{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:53:29Z","timestamp":1792083209233,"version":"4.4.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.mrfmmm.2005.03.028","type":"journal-article","created":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T16:00:22Z","timestamp":1122566422000},"page":"182-188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Protection against paracetamol-induced hepatic injury by prazosin pre-treatment in CD-1 mice"],"prefix":"10.1016","volume":"579","author":[{"given":"Yuri N.","family":"Clement","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene F.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrfmmm.2005.03.028_bib1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/20014091111677","article-title":"Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechansims, analogues and protective approaches","volume":"31","author":"Bessems","year":"2001","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1021\/tx00034a019","article-title":"Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics","volume":"6","author":"Patten","year":"1993","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/0003-9861(89)90278-6","article-title":"Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2","volume":"271","author":"Raucy","year":"1989","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib4","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1073\/pnas.81.5.1327","article-title":"N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen","volume":"81","author":"Dahlin","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib5","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1016\/0006-2952(79)90123-0","article-title":"Evidence for the involvement of N-acetyl-p-quinoneimine in acetaminophen metabolism","volume":"28","author":"Miner","year":"1979","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib6","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1096\/fasebj.13.10.1169","article-title":"Regulation of hepatic glutathione synthesis: current concepts abd controversies","volume":"13","author":"Lu","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/10715769900300851","article-title":"Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress","volume":"31","author":"Hayes","year":"1999","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-3565(25)29666-5","article-title":"Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione","volume":"187","author":"Mitchell","year":"1973","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-3565(25)29664-1","article-title":"Acetaminophen-induced hepatic necrosis. 2. Role of covalent binding in vivo","volume":"187","author":"Jollow","year":"1973","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/03602539509029827","article-title":"The role of covalent binding to microsomal proteins in the hepatotoxicity of acetaminophen","volume":"27","author":"Holtzman","year":"1995","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3109\/03602539509029816","article-title":"Mechanisms of acetaminophen toxicity: immunochemical detection of drug-protein adducts","volume":"27","author":"Hinson","year":"1995","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib12","first-page":"279","article-title":"Biochemical toxicology of acetaminophen","volume":"69","author":"Hinson","year":"1980","journal-title":"Rev. Biochem. Toxicol."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1006\/taap.1993.1021","article-title":"Phenylpropanolamine potentiation of acetoaminophen-induced hepatotoxicity: evidence for a glutathione-dependent mechanism","volume":"118","author":"James","year":"1993","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0041-008X(91)90022-7","article-title":"Potentiation of carbon tetrachloride by phenylpropanolamine","volume":"111","author":"Roberts","year":"1991","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib15","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0022-3565(25)23799-5","article-title":"Methamphetamine potentiation of carbon tetrachloride hepatotoxicity in mice","volume":"271","author":"Roberts","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0300-483X(94)02924-J","article-title":"Mechanistic studies on the potentiation of carbon tetrachloride hepatotoxicity by methamphetamine","volume":"97","author":"Roberts","year":"1995","journal-title":"Toxicology"},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib17","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0300-483X(91)90187-6","article-title":"Hepatic glutathione suppression by the \u03b1-adrenceptor stimulating agents phenylephrine and clonidine","volume":"69","author":"Harbison","year":"1991","journal-title":"Toxicology"},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib18","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0272-0590(83)80144-4","article-title":"The perturbation of hepatic glutathione by \u03b12-adrenceptor agonists","volume":"3","author":"James","year":"1983","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/BF00755791","article-title":"A microtiter plate assay for total glutathione and glutathione disulphide contents in cultured\/isolated cells: performance study of a new miniaturized protocol","volume":"10","author":"Vandeputte","year":"1994","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib20","first-page":"1085","article-title":"Comparison of the modulatory effects of human and rat liver microsomal metabolism on the estrogenicity of bisphenol A: implications for extrapolation to humans","volume":"280","author":"Elsby","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0891-5849(95)00023-Q","article-title":"Oxidative stress by acute acetaminophen administration in mouse liver","volume":"19","author":"Arnaiz","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrfmmm.2005.03.028_bib23","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0378-4274(03)00239-X","article-title":"The role of axidant stress and reactive nitrogen species in acetaminophen hepatotoxicity","volume":"144","author":"Jaeschke","year":"2003","journal-title":"Toxicol. Lett."}],"container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510705002551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510705002551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T09:30:49Z","timestamp":1764667849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0027510705002551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":23,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0027510705002551"],"URL":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2005.03.028","relation":{},"ISSN":["1386-1964"],"issn-type":[{"value":"1386-1964","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protection against paracetamol-induced hepatic injury by prazosin pre-treatment in CD-1 mice","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2005.03.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}