{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:23:28Z","timestamp":1790040208406,"version":"4.0.1"},"reference-count":126,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES 11172"],"award-info":[{"award-number":["ES 11172"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL 77419"],"award-info":[{"award-number":["HL 77419"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.mrfmmm.2007.02.010","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:46:45Z","timestamp":1172839605000},"page":"61-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["The role of tobacco smoke induced mitochondrial damage in vascular dysfunction and atherosclerosis"],"prefix":"10.1016","volume":"621","author":[{"given":"Zhen","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey M.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gin C.","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W.","family":"Ballinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrfmmm.2007.02.010_bib1","unstructured":"World Health Organization, The world health report 2003 \u2013 shaping the future: Neglected Global Epidemics, World Health Organization, Geneva, Switzerland, 2003, pp. 83\u2013102."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib2","unstructured":"American Heart Association, Heart Disease and Stroke Statistics \u2013 2005 Update, American Heart Association, Dallas, TX, 2005, pp. 1a\u201360."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib3","first-page":"1","article-title":"Heart disease and stroke statistics \u2013 2006 update","volume":"105","author":"American Heart","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Mechanisms of disease: atherosclerosis - an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib5","doi-asserted-by":"crossref","first-page":"7A","DOI":"10.1016\/S0002-9149(02)03144-2","article-title":"Role of oxidative stress in atherosclerosis","volume":"91","author":"Harrison","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1161\/01.ATV.0000150649.39934.13","article-title":"Oxidative stress and vascular disease","volume":"25","author":"Madamanchi","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib7","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s11373-005-9024-z","article-title":"Molecular aspects of atherogenesis: new insights and unsolved questions","volume":"12","author":"Puddu","year":"2005","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.abb.2003.06.002","article-title":"Oxidative stress in cardiovascular disease: myth or fact?","volume":"420","author":"Ceconi","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib9","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1056\/NEJM199708073370607","article-title":"Mechanisms of disease \u2013 antioxidants and atherosclerotic heart disease","volume":"337","author":"Diaz","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib10","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/01.RES.87.10.840","article-title":"Endothelial dysfunction in cardiovascular diseases \u2013 the role of oxidant stress","volume":"87","author":"Cai","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib11","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/00004872-200018060-00002","article-title":"Role of oxidative stress in cardiovascular diseases","volume":"18","author":"Dhalla","year":"2000","journal-title":"J. Hypertens."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib12","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1007\/s11745-001-0680-1","article-title":"The oxidant stress hypothesis of atherogenesis","volume":"36","author":"Iuliano","year":"2001","journal-title":"Lipids"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/01.CIR.94.1.19","article-title":"Modulation of oxidant stress in vivo in chronic cigarette smokers","volume":"94","author":"Reilly","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib14","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1161\/01.CIR.98.25.2822","article-title":"Increased formation of distinct F2 isoprostanes in hypercholesterolemia","volume":"98","author":"Reilly","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib15","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/2685","article-title":"Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in apoE deficient mice","volume":"4","author":"Pratico","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib16","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1073\/pnas.95.7.3449","article-title":"IPF2\u03b1\u2212I: an index of lipid peroxidation in humans","volume":"95","author":"Pratico","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib17","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3109\/10641969509033636","article-title":"Decreased superoxide dismutase activity and increased superoxide anion production in cardiac hypertrophy of spontaneously hypertensive rats","volume":"17","author":"Ito","year":"1995","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/(SICI)1097-4652(199601)166:1<144::AID-JCP17>3.0.CO;2-F","article-title":"Atherogenic levels of low-density lipoprotein increase hydrogen peroxide generation in cultured human endothelial cells: possible mechanism of heightened endocytosis","volume":"166","author":"Holland","year":"1996","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib19","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1172\/JCI116491","article-title":"Hypercholesterolemia increases endothelial superoxide anion production","volume":"91","author":"Ohara","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0021-9150(98)00170-1","article-title":"Dyslipoproteinaemia and hyperoxidative stress in the pathogenesis of endothelial dysfunction in a non-insulin dependent diabetes mellitus: an hypothesis","volume":"141","author":"Watts","year":"1998","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib21","first-page":"163","article-title":"Consequences of the diabetic status on the oxidant\/antioxidant balance","volume":"26","author":"Rousselot","year":"2000","journal-title":"Diab. Metab."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib22","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1126\/science.1088434","article-title":"Effects of purifying and adaptive selection on regional variation in human mtDNA","volume":"303","author":"Ruiz-Pesini","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.gene.2005.05.001","article-title":"The mitochondrial genome in human adaptive radiation and disease: on the road to therapeutics and performance enhancement","volume":"354","author":"Wallace","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","article-title":"A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine","volume":"39","author":"Wallace","year":"2005","journal-title":"Annu. Rev Genet."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib25","doi-asserted-by":"crossref","first-page":"16330","DOI":"10.1016\/S0021-9258(17)46227-2","article-title":"The oxidative inactivation of mitochondrial electron transport chain components and ATPase","volume":"265","author":"Zhang","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib26","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species","volume":"552","author":"Turrens","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib27","series-title":"Free Radicals in Biology","first-page":"65","author":"Forman","year":"1982"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib28","series-title":"Free Radicals in Biology","first-page":"65","article-title":"Superoxide radical and hydrogen peroxide in mitochondria","author":"Forman","year":"1982"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib29","series-title":"Chemical and Biochemical Aspects of Superoxide and Superoxide Dismutase","first-page":"84","article-title":"Production of superoxide anion by the NADH dehydrogenase of mammalian mitochondria","author":"Boveris","year":"1980"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib30","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1042\/bj1910421","article-title":"Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria","volume":"191","author":"Turrens","year":"1980","journal-title":"Biochem. J."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib31","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1152\/physrev.1979.59.3.527","article-title":"Hydroperoxide metabolism in mammalian organs","volume":"59","author":"Chance","year":"1979","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1161\/01.RES.77.1.29","article-title":"Differential activation of mitogen-activated protein kinases by H2O2 and O2\u2212 in vascular smooth muscle cells","volume":"77","author":"Baas","year":"1995","journal-title":"Circ. Res."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib33","doi-asserted-by":"crossref","first-page":"16045","DOI":"10.1074\/jbc.M011766200","article-title":"c-Jun-N-terminal kinase activation by hydrogen peroxide in endothelial cells involves Src-dependent epidermal growth factor receptor transactivation","volume":"276","author":"Chen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib34","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1074\/jbc.271.8.4138","article-title":"Activation of mitogen-activated protein kinase by by H2O2","volume":"271","author":"Guyton","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/emm.1998.32","article-title":"The effects of oxygen radicals on the activity of nitric oxide synthase and guanylate cyclase","volume":"30","author":"Kim","year":"1998","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib36","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.270.5234.296","article-title":"Requirement for generation of H2O2 for platelet-derived growth factor signal transduction","volume":"270","author":"Sundaresan","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib37","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1161\/01.RES.86.2.152","article-title":"Direct evidence for increased hydroxyl radicals orginating from superoxide in the failing myocardium","volume":"86","author":"Ide","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib38","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1021\/tx970160x","article-title":"Formation and properties of peroxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, and pulse radiolysis","volume":"10","author":"Kissner","year":"1997","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib39","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/01.RES.86.9.960","article-title":"Hydrogen peroxide and peroxynitrite induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells","volume":"86","author":"Ballinger","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib40","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1074\/jbc.272.3.1433","article-title":"Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima","volume":"272","author":"Leeuwenburgh","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib41","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1021\/bi971894b","article-title":"Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical gyrosine residues","volume":"37","author":"MacMillan-Crow","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib42","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1089\/152308601300185188","article-title":"Mechanisms of cell signaling by nitric oxide and peroxynitrite: from mitochondria to MAP kinases","volume":"3","author":"Levonen","year":"2001","journal-title":"Antioxid Redox Signal."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/abbi.1998.0755","article-title":"Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species","volume":"356","author":"Ischiropoulos","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib44","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1021\/tx9501445","article-title":"Oxidative damage and tyrosine nitration from peroxynitrite","volume":"9","author":"Beckman","year":"1996","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib45","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1161\/01.HYP.0000163462.98381.7f","article-title":"Role of NAD(P)H oxidase- and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II","volume":"45","author":"Kimura","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib46","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S0891-5849(02)01142-5","article-title":"Mitochondria, nitric oxide, and cardiovascular dysfunction","volume":"33","author":"Ramachandran","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib47","doi-asserted-by":"crossref","first-page":"6643","DOI":"10.1073\/pnas.102019899","article-title":"Inhibition of mitochondrial protein synthesis results in increased endothelial cell susceptibility to nitric oxide-induced apoptosis","volume":"99","author":"Ramachandran","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib48","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/abbi.1996.0178","article-title":"Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport","volume":"328","author":"Cassina","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib49","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1073\/pnas.0304653101","article-title":"Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: role of mitochondrial respiratory complexes and heat shock proteins","volume":"101","author":"Ramachandran","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib50","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1042\/bst0290803","article-title":"Mechanism of uncoupling proteins action","volume":"29","author":"Garlid","year":"2001","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib51","doi-asserted-by":"crossref","first-page":"26003","DOI":"10.1074\/jbc.274.37.26003","article-title":"Transport function and regulation of mitochondrial uncoupling proteins 2 and 3","volume":"274","author":"Jaburek","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib52","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1042\/bst0290806","article-title":"Uncoupling protein, H+ transport and regulation","volume":"29","author":"Klingenberg","year":"2001","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib53","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1042\/bst0290756","article-title":"Life without UCP1: mitochondrial, cellular, and organismal characteristics of the UCP1-ablated mice","volume":"29","author":"Nedergaard","year":"2001","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib54","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0005-2728(00)00243-7","article-title":"Mitochondrial proton leak and the uncoupling protein 1 homologues","volume":"1504","author":"Stuart","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib55","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1042\/bst0290785","article-title":"Uncoupling protein 3 and fatty acid metabolism","volume":"29","author":"Dulloo","year":"2001","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib56","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1113\/eph8802502","article-title":"The \u201cnovel\u201d \u201cuncoupling\u201d proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions","volume":"88","author":"Nedergaard","year":"2003","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib57","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-5793(03)01386-3","article-title":"Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3","volume":"556","author":"Talbot","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib58","doi-asserted-by":"crossref","first-page":"13245","DOI":"10.1074\/jbc.273.21.13245","article-title":"Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1","volume":"273","author":"Manna","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib59","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1016\/S0021-9258(18)42768-8","article-title":"Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation","volume":"267","author":"Schulze-Osthoff","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib60","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1096\/fj.00-0909fje","article-title":"Early growth-responsive-1-dependent manganese superoxide dismutase gene transcription mediated by platelet-derived growth factor","volume":"15","author":"Maehara","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib61","doi-asserted-by":"crossref","first-page":"12896","DOI":"10.1073\/pnas.95.22.12896","article-title":"Mitochondrial adenine nucleotide translocase is modified oxidatively during aging","volume":"95","author":"Yan","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib62","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1073\/pnas.94.2.514","article-title":"Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress","volume":"94","author":"Yakes","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib63","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1139\/y89-114","article-title":"Relationship between oxidative phosphorylation and adenine nucleotide translocase activity in two populations of cardiac mitochondria and mechanical recovery of ischemic hearts following reperfusion","volume":"67","author":"Duan","year":"1989","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib64","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/ng0492-11","article-title":"Maternally trasnmitted diabetes and deafness associated with a 10.4kb mitochondrial DNA deletion","volume":"1","author":"Ballinger","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib65","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1006\/exer.1998.0661","article-title":"Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells","volume":"68","author":"Ballinger","year":"1999","journal-title":"Exper. Eye Res."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib66","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0891-5849(00)00423-8","article-title":"Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damage to specific mitochondrial proteins","volume":"29","author":"Yan","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib67","doi-asserted-by":"crossref","first-page":"11853","DOI":"10.1073\/pnas.93.21.11853","article-title":"Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts","volume":"93","author":"MacMillan-Crow","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib68","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0076-6879(84)05013-8","article-title":"Superoxide dismutase assays","volume":"105","author":"Flohe","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib69","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0076-6879(96)69007-7","article-title":"Measuring nitric oxide and superoxide: rate constants for aconitase reactivity","volume":"269","author":"Hausladen","year":"1996","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib70","doi-asserted-by":"crossref","first-page":"R431","DOI":"10.1152\/ajpregu.00361.2003","article-title":"Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations","volume":"286","author":"Tarpey","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib71","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.abb.2003.08.033","article-title":"Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration","volume":"421","author":"Castro","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib72","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/hc0702.103977","article-title":"Cigarette smoke exposure and hypercholesterolemia increase mitochondrial damage in cardiovascular tissues","volume":"105","author":"Knight-Lozano","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib73","doi-asserted-by":"crossref","first-page":"21409","DOI":"10.1074\/jbc.M909978199","article-title":"Cytochrome c nitration by peroxynitrite","volume":"275","author":"Cassina","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib74","doi-asserted-by":"crossref","first-page":"29781","DOI":"10.1074\/jbc.M200709200","article-title":"Protein oxidation of cytochrome c by reactive halogen species enhances its peroxidase activity","volume":"277","author":"Chen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib75","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/jmcc.2000.1276","article-title":"Increased sensitivity of mitochondrial respiration to inhibition by nitric oxide in cardiac hypertrophy","volume":"33","author":"Brookes","year":"2001","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib76","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0006-2952(95)02011-Z","article-title":"Redox signaling by transcription factors NF-\u03baB and AP-1 in lymphocytes","volume":"50","author":"Schulze-Osthoff","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib77","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1126\/science.8367725","article-title":"NF-kappa B activation by ultraviolet light not dependent on a nuclear signal","volume":"261","author":"Devary","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib78","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2307\/3578574","article-title":"Induction of nuclear factor \u03baB after low-dose ionizing radiation involves a reactive oxygen intermediate signaling pathway","volume":"140","author":"Mohan","year":"1994","journal-title":"Rad. Res."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib79","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1002\/j.1460-2075.1993.tb05978.x","article-title":"Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF","volume":"12","author":"Schulze-Osthoff","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib80","article-title":"Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling","author":"Chen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib81","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/01.CIR.0000023921.93743.89","article-title":"Mitochondrial integrity and function in atherogenesis","volume":"106","author":"Ballinger","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib82","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1177\/153537020122600510","article-title":"High glucose concentrations induce oxidative damage to mitochondrial DNA in explanted vascular smooth muscle cells","volume":"226","author":"Li","year":"2001","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib83","doi-asserted-by":"crossref","first-page":"42468","DOI":"10.1074\/jbc.M101419200","article-title":"Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway","volume":"276","author":"Yao","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib84","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1161\/01.RES.0000051886.43510.90","article-title":"Oxidized LDL promotes peroxide mediated mitochondrial dysfunction and cell death in human macrophages","volume":"92","author":"Asmis","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib85","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00796524","article-title":"Exposure of rats to low concentrations of cigarette smoke increases myocardial sensitivity to ischaemia\/reperfusion","volume":"87","author":"van Jaarsveld","year":"1992","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib86","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/cvr\/18.4.229","article-title":"Smoke cardiomyopathy: disturbance of oxidative processes in myocardial mitochondria","volume":"18","author":"Gvozdjakova","year":"1984","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib87","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0921-8734(92)90021-G","article-title":"Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease","volume":"275","author":"Corral-Debrinski","year":"1992","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib88","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1001\/jama.1991.03470130092035","article-title":"Hypoxemia is associated with mitochondrial DNA damage and gene induction: implications for cardiac disease","volume":"266","author":"Corral-Debrinski","year":"1991","journal-title":"JAMA"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib89","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1749-6632.2002.tb04798.x","article-title":"Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice","volume":"977","author":"Aliev","year":"2002","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib90","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/01.RES.88.5.529","article-title":"Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction","volume":"88","author":"Ide","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib91","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1006\/jmcc.1998.0789","article-title":"Overexpression of MnSOD protects against myocardial ischemia\/reperfusion injury in transgenic mice","volume":"30","author":"Chen","year":"1998","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib92","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1161\/hc0802.104502","article-title":"Postischemic recovery of contractile function is impaired in SOD2 (+\/\u2212) but not SOD1 (+\/\u2212) mouse hearts","volume":"105","author":"Asimakis","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib93","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/01.CIR.0000051722.66074.60","article-title":"Protective role of uncoupling protein 2 in atherosclerosis","volume":"107","author":"Blanc","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib94","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1161\/01.RES.0000085581.60197.4D","article-title":"Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes","volume":"93","author":"Teshima","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib95","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0022-2828(03)00147-0","article-title":"Stable transfection of UCP1 confers resistance to hypoxia\/reoxygenation in a heart-derived cell line","volume":"35","author":"Bienengraeber","year":"2003","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib96","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nature03527","article-title":"Vascular respiratory uncoupling increases blood pressure and atherosclerosis","volume":"435","author":"Bernal-Mizrachi","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib97","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1161\/01.ATV.0000019404.65403.71","article-title":"Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice","volume":"22","author":"Bernal-Mizrachi","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib98","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/01.RES.0000149564.49410.0d","article-title":"Retardation of atherosclerosis by overexpression of catalase or both Cu\/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E","volume":"95","author":"Yang","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib99","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1161\/01.CIR.0000149747.82157.01","article-title":"Prenatal environmental tobacco smoke exposure promotes adult atherogenesis and mitochondrial damage in apoE\u2212\/\u2212 mice fed a chow diet","volume":"110","author":"Yang","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib100","first-page":"47","article-title":"The effect of smoking on myocardial metabolism","volume":"10","author":"Gvozdjak","year":"1987","journal-title":"Czech. Med."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib101","first-page":"81","article-title":"Effect of smoking on the oxidative processes of cardiomyocytes","volume":"1992","author":"Gvozdjakova","year":"1992","journal-title":"Cardiology"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib102","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/10715769209079518","article-title":"Antioxidant vitamin supplementation of smoke exposed rats partially protects against myocardial ischemic\/reperfusion injury","volume":"17","author":"van Jaarsveld","year":"1992","journal-title":"Free Radic. Res. Commun."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib103","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1001\/archinte.1989.00390020096020","article-title":"Passive smoking affects endothelium and platelets","volume":"149","author":"Davis","year":"1989","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib104","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/biof.5520100107","article-title":"Captopril increased mitochondrial coenzyme Q10 level, improved respiratory chain function and energy production in the left ventricle in rabbits with smoke mitochondrial cardiomyopathy","volume":"10","author":"Gvozdjakova","year":"1999","journal-title":"BioFactors"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib105","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1161\/01.CIR.90.3.1363","article-title":"Inhalation of steady-state sidestream smoke from one cigarette promotes atherosclerotic plaque development","volume":"90","author":"Penn","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib106","doi-asserted-by":"crossref","first-page":"H1293","DOI":"10.1152\/ajpheart.2001.280.3.H1293","article-title":"Effects of tobacco smoke and benzo[a]pyrene on human endothelial cell and monocyte stress responses","volume":"280","author":"Vayssier-Taussat","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib107","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0021-9150(01)00581-0","article-title":"Differential expression of ribosomal L31, Zis, gas-5 and mitochondrial mRNAs following oxidant induction of proliferative vascular smooth muscle cell phenotypes","volume":"160","author":"Lu","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib108","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/15287399409531918","article-title":"Protective role of manganese superoxide dismutase against cigarette smoke-induced cytotoxicity","volume":"43","author":"St Clair","year":"1994","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib109","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/01.HYP.0000115922.98155.23","article-title":"Childhood blood pressure as a predictor of arterial stiffness in young adults \u2013 the Bogalusa Heart Study","volume":"43","author":"Li","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib110","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1161\/01.ATV.20.3.836","article-title":"Effects of coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery","volume":"20","author":"McGill","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib111","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1161\/01.RES.36.5.579","article-title":"Intimal ultrastructure of human umbilical arteries","volume":"36","author":"Asmussen","year":"1975","journal-title":"Circ. Res."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib112","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1001\/jama.290.17.2277","article-title":"Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: The cardiovascular risk in young Finns study","volume":"290","author":"Raitakari","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib113","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s00428-005-1224-4","article-title":"Early atherosclerotic lesions in infancy: role of parental cigarette smoking","volume":"447","author":"Matturri","year":"2005","journal-title":"Virchows Archiv."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib114","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S0735-1097(98)00217-4","article-title":"In-utero and neonatal exposure to secondhand smoke causes vascular dysfunction in newborn rats","volume":"32","author":"Hutchison","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib115","article-title":"Oxidant stress regulates basal endothelin-1 production by cultured rat pulmonary endothelial cells","volume":"273","author":"Michael","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib116","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1016\/S0735-1097(97)00364-1","article-title":"Effects of second-hand smoke and gender on infarct size of young rats exposed in utero and in the neonatal to adolescent period","volume":"30","author":"Zhu","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib117","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1373\/clinchem.2005.055798","article-title":"Biological determinants of an reference vaules for plasma interleukin-8, monocyte chemoattractant protein-1, epidermal growth factor, and vascular endothelial growth factor: results from the STANISLAS cohort","volume":"52","author":"Berrahmoune","year":"2006","journal-title":"Clin. Chem."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib118","doi-asserted-by":"crossref","first-page":"E171","DOI":"10.1152\/ajpendo.00260.2003","article-title":"Maternal smoking is associated with mitochondrial DNA depletion and respiratory chain complex III deficiency in placenta","volume":"288","author":"Bouhours-Nouet","year":"2005","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib119","first-page":"3046","article-title":"32P-Postlabeling assay in mice of transplacental DNA damage induced by the environmental carcinogens safrole, 4-aminobiphenyl, and benzo(a)pyrene","volume":"46","author":"Lu","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib120","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0891-5849(90)90152-9","article-title":"Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?","volume":"8","author":"Bandy","year":"1990","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib121","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0741-5214(86)90046-7","article-title":"On the arterial consequences of smoking","volume":"3","author":"Couch","year":"1986","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib122","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1161\/01.CIR.0000013090.96919.FA","article-title":"Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray","volume":"105","author":"Napoli","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib123","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1196\/annals.1322.030","article-title":"Estrogen's effects on mitochondrial gene expression: mechanisms and potential contributions to estrogen carcinogenesis","volume":"1028","author":"Chen","year":"2004","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib124","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/jcb.20178","article-title":"Binding of MCF-7 cell mitochondrial proteins and recombinant human estrogen receptors alpha and beta to human mitochondrial DNA estrogen response elements","volume":"93","author":"Chen","year":"2004","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib125","doi-asserted-by":"crossref","first-page":"E1011","DOI":"10.1152\/ajpendo.00508.2003","article-title":"Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells","volume":"286","author":"Chen","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mrfmmm.2007.02.010_bib126","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.mehy.2003.12.056","article-title":"Mitochondrial signals to nucleus regulate estrogen-induced cell growth","volume":"64","author":"Felty","year":"2005","journal-title":"Med. Hypotheses"}],"container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510707000905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510707000905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T05:43:40Z","timestamp":1764740620000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0027510707000905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":126,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0027510707000905"],"URL":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2007.02.010","relation":{},"ISSN":["1386-1964"],"issn-type":[{"value":"1386-1964","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of tobacco smoke induced mitochondrial damage in vascular dysfunction and atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2007.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}