{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:35:15Z","timestamp":1791192915025,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.mrfmmm.2005.03.008","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T11:02:16Z","timestamp":1117191736000},"page":"284-292","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["DNA adducts as markers of exposure and risk"],"prefix":"10.1016","volume":"577","author":[{"given":"David H.","family":"Phillips","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrfmmm.2005.03.008_bib1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/carcin\/3.8.929","article-title":"Repair replication characteristics of human cells exposed to 1\u2032-acetoxysafrole or 1\u2032-acetoxyestragole","volume":"3","author":"Phillips","year":"1982","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib2","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/carcin\/3.8.935","article-title":"Alkali-sensitive sites in DNA from human cells treated with ultraviolet light, 1\u2032-acetoxysafrole or 1\u2032-acetoxyestragole","volume":"3","author":"Phillips","year":"1982","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1046\/j.1525-1500.1998.CDOA38.x","article-title":"Carcinogen DNA and protein adducts as biomarkers of human exposure in environmental cancer epidemiology","volume":"22","author":"Wild","year":"1998","journal-title":"Cancer Detect. Prev."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib4","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/carcin\/21.3.353","article-title":"Carcinogen macromolecular adducts and their measurement","volume":"21","author":"Poirier","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib5","first-page":"71","article-title":"Exposure biomarkers for the study of toxicological impact on carcinogenic processes","author":"Farmer","year":"2004","journal-title":"IARC Sci. Publ."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib6","first-page":"1","article-title":"Detection of DNA modifications by the 32P-postlabelling assay","volume":"378","author":"Phillips","year":"1997","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib7","series-title":"The Cancer Handbook","first-page":"293","article-title":"The formation of DNA adducts","author":"Phillips","year":"2002"},{"issue":"Suppl 3","key":"10.1016\/j.mrfmmm.2005.03.008_bib8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1289\/ehp.96104s3453","article-title":"DNA adducts in human tissues: biomarkers of exposure to carcinogens in tobacco smoke","volume":"104","author":"Phillips","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib9","unstructured":"D.H. Phillips Macromolecular adducts as biomarkers of human exposure to polycyclic aromatic hydrocarbons, in: A. Luch (Ed.), The Carcinogensic Effects of Polycyclic Aromatic Hydrocarbons, Imperial College Press, in press."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib10","first-page":"51","article-title":"Air pollution exposure-DNA adduct dosimetry in humans and rodents: evidence for non-linearity at high doses","volume":"378","author":"Lewtas","year":"1997","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib11","first-page":"65","article-title":"32P-postlabelling of aromatic DNA adducts in white blood cells and alveolar macrophages of smokers: saturation at high exposures","volume":"378","author":"Van Schooten","year":"1997","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib12","first-page":"341","article-title":"Contribution of occupation and diet to white blood cell polycyclic aromatic hydrocarbon-DNA adducts in wildland firefighters","volume":"2","author":"Rothman","year":"1993","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib13","first-page":"545","article-title":"Biomonitoring of United States Army soldiers serving in Kuwait in 1991","volume":"7","author":"Poirier","year":"1998","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1289\/ehp.939983","article-title":"DNA adducts as biomarkers for assessing exposure to polycyclic aromatic hydrocarbons in tissues from Xuan Wei women with high exposure to coal combustion emissions and high lung cancer mortality","volume":"99","author":"Mumford","year":"1993","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib15","series-title":"Postlabelling methods for detection of DNA adducts","first-page":"283","article-title":"DNA adduct profiles and levels in placenta blood and lung in relation to cigarette smoking and smoky coal emissions","author":"Gallagher","year":"1993"},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib16","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1093\/carcin\/23.12.1979","article-title":"Smoking-related DNA and protein adducts in human tissues","volume":"23","author":"Phillips","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/jnci\/djh014","article-title":"Tobacco and cancer: recent epidemiological evidence","volume":"96","author":"Vineis","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib18","unstructured":"IARC Tobacco smoke and involuntary smoking, International Agency for Research on Cancer, Lyon, 2004."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1158\/1055-9965.61.14.1","article-title":"Breast cancer risk among women who start smoking as teenagers","volume":"14","author":"Gram","year":"2005","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib20","unstructured":"IARC Tobacco Smoking, IARC, Lyon, 1986."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1056\/NEJM198501313120516","article-title":"Cigarette smoking and neoplasia of the uterine cervix: smoke constituents in cervical mucus","volume":"312","author":"Sasson","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib22","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1093\/jnci\/89.12.868","article-title":"Identification of tobacco-specific carcinogen in the cervical mucus of smokers and nonsmokers","volume":"89","author":"Prokopczyk","year":"1997","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0165-1161(94)90057-4","article-title":"DNA adducts in cervical tissue of smokers and non-smokers","volume":"313","author":"Phillips","year":"1994","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib24","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1046\/j.1525-1438.1994.04030188.x","article-title":"Detection and measurement of DNA adducts in the cervix of smokers and non-smokers","volume":"4","author":"Ali","year":"1994","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1006\/gyno.1999.5525","article-title":"Polycyclic aromatic hydrocarbon-DNA adducts in cervical smears of smokers and nonsmokers","volume":"75","author":"Mancini","year":"1999","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3835(99)00203-7","article-title":"Identification of benzo[a]pyrene metabolites in cervical mucus and DNA adducts in cervical tissues in humans by gas chromatography-mass spectrometry","volume":"146","author":"Melikian","year":"1999","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib27","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/oxfordjournals.aje.a116270","article-title":"Cigarette smoking and the risk of anogenital cancer","volume":"135","author":"Daling","year":"1992","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.mrgentox.2004.02.014","article-title":"Smoking-related DNA adducts in anal epithelium","volume":"560","author":"Phillips","year":"2004","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib29","first-page":"627","article-title":"Decline of DNA damage and other biomarkers in peripheral blood following smoking cessation","volume":"4","author":"Mooney","year":"1995","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib30","first-page":"341","article-title":"A molecular epidemiological case-control study of lung cancer","volume":"4","author":"Tang","year":"1995","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib31","first-page":"4910","article-title":"Correlation of DNA adducts in blood mononuclear cells with tobacco carcinogen-induced damage in human lung","volume":"55","author":"Wiencke","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib32","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/jnci\/91.7.614","article-title":"Early age at smoking initiation and tobacco carcinogen DNA damage in the lung","volume":"91","author":"Wiencke","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib33","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/carcin\/13.6.987","article-title":"Polycyclic aromatic hydrocarbon\u2014DNA adducts in white blood cells from lung cancer patients: no correlation with adduct levels in lung","volume":"13","author":"van Schooten","year":"1992","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/carcin\/23.2.227","article-title":"Women who smoke: are women more susceptible to tobacco-induced lung cancer?","volume":"23","author":"Haugen","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1097-0215(19960927)68:1<39::AID-IJC8>3.0.CO;2-Y","article-title":"Trends in the incidence of smoking-associated cancers in Norway, 1954-93","volume":"68","author":"Engeland","year":"1996","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib36","article-title":"Different susceptibility to smoking-induced DNA damage among male and female lung cancer patients","volume":"54.","author":"Ryberg","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib37","first-page":"3317","article-title":"Sex differences in lung CYP1A1 expression and DNA adduct levels among lung cancer patients","volume":"59","author":"Mollerup","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib38","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/carcin\/16.5.993","article-title":"Gender comparisons in human lung cancer: analysis of p53 mutations, anti-p53 serum antibodies and C-erbB-2 expression","volume":"16","author":"Guinee","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib39","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/carcin\/17.10.2201","article-title":"p53 mutations in lung tumours: relationship to gender and lung DNA adduct levels","volume":"17","author":"Kure","year":"1996","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib40","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1126\/science.274.5286.430","article-title":"Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53","volume":"274","author":"Denissenko","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib41","first-page":"3","article-title":"A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China","volume":"3","author":"Qian","year":"1994","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib42","first-page":"6708","article-title":"Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health study","volume":"61","author":"Tang","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib43","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/carcin\/23.10.1641","article-title":"Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians\u2019 Health Cohort Study","volume":"23","author":"Perera","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2005.03.008_bib44","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1093\/carcin\/18.7.1285","article-title":"Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk","volume":"18","author":"Ryberg","year":"1997","journal-title":"Carcinogenesis"}],"container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510705001648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510705001648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T14:09:04Z","timestamp":1764684544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0027510705001648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":44,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0027510705001648"],"URL":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2005.03.008","relation":{},"ISSN":["1386-1964"],"issn-type":[{"value":"1386-1964","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA adducts as markers of exposure and risk","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2005.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}