title":"Multiple activated oncogenes in human tumor's","volume":"1","author":"Suarez","year":"1987","journal-title":"Oncogene Res."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib130","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1001\/archderm.1990.01670270056009","article-title":"cHa-ras proto-oncogene: amplification and overexpression in UV-B -induced mouse skin papillomas and carcinomas","volume":"126","author":"Husain","year":"1990","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib131","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2741\/matsumur","article-title":"Molecular mechanisms of photocarcinogenesis","volume":"7","author":"Matsumura","year":"2002","journal-title":"Front Biosci."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib132","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/366704a0","article-title":"A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D\/CDK4","volume":"366","author":"Serrano","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib133","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0092-8674(00)81400-2","volume":"92","author":"Pomerantz","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib134","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1046\/j.1365-2133.1998.2378a.x","article-title":"Lack of mutation in the INK4a locus in basal cell carcinomas","volume":"139","author":"Kubo","year":"1998","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib135","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1038\/sj.onc.1202915","article-title":"p16 UV mutations in skin epithelial tumours","volume":"18","author":"Soufir","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2004.11.015_bib136","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/j.0022-202X.2004.22501.x","article-title":"p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma","volume":"122","author":"Brown","year":"2004","journal-title":"J. Invest. Dermatol."}],"container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510704004889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510704004889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T14:08:26Z","timestamp":1764684506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0027510704004889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":136,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0027510704004889"],"URL":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2004.11.015","relation":{},"ISSN":["1386-1964"],"issn-type":[{"value":"1386-1964","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular and molecular events leading to the development of skin cancer","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2004.11.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}